Antibodies to hepatitis C virus envelope proteins correlate with hepatitis C viraemia after liver transplantation.

Abstract:

BACKGROUND:Liver transplant recipients for hepatitis C virus (HCV)-related cirrhosis usually remain anti-HCV-seropositive after transplantation. The aim of this study was to characterize, longitudinally, the profile of HCV-specific antibodies and cryoglobulins in liver transplant recipients with recurrent HCV infection. METHODS:Serial serum samples were collected prospectively before, at 1 month after, and at 12 months after transplantation for HCV cirrhosis in 30 patients infected with genotype 1. The antibodies against HCV envelope proteins (E1 and E2) were quantitated by enzyme-linked immunosorbent assay and antibodies against core, E2/hypervariable region I (HVRI), NS3, NS4, and NS5A antigens by a line immunoassay. Sera were also tested for cryoglobulins. RESULTS:The titer of each anti-HCV antibody had fallen at 1 month after transplantation (P<0.05) with the exception of anti-E1 levels, which had risen in 16 patients with acute hepatitis C at that time (P=0.01). Anti-E1 and anti-E2 titers, but not antibodies against other HCV antigens, increased to pre-transplantation levels or higher at 12 months, which correlated with serum HCV RNA levels. Cryoglobulinemia was present in nine patients after transplantation (30%) and was associated with lower anti-E1 levels (P=0.04) and more severe graft damage. CONCLUSIONS:The early increase in antibodies to HCV envelope proteins in correlation with viremia suggests that the envelope-specific humoral immune response may be directly stimulated by HCV replication. Anti-E1 levels may be a useful marker in monitoring patients with recurrent HCV infection.

journal_name

Transplantation

journal_title

Transplantation

authors

Gane EJ,Maertens G,Ducatteeuw A,Qian KP,Lau JY,Jones H,Davies E,Naoumov NV,Williams R

doi

10.1097/00007890-199901150-00013

subject

Has Abstract

pub_date

1999-01-15 00:00:00

pages

78-84

issue

1

eissn

0041-1337

issn

1534-6080

journal_volume

67

pub_type

杂志文章
  • Prevention of acute allograft rejection in nonhuman primate lung transplant recipients: induction with chimeric anti-interleukin-2 receptor monoclonal antibody improves the tolerability and potentiates the immunosuppressive activity of a regimen using low

    abstract:BACKGROUND:In previous studies of cynomolgus monkey lung allograft recipients, we demonstrated significant immunosuppressive efficacy but reduced tolerability after combined treatment with high doses of microemulsion cyclosporine (CsA) and SDZ RAD (40-O-(2-hydroxyethyl)-rapamycin). The current study was designed to com...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-200002270-00005

    authors: Hausen B,Gummert J,Berry GJ,Christians U,Serkova N,Ikonen T,Hook L,Legay F,Schuler W,Schreier MH,Morris RE

    更新日期:2000-02-27 00:00:00

  • Split Liver Transplantation and Pediatric Waitlist Mortality in the United States: Potential for Improvement.

    abstract:BACKGROUND:In the United States, 1 in 10 infants and 1 in 20 older children die on the liver transplant waiting list. Increasing split liver transplantation could increase organ availability for these children, without decreasing transplants in adults. METHODS:Using United Network for Organ Sharing Standard Transplant...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0000000000002249

    authors: Perito ER,Roll G,Dodge JL,Rhee S,Roberts JP

    更新日期:2019-03-01 00:00:00

  • Fractionation of feline bone marrow with the soybean agglutinin lectin yields populations enriched for erythroid and myeloid elements: transplantation of soybean agglutinin-negative cells into lethally irradiated recipients.

    abstract::Feline bone marrow cells treated with the soybean agglutinin (SBA) lectin are separated into two populations, the agglutinated SBA(+) fraction containing predominantly cells of myeloid origin and the nonagglutinated SBA(-) fraction consisting of cells primarily of the erythroid lineage. FACScan analyses revealed a cle...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199708150-00022

    authors: Gengozian N,Reyes L,Pu R,Homer BL,Bova FJ,Yamamoto JK

    更新日期:1997-08-15 00:00:00

  • Correction of hyperoxaluria by liver repopulation with hepatocytes in a mouse model of primary hyperoxaluria type-1.

    abstract:BACKGROUND:Primary hyperoxaluria type-1 (PH1) is an autosomal recessive disease characterized by excessive oxalate production by hepatocytes caused by the deficiency of peroxisomal alanine-glyoxylate aminotransferase (AGT) activity. Persistent hyperoxaluria causes nephrocalcinosis and urolithiasis, leading to renal fai...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0b013e31816de49e

    authors: Jiang J,Salido EC,Guha C,Wang X,Moitra R,Liu L,Roy-Chowdhury J,Roy-Chowdhury N

    更新日期:2008-05-15 00:00:00

  • Clinicopathologic features of graft rejection of the first human hand allograft.

    abstract:BACKGROUND:The first human hand allograft, performed in Lyon, France, on September 23, 1998, was removed during month 29 posttransplantation as the result of rejection because the patient did not comply with the immunosuppressive treatment. METHODS:The patient was regularly examined from the day of transplantation to ...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/01.TP.0000079458.81970.9A

    authors: Kanitakis J,Jullien D,Petruzzo P,Hakim N,Claudy A,Revillard JP,Owen E,Dubernard JM

    更新日期:2003-08-27 00:00:00

  • Attenuation of acute xenograft rejection by short-term treatment with LF15-0195 and monoclonal antibody against CD45RB in a rat-to-mouse cardiac transplantation model.

    abstract:BACKGROUND:We previously reported that Lewis rat hearts transplanted into BALB/c mice developed typical acute vascular rejection (AVR). The present study was undertaken to determine the efficacy of LF15-0195, a new analogue of 15-deoxyspergualin, in the prevention of AVR and to determine whether a combination of LF15-0...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/01.TP.0000057245.59998.95

    authors: Wang H,Hosiawa KA,Garcia B,Shum JB,Dutartre P,Kelvin DJ,Zhong R

    更新日期:2003-05-15 00:00:00

  • Ten-year results of a randomized trial comparing tacrolimus versus cyclosporine a in combination with mycophenolate mofetil after heart transplantation.

    abstract:BACKGROUND:Long-term results of prospective randomized trials comparing triple immunosuppressive strategies combining tacrolimus (TAC) or cyclosporine A (CsA) with mycophenolate mofetil (MMF) and steroids after heart transplantation (HTX) are rarely published. Therefore, we collected long-term follow-up data of an inte...

    journal_title:Transplantation

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/TP.0b013e318277e378

    authors: Guethoff S,Meiser BM,Groetzner J,Eifert S,Grinninger C,Ueberfuhr P,Reichart B,Hagl C,Kaczmarek I

    更新日期:2013-02-27 00:00:00

  • Evidence that addition of azathioprine improves renal function in cyclosporine-treated patients with allograft dysfunction.

    abstract::Several approaches have been attempted to manage renal allograft dysfunction in cyclosporine-prednisone (CsA-Pred)-treated patients. Conversion to conventional therapy and perioperative triple drug have been associated with high rates of acute rejection episodes, infections, or neoplasms. We report our experience in d...

    journal_title:Transplantation

    pub_type: 临床试验,杂志文章

    doi:10.1097/00007890-199108000-00017

    authors: Pascual J,Marcén R,Orofino L,Quereda C,Mampaso F,Liaño F,Ortuño J

    更新日期:1991-08-01 00:00:00

  • The effect of mismatching for HLA-DR in recipients of renal allografts sharing one HLA-ABC haplotype with related donors.

    abstract::The effects of mismatching for DR antigens on renal allograft survival rates have largely been restricted to analyses of cadaver transplant results. Analyses of HLA matching in recipients of transplants from related donors have focused on the number of haplotypes shared between the recipients without regard to DR, or ...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-198336060-00011

    authors: Sutherland DE,Morrow CE,Kaufman D,Fryd DS,Najarian JS,Burke M,Noreen H,Segall M,Bach FH

    更新日期:1983-12-01 00:00:00

  • Prolonged preservation in University of Wisconsin solution associated with hepatic artery thrombosis after orthotopic liver transplantation.

    abstract::Hepatic artery thrombosis (HAT) after liver transplantation (LTx) usually mandates retransplantation. Prolonged preservation with Eurocollins solution has been associated with HAT. We reviewed our experience with 359 LTx patients to identify risk factors for HAT. All grafts were preserved in University of Wisconsin so...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199312000-00024

    authors: Mor E,Schwartz ME,Sheiner PA,Menesses P,Hytiroglou P,Emre S,Kishikawa K,Chiodini S,Miller CM

    更新日期:1993-12-01 00:00:00

  • Prediction of successful allograft rejection retreatment with OKT3.

    abstract::OKT3 is considered to be effective in the prophylaxis and treatment of rejection. However, anti-OKT3 immunization is still a major side-effect. Only the IgG antiidiotypic component of the response is responsible for neutralization of OKT3 therapeutic activity by inhibiting OKT3's binding to T cells (i.e., blocking ant...

    journal_title:Transplantation

    pub_type: 临床试验,杂志文章

    doi:10.1097/00007890-199201000-00016

    authors: Legendre C,Kreis H,Bach JF,Chatenoud L

    更新日期:1992-01-01 00:00:00

  • A randomized long-term trial of tacrolimus/sirolimus versus tacrolimus/mycophenolate mofetil versus cyclosporine (NEORAL)/sirolimus in renal transplantation. II. Survival, function, and protocol compliance at 1 year.

    abstract:BACKGROUND:In an attempt to reduce chronic calcineurin inhibitor induced allograft nephropathy in first cadaver and human leukocyte antigen non-identical living-donor renal transplantation, sirolimus (Siro) or mycophenolate mofetil (MMF) was tested as adjunctive therapy, with planned dose reductions of tacrolimus (Tacr...

    journal_title:Transplantation

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/01.TP.0000101495.22734.07

    authors: Ciancio G,Burke GW,Gaynor JJ,Mattiazzi A,Roth D,Kupin W,Nicolas M,Ruiz P,Rosen A,Miller J

    更新日期:2004-01-27 00:00:00

  • Treatment of chronic hepatitis C with recombinant interferon alpha in kidney transplant recipients.

    abstract::Chronic hepatitis C is a common cause of viral liver disease in kidney transplant (KT) recipients. To assess the efficacy and safety of therapy with interferon alpha we conducted a prospective study where 14 cadaveric KT recipients with chronic hepatitis C received recombinant interferon alpha-2b (IFNa) 3 million unit...

    journal_title:Transplantation

    pub_type: 临床试验,杂志文章

    doi:10.1097/00007890-199505270-00012

    authors: Rostaing L,Izopet J,Baron E,Duffaut M,Puel J,Durand D

    更新日期:1995-05-27 00:00:00

  • Financial incentives for cadaver organ donation: an ethical reappraisal.

    abstract::A panel of ethicists, organ procurement organization executives, physicians, and surgeons was convened by the sponsorship of the American Society of Transplant Surgeons to determine whether an ethically acceptable pilot trial could be proposed to provide a financial incentive for a family to consent to the donation of...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-200204270-00034

    authors: Arnold R,Bartlett S,Bernat J,Colonna J,Dafoe D,Dubler N,Gruber S,Kahn J,Luskin R,Nathan H,Orloff S,Prottas J,Shapiro R,Ricordi C,Youngner S,Delmonico FL

    更新日期:2002-04-27 00:00:00

  • Immunologic diagnosis of kidney rejection using FACS analysis of graft-infiltrating functional and activated T and NK cell subsets.

    abstract::In human organ transplantation, the correct diagnosis of rejection may be difficult using clinical and/or histopathologic criteria, and immunologic assays should therefore be considered. We have applied monoclonal antibodies in 2-color flow cytometric (FACS) analysis to study phenotypic patterns of kidney-infiltrating...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-198905000-00014

    authors: Tötterman TH,Hanås E,Bergström R,Larsson E,Tufveson G

    更新日期:1989-05-01 00:00:00

  • The effect of trophic factor supplementation on cold ischemia-induced early apoptotic changes.

    abstract::We have previously shown that trophic factor supplementation (TFS) of University of Wisconsin (UW) solution enhanced kidney viability after cold storage. Here, we use an in vitro model to study the effect of TFS on early apoptotic changes after cold ischemic storage. Mitochondrial membrane potential was determined by ...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/01.tp.0000242524.35562.4b

    authors: Kwon YS,Foley JD,Murphy CJ,McAnulty JF

    更新日期:2007-01-15 00:00:00

  • The prevalence of coronary artery disease in liver transplant candidates over age 50.

    abstract::The prevalence of angiographically proven coronary artery disease (CAD) in adults with end-stage liver disease who undergo evaluation for liver transplantation is unknown; also it is unclear if cholestatic liver disease represents an independent risk factor. Patients with end-stage liver disease over age 50 having liv...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:

    authors: Carey WD,Dumot JA,Pimentel RR,Barnes DS,Hobbs RE,Henderson JM,Vogt DP,Mayes JT,Westveer MK,Easley KA

    更新日期:1995-03-27 00:00:00

  • In vitro generation of human mixed lymphocyte culture suppressor cells. I. Cellular characterization and specificity.

    abstract::The mixed leukocyte culture (MLC) of peripheral blood lymphocytes (PBLs) from two prospective kidney transplant recipients and their respective donors, produced a primed cell population that functioned as suppressors. The primed cells suppressed the primary and secondary MLC when added as third components, without dem...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-198001000-00012

    authors: Fuller L,Kyriakides G,Flaa C,Esquenazi V,Miller J

    更新日期:1980-01-01 00:00:00

  • Late-onset cytomegalovirus disease in liver transplant recipients despite antiviral prophylaxis.

    abstract:BACKGROUND:The incidence and impact of cytomegalovirus (CMV) disease that occurs despite CMV prophylaxis among liver transplant recipients have been incompletely defined. METHODS:The incidence and risk factors for CMV disease during the first posttransplant year in a cohort of liver transplant recipients who received ...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/01.tp.0000145989.22373.03

    authors: Limaye AP,Bakthavatsalam R,Kim HW,Kuhr CS,Halldorson JB,Healey PJ,Boeckh M

    更新日期:2004-11-15 00:00:00

  • Statement of the Declaration of Istanbul Custodian Group Regarding Payments to Families of Deceased Organ Donors.

    abstract::Governmental and private programs that pay next of kin who give permission for the removal of their deceased relative's organs for transplantation exist in a number of countries. Such payments, which may be given to the relatives or paid directly for funeral expenses or hospital bills unrelated to being a donor, aim t...

    journal_title:Transplantation

    pub_type: 指南,杂志文章

    doi:10.1097/TP.0000000000001198

    authors: Capron AM,Delmonico FL,Dominguez-Gil B,Martin DE,Danovitch GM,Chapman J

    更新日期:2016-09-01 00:00:00

  • A comparison of gene expression in murine cardiac allografts and isografts by means DNA microarray analysis.

    abstract:BACKGROUND:Acute rejection of allografts remains a significant problem in clinical transplantation, and the fundamental mechanism underlying this rejection are as yet only poorly elucidated. Recently, DNA microarrays have come into use for the study of gene expression profiles, and we have taken advantage of this new t...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-200107270-00027

    authors: Saiura A,Mataki C,Murakami T,Umetani M,Wada Y,Kohro T,Aburatani H,Harihara Y,Hamakubo T,Yamaguchi T,Hasegawa G,Naito M,Makuuchi M,Kodama T

    更新日期:2001-07-27 00:00:00

  • Pharmacokinetics of methylprednisolone and rejection episodes in kidney transplant patients.

    abstract::Rejection crises after kidney transplantation could be associated with individual variability of pharmacokinetic parameters of steroids. We therefore investigated the individual pharmacokinetics of methylprednisolone on day 2 (60 mg intravenously) and day 4 (60 mg per os) in 40 patients after kidney transplantation. M...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199508270-00005

    authors: Keller F,Hemmen T,Schöneshöfer M,Schwarz A,Offermann G

    更新日期:1995-08-27 00:00:00

  • Metabolic syndrome and atherosclerotic events in renal transplant recipients.

    abstract:BACKGROUND:Metabolic syndrome (MS) is a known cardiovascular risk factor in the general population. We explored the influence of MS on the occurrence of atherosclerotic events (AEs) after renal transplantation. METHODS:Three hundred thirty-seven renal transplant recipients were included in the study. Various parameter...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/01.tp.0000266898.93894.3d

    authors: Courivaud C,Kazory A,Simula-Faivre D,Chalopin JM,Ducloux D

    更新日期:2007-06-27 00:00:00

  • The Safety of Neuromuscular Blockade Reversal in Patients With Cardiac Transplantation.

    abstract:BACKGROUND:Neuromuscular blockade (NMB) reversal with neostigmine and glycopyrrolate has been reported to cause cardiac arrest in patients with a history of cardiac transplantation. The purpose of this study was to examine the safety of NMB reversal with acetylcholinesterase inhibitors and muscarinic anticholinergics i...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0000000000001060

    authors: Barbara DW,Christensen JM,Mauermann WJ,Dearani JA,Hyder JA

    更新日期:2016-12-01 00:00:00

  • Multivariate analysis of donor risk factors for graft survival in kidney transplantation.

    abstract:BACKGROUND:The results of the transplantation of marginal donor kidneys remain controversial. This study aimed to investigate the impact of donor risk factors as predictors of kidney-graft outcome. METHODS:Allograft failure risk factors were studied in 7,209 cadaveric kidney-transplant recipients reporting to the Etab...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/01.TP.0000044171.97375.61

    authors: Pessione F,Cohen S,Durand D,Hourmant M,Kessler M,Legendre C,Mourad G,Noël C,Peraldi MN,Pouteil-Noble C,Tuppin P,Hiesse C

    更新日期:2003-02-15 00:00:00

  • Section 8. Management of portal venous complications in pediatric living donor liver transplantation.

    abstract::Portal vein (PV) complications after living donor liver transplant (LDLT) have been a major concern in pediatric liver transplantation. The incidence of PV complications is more in pediatric (0%-33%) than in adult recipients. Early diagnosis and treatment of PV complications may ensure optimal graft function and good ...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/01.tp.0000446272.05687.ce

    authors: Cheng YF,Ou HY,Yu CY,Tsang LL,Huang TL,Chen TY,Concejero A,Wang CC,Wang SH,Lin TS,Liu YW,Yang CH,Yong CC,Chiu KW,Jawan B,Eng HL,Chen CL

    更新日期:2014-04-27 00:00:00

  • Outcomes of kidney transplant tourism and risk factors for de novo urothelial carcinoma.

    abstract:BACKGROUND:To date, the outcomes of transplant tourism have not been reported extensively. In addition, data about the accuracy of urine cytology for the detection and the role of the BK virus (BKV) in the carcinogenesis of urothelial carcinoma (UC) after renal transplantation are lacking. METHODS:Three hundred seven ...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0000000000000023

    authors: Tsai HL,Chang JW,Wu TH,King KL,Yang LY,Chan YJ,Yang AH,Chang FP,Pan CC,Yang WC,Loong CC

    更新日期:2014-07-15 00:00:00

  • Use of steatotic graft in living-donor liver transplantation.

    abstract:BACKGROUND:The degree of fatty infiltration in hepatic grafts is known to be an important risk factor for primary graft nonfunction in cadaveric liver transplantation. However, the effect of hepatic steatosis in living-donor liver transplantation (LDLT) has not yet been well defined. In this study, we evaluated the imp...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/01.TP.0000071205.52835.A4

    authors: Soejima Y,Shimada M,Suehiro T,Kishikawa K,Yoshizumi T,Hashimoto K,Minagawa R,Hiroshige S,Terashi T,Ninomiya M,Shiotani S,Harada N,Sugimachi K

    更新日期:2003-07-27 00:00:00

  • The global role of kidney transplantation.

    abstract::World Kidney Day on March 8, 2012, provides a chance to reflect on the success of kidney transplantation as a therapy for end-stage kidney disease that surpasses dialysis treatments both for the quality and quantity of life that it provides and for its cost-effectiveness. Anything that is both cheaper and better, but ...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0b013e318245f186

    authors: Garcia GG,Harden P,Chapman J,World Kidney Day Steering Committee 2012.

    更新日期:2012-02-27 00:00:00

  • Early indices of warm ischemic damage in autotransplanted canine kidneys preserved by simple hypothermic storage.

    abstract::After measurement of normal renal function, dog kidneys (n = 52) were subjected to 3, 15, or 30 min of normothermic warm ischemia (WI). After 24 hr of preservation by simple hypothermic storage (SHS) in a modified Collins solution, autotransplant was done and renal function was again measured beginning at 1 hr. Compar...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-198611000-00003

    authors: Gregg CM,Lai MK,Mandour WA,Linke CA

    更新日期:1986-11-01 00:00:00