Abstract:
BACKGROUND:Graft arterial disease (GAD) is a major cause of late graft loss after organ transplantation. Alloimmune responses and vascular remodeling eventually cause the transplant organ to develop GAD. In this study, we aimed to limit the development of GAD by inhibiting alloimmune responses and vascular smooth muscle cell (VSMC) proliferation with a new compound, 3-[(dodecylthiocarbonyl)methyl]-glutarimide ([DTCM]-glutarimide), in a murine cardiac model of GAD. METHODS:The hearts from B6.CH-2 mice were transplanted into C57BL/6 mouse recipients to examine the extent of GAD. The recipients were treated with either vehicle or DTCM-glutarimide intraperitoneally (40 mg/kg per day) for 4 weeks. RESULTS:The administration of DTCM-glutarimide attenuated GAD formation (luminal occlusion: 37.9 ± 5.9% vs 14.8 ± 5.4%, P < 0.05) by inhibiting the number of graft-infiltrating cells and decreasing alloreactive interferon (IFN)-γ production compared with control mice, as measured by the Enzyme-linked ImmunoSpot assay. In vitro, VSMCs proliferated on stimulation with either basic fibroblast growth factor or IFN-γ and splenocytes after transplantation, but the addition of DTCM-glutarimide resulted in the inhibition of VSMC proliferation. Moreover, DTCM-glutarimide suppressed cyclin D1 expression and inhibited cell cycle progression from G1 to S in VSMCs. CONCLUSIONS:The compound DTCM-glutarimide suppressed GAD development by inhibiting not only alloimmune responses but also VSMC proliferation in the graft.
journal_name
Transplantationjournal_title
Transplantationauthors
Zaitsu M,Yamashita K,Shibasaki S,Tsunetoshi Y,Fukai M,Ogura M,Yoshida T,Igarashi R,Kobayashi N,Umezawa K,Todo Sdoi
10.1097/TP.0000000000000576subject
Has Abstractpub_date
2015-05-01 00:00:00pages
948-56issue
5eissn
0041-1337issn
1534-6080journal_volume
99pub_type
杂志文章相关文献
TRANSPLANTATION文献大全abstract::In vivo cell-mediated effector mechanisms of allograft destruction were investigated in a canine single-lung transplantation model. This large animal model permits direct longitudinal studies of immune effector cells from the grafts of individual recipients by bronchoalveolar lavage (BAL). Evidence was obtained that t...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198911000-00026
更新日期:1989-11-01 00:00:00
abstract:BACKGROUND:Anti-thymocyte globulin (ATG) is used frequently as induction therapy in renal transplant recipients. It has been standard practice that the various polyclonal anti-lymphocyte preparations be administered via central line, vascular shunt, or arteriovenous fistula to avoid thrombophlebitis. METHODS:We have s...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200005150-00038
更新日期:2000-05-15 00:00:00
abstract::After measurement of normal renal function, dog kidneys (n = 52) were subjected to 3, 15, or 30 min of normothermic warm ischemia (WI). After 24 hr of preservation by simple hypothermic storage (SHS) in a modified Collins solution, autotransplant was done and renal function was again measured beginning at 1 hr. Compar...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198611000-00003
更新日期:1986-11-01 00:00:00
abstract:BACKGROUND:Pneumocystis jirovecii pneumonia (PJP) is an important infection-related complication, whose mode of transmission remains uncertain. METHODS:We investigated a nosocomial cluster of 14 PJP cases (11 confirmed and 3 probable) in kidney transplant recipients using epidemiological and genotyping methods. RESUL...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3182384b57
更新日期:2011-12-27 00:00:00
abstract::A series of rat monoclonal antibodies against the human leukocyte-common antigen were isolated and, by means of competitive binding assays with purified antigen, two distinct groups were defined that recognize different epitopes of the molecule. None of these antibodies were lytic with human complement, but when antib...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198511000-00013
更新日期:1985-11-01 00:00:00
abstract:BACKGROUND:Several single nucleotide polymorphisms (SNPs) in the multidrug resistance (MDR1) gene may play a role in the interindividual variation of cyclosporine A (CsA) absorption in renal transplant patients. METHODS:An analysis of CsA absorption measured by the dose- and weight-adjusted 4 hr area under the time-co...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000264197.88129.2e
更新日期:2007-05-27 00:00:00
abstract:BACKGROUND:Human herpesvirus-6 (HHV-6) is known to reactivate after renal transplantation and has been associated with several clinical manifestations. Risk factors for sustained viral replication, however, remain unclear. METHODS:Thirty consecutive kidney transplant patients were prospectively followed for HHV-6 repl...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3182807ab7
更新日期:2013-03-27 00:00:00
abstract::Platelet activating factor (PAF, 1-alkyl-2(R)-acetyl-glycero-3- phosphorylcholine) is a phospholipid that is released by a variety of cells. The similarity between the pathophysiological effects of PAF and posttransplant pulmonary dysfunction led to an evaluation of a PAF antagonist as an adjunct to lung preservation....
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199106000-00002
更新日期:1991-06-01 00:00:00
abstract::Endothelial chimerism in transplanted organs is a fascinating phenomenon, indicative of a mechanism by which progenitor recipient cells replace the donor endothelium. It has been hypothesized that this replacement could lead to a decrease in alloreactivity and thus would positively influence graft outcome. However, re...
journal_title:Transplantation
pub_type: 杂志文章,评审
doi:10.1097/01.tp.0000231446.41051.98
更新日期:2006-07-15 00:00:00
abstract:BACKGROUND:Tacrolimus is a potent immunosuppressive agent that provides higher freedom from acute and chronic rejection than cyclosporine after liver transplantation (LTx). Initially, a steroid-free state was observed in about 70% of patients at 1 year; this did not change over the next 5 years. The present study ident...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200104270-00016
更新日期:2001-04-27 00:00:00
abstract:BACKGROUND:Inhibition of complement in small animal models of xenotransplantation has demonstrated graft infiltration with natural killer (NK) cells and monocytes associated with endothelial cell (EC) activation. We have previously demonstrated that human NK cells activate porcine EC in vitro, which results in adhesion...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199811150-00017
更新日期:1998-11-15 00:00:00
abstract::Lethally irradiated (850 rads) DBA/2 mice which had been transplanted 10 months previously with 2 times 10-6 bone marrow cells from 3-week-old donors of the H-2-histocompatible NZB, BALB/c and DBA/2 strains were examined for manifestations of autoimmune disease. Also studied were lethally irradiated (950 rads) NZB mic...
journal_title:Transplantation
pub_type: 杂志文章
doi:
更新日期:1975-06-01 00:00:00
abstract::Although extrinsic denervation is inevitable after intestinal transplantation and leads to poor intestinal function, little is known about the occurrence of extrinsic reinnervation. In this study, extrinsic sympathetic reinnervation was investigated morphologically following syngeneic intestinal transplantation perfor...
journal_title:Transplantation
pub_type: 杂志文章
doi:
更新日期:1995-02-15 00:00:00
abstract:BACKGROUND:Orthotopic liver transplantation (OLT) has been associated with major blood loss and the need for blood product transfusions. During the last decade, improved surgical and anesthetic management has reduced intraoperative blood loss and blood product transfusions. A first report from our group published in 20...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e318250fc25
更新日期:2012-06-27 00:00:00
abstract::A novel method for quantifying the fatty change of the graft liver by characterizing the optical property of the tissue was introduced. A wide range of lipid content in the rat liver was obtained by using different feeding regimens, with lipotropic chow (choline/methionine deficient or low chow). The liver was removed...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199609150-00018
更新日期:1996-09-15 00:00:00
abstract:BACKGROUND:It is unclear whether ischemic preconditioning (IPC) of solid organs induces remote IPC (RIPC) in donors after brain death (DBD). METHODS:Outcomes in kidney recipients from 163 DBD in two randomized trials of liver IPC (5 min=62 and 10 min=101) were obtained retrospectively from the Scientific Registry of T...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000436926.30897.56
更新日期:2014-02-15 00:00:00
abstract:BACKGROUND:Oral ingestion of potassium dichromate produces a complex spectrum of complications. It has an extremely poor prognosis and usually leads to rapid death. METHODS:We report the case of a 16-year-old male patient who was admitted to hospital after oral ingestion of potassium dichromate with suicidal intention...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200006150-00044
更新日期:2000-06-15 00:00:00
abstract:BACKGROUND:Rising numbers of patients reaching end-stage kidney disease intensify the demand for expansion of the living-kidney-donor pool. On the basis of low risk in white donors with essential hypertension, our transplant center undertook a structured program of accepting hypertensive donors if kidney function and u...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000128168.97735.b3
更新日期:2004-07-27 00:00:00
abstract::Rat liver transplantation was utilized to study the effect of hepatic iron on the control of iron absorption. Six iron-loaded and six normal livers were transplanted into normal or iron-loaded animals. Iron absorption was measured pretransplant and 10 days posttransplant by total-body counting (59Fe). The animals were...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198907000-00005
更新日期:1989-07-01 00:00:00
abstract:BACKGROUND:In a pig liver transplantation model, we compared the effects of Celsior solution (CS), an extracellular preservation solution, with Viaspan (University of Wisconsin solution, UW) on graft function and animal survival. METHODS:Pig livers were flushed with either CS or UW solution and cold-stored for 12 hr (...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200106270-00005
更新日期:2001-06-27 00:00:00
abstract:BACKGROUND:Liver transplant recipients for hepatitis C virus (HCV)-related cirrhosis usually remain anti-HCV-seropositive after transplantation. The aim of this study was to characterize, longitudinally, the profile of HCV-specific antibodies and cryoglobulins in liver transplant recipients with recurrent HCV infection...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199901150-00013
更新日期:1999-01-15 00:00:00
abstract:BACKGROUND:To investigate the transparency, biocompatibility, and safety of human-derived acellular dermal matrix for application in corneal stromal transplantation. METHODS:Twenty-four patients (24 eyes) with pellucid marginal corneal degeneration were enrolled, and intrastromal keratoplasty was performed with human-...
journal_title:Transplantation
pub_type: 临床试验,杂志文章
doi:10.1097/TP.0000000000002681
更新日期:2019-06-01 00:00:00
abstract:BACKGROUND:Immunosuppression in renal transplantation, although manageable in the short-term, is a major hurdle for long-term graft survival. Recently, increased frequencies of CD4CD25 regulatory T cells (Tregs) have been described as an additional mechanism that induces alloimmune tolerance. METHODS:We assessed 64 re...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000229473.95202.50
更新日期:2006-08-27 00:00:00
abstract::Hepatic artery thrombosis is a continuing source of morbidity and mortality following orthotopic liver transplantation. The cornerstone of therapy has been urgent retransplantation that is limited by organ availability. For this reason we developed a policy of urgent revascularization for allograft rescue. Hepatic art...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199101000-00013
更新日期:1991-01-01 00:00:00
abstract::The renal handling of cyclosporine was studied in ischemically damaged kidneys in New Zealand White rabbits and nonischemic control animals. CsA, 25 mg/kg/day, was administered intravenously for 10 days starting with the day of operation. Blood CsA (B CsA) was higher in the ischemic group compared with the controls (m...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199003000-00004
更新日期:1990-03-01 00:00:00
abstract::The use of cyclosporine has been associated with an increased incidence of thrombosis and endothelial cell perturbation. To explore possible mechanisms involved, we examined the effects of CSA on the activation of protein C by thrombomodulin. Cultured bovine aortic endothelial cell monolayers were incubated for 24 hr ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199103000-00030
更新日期:1991-03-01 00:00:00
abstract:BACKGROUND:Although the outcome of islet transplantation has improved, there remains a major obstacle in isolating viable islets from prolonged preserved pancreas. We previously reported that the two-layer cold storage method (TLM) improved the yield and in vitro function. In this study, we performed in vivo accurate f...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000154914.34121.72
更新日期:2005-06-15 00:00:00
abstract::In this study, we have investigated whether lymphocyte growth from 196 liver transplant biopsies is correlated with the histologic diagnosis of graft rejection. One fragment of each biopsy was cultured in IL-2 to expand activated T cells, and the remainder of the biopsy was analyzed histologically. A significantly hig...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199001000-00024
更新日期:1990-01-01 00:00:00
abstract:BACKGROUND:The significance of late urinary tract infections (UTIs) after renal transplantation and their association with scarring and graft dysfunction remains controversial. We sought to define the prevalence of renal scarring in allograft recipients with a history of late recurrent UTIs, to determine whether the pr...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000275377.09660.fa
更新日期:2007-08-15 00:00:00
abstract:BACKGROUND:Aspartylglucosaminuria is a rare, inherited lysosomal disease characterized by a slowly progressive mental retardation and coarse facial and body features. With the intent to provide the deficient enzyme aspartylglucosaminidase, allogeneic stem-cell transplantation (ASCT) has been attempted. Only a few cases...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200408150-00015
更新日期:2004-08-15 00:00:00