Abstract:
:The prevalence of angiographically proven coronary artery disease (CAD) in adults with end-stage liver disease who undergo evaluation for liver transplantation is unknown; also it is unclear if cholestatic liver disease represents an independent risk factor. Patients with end-stage liver disease over age 50 having liver transplantation were studied using coronary angiography. Arterial stenosis was graded as normal, mild (< 30%), moderate (30 to 70%), or severe (> 70%). Risk factors for CAD were also assessed (male sex, smoking, hypertension, diabetes, family history of premature heart disease). Complications related to the angiography and decision making based on the findings were recorded. Thirty seven patients (23 females) with a median age of 61 years (range 50 to 71) underwent angiography. Thirteen patients (35.1%) had cholestatic liver disease. Thirty patients had no history of heart disease. The overall prevalence of severe coronary artery disease was 16.2% (95% confidence interval [CI] = 6.2% to 32.0%). No association was detected between CAD and cholestatic liver disease (P = 0.72). After eliminating seven patients with a prior history of angina (n = 1), myocardial infarction (n = 1), or coronary revascularization (n = 5), the frequency of moderate or severe CAD was 13.3% (95% CI = 3.8% to 30.7%). No association was detected between unsuspected CAD and cholestatic liver disease (P = 0.61). Diabetes was the most important risk factor for moderate or severe disease (P = 0.01). Patients without risk factors had significantly less CAD than the group as a whole regardless of the liver disease type (P = 0.02). Two patients experienced transient renal insufficiency after the angiography. Three patients with severe CAD were denied transplantation. We conclude that CAD represents a significant problem in patients over age 50 undergoing liver transplant evaluation. Cholestatic liver disease was not associated with a significantly higher prevalence of moderate or severe CAD in our population. Diabetes was the most predictive risk factor, and those without risk factors do not require extensive preoperative cardiac evaluation.
journal_name
Transplantationjournal_title
Transplantationauthors
Carey WD,Dumot JA,Pimentel RR,Barnes DS,Hobbs RE,Henderson JM,Vogt DP,Mayes JT,Westveer MK,Easley KAsubject
Has Abstractpub_date
1995-03-27 00:00:00pages
859-64issue
6eissn
0041-1337issn
1534-6080journal_volume
59pub_type
杂志文章相关文献
TRANSPLANTATION文献大全abstract:BACKGROUND:Vitamin D deficiency has been reported in different chronic pulmonary diseases like asthma and chronic obstructive pulmonary disease, but little is known in lung transplant recipients. METHODS:Serum 25-hydroxyvitamin D (25-OHD) levels and pulmonary function (forced expiratory volume in 1 sec [FEV(1)] %predi...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31823d98bc
更新日期:2012-01-27 00:00:00
abstract:BACKGROUND:Recent changes in policies guiding allocation of transplant kidneys are predicted to increase sharing between distant geographic regions. The potential exists for an increase in cold ischemia time (CIT) with resulting increases in delayed graft function (DGF) and transplant-related costs (TRC). We sought to ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000002309
更新日期:2019-02-01 00:00:00
abstract:BACKGROUND:Pneumocystis jirovecii pneumonia (PJP) is an important infection-related complication, whose mode of transmission remains uncertain. METHODS:We investigated a nosocomial cluster of 14 PJP cases (11 confirmed and 3 probable) in kidney transplant recipients using epidemiological and genotyping methods. RESUL...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3182384b57
更新日期:2011-12-27 00:00:00
abstract:BACKGROUND:Interleukin- (IL) 10 may be a potent regulator for controlling of allograft rejection. A single administration of IL-10 is not effective for controlling graft rejection. Gene transfer is an attractive vehicle for prolonging the expression of short-lived proteins. METHODS:Donor or recipient livers were trans...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200007270-00018
更新日期:2000-07-27 00:00:00
abstract:BACKGROUND:Guillain-Barre Syndrome (GBS) is believed to be caused by autoimmune mechanisms that are predominantly T-cell mediated. We report GBS in organ transplant patients and bone marrow transplant patients, both of whom have iatrogenically suppressed T-cell function. METHODS:We reviewed the Duke University Medical...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200104270-00026
更新日期:2001-04-27 00:00:00
abstract::Precision medicine is an emerging integrative approach for disease prevention, early detection, and treatment which takes into account individual variability in genetic and other molecular measurements, medical history, environmental exposures, and lifestyle. The development and availability of genomic and other molec...
journal_title:Transplantation
pub_type: 杂志文章,评审
doi:10.1097/TP.0000000000001664
更新日期:2017-08-01 00:00:00
abstract::A controlled trial was carried out to assess the value of intensive plasma exchange in 27 renal transplant recipients with clinical and histological evidence of acute vascular rejection. In addition to standard immunosuppression, 13 patients received plasma exchange on six consecutive days at a mean exchange volume of...
journal_title:Transplantation
pub_type: 临床试验,杂志文章
doi:10.1097/00007890-198305000-00006
更新日期:1983-05-01 00:00:00
abstract:BACKGROUND:An artificial neural networks (ANNs) model was developed to predict 5-year graft survival of living-donor kidney transplants. Predictions from the validated ANNs were compared with Cox regression-based nomogram. METHODS:Out of 1900 patients with living-donor kidney transplant; 1581 patients were used for tr...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31818b221f
更新日期:2008-11-27 00:00:00
abstract::Spodoptera frugiperda (Sf9) insect cells secreted a class I MHC RT1.Aa heavy chain protein when infected with baculovirus that bore a construct that contained a honeybee melittin secretion (ms) signal attached to RT1.Aa cDNA. The RT1.Aa heavy chain protein in the culture supernatant and cell lysate immunoprecipitated ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199602150-00024
更新日期:1996-02-15 00:00:00
abstract::Hepatocyte transplantation (HT) has been performed in patients with liver-based metabolic disease and acute liver failure as a potential alternative to liver transplantation. The results are encouraging in genetic liver conditions where HT can replace the missing enzyme or protein. However, there are limitations to th...
journal_title:Transplantation
pub_type: 社论,评审
doi:10.1097/TP.0b013e31823b72d6
更新日期:2012-02-27 00:00:00
abstract::Donor-specific transfusion effects were studied in the ACI-to-Lewis rat heterotopic heart allograft model using cyclosporine immunosuppression. Low-dose CsA for 1 week plus a single fresh or stored DST given 1 day before allografting significantly prolonged graft survival over CsA therapy alone (median survival time 2...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199109000-00032
更新日期:1991-09-01 00:00:00
abstract:BACKGROUND:BK polyomavirus infection has been reported in 10% to 60% of renal transplant recipients with progression to BK nephropathy (BKN) occurring in 1% to 5% of patients. Graft loss occurs in up to 60% of renal transplant recipients with BKN. Because BK polyomavirus infection is believed, in part, to be a manifest...
journal_title:Transplantation
pub_type: 杂志文章,随机对照试验
doi:10.1097/TP.0b013e3181f2c94b
更新日期:2010-10-27 00:00:00
abstract:BACKGROUND:Intrathymic events undergoing allograft rejection remain undefined. The present study investigated the role of tumor necrosis factor-beta on acute thymic involution in rat hepatic allograft recipients during rejection. METHODS:Apoptosis and cellular phenotypic changes in the thymus were studied after hepati...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199810150-00014
更新日期:1998-10-15 00:00:00
abstract:BACKGROUND:Controversy exists about the conditions effecting the development of forkhead/winghead helix transcription factor P3 (FOXP3) expressing T cells and their relevance in transplant recipients. METHODS:We generated carboxy-fluorescein diacetate succinimidyl ester-labeled CD4+CD25 high FOXP3+ cells in mixed lymp...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3181bbee98
更新日期:2009-12-15 00:00:00
abstract:BACKGROUND:Administration of donor bone marrow (BM)-derived dendritic cell (DC) progenitors (DCp) that are major histocompatibility complex (MHC) class II+ but costimulatory molecule (CD40, CD80, CD86)-deficient can prolong mouse heart allograft survival This is associated with microchimerism and inhibition of antidono...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199812270-00040
更新日期:1998-12-27 00:00:00
abstract::The psychosocial and psychiatric impact of donating bone marrow (BM) has received little study. This mail questionnaire study of bone marrow donors whose recipient had survived more than one year post-BMT was undertaken to document the psychosocial consequences of donation on "successful" BM donors. Demographic, mood ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198604000-00014
更新日期:1986-04-01 00:00:00
abstract::We report the management of a patient with the late onset of chronic graft-versus-host disease (GVHD) after orthotopic liver transplantation. GVHD is a rare complication of solid organ transplants that usually presents early after transplantation and is fatal in the majority of cases. Our patient differs from the typi...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200105270-00022
更新日期:2001-05-27 00:00:00
abstract:BACKGROUND:To reduce the morbidity of living kidney donors we introduced ketorolac-based analgesia for patients undergoing open donor nephrectomy in August 1999. There are no prior reports on the use of ketorolac for patients undergoing donor nephrectomy. METHODS:We conducted a retrospective review of all 198 consecut...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200203150-00014
更新日期:2002-03-15 00:00:00
abstract:BACKGROUND:Significant disparity exists in the United Kingdom between the need for organ transplant and supply of deceased donor organs. In the recent years, efforts to increase donation has improved the rate of mainly deceased donors after circulatory death and from older donors. The rate of donation from pediatric po...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000000575
更新日期:2015-09-01 00:00:00
abstract::We have investigated retrospectively sera from 70 renal allograft recipients for the presence of antibodies binding to a preanastomosis biopsy of the donor kidney by an indirect immunoperoxidase technique. All recipients had a negative T cell lymphocytotoxic crossmatch. A positive immunoperoxidase crossmatch for kidne...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198812000-00011
更新日期:1988-12-01 00:00:00
abstract:BACKGROUND:Clinical studies suggest that the immunosuppressant mycophenolate mofetil is associated with anemia. However, the mechanism for this is not known. Here, we studied the effect of mycophenolic acid (MPA), the active metabolite of mycophenolate mofetil, on erythropoiesis in vitro. METHODS:Both UT-7 cells and p...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e318238da98
更新日期:2011-12-27 00:00:00
abstract::Cyclosporine A administration produces an increase in renal vascular resistance and a decrease in glomerular filtration rate in both human and animal models. CsA usage in humans has also been shown to alter the ability of the kidney to adapt to alterations in renal hemodynamics. CsA alters the production of prostaglan...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199110000-00025
更新日期:1991-10-01 00:00:00
abstract::Although cyclosporine has high specificity for the immune system, immunosuppressive therapy with CsA is often complicated by nephrotoxicity. The main morphologic targets of CsA nephrotoxicity include the tubular epithelial and endothelial cells. These cells were investigated in vitro. CsA caused a dose- and time-depen...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198808001-00017
更新日期:1988-08-01 00:00:00
abstract:BACKGROUND:In live donor liver transplantation portal flush only of the graft is done on the bench. There are no data on antegrade arterial flush along with portal flush of the graft. METHODS:Consecutive patients undergoing elective right lobe live donor liver transplantation were block-randomized to receive either po...
journal_title:Transplantation
pub_type: 杂志文章,随机对照试验
doi:10.1097/TP.0000000000002088
更新日期:2018-04-01 00:00:00
abstract:BACKGROUND:We recently described a new approach that enables the generation of human/mouse chimera by adoptive transfer of human peripheral blood mononuclear cells into lethally irradiated normal strains of mice or rats, radioprotected with bone marrow from donors with severe combined immune deficiency. In such human/m...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199704270-00018
更新日期:1997-04-27 00:00:00
abstract:BACKGROUND:For men with significant genitourinary injury, penile transplantation is being considered as an option when reconstruction is not feasible or proves unacceptable to the injured patient. METHODS:A review of the literature was conducted to assess the current state of penile reconstruction and transplantation ...
journal_title:Transplantation
pub_type: 杂志文章,评审
doi:10.1097/TP.0000000000001352
更新日期:2017-06-01 00:00:00
abstract:INTRODUCTION:Celsior (CEL) was formulated specifically for heart preservation. Recently some preliminary reports have suggested that CEL is also effective for liver preservation. In this study liver preservation with CEL was compared to colloid-free University of Wisconsin solution (MUW). METHODS:Arterialized rat live...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200010270-00002
更新日期:2000-10-27 00:00:00
abstract:BACKGROUND:Kidneys from infectious risk donors (IRD) confer substantial survival benefit in adults, yet the benefit of IRD kidneys to pediatric candidates remains unclear in the context of high waitlist prioritization. METHODS:Using 2010-2016 Scientific Registry of Transplant Recipients data, we studied 2417 pediatric...
journal_title:Transplantation
pub_type: 杂志文章,多中心研究
doi:10.1097/TP.0000000000002674
更新日期:2019-12-01 00:00:00
abstract:BACKGROUND:In chronic graft-versus-host disease (cGvHD), skin fibrosis, contractures, and an increase in collagen content form the hallmark. We report a successful treatment of a cGvHD patient by topical application of halofuginone, an inhibitor of collagen alpha1(I) gene expression. METHODS:Halofuginone-containing oi...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199912150-00027
更新日期:1999-12-15 00:00:00
abstract::T cells must be activated before they can elicit damage to allografts, through interaction of their T cell receptor (TCR) with peptide-MHC complex and through accessory molecules. Signaling through accessory molecules or costimulatory molecules is a critical way for the immune system to fine tune T cell activation. An...
journal_title:Transplantation
pub_type: 杂志文章,评审
doi:10.1097/TP.0b013e31826d4672
更新日期:2013-02-27 00:00:00