Abstract:
:Pre- and post transplant sera from 51 cases of bone marrow transplants performed for severe aplastic anemia were tested on monocytes (M) and corresponding B cells (B) from a panel of unrelated donors. One-third of the sera were cytotoxic for B and M either from different or from the same individuals, while 45% reacted only to M and appeared to recognize non-HLA M-associated antigens. No significant reaction to endothelial cells was obtained from these sera. The subsequent clinical course was not associated with any reaction pattern of pre-transplant sera. There was a significant relationship between rejection and the development of M antibodies after grafting, but since these were also found in many other patients without rejection, their occurrence has no predictive value for an individual patient.
journal_name
Transplantationjournal_title
Transplantationauthors
Gluckman JC,Gluckman E,Azogui O,Guillet J,Baldwin WM,Devergie A,Chapuis F,Brisson E,Andersen E,Dausset Jdoi
10.1097/00007890-198206000-00006subject
Has Abstractpub_date
1982-06-01 00:00:00pages
599-602issue
6eissn
0041-1337issn
1534-6080journal_volume
33pub_type
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