Abstract:
:Experimental evidence suggests storing lungs inflated with oxygen and with oxidizable substrate improves results of lung transplantation. Glucose is included in the low-potassium-dextran (LPD) solution Perfadex to achieve this goal. The authors hypothesized that other substrates might be more effective. Rat lungs were stored for 6 or 24 hr in LPD solution with the following carbon-13--labeled substrates: 5 mM glucose (Perfadex group), 32 mM pyruvate (pyruvate group), or both (combination group). Metabolism was assessed by magnetic resonance spectroscopy. Small amounts of exogenous glucose were oxidized in the Perfadex group. In contrast, exogenous pyruvate was the major substrate oxidized in the pyruvate and combination groups (P<0.01 vs. Perfadex). Carbon-13--labeled glucose and glycogen were detected in the pyruvate group, suggesting that gluconeogenesis and glycogen synthesis occur in glucose-deprived lungs. Lungs for transplantation metabolize substrates through both anabolic and catabolic pathways. These reactions may be important in designing improved solutions for lung preservation.
journal_name
Transplantationjournal_title
Transplantationauthors
Peltz M,He TT,Adams GA 4th,Chao RY,Meyer DM,Jessen MEdoi
10.1097/01.tp.0000169129.45433.b6subject
Has Abstractpub_date
2005-08-15 00:00:00pages
417-20issue
3eissn
0041-1337issn
1534-6080pii
00007890-200508150-00020journal_volume
80pub_type
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