Response to varicella immunization in pediatric liver transplant recipients.

abstract：:We report the successful application of a hybrid artificial pancreas device for the treatment of severe diabetes mellitus induced by total pancreatectomy in two dogs. Control of the blood sugar was achieved for more than 1 year in these two animals without any immunosuppressive therapy. Although exogenous insulin was ...

journal_title：Transplantation

authors： Maki T,Lodge JP,Carretta M,Ohzato H,Borland KM,Sullivan SJ,Staruk J,Muller TE,Solomon BA,Chick WL

更新日期：1993-04-01 00:00:00

abstract：BACKGROUND:Guillain-Barre Syndrome (GBS) is believed to be caused by autoimmune mechanisms that are predominantly T-cell mediated. We report GBS in organ transplant patients and bone marrow transplant patients, both of whom have iatrogenically suppressed T-cell function. METHODS:We reviewed the Duke University Medical...

journal_title：Transplantation

authors： Bulsara KR,Baron PW,Tuttle-Newhall JE,Clavien PA,Morgenlander J

更新日期：2001-04-27 00:00:00

abstract：BACKGROUND:Deceased donor kidneys with acute kidney injury (AKI) and deceased after circulatory death kidneys are viable sources of organs. The outcomes of renal transplantation from deceased after circulatory death (DCD) donors with AKI are not known. METHODS:A retrospective review of deceased donor renal transplants...

journal_title：Transplantation

authors： Lia D,Singer P,Nair V,Yang J,Teperman L,Grodstein E

更新日期：2020-05-15 00:00:00

abstract：:Acute rejection (AR) remains the biggest challenge during the first year after heart transplantation despite advances in immunosuppressive therapy. The early detection and curbing of AR are crucial to the survival of transplant recipients. However, as the criterion standard for AR, endomyocardial biopsy has several li...

journal_title：Transplantation

authors： Chen Y,Zhang L,Liu J,Zhang P,Chen X,Xie M

更新日期：2017-09-01 00:00:00

abstract：BACKGROUND:Cold preservation is the most practical method to maintain the viability of isolated lungs. However, rapid cooling may affect pulmonary endothelial function. We examined the effects of microtubule stabilization with paclitaxel on pulmonary endothelial barrier integrity under cold temperature. METHODS:Human ...

journal_title：Transplantation

authors： Suzuki S,Bing H,Sugawara T,Matsuda Y,Tabata T,Hoshikawa Y,Saijo Y,Kondo T

更新日期：2004-08-27 00:00:00

abstract：:Antithymocyte globulin (ATG) has been used successfully for induction therapy as well as for treatment of established allograft rejection. However, this therapy has often been associated with problems of overimmunosuppression and increased costs. In a randomized clinical trial, we compared the immunosuppressive benefi...

journal_title：Transplantation

authors： Abouna GM,al-Abdullah IH,Kelly-Sullivan D,Kumar MS,Loose J,Phillips K,Yost S,Seirka D

更新日期：1995-06-15 00:00:00

abstract：BACKGROUND:Mammalian target of rapamycin inhibitors may confer cardioprotective advantages, but clinical data are limited. METHODS:In the open-label ELEVATE trial, kidney transplant patients were randomized at 10 to 14 weeks after transplant to convert from calcineurin inhibitor (CNI) to everolimus or remain on standa...

journal_title：Transplantation

authors： Holdaas H,de Fijter JW,Cruzado JM,Massari P,Nashan B,Kanellis J,Witzke O,Gutierrez-Dalmau A,Turkmen A,Wang Z,Lopez P,Bernhardt P,Kochuparampil J,van der Giet M,Murbraech K,ELEVATE Study Group.

更新日期：2017-10-01 00:00:00

abstract：BACKGROUND:Intracellular concentration of reactive oxygen species is held within tight physiological limits by enzymes with scavenging and repair functions. Under extreme conditions such as prolonged cold ischemia, these enzymes may be unable to adequately protect the organ, resulting in reperfusion injury that renders...

journal_title：Transplantation

authors： St Peter SD,Imber CJ,Jones DC,Fuggle SV,Watson CJ,Friend PJ,Marshall SE

更新日期：2002-09-27 00:00:00

abstract：:Up-regulated expression of adhesion molecules on vascular endothelial cells (ECs) is an initial event in leukocyte adhesion to ECs, which is a crucial step in the process of inflammatory or immune reaction leading to organ transplant rejection. Verapamil and other calcium channel blockers have been reported to improve...

journal_title：Transplantation

authors： Yamaguchi M,Suwa H,Miyasaka M,Kumada K

更新日期：1997-03-15 00:00:00

abstract：BACKGROUND:Goal tacrolimus concentrations for the prevention of rejection in sensitized renal transplant recipients are not well established. METHODS:We evaluated the association between discharge tacrolimus trough concentration and the incidence of biopsy-proven acute rejection (BPAR) in 216 moderately sensitized ren...

journal_title：Transplantation

authors： Richards KR,Hager D,Muth B,Astor BC,Kaufman D,Djamali A

更新日期：2014-05-27 00:00:00

abstract：:Predictors of survival after lung transplant were analyzed in a large cohort of 990 lung transplanted patients from a single center. The overall survival was 41.6%, (41.5% in males, and 41.8% in females), the average length of the follow up was 45.84+/-51.98 months (range 0-282.47 months). Females tend to live longer ...

journal_title：Transplantation

authors： Creel M,Studer SM,Schwerha J,Harper J,Ortiz L,Ragin C,Taioli E

更新日期：2008-04-27 00:00:00

abstract：:The influence of methotrexate on the development of immunity to the line 10 hepatoma was studied in guinea pigs. Chronic methotrexate treatment had no apparent effect on the ability of immune guinea pigs to suppress the growth of inoculated tumor cells. In contrast, the same methotrexate regimen inhibited the developm...

journal_title：Transplantation

authors： Shu S,Fonseca LS,Hunter JT,Rapp HJ

更新日期：1983-01-01 00:00:00

abstract：BACKGROUND:The hepatic arteries (HAs) in a hepatic graft are usually reconstructed using the recipient's left or right HAs in living donor liver transplantation (LDLT). There have been no apparent selection criteria concerning which of the recipient's HAs should be used. This study retrospectively investigated whether ...

journal_title：Transplantation

authors： Uchiyama H,Ikegami T,Soejima Y,Ninomiya M,Kayashima H,Taketomi A,Shirabe K,Maehara Y

更新日期：2010-04-27 00:00:00

abstract：:Neither the presence nor the specific role of secretory cytokines in in vivo allograft rejection has been extensively studied. We quantitated the levels of colony-stimulating factors, tumor necrosis factor, and interleukin 1 within the rejecting allograft. BALB/c (H-2d) mice were implanted with polyurethane sponges co...

journal_title：Transplantation

authors： Ford HR,Hoffman RA,Wing EJ,Magee DM,McIntyre LA,Simmons RL

更新日期：1990-09-01 00:00:00

abstract：BACKGROUND:We previously reported that Lewis rat hearts transplanted into BALB/c mice developed typical acute vascular rejection (AVR). The present study was undertaken to determine the efficacy of LF15-0195, a new analogue of 15-deoxyspergualin, in the prevention of AVR and to determine whether a combination of LF15-0...

journal_title：Transplantation

authors： Wang H,Hosiawa KA,Garcia B,Shum JB,Dutartre P,Kelvin DJ,Zhong R

更新日期：2003-05-15 00:00:00

abstract：BACKGROUND:A successful kidney transplant from a living-related donor (LRD) remains the most effective renal replacement therapy for children with end-stage renal failure. The use of LRD kidneys results in decreased time on dialysis, increased graft survival, and better function compared with kidneys transplanted from ...

journal_title：Transplantation

authors： Ishitani M,Isaacs R,Norwood V,Nock S,Lobo P

更新日期：2000-07-27 00:00:00

abstract：:Two hundred twenty-eight patients from a total of 466 (49%) receiving renal allografts under cyclosporine/prednisone (CsA/Pred) immunosuppression experienced at least one episode of posttransplant hepatotoxicity. All patients were documented to have normal serum bilirubin, serum glutamic oxaloacetic transaminase (SGOT...

journal_title：Transplantation

authors： Lorber MI,Van Buren CT,Flechner SM,Williams C,Kahan BD

更新日期：1987-01-01 00:00:00

abstract：:The immunosuppressive effects of leflunomide and cyclosporine were evaluated in a rat neurovascularized myocutaneous allograft model. Inbred Brown-Norway and Lewis rats were served as donors and recipients, respectively. All recipients were observed for 60 days or until allograft rejection occurred. All isograft contr...

journal_title：Transplantation

authors： Yeh LS,Gregory CR,Griffey SM,Lecouteur RA,Morris RE

更新日期：1996-09-27 00:00:00

abstract：BACKGROUND:Delayed xenograft rejection (DXR) remains a roadblock to successful xenotransplantation. A feature of DXR is early recruitment of monocytes to the xenograft. Naïve human monocytes can recognize and adhere to unstimulated porcine aortic endothelial cells (PAEC) more than human aortic endothelial cells, partly...

journal_title：Transplantation

authors： Greenwald AG,Jin R,Waddell TK

更新日期：2009-01-15 00:00:00

abstract：BACKGROUND:Selective inhibition of lymphocyte activation through abrogation of signal 3-cytokine transduction emerges as a new strategy for immunosuppression. This is the first report on the novel Janus kinase (JAK)1/3 inhibitors R507 and R545 for prevention of acute allograft rejection. METHODS:Pharmacokinetic and in...

journal_title：Transplantation

authors： Deuse T,Hua X,Taylor V,Stubbendorff M,Baluom M,Chen Y,Park G,Velden J,Streichert T,Reichenspurner H,Robbins RC,Schrepfer S

更新日期：2012-10-15 00:00:00

abstract：:The mode of action of glucocorticosteroids as immunosuppressive and antiinflammatory agents is not fully understood. Glucocorticosteroids block synthesis of interleukin 1 by interfering with the transcription of the IL-1 beta gene. Glucocorticosteroids may also induce rapid degradation of IL-1 mRNA. In the presence of...

journal_title：Transplantation

authors： Zanker B,Walz G,Wieder KJ,Strom TB

更新日期：1990-01-01 00:00:00

abstract：:It was the objective of these experiments to study the time-related changes in the responsiveness of the cellular elements of the immune system following contact with single non-H-2 or multiple H-2 histocompatibility antigens. The reactivity of spleen cells from mice that received injections of spleen cells bearing H-...

journal_title：Transplantation

authors： Graff RJ,Kurtz ME,Russell H,Martin-Morgan D

更新日期：1988-02-01 00:00:00

abstract：BACKGROUND:Clinical studies suggest that the immunosuppressant mycophenolate mofetil is associated with anemia. However, the mechanism for this is not known. Here, we studied the effect of mycophenolic acid (MPA), the active metabolite of mycophenolate mofetil, on erythropoiesis in vitro. METHODS:Both UT-7 cells and p...

journal_title：Transplantation

authors： Pile T,Kieswich J,Harwood S,Yaqoob MM

更新日期：2011-12-27 00:00:00

abstract：BACKGROUND:Recently published pediatric trial of Rituximab for the treatment of CD20+ acute renal allograft rejection (AR) demonstrated transient depletion of circulating/intragraft B cells (Zarkhin et al., Am J Transplant 2008; 8: 2607). In this study, we have evaluated phenotypic definition of circulating B-cell subs...

journal_title：Transplantation

authors： Zarkhin V,Lovelace PA,Li L,Hsieh SC,Sarwal MM

更新日期：2011-05-15 00:00:00

abstract：BACKGROUND:To optimize the methods used for human islet isolation for transplantation, it is important to improve our understanding of the structure of the islet-exocrine interface. In this study, the composition of collagen subtypes in the interface have been characterized and quantified in human pancreas. METHODS:Hu...

journal_title：Transplantation

authors： Hughes SJ,Clark A,McShane P,Contractor HH,Gray DW,Johnson PR

更新日期：2006-02-15 00:00:00

abstract：BACKGROUND:Bone marrow transplantation (BMT) for class 3 patients with thalassemia is challenging due to high rates of graft rejection and transplant-related mortality. Since the first studies of BMT in the late 1980s, a number of conditioning regimens have been designed to improve outcomes, but with suboptimal results...

journal_title：Transplantation

authors： Gaziev J,Isgrò A,Sodani P,Marziali M,Paciaroni K,Gallucci C,De Angelis G,Andreani M,Testi M,Alfieri C,Ribersani M,Galluccio T,Battarra MR,Morrone A,Lucarelli G

更新日期：2016-04-01 00:00:00

abstract：:A non-complement-binding monoclonal antibody, TA-1, recognizing determinants on human T lymphocytes, was linked to the plant seed toxin ricin, either the intact molecule or purified ricin A chain. Peripheral blood lymphocytes were pretreated with conjugate for 2 hr, washed, and then measured in vitro for T cell prolif...

journal_title：Transplantation

authors： Vallera DA,Quinones RR,Azemove SM,Soderling CC

更新日期：1984-04-01 00:00:00

abstract：BACKGROUND:Solitary pancreas transplants, both pancreas transplant alone (PTA) and pancreas after kidney (PAK), have higher rejection rates and lower graft survivals than simultaneous pancreas-kidney transplants (SPK). The aim of this study is to compare three different antibody induction regimens in solitary pancreas ...

journal_title：Transplantation

authors： Stegall MD,Kim DY,Prieto M,Cohen AJ,Griffin MD,Schwab TR,Nyberg SL,Velosa JA,Gloor JM,Innocenti F,Bohorquez H,Dean PG,Carpenter HA,Leontovich ON,Sterioff S,Larson TS

更新日期：2001-11-27 00:00:00

abstract：BACKGROUND:U.S. allocation policies currently place less emphasis on human leukocyte antigen (HLA) matching in pediatric kidney transplant candidates to minimize dialysis time. The impact this may have on pediatric recipients after graft failure has not been extensively examined. METHODS:Using the Scientific Registry ...

journal_title：Transplantation

authors： Gralla J,Tong S,Wiseman AC

更新日期：2013-05-27 00:00:00

abstract：:Prominent components of vascularized xenograft rejection such as platelet activation and microvascular thrombosis may be dependent upon thrombin generation in vivo. To study potential therapeutic benefits of a synthetic low-molecular-weight thrombin inhibitor, SDZ MTH 958, in hyperacute porcine heart rejection by huma...

journal_title：Transplantation

authors： Robson SC,Young VK,Cook NS,Metternich R,Kasper-Konig W,Lesnikoski BA,Pierson RN 3rd,Hancock WW,Candinas D,White DJ,Bach FH

更新日期：1996-03-27 00:00:00