Abstract:
BACKGROUND:Guillain-Barre Syndrome (GBS) is believed to be caused by autoimmune mechanisms that are predominantly T-cell mediated. We report GBS in organ transplant patients and bone marrow transplant patients, both of whom have iatrogenically suppressed T-cell function. METHODS:We reviewed the Duke University Medical Center database from 1989-1999 for all patients who met the criteria for GBS. There were a total of 212 patients. Of these patients, two had undergone organ transplantation and two had undergone autologous bone marrow transplantation. RESULTS:Our report supports the notion that the humoral immune system is involved in the pathogenesis of GBS. Contrary to previous reports, however, functional recovery can occur without return of T-cell function. CONCLUSIONS:This suggests that in organ transplant patients, GBS may be humorally mediated and, even more importantly, responds well to treatment.
journal_name
Transplantationjournal_title
Transplantationauthors
Bulsara KR,Baron PW,Tuttle-Newhall JE,Clavien PA,Morgenlander Jdoi
10.1097/00007890-200104270-00026subject
Has Abstractpub_date
2001-04-27 00:00:00pages
1169-72issue
8eissn
0041-1337issn
1534-6080journal_volume
71pub_type
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