Expression of HLA system antigens on placenta.

Abstract:

:The levels of HLA-A and -B antigens expressed by placenta have been assessed relative to parental and other A and B antigen types that were not shared by the foetus. A purified preparation of placenta plasma membrane was used to estimate the antigen activities. The results indicate that maternally and paternally inherited A and B antigen activities and beta2-microglobulin are expressed to similar extents but at much lower levels than in spleen lymphocytes (less than 5%). The possibility that the amounts detected were caused by contamination with blood or maternal tissue was ruled out. The low levels of A and B antigens may account for the lack of a cellular immune response to the other polymorphic cell surface antigens of the trophoblast. No evidence was obtained for the expression of a significant level of Ia antigens.

journal_name

Transplantation

journal_title

Transplantation

authors

Goodfellow PN,Barnstable CJ,Bodmer WF,Snary D,Crumpton MJ

doi

10.1097/00007890-197612000-00009

subject

Has Abstract

pub_date

1976-12-01 00:00:00

pages

595-603

issue

6

eissn

0041-1337

issn

1534-6080

journal_volume

22

pub_type

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