Fine specificity and idiotype diversity of the murine anti-HLA-A2, A28 monoclonal antibodies CR11-351 and KS1.

abstract：BACKGROUND:In a recent trial, targeted mild hypothermia in brain-dead organ donors significantly reduced the incidence of delayed graft function after kidney transplantation. This trial was stopped early for efficacy. Here, we report long-term graft survival for all organs along with donor critical care end points. ME...

journal_title：Transplantation

authors： Malinoski D,Patel MS,Axelrod DA,Broglio K,Lewis RJ,Groat T,Niemann CU

更新日期：2019-11-01 00:00:00

abstract：:The levels of HLA-A and -B antigens expressed by placenta have been assessed relative to parental and other A and B antigen types that were not shared by the foetus. A purified preparation of placenta plasma membrane was used to estimate the antigen activities. The results indicate that maternally and paternally inher...

journal_title：Transplantation

authors： Goodfellow PN,Barnstable CJ,Bodmer WF,Snary D,Crumpton MJ

更新日期：1976-12-01 00:00:00

abstract：BACKGROUND:Combined lung and liver transplantation (Lu-LTx) is a therapeutic option for selected patients with coexisting lung and liver disease. For several reasons, Lu-LTx is performed in few centers and information about the technical issues, posttransplant management and long-term outcomes associated with this proc...

journal_title：Transplantation

authors： Grannas G,Neipp M,Hoeper MM,Gottlieb J,Lück R,Becker T,Simon A,Strassburg CP,Manns MP,Welte T,Haverich A,Klempnauer J,Nashan B,Strueber M

更新日期：2008-02-27 00:00:00

abstract：:Pulmonary thrombus formation in the region of atrial anastomosis following lung transplantation has been reported by several authors. Such patients typically present immediately after surgery with significant hemodynamic compromise causing pulmonary edema and hypoxemia. We describe a patient who presented with bilater...

journal_title：Transplantation

authors： Stang MR,Hinderliter AL,Gott KK,Paradowski LJ,Aris RM

更新日期：1996-09-15 00:00:00

abstract：BACKGROUND:This study investigated the use of deceased heart-beating donor livers offered for transplantation during a 10-year period, during which there has been an increasing disparity between organ supply and demand in the United Kingdom. METHODS:Summary data from the National Transplant Database were analyzed on a...

journal_title：Transplantation

authors： Devey LR,Friend PJ,Forsythe JL,Mumford LL,Wigmore SJ

更新日期：2007-07-15 00:00:00

abstract：:In keeping with the in vitro mitogenic properties of anti-CD3 MoAbs, the first injections of anti-CD3 are invariably responsible for an in vivo cellular activation. This activation induces a massive cytokine release in the circulation (TNF, IFN gamma, IL-2, IL-6, and IL-3). Paralleling this release, a severe clinical ...

journal_title：Transplantation

authors： Ferran C,Dy M,Merite S,Sheehan K,Schreiber R,Leboulenger F,Landais P,Bluestone J,Bach JF,Chatenoud L

更新日期：1990-10-01 00:00:00

abstract：:First cadaver, unrelated kidney graft survival at one year from 50 Eurotransplant centers was analyzed and found to show marked changes in survival rates over the 20-year period from 1967 to 1986 inclusive. Full information on HLA-A, -B, and -DR matching and use of cyclosporine therapy was only available for the perio...

journal_title：Transplantation

authors： Thorogood J,van Houwelingen JC,van Rood JJ,Persijn GG

更新日期：1988-11-01 00:00:00

abstract：BACKGROUND:Tolerogenic dendritic cells (Tol-DCs) play a critical role in inducing and maintaining tolerance. Recognizing that both T-cell inactivation and activation are contingent on signals provided by DCs and that graft-specific activated T cells are major mediators of transplant rejection, we aimed to create an env...

journal_title：Transplantation

authors： Lan Z,Ge W,Arp J,Jiang J,Liu W,Gordon D,Healey D,DeBenedette M,Nicolette C,Garcia B,Wang H

更新日期：2010-12-27 00:00:00

abstract：BACKGROUND:Cell-based insulin therapies can potentially improve glycemic regulation in insulin-dependent diabetic patients. Enteroendocrine cells engineered to secrete recombinant insulin have exhibited glycemic efficacy, but have been primarily studied as uncontrollable growth systems in immune incompetent mice. Furth...

journal_title：Transplantation

authors： Tiernan AR,Thulé PM,Sambanis A

更新日期：2014-09-15 00:00:00

abstract：BACKGROUND:The impact of community-acquired respiratory virus (CARV) infections on bronchiolitis obliterans syndrome (BOS) and outcome after lung transplantation (LTx) and diagnostic techniques were prospectively evaluated. METHODS:A single-center prospective cohort study was performed in LTx-outpatients between Octob...

journal_title：Transplantation

authors： Gottlieb J,Schulz TF,Welte T,Fuehner T,Dierich M,Simon AR,Engelmann I

更新日期：2009-05-27 00:00:00

abstract：BACKGROUND:Oral administration of alloantigens induces down-regulation of Th1 immune responses and reduces the incidence of corneal graft rejection. This study examined the role of Th1 and Th2 cytokines, accessory cells, and lymphoid organs that are known to be instrumental in other forms of antigen-specific tolerance....

journal_title：Transplantation

authors： Niederkorn JY,Mayhew E

更新日期：2002-05-15 00:00:00

abstract：:Distribution of cadaveric donor kidneys, based upon the donor-recipient HLA match grade, remains one of the major controversies in transplantation. To determine whether matching results in fewer rejection episodes and better graft survival, we retrospectively studied our single-center patient population of 683 cyclosp...

journal_title：Transplantation

authors： Kerman RH,Kimball PM,Lindholm A,Van Buren CT,Katz SM,Lewis RM,McClain J,Podbielski J,Williams J,Kahan BD

更新日期：1993-11-01 00:00:00

abstract：BACKGROUND:Long-term acceptance of semi-identical orthotopic liver transplants (OLTs) in inbred swine is induced by a 12-day course of FK506. To study whether acceptance is attributable to central or peripheral immune mechanisms, the effect of complete thymectomy was determined. METHODS:Total thymectomy was performed ...

journal_title：Transplantation

authors： Uryuhara K,Ambiru S,Dehoux JP,Oike F,Talpe S,Gianello P

更新日期：2004-04-27 00:00:00

abstract：:In a prospective longitudinal study, detection of cytomegalovirus (CMV) DNA in plasma (plasma polymerase chain reaction [PCR]) was compared with PCR of CMV DNA in peripheral blood leukocytes (PBL PCR), the CMV pp65 antigenemia assay, and viral cultures from blood, urine, and throat of 29 patients, 14 of whom received ...

journal_title：Transplantation

authors： Boeckh M,Gallez-Hawkins GM,Myerson D,Zaia JA,Bowden RA

更新日期：1997-07-15 00:00:00

abstract：BACKGROUND:Hemostatic complications are not uncommon after bone marrow transplantation (BMT). However, little is known about the frequency, localization, determinants, and outcome of hemostatic events in autologous and allogeneic BMT. METHODS:Four hundred forty-seven patients (364 allogeneic, 83 autologous transplants...

journal_title：Transplantation

authors： Pihusch R,Salat C,Schmidt E,Göhring P,Pihusch M,Hiller E,Holler E,Kolb HJ

更新日期：2002-11-15 00:00:00

abstract：:Fine-needle aspiration biopsies were used for clinical monitoring of liver allografts; 21 patients with an inflammatory episode of acute rejection (12.0 +/- 3.3 CIU at the peak) were studied; all episodes were reversible. The inflammatory infiltrate consisted mainly of lymphoid cells, including lymphoid blasts, with i...

journal_title：Transplantation

authors： Lautenschlager I,Höckerstedt K,Salmela K,Isoniemi H,Holmberg C,Jalanko H,Häyry P

更新日期：1990-11-01 00:00:00

abstract：:The nephrotoxic effects of cyclosporine (CsA) seem to be augmented by co-existing renal injury. A high rate of prolonged delayed function (acute tubular necrosis [ATN]) and non-function (NF) has been associated with the use of CsA prior to and following renal transplantation. Cyclosporine has also been associated with...

journal_title：Transplantation

authors： Sommer BG,Henry M,Ferguson RM

更新日期：1987-01-01 00:00:00

abstract：:Since the earliest days of transplantation, immunobiologists have sought means to prevent recognition and rejection of foreign tissue. The goal of these strategies is the retention of recipient immune function while selectively avoiding graft injury. Although considerable theoretical and technical problems remain, an ...

journal_title：Transplantation

authors： Lynch RJ,Platt JL

更新日期：2009-12-15 00:00:00

abstract：BACKGROUND:Human islet transplantation is a great potential therapy for type I diabetes. To investigate islet graft survival and function, we recently showed the improved effects after co-culture and co-transplantation with vascular endothelial cells (ECs) in diabetic rats. METHODS:ECs were isolated, and the viability...

journal_title：Transplantation

authors： Pan X,Xue W,Li Y,Feng X,Tian X,Ding C

更新日期：2011-12-15 00:00:00

abstract：BACKGROUND:Targeting 2-hr postdose cyclosporine (C2) levels to 1,000 to 1,700 mg/dL during the first 6 months after renal transplantation is recommended for triple immunosuppressive regimens. This trial determines whether lower C2 levels could be targeted safely in de novo kidney transplant recipients under a quadruple...

journal_title：Transplantation

authors： Hardinger KL,Schnitzler MA,Koch MJ,Enkvetchakul D,Desai N,Jendrisak M,Lowell JA,Miller B,Shenoy S,Brennan DC

更新日期：2004-10-27 00:00:00

abstract：:Heterotopic renal allografts following bilateral nephrectomies were placed in 21 healthy mongrel dogs. One group of 11 dogs received cyclosporine (5 mg/kg/24 hr, orally), and 1 group of 10 dogs received cyclosporine and mizoribine (5 mg/kg and 3 mg/kg/24 hr, orally). Body weights, blood cell counts, serum chemistry pr...

journal_title：Transplantation

authors： Gregory CR,Gourley IM,Cain GR,Broaddus TW,Cowgill LD,Willits NH,Patz JD,Ishizaki G

更新日期：1988-05-01 00:00:00

abstract：:Neonatal tolerance to alloantigens and autoantigens in mice is mediated by T helper (Th)2 immunity. If a strong and pure Th2 response could be engaged to alloantigens in adult mice, it might result in allograft tolerance. In an attempt to induce Th2 immunity in adults, we studied the T-cell response to peptide I-A bet...

journal_title：Transplantation

authors： Lehmann PV,Matesic D,Benichou G,Heeger PS

更新日期：1997-07-27 00:00:00

abstract：BACKGROUND:A pancreas transplant alone (PTA) in a nonuremic patient with brittle diabetes mellitus remains a rare procedure because the tradeoff for insulin independence is lifelong immunosuppression. METHODS:Herein we report our results at the University of Minnesota of 513 PTAs from December 17, 1966, through Decemb...

journal_title：Transplantation

authors： Gruessner RW,Sutherland DE,Kandaswamy R,Gruessner AC

更新日期：2008-01-15 00:00:00

abstract：BACKGROUND:The deceased donor score (DDS), expanded criteria donor (ECD) definition, and resistive index (RI) were developed for pretransplant evaluation of donors. DDS and ECD are determined by a calculation of risk from donor variables, while RI is determined from flow characteristics of kidneys during machine preser...

journal_title：Transplantation

authors： Nyberg SL,Baskin-Bey ES,Kremers W,Prieto M,Henry ML,Stegall MD

更新日期：2005-10-15 00:00:00

abstract：BACKGROUND:To determine the prevalence of GB virus-C/hepatitis G virus (GBV-C/HGV) infection in liver transplant recipients transplanted for non-hepatitis C virus indications, 44 patients transplanted for cryptogenic, autoimmune, hepatitis B, or cholestatic liver disease and 91 non-liver transplantation (LT) patients w...

journal_title：Transplantation

authors： Dickson RC,Qian KP,Lau JY

更新日期：1997-06-15 00:00:00

abstract：BACKGROUND:Natural antibodies (NAbs) against a terminal alpha1-3 galactosyl (alphaGal) epitope have been identified as the major human anti-pig NAbs. METHODS AND RESULTS:We used two synthetic alphaGal trisaccharides--type 6 (alphaGal6) and type 2(alphaGal2)--linked to an inert matrix to remove NAbs from human plasma i...

journal_title：Transplantation

authors： Xu Y,Lorf T,Sablinski T,Gianello P,Bailin M,Monroy R,Kozlowski T,Awwad M,Cooper DK,Sachs DH

更新日期：1998-01-27 00:00:00

abstract：:Cytomegalovirus disease is an important cause of morbidity following liver transplantation. To date there has not been an effective prophylaxis for CMV disease after liver transplantation. One hundred forty-three patients were randomized to receive either high dose oral acyclovir (800 mg 4 times a day) alone for 3 mon...

journal_title：Transplantation

authors： Martin M,Mañez R,Linden P,Estores D,Torre-Cisneros J,Kusne S,Ondick L,Ptachcinski R,Irish W,Kisor D

更新日期：1994-10-15 00:00:00

abstract：BACKGROUND:In recent years, transplantation of islets and pancreas has become a viable option for patients debilitated with type I diabetes. The success of islet transplantation has been attributed to the ability to isolate high quality islets for transplantation and capacity to maintain the recipient's immunosuppressi...

journal_title：Transplantation

authors： Mohanakumar T,Narayanan K,Desai N,Ramachandran S,Shenoy S,Jendrisak M,Susskind BM,Olack B,Benshoff N,Phelan DL,Brennan DC,Fernandez LA,Odorico JS,Polonsky KS

更新日期：2006-07-27 00:00:00

abstract：BACKGROUND:Diarrhea is common in solid organ transplant recipients. Colonoscopy with random biopsies is performed frequently in the diagnostic evaluation of the posttransplant population with diarrhea. The purpose of this study was to determine the sensitivity of colonoscopy with random biopsy in determining a specific...

journal_title：Transplantation

authors： Rice JP,Spier BJ,Cornett DD,Walker AJ,Richie K,Pfau PR

更新日期：2009-08-15 00:00:00

abstract：:Patient entry is now complete in a prospective trial of anti-Tac, a murine IgG2a monoclonal antibody directed against the p55 chain of the human IL-2 receptor, for the prevention of renal allograft rejection. Recipients of primary cadaver allografts were randomized to receive either anti-Tac (20 mg q.d. x 10 days begi...

journal_title：Transplantation

authors： Kirkman RL,Shapiro ME,Carpenter CB,McKay DB,Milford EL,Ramos EL,Tilney NL,Waldmann TA,Zimmerman CE,Strom TB

更新日期：1991-01-01 00:00:00