Biopsy diagnosis and clinical outcome of persistent focal pulmonary lesions after marrow transplantation.

Abstract:

:We reviewed the results of all percutaneous fine needle aspirations (FNA) and open lung biopsies (OLB) after bone marrow transplantation at our center (1984-1987) for the evaluation of focal lung lesions that developed or persisted despite antibiotic administration. We sought to determine the prevalence and types of infections, the yield of diagnostic procedures, and the clinical outcome of these focal lesions. Infection was documented in 78% (18/23) of all lesions and was fungal in each case. FNA detected fungal lung infection with a sensitivity of 67% (10/15) but had a negative predictive value of only 50% (5/10). Complications occurred in 15% of FNA. OLB without prior FNA was performed in 6 cases and demonstrated fungal infections in 5. Overall, seven of the 18 patients with localized invasive fungal lung disease recovered after antifungal therapy. This study demonstrates that focal lung lesions that develop or persist despite antibiotics after BMT are most often fungal. FNA may safely identify these localized infections in selected patients and with appropriate treatment recovery may be achieved.

journal_name

Transplantation

journal_title

Transplantation

authors

Crawford SW,Hackman RC,Clark JG

doi

10.1097/00007890-198908000-00017

subject

Has Abstract

pub_date

1989-08-01 00:00:00

pages

266-71

issue

2

eissn

0041-1337

issn

1534-6080

journal_volume

48

pub_type

杂志文章
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    abstract:BACKGROUND:The effective use of new steroid-sparing immunosuppressive regimens may lower cumulative glucocorticoid use among renal transplant recipients. However, it is unknown what effect this therapeutic trend has had on bone disease. METHODS:Unselected newly transplanted inpatients (n=45) were identified and compre...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-200301150-00009

    authors: Mikuls TR,Julian BA,Bartolucci A,Saag KG

    更新日期:2003-01-15 00:00:00

  • Alpha-glutathione-S-transferase in acute rejection of liver transplant recipients.

    abstract:BACKGROUND:Alpha-glutathione-S-transferase (alphaGST) has been suggested as a sensitive marker of acute cellular rejection in liver transplantation. This study evaluated the usefulness of alphaGST as a marker of acute rejection in comparison with standard liver function tests. METHODS:Daily measurements of liver funct...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199802150-00019

    authors: Nagral A,Butler P,Sabin CA,Rolles K,Burroughs AK

    更新日期:1998-02-15 00:00:00

  • Characterization of rabbit antithymocyte globulins-induced CD25+ regulatory T cells from cells of patients with end-stage renal disease.

    abstract::BACKGROUND.: Rabbit antithymocyte globulins (rATGs) are known to convert CD4CD25FoxP3 T cells from healthy individuals to CD4CD25FoxP3 T cells. In this study, we investigated the effect of rATG on the induction of regulatory T cells (Tregs) from blood cells of patients with end-stage renal disease who are candidates f...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0b013e3181c9cc7a

    authors: Sewgobind VD,van der Laan LJ,Kho MM,Kraaijeveld R,Korevaar SS,van Dam T,Ijzermans JN,Weimar W,Baan CC

    更新日期:2010-03-27 00:00:00

  • Accommodation: does it apply to human leukocyte antigens?

    abstract::The term "accommodation" was invoked to describe endothelial cell resistance to antibody-mediated rejection after ABO-incompatible kidney or experimental xenograft transplantation. Currently, there is much interest in how to achieve successful human leukocyte antigen (HLA)-incompatible allograft transplantation in HLA...

    journal_title:Transplantation

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    doi:10.1097/TP.0b013e31823f468c

    authors: Rose ML,West LJ

    更新日期:2012-02-15 00:00:00

  • Initial liver involvement in acute GVHD is predictive for nonrelapse mortality.

    abstract:BACKGROUND:Current grading systems in acute graft-versus-host disease (GVHD) are not able to identify patients with poor prognosis at time of onset, because they take into account maximal grade. The aim of this study was to evaluate potential predictors for overall survival at disease onset. METHODS:The study sample w...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0b013e3181bc2583

    authors: Robin M,Porcher R,de Castro R,Fisher G,de Latour RP,Ribaud P,Petropoulou AD,Rocha V,Devergie A,Mary JY,Socié G

    更新日期:2009-11-15 00:00:00

  • Long-term outcome of controlled, non-heart-beating donor liver transplantation.

    abstract:BACKGROUND:Previous reports have established the feasibility of using livers from controlled, non-heart-beating donors (CNHBD) with good immediate graft function. This has been largely borne out of necessity because of the donor shortage. METHODS:Retrospective database review for the last 7 years (1995-2002), encompas...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/01.tp.0000128327.95311.e3

    authors: Manzarbeitia CY,Ortiz JA,Jeon H,Rothstein KD,Martinez O,Araya VR,Munoz SJ,Reich DJ

    更新日期:2004-07-27 00:00:00

  • Sotrastaurin (AEB071) alone and in combination with cyclosporine A prolongs survival times of non-human primate recipients of life-supporting kidney allografts.

    abstract:BACKGROUND:Sotrastaurin (STN), a novel oral protein kinase C inhibitor that inhibits early T-cell activation, was assessed in non-human primate recipients of life-supporting kidney allografts. METHODS:Cynomolgus monkey recipients of life-supporting kidney allografts were treated orally with STN alone or in combination...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0b013e31823cf92f

    authors: Bigaud M,Wieczorek G,Beerli C,Audet M,Blancher A,Heusser C,Morris RE,Wagner J

    更新日期:2012-01-27 00:00:00

  • The effect of mismatching for HLA-DR in recipients of renal allografts sharing one HLA-ABC haplotype with related donors.

    abstract::The effects of mismatching for DR antigens on renal allograft survival rates have largely been restricted to analyses of cadaver transplant results. Analyses of HLA matching in recipients of transplants from related donors have focused on the number of haplotypes shared between the recipients without regard to DR, or ...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-198336060-00011

    authors: Sutherland DE,Morrow CE,Kaufman D,Fryd DS,Najarian JS,Burke M,Noreen H,Segall M,Bach FH

    更新日期:1983-12-01 00:00:00

  • First in man renal transplantation after ex vivo normothermic perfusion.

    abstract:BACKGROUND:Normothermic perfusion is an alternative but little studied method of organ preservation. Herein, we report the first case of ex vivo normothermic renal transplant perfusion in man. METHODS:The 62-year-old extended criteria donor died of an intracranial hemorrhage and had undergone cardiopulmonary resuscita...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0b013e31822d4e04

    authors: Hosgood SA,Nicholson ML

    更新日期:2011-10-15 00:00:00

  • Pulmonary hemorrhage as a cause of death in allogeneic bone marrow recipients with severe acute graft-versus-host disease.

    abstract::Acute graft-versus-host disease (GVHD) has recently been associated with endothelial cell injury. The potential clinical significance was explored here in an autopsy review. Thirty-seven allogeneic bone marrow recipients were identified in the autopsy files at The Johns Hopkins Hospital with no evidence of systemic in...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199401000-00016

    authors: Wojno KJ,Vogelsang GB,Beschorner WE,Santos GW

    更新日期:1994-01-01 00:00:00

  • Kidney transplantation from small pediatric donors: does recipient body mass index matter?

    abstract:BACKGROUND:The influence of recipient body mass index (BMI) on pediatric-donor kidney transplant outcomes is unclear. We aimed to determine graft survival and functional outcomes of pediatric-donor kidneys compared with adult kidneys stratified by recipient BMI group. METHODS:Scientific Registry of Transplant Recipien...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0b013e318241d57d

    authors: Kayler LK,Zendejas I,Gregg A,Wen X

    更新日期:2012-02-27 00:00:00

  • Effect of poverty and other socioeconomic variables on renal allograft survival.

    abstract:BACKGROUND:Socioeconomic variables including low income and noncompliance impact negatively upon long-term renal allograft survival, especially in African Americans. We sought to determine whether other socioeconomic variables contributed to noncompliance and allograft survival. METHODS:A detailed history of socioecon...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-200107270-00017

    authors: Butkus DE,Dottes AL,Meydrech EF,Barber WH

    更新日期:2001-07-27 00:00:00

  • Tolerance induction in a fully allogeneic combination using anti-T cell receptor-alpha beta monoclonal antibody, low dose irradiation, and donor bone marrow transfusion.

    abstract::In a murine strain combination disparate in both H-2 antigens and minor histocompatibility antigens consisting of C57BL/6 (B6; H-2b, Mls-1b) mice as recipients and AKR/J (AKR; H-2k, Mls-1a) mice as donors, we reported that the administration of anti-TCR-alpha beta mAb nonspecifically suppresses the ability to reject a...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:

    authors: Nomoto K,Yung-Yun K,Omoto K,Umesue M,Murakami Y,Matsuzaki G,Nomoto K

    更新日期:1995-02-15 00:00:00

  • De novo sirolimus-based immunosuppression after liver transplantation for hepatocellular carcinoma: long-term outcomes and side effects.

    abstract:BACKGROUND:We report long-term outcomes and side effects after transplantation for hepatocellular carcinoma (HCC) using de novo, sirolimus-based immunosuppression (IS). METHODS:A total of 70 patients with HCC (mean age: 54.4+/-7 years, female/male: 12/58) were transplanted and included in the study. Immunosuppression ...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/01.tp.0000262607.95372.e0

    authors: Toso C,Meeberg GA,Bigam DL,Oberholzer J,Shapiro AM,Gutfreund K,Ma MM,Mason AL,Wong WW,Bain VG,Kneteman NM

    更新日期:2007-05-15 00:00:00

  • Liver transplantation using an organ donor with HELLP syndrome.

    abstract:BACKGROUND:The shortage of organs for liver transplantation has forced transplant centers to expand the donor pool by using donors traditionally labeled as marginal. One such example is liver transplantation using a donor with HELLP syndrome (hemolysis, elevated liver enzymes, and low platelets), a disorder of late pre...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/01.TP.0000101510.01404.F0

    authors: Briceno PJ,Ortiz JA,Manzarbeitia C,Jeon H,Munoz SJ,Rothstein KD,Araya V,Gala I,Reich DJ

    更新日期:2004-01-15 00:00:00

  • Peripheral blood gene expression analysis in intestinal transplantation: a feasibility study for detecting novel candidate biomarkers of graft rejection.

    abstract:INTRODUCTION:We investigated the putative candidate biomarkers of graft rejection in peripheral blood of intestinal transplant patients. MATERIALS AND METHODS:Peripheral blood gene expression analysis was performed in intestinal transplant patients. The results were matched with concurrent graft biopsies using bioinfo...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0b013e3182370db1

    authors: Andreev VP,Tryphonopoulos P,Blomberg BB,Tsinoremas N,Weppler D,Neuman DR,Volsky A,Nishida S,Tekin A,Selvaggi G,Levi DM,Tzakis AG,Ruiz P

    更新日期:2011-12-27 00:00:00

  • Successful retreatment of allograft rejection with OKT3.

    abstract::OKT3 is a murine monoclonal antibody to the CD3 antigen of human T lymphocytes. The production of human antimurine antibodies after treatment with OKT3 has been perceived as a major limitation to its extended use and reuse. Treatment of 142 patients with 168 courses of OKT3 resulted in the development of antimouse ant...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-198901000-00020

    authors: First MR,Schroeder TJ,Hurtubise PE,Mansour ME,Penn I,Munda R,Balistreri WF,Alexander JW,Melvin DB,Fidler JP

    更新日期:1989-01-01 00:00:00

  • Evolution of attitudes at U.S. transplant centers toward kidney donation by friends and altruistic strangers.

    abstract::A severe shortage of organs is one of the major barriers facing transplantation today. One of the proposals designed to overcome this serious problem is to increase the use of genetically unrelated living kidney donors. Excellent results have been achieved with these volunteers and cogent arguments have been made that...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-200004270-00035

    authors: Spital A

    更新日期:2000-04-27 00:00:00

  • The association of kidney graft outcome with pretransplant serum IgG-anti-F(ab')2 gamma activity.

    abstract::Pretransplant sera of 474 kidney graft recipients were tested for IgG-anti-F(ab')2 gamma activity. The patients had significantly higher IgG-anti-F(ab')2 gamma activity than healthy controls (P = 0.0004). Serum lymphocytotoxic antibodies were correlated with IgG-anti-F(ab')2 gamma (P = 0.004), whereas CMV infection an...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199210000-00012

    authors: Süsal C,Groth J,Oberg HH,Terness P,May G,Opelz G

    更新日期:1992-10-01 00:00:00

  • Ethnically diverse populations and their participation in living kidney donation programs.

    abstract:BACKGROUND:The number of living donor kidney transplantations increases steeply in Europeans, whereas the non-Europeans are dependent on deceased donor transplantations. We wondered whether a low attendance or a high decline of potential non-European donors could explain this difference. METHODS:This retrospective stu...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0b013e3181d84ca7

    authors: Roodnat JI,van de Wetering J,Zuidema W,van Noord MA,Kal-van Gestel JA,Ijzermans JN,Weimar W

    更新日期:2010-05-27 00:00:00

  • Incidence of tuberculosis in deceased-organ donors and transmission risk to recipients in Spain.

    abstract:BACKGROUND:Globalization and migration patterns have increased the number of donors from countries with high incidence rates of tuberculosis (TB) in low incidence countries, with the subsequent increase in risk of TB transmission to the recipients. METHODS:Retrospective cohort study, including all actual deceased dono...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0b013e3182977adf

    authors: Coll E,Torre-Cisneros J,Calvo R,Garrido G,Matesanz R

    更新日期:2013-07-27 00:00:00

  • Xenoantisera to allotypic specificities of HLA-A and B antigens. Serological characterization.

    abstract::By using the lysostrip and the blocking of cytotoxicity by Fab2 fragments, HLA-A and B antibodies were detected in sera from rabbits and goats immunized with human high-density lipoprotein (HDL)-associated HLA antigens isolated from sera and from cultured lymphoid cells. After appropriate absorptions, the xenoantisera...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-197910000-00014

    authors: Richiardi P,Pellegrino MA,Ferrone S

    更新日期:1979-10-01 00:00:00

  • Improvement of donor myocardial function after treatment of autonomic storm during brain death.

    abstract:BACKGROUND:In experimental brain death models, autonomic storm (AS) triggers severe myocardial dysfunction, which can be attenuated by pharmacologic treatment. The aim of this study was to determine the incidence of AS in a cohort of human organ donors and to evaluate the potential interest of AS treatment on myocardia...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/01.tp.0000235825.97538.d5

    authors: Audibert G,Charpentier C,Seguin-Devaux C,Charretier PA,Grégoire H,Devaux Y,Perrier JF,Longrois D,Mertes PM

    更新日期:2006-10-27 00:00:00

  • Financial Feasibility Analysis of a Culturally and Linguistically Competent Hispanic Kidney Transplant Program.

    abstract:BACKGROUND:In 2006, Northwestern Medicine implemented a culturally targeted and linguistically congruent Hispanic Kidney Transplant Program (HKTP). The HKTP has been associated with a reduction in Hispanic/Latino disparities in live donor kidney transplantation. This paper assessed the financial feasibility of implemen...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0000000000003269

    authors: Wang A,Caicedo JC,McNatt G,Abecassis M,Gordon EJ

    更新日期:2020-04-09 00:00:00

  • The high incidence of BK polyoma virus infection among renal transplant recipients in India.

    abstract::BK polyoma virus causes allograft dysfunction as a result of tubulo-interstitial nephritis in 2% to 5% of renal transplant recipients. The incidence of BK virus infection among renal transplant recipients in India is unknown. We used routine histologic examination, immunohistochemistry, and electron microscopy to retr...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/01.TP.0000113163.02039.30

    authors: Sachdeva MS,Nada R,Jha V,Sakhuja V,Joshi K

    更新日期:2004-02-15 00:00:00

  • The successful allotransplantation of neonatal rat islets across multiple combined major and minor histocompatibility barriers.

    abstract::Cultured neonatal rat islets were transplanted across six strain combinations into nonimmunosuppressed allogeneic recipients. Islets were isolated nonenzymatically by an in vitro method and were cultured at 37 degrees C in 5% CO2 in air for 10 days prior to transplant. Transplants to nondiabetic recipients across four...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-198712000-00003

    authors: Serie JR,Hegre OD,Eide CR,Weinhaus AJ,Marshall S

    更新日期:1987-12-01 00:00:00

  • T-cell and major histocompatibility complex requirements for obliterative airway disease in heterotopically transplanted murine tracheas.

    abstract:BACKGROUND:One third of human lung allografts develop chronic rejection manifested as obliterative bronchiolitis. Heterotopically transplanted allogeneic murine tracheas develop obliterative airway disease (OAD) leading to a lesion resembling human obliterative bronchiolitis. The purpose of this study was to determine ...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199809270-00011

    authors: Kelly KE,Hertz MI,Mueller DL

    更新日期:1998-09-27 00:00:00

  • Fifty-percent partial liver transplantation in the rat.

    abstract::Reduced-size liver transplantation in the rat has been useful in the study of hepatic regeneration. We describe a modified technique for partial liver transplantation in the rat using a 50% reduced-size graft. Male Lewis rats (RT1(1)), weighing 250 to 280 g, were used as donors and recipients. The harvested donor live...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199607270-00023

    authors: Omura T,Ascher NL,Emond JC

    更新日期:1996-07-27 00:00:00

  • Prolongation of liver allograft survival after interleukin-10 gene transduction 24-48 hours before donation.

    abstract:BACKGROUND:Interleukin- (IL) 10 may be a potent regulator for controlling of allograft rejection. A single administration of IL-10 is not effective for controlling graft rejection. Gene transfer is an attractive vehicle for prolonging the expression of short-lived proteins. METHODS:Donor or recipient livers were trans...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-200007270-00018

    authors: Tashiro H,Shinozaki K,Yahata H,Hayamizu K,Okimoto T,Tanji H,Fudaba Y,Yamamoto H,Fan X,Ito H,Asahara T

    更新日期:2000-07-27 00:00:00

  • 3-[(dodecylthiocarbonyl)methyl]-glutarimide attenuates graft arterial disease by suppressing alloimmune responses and vascular smooth muscle cell proliferation.

    abstract:BACKGROUND:Graft arterial disease (GAD) is a major cause of late graft loss after organ transplantation. Alloimmune responses and vascular remodeling eventually cause the transplant organ to develop GAD. In this study, we aimed to limit the development of GAD by inhibiting alloimmune responses and vascular smooth muscl...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0000000000000576

    authors: Zaitsu M,Yamashita K,Shibasaki S,Tsunetoshi Y,Fukai M,Ogura M,Yoshida T,Igarashi R,Kobayashi N,Umezawa K,Todo S

    更新日期:2015-05-01 00:00:00