Endothelial chimerism in transplantation: Looking for needles in a haystack.

abstract：BACKGROUND:The incidence of stroke and risk factors for different subtypes of cerebrovascular (CBV) events in renal transplant recipients have not been examined in any large prospective controlled trial. METHODS:The Assessment of Lescol in Renal Transplantation was a randomized, double-blind, placebo-controlled study ...

journal_title：Transplantation

authors： Abedini S,Holme I,Fellström B,Jardine A,Cole E,Maes B,Holdaas H,ALERT Study Group.

更新日期：2009-01-15 00:00:00

abstract：:Reduced-size liver transplantation in the rat has been useful in the study of hepatic regeneration. We describe a modified technique for partial liver transplantation in the rat using a 50% reduced-size graft. Male Lewis rats (RT1(1)), weighing 250 to 280 g, were used as donors and recipients. The harvested donor live...

journal_title：Transplantation

authors： Omura T,Ascher NL,Emond JC

更新日期：1996-07-27 00:00:00

abstract：BACKGROUND:Human T-cell lymphotropic virus type I (HTLV-I) causes a subacute myelopathy in less than 5% of chronic carriers. However, the risk of neurologic disease appears to increase in persons infected through blood transfusion. METHODS:We report three recipients of solid organ transplants who developed a subacute ...

journal_title：Transplantation

authors： Toro C,Rodés B,Poveda E,Soriano V

更新日期：2003-01-15 00:00:00

abstract：:Induction immunosuppression is intense, prophylactic therapy used at the time of transplantation based on the empiric observation that more powerful immunosuppression is required to prevent acute rejection early. In the past decade, there has been a growing trend towards the use of specialized agents such as antibody ...

journal_title：Transplantation

authors： Kirk AD

更新日期：2006-09-15 00:00:00

abstract：BACKGROUND:The use of kidneys from non-heartbeating donors (NHB) remains controversial. An increased incidence of delayed primary function and primary nonfunction is common. We report a characteristic syndrome of transaminitis and thrombocytopenia after NHB renal transplantation, which may be predictive of graft outcom...

journal_title：Transplantation

authors： Andrews PA,Denton MD,Compton FC,Koffman CG

更新日期：1997-05-27 00:00:00

abstract：:For many individuals suffering from end-stage liver disease (ESLD), the only treatment option is liver transplantation. However, liver transplant rejection is observed in 24-80% of transplant patients and lifelong drug regimens that follow the transplant procedure lead to serious side effects. Furthermore, the pool of...

journal_title：Transplantation

authors： Wang X,MacParland SA,Perciani CT

更新日期：2021-01-06 00:00:00

abstract：:The generation of Gal knockout (KO) pigs is likely to be an important advance in xenotransplantation. However, recent reports suggesting that expression of Gal may not be completely eliminated raise the possibility of a continuing anti-Gal immune response. The authors used a Gal-mismatched skin graft model to study ce...

journal_title：Transplantation

authors： Gock H,Murray-Segal L,Salvaris E,Cowan P,D'Apice AJ

更新日期：2004-03-15 00:00:00

abstract：BACKGROUND:Randomized controlled trials and U.S. Registry data have demonstrated that mycophenolate mofetil (MMF) reduces acute rejection rates and improves graft survival. We undertook the first paired kidney analysis comparing the effects of MMF and azathioprine on graft outcome in the United Kingdom. METHODS:In all...

journal_title：Transplantation

authors： Shah S,Collett D,Johnson R,Thuraisingham RC,Raftery MJ,Rudge CJ,Yaqoob MM

更新日期：2006-12-27 00:00:00

abstract：:Although solid organ transplant results have improved significantly in recent decades, a pivotal cause of impaired long-term outcome is the development of antibody-mediated rejection (AMR), a condition characterized by the presence of donor specific antibodies to human leukocyte antigen (HLA) or non-HLA antigens. High...

journal_title：Transplantation

authors： Kardol-Hoefnagel T,Otten HG

更新日期：2020-11-17 00:00:00

abstract：:Acute graft-versus-host disease (GVHD) has recently been associated with endothelial cell injury. The potential clinical significance was explored here in an autopsy review. Thirty-seven allogeneic bone marrow recipients were identified in the autopsy files at The Johns Hopkins Hospital with no evidence of systemic in...

journal_title：Transplantation

authors： Wojno KJ,Vogelsang GB,Beschorner WE,Santos GW

更新日期：1994-01-01 00:00:00

abstract：BACKGROUND:Pancreatic islets are avascular immediately after transplantation and depend on revascularization. Recently, the authors found decreased vascular density in mouse islets 1 month after implantation into nondiabetic recipients. This study investigated possible differences in revascularization between islets im...

journal_title：Transplantation

authors： Mattsson G,Jansson L,Nordin A,Carlsson PO

更新日期：2003-03-15 00:00:00

abstract：BACKGROUND:There are few prospective studies of prednisone-free immunosuppression (IS) in pediatric kidney transplant (KTx) recipients. We studied the outcomes of a protocol using rapid discontinuation of prednisone (RDP, <1 week) and thymoglobulin induction. METHODS:Twenty-one RDP recipients (mean age 14+/-3 years) r...

journal_title：Transplantation

authors： Chavers BM,Chang YC,Gillingham KJ,Matas A

更新日期：2009-07-27 00:00:00

abstract：:We examined the effect of methotrexate (MTX) combined with cyclosporine (CSP) on the prevention of graft-versus-host disease (GVHD) in dogs. Ten recipients were prepared for grafting with 9 Gy of total-body irradiation and given marrow and buffy coat cells from littermate donors differing for one DLA haplotype (AA lea...

journal_title：Transplantation

authors： Deeg HJ,Storb R,Appelbaum FR,Kennedy MS,Graham TC,Thomas ED

更新日期：1984-01-01 00:00:00

abstract：:Islet transplantation may be optimized by islet immunoisolation to prevent direct contact between the islet graft and the host tissue. In this study, we examined the glycemia and insulin secretion in streptozotocin-diabetic rats transplanted with islets subjected to immunoisolation with Algire diffusion chamber or wit...

journal_title：Transplantation

authors： Ar'Rajab A,Bengmark S,Ahrén B

更新日期：1991-03-01 00:00:00

abstract：:It has been postulated that the establishment of acquired, neonatal immunologic tolerance is due to a "deficit" in interleukin 2 (IL-2). To test this hypothesis, chickens were made immunologically tolerant to both major and minor histocompatibility antigens by transplantation of skin grafts onto newly hatched recipien...

journal_title：Transplantation

authors： Tempelis CH,Hála K,Krömer G,Schauenstein K,Wick G

更新日期：1988-02-01 00:00:00

abstract：BACKGROUND:The inflammatory reaction that occurs during the 5 days after transplantation led at 3 days to the death of 70% of injected myoblasts. Use of anti-inflammatory agents appeared to be a possible way to increase myoblast survival. The application of gene transfer techniques to cell transplantation offers the po...

journal_title：Transplantation

authors： Merly F,Huard C,Asselin I,Robbins PD,Tremblay JP

更新日期：1998-03-27 00:00:00

abstract：:Several studies have reported the development of antiidiotypic antibodies to anti-HLA alloantibodies in renal allograft transplant recipients, postulating their potential beneficial role in allograft survival. In order to evaluate the role of anti-HLA antiidiotypic antibodies in human liver transplant recipients and t...

journal_title：Transplantation

authors： Chauhan B,Phelan DL,Marsh JW,Mohanakumar T

更新日期：1993-08-01 00:00:00

abstract：:Although bisphosponates are proposed as first-line treatment for posttransplant bone disease they are not optimal in all situations. A kidney transplant recipient developed hypercalcemia from mobilization of extraskeletal calcium. He had low serum parathyroid hormone and vitamin D; high calcium excretion; and normal c...

journal_title：Transplantation

authors： Dhingra RK,Sprague SM,Ojo AO,Leavey SF

更新日期：2001-06-27 00:00:00

abstract：BACKGROUND:Interspecies differences create important shortcomings in existing animal models used to describe in vivo events responsible for allograft rejection. Alloimmune destruction of human dermal microvessels, histologically consistent with rejection, has been demonstrated in human skin-grafted severe combined immu...

journal_title：Transplantation

authors： Lorber MI,Wilson JH,Robert ME,Schechner JS,Kirkiles N,Qian HY,Askenase PW,Tellides G,Pober JS

更新日期：1999-03-27 00:00:00

abstract：:Acute graft-versus-host-disease is classically described as reactivity of donor lymphocytes to recipient alloantigens. To date there is debate as to whether GVHD can be induced across a species barrier. We recently reported the induction of stable xenogeneic chimerism (rat-->mouse) and donor-specific transplantation t...

journal_title：Transplantation

authors： Cooper MH,Nalesnik MA,Watkins SC,Hoffman RA,Ildstad ST

更新日期：1993-10-01 00:00:00

abstract：BACKGROUND:The National Marrow Donor Program (NMDP) has approximately 5 million registered potential donors and continues to add more than 30,000 new recruits to the registry monthly. However, more than 30% of potential donors are not available or decline to donate at key decision points in the donation process. Althou...

journal_title：Transplantation

authors： Myaskovsky L,Switzer GE,Dew MA,Goycoolea JM,Confer DL,Abress L

更新日期：2004-03-27 00:00:00

abstract：BACKGROUND:Systemic amyloidosis complicated by heart failure is associated with high cardiovascular morbidity and mortality. Heart transplantation for patients with systemic amyloidosis is controversial due to recurrence of disease in the transplanted organ or progression of disease in other organs. METHODS:All patien...

journal_title：Transplantation

authors： Maurer MS,Raina A,Hesdorffer C,Bijou R,Colombo P,Deng M,Drusin R,Haythe J,Horn E,Lee SH,Marboe C,Naka Y,Schulman L,Scully B,Shapiro P,Prager K,Radhakrishnan J,Restaino S,Mancini D

更新日期：2007-03-15 00:00:00

abstract：:To determine the extent to which pretransplant immunity resulting from natural infection protects against cytomegalovirus (CMV) disease, we analyzed CMV serology on 153 kidney donor and recipient pairs and followed transplant patients to determine incidence and severity of CMV disease. The overall incidence of CMV dis...

journal_title：Transplantation

authors： Smiley ML,Wlodaver CG,Grossman RA,Barker CF,Perloff LJ,Tustin NB,Starr SE,Plotkin SA,Friedman HM

更新日期：1985-08-01 00:00:00

abstract：:To examine whether cyclosporine (CsA) has mutagenic potential against human cells, we analyzed sister chromatid exchange (SCE) induction by CsA using human lymphocytes in vitro. SCE frequencies increased significantly in the lymphocytes treated with 1 microgram/ml and 5 micrograms/ml CsA, though the frequencies seemed...

journal_title：Transplantation

authors： Yuzawa K,Kondo I,Fukao K,Iwasaki Y,Hamaguchi H

更新日期：1986-07-01 00:00:00

abstract：:The lung is one of the primary targets of acute graft-versus-host disease (GVHD), which is the principal complication that occurs after allogeneic intestinal transplantation. The purpose of this study is to investigate the involvement of Fas/Fas ligand system in pulmonary injury after rat semi-allogeneic intestinal tr...

journal_title：Transplantation

authors： Hiroyasu S,Shiraishi M,Koji T,Mamadi T,Sugawa H,Tomori H,Muto Y

更新日期：1999-10-15 00:00:00

abstract：BACKGROUND:Immunosuppression involves the nature of the immunosuppressive agents and individual differences in patient factors. We investigated whether the effect of mycophenolate mofetil (MMF) is measurable using an in vitro measure of immunocompetence and related its effects to cyclosporine (CsA) in vitro. METHODS:L...

journal_title：Transplantation

authors： Ogawa N,Nagashima N,Nakamura M,Shalabi A,Maley WR,Burdick JF

更新日期：2001-08-15 00:00:00

abstract：BACKGROUND:Graft coronary arteriosclerosis (GCA) is the major limiting factor for long-term survival after heart transplantation. In this study, we investigated the effect of Multiglycosidorum tripterygii (MT) on GCA and platelet-derived growth factor A (PDGF-A) mRNA expression of transplanted hearts. METHODS:Two grou...

journal_title：Transplantation

authors： Hachida M,Zhang XL,Lu H,Hoshi H,Koyanagi H

更新日期：1998-06-15 00:00:00

abstract：BACKGROUND:HLAMatchmaker is a computer algorithm that determines human leukocyte antigen (HLA) compatibility at the level of polymorphic amino acid triplets in antibody-accessible sequence positions. Recent studies have shown that HLA-DR-matched kidney transplant recipients with zero to two triplet mismatches had almos...

journal_title：Transplantation

authors： Duquesnoy RJ,Howe J,Takemoto S

更新日期：2003-03-27 00:00:00

abstract：BACKGROUND:Donor hepatectomy with maximal safety while preserving graft viability is of principal concern in living donor liver transplantation. There are compelling reasons for avoiding blood transfusion, even with autologous blood, to avoid the potential risks it imposes on healthy donors. This study aims to describe...

journal_title：Transplantation

authors： Chen CL,Chen YS,de Villa VH,Wang CC,Lin CL,Goto S,Wang SH,Cheng YF,Huang TL,Jawan B,Cheung HK

更新日期：2000-06-27 00:00:00

abstract：BACKGROUND:Patients with long-term functioning organ allografts may have developed different mechanisms that explain the lack of graft rejection. However, it is not known how these mechanisms interplay or whether one of them predominates in such situations. METHODS:The authors analyzed the expression of T-cell surface...

journal_title：Transplantation

authors： Alvarez CM,Paris SC,Arango L,Arbelaez M,Garcia LF,RAD B201 study group.

更新日期：2004-11-27 00:00:00