Abstract:
:The levels of HLA-A and -B antigens expressed by placenta have been assessed relative to parental and other A and B antigen types that were not shared by the foetus. A purified preparation of placenta plasma membrane was used to estimate the antigen activities. The results indicate that maternally and paternally inherited A and B antigen activities and beta2-microglobulin are expressed to similar extents but at much lower levels than in spleen lymphocytes (less than 5%). The possibility that the amounts detected were caused by contamination with blood or maternal tissue was ruled out. The low levels of A and B antigens may account for the lack of a cellular immune response to the other polymorphic cell surface antigens of the trophoblast. No evidence was obtained for the expression of a significant level of Ia antigens.
journal_name
Transplantationjournal_title
Transplantationauthors
Goodfellow PN,Barnstable CJ,Bodmer WF,Snary D,Crumpton MJdoi
10.1097/00007890-197612000-00009subject
Has Abstractpub_date
1976-12-01 00:00:00pages
595-603issue
6eissn
0041-1337issn
1534-6080journal_volume
22pub_type
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