Fine-needle aspiration biopsy in the monitoring of liver allografts. Different cellular findings during rejection and cytomegalovirus infection.

abstract：BACKGROUND:Dendritic cells (DC) can exert powerful immune stimulatory as well as regulatory functions and are therefore important tools for therapeutic strategies. Dexamethasone (Dex) was previously shown to inhibit DC maturation and to induce regulatory properties both in vitro and in vivo. Here, we investigated the i...

journal_title：Transplantation

authors： Stax AM,Gelderman KA,Schlagwein N,Essers MC,Kamerling SW,Woltman AM,van Kooten C

更新日期：2008-11-15 00:00:00

abstract：BACKGROUND:The quantitation of donor leukocyte chimerism may aid in establishing the etiology of neutropenia after liver transplantation. METHODS:The incidence and clinical and laboratory characteristics of severe neutropenia were studied in adults who have undergone liver transplantation at our institution over the l...

journal_title：Transplantation

authors： Jonsson JR,Gill D,Hogan PG,Clouston AD,Edwards-Smith C,Griffin AD,Balderson GA,Lynch SV,Strong RW,Powell EE

更新日期：1999-05-27 00:00:00

abstract：:In a DBA/2 (H-2d) pancreatic islet-to-B6AF1 (H-2b/k.d) recipient combination, the graft survival of hand-picked islets was compared with that of "crude digested" islets that were prepared simply by collagenase digestion and Ficoll gradient separation and were contaminated with lymph nodes and vascular and ductal tissu...

journal_title：Transplantation

authors： Gotoh M,Maki T,Satomi S,Porter J,Monaco AP

更新日期：1986-10-01 00:00:00

abstract：:Immunomodulatory properties are attributed to apoptotic cells. These properties have been used to modulate allogeneic immune responses in experimental transplantation settings. In independent studies, apoptotic cell infusion has been shown to favor hematopoietic cell engraftment, to increase heart graft survival, and ...

journal_title：Transplantation

authors： Saas P,Bonnefoy F,Kury-Paulin S,Kleinclauss F,Perruche S

更新日期：2007-07-15 00:00:00

abstract：BACKGROUND:Black kidney transplant recipients experience disproportionately high rates of graft loss. This disparity has persisted for 40 years, and improvements may be impeded based on the current public reporting of overall graft loss by US regulatory organizations for transplantation. METHODS:Longitudinal cohort st...

journal_title：Transplantation

authors： Taber DJ,Gebregziabher M,Payne EH,Srinivas T,Baliga PK,Egede LE

更新日期：2017-02-01 00:00:00

abstract：:Four skin graft models are created which vary in the rates of lymphatic and vascular reconstitution. Rat allografts (Brown Norway or (L times BN)F1 hybrid) transplanted to Lewis recipients by conventional (immediate lymphatic, delayed vascular), surgical anastomosis (immediate lymphatic, immediate vascular) or isolate...

journal_title：Transplantation

authors： Wustrack KO,Gruber RP,Lucas ZJ

更新日期：1975-02-01 00:00:00

abstract：BACKGROUND:Neonatal primates have been reported to receive pig hearts without hyperacute rejection (HAR). We examined the ontogeny of the anti-pig xenoantibody (XenoAb) and HAR in the neonatal and infant monkeys. METHODS:Twenty-six serum samples from 15 monkeys ages 14-192 days were subjected to hemagglutination titra...

journal_title：Transplantation

authors： Kawauchi M,Nakajima J,Endoh M,Oka T,Takamoto S

更新日期：2000-08-27 00:00:00

abstract：BACKGROUND:Heart transplantation (HTx) remains the most effective long-term treatment for advanced heart failure. Primary graft dysfunction (PGD) continues to be a potentially life-threatening early complication. In 2014, a consensus statement released by International Society for Heart and Lung Transplantation (ISHLT)...

journal_title：Transplantation

authors： Avtaar Singh SS,Banner NR,Rushton S,Simon AR,Berry C,Al-Attar N

更新日期：2019-02-01 00:00:00

abstract：:Two patients at our institution underwent single lung transplantation. The procedure and the patient's postoperative course were uncomplicated in each case. Pathological examination of each pneumonectomy specimen revealed a well-differentiated adenocarcinoma; both were less than 1 cm in size. The remainder of each lun...

journal_title：Transplantation

authors： Svendsen CA,Bengtson RB,Park SJ,Shumway SJ

更新日期：1998-10-27 00:00:00

abstract：:Adhesion of leukocytes to vascular endothelium is a necessary step leading to the migration of cells into underlying tissues. Vascular adhesion molecules regulate this process and may play an important role in graft rejection. Immunocytochemical studies have been used to investigate the expression of vascular adhesion...

journal_title：Transplantation

authors： Taylor PM,Rose ML,Yacoub MH,Pigott R

更新日期：1992-09-01 00:00:00

abstract：:The study purpose was to identify risks, benefits and costs associated with an expanded donor protocol. The protocol design evaluated organs rescued using expanded donor criteria and weighed all costs associated with doing so. Costs were measured against conditions experienced with expanded and traditional criteria an...

journal_title：Transplantation

authors： Jacobbi LM,McBride VA,Etheredge EE,McDonald JC,Cooper ES,Frey D,Boudreaux JP,Gonzalez F,Van Meter C,McMillan R

更新日期：1995-12-27 00:00:00

abstract：:To establish the impact of transplantation on the course of chronic hepatitis B liver disease we performed a prospective study of the clinical and pathological sequelae of hepatitis B disease in all 22 patients who had renal allografts that functioned for more than 1 year and who were hepatitis B surface antigen (HBsA...

journal_title：Transplantation

authors： Parfrey PS,Forbes RD,Hutchinson TA,Kenick S,Farge D,Dauphinee WD,Seely JF,Guttmann RD

更新日期：1985-06-01 00:00:00

abstract：:Thromboxane (Tx) plays a vital role in the dysfunction and ultimate rejection of MHC-disparate renal allografts. In addition to its potent vasoconstrictory properties, in vivo studies have implied that Tx is capable of promoting immune cytotoxic T cell function within transplants. In this study, we have examined the i...

journal_title：Transplantation

authors： Ruiz P,Rey L,Spurney R,Coffman T,Viciana A

更新日期：1992-09-01 00:00:00

abstract：:During acute rejection of rat renal allografts, numerous activated monocytes accumulate in the vasculature of the graft. These monocytes seem to be involved in allograft destruction. Proinflammatory and effector functions of monocytes and macrophages can be down-regulated by peroxisome proliferators, which are probabl...

journal_title：Transplantation

authors： Grau V,Garn H,Bette M,Spener F,Steiniger B,Gemsa D,Stehling O

更新日期：2003-03-15 00:00:00

abstract：:A new method of thymus transplantation is introduced, in which the graft is directly connected with the recipient's vascular system. This procedure was used both in euthymic rats and congenitally athymic nude rats. At all tested intervals after transplantation thymus grafts hardly differed from the recipient's own thy...

journal_title：Transplantation

authors： Kampinga J,Schuurman HJ,Pol GH,Bartels H,Broekhuizen R,Vaessen LM,Tielen FJ,Rozing J,Blaauw EH,Roser B

更新日期：1990-10-01 00:00:00

abstract：BACKGROUND:Decapeptides derived from human HLA class I sequences have been shown to prolong allograft survival. The mechanism of action of these peptides has been uncertain, because they act in an MHC unrestricted manner. Recently, it was found that these peptides bind heme oxygenase 1 (HO-1). In the present study, we ...

journal_title：Transplantation

authors： DeBruyne LA,Magee JC,Buelow R,Bromberg JS

更新日期：2000-01-15 00:00:00

abstract：BACKGROUND:Assays of drug blood levels are used for therapeutic immunosuppressive drug monitoring (pharmacokinetics, PK). We monitored lymphocyte functions (pharmacodynamics, PD) in allograft recipients treated with mycophenolic acid (MPA) to determine its mechanisms and the relationships among dose levels, PK, PD, and...

journal_title：Transplantation

authors： Gummert JF,Barten MJ,van Gelder T,Billingham ME,Morris RE

更新日期：2000-10-15 00:00:00

abstract：:Several approaches have been attempted to manage renal allograft dysfunction in cyclosporine-prednisone (CsA-Pred)-treated patients. Conversion to conventional therapy and perioperative triple drug have been associated with high rates of acute rejection episodes, infections, or neoplasms. We report our experience in d...

journal_title：Transplantation

authors： Pascual J,Marcén R,Orofino L,Quereda C,Mampaso F,Liaño F,Ortuño J

更新日期：1991-08-01 00:00:00

abstract：:The number of patients awaiting hepatic transplantation continues to exceed organ donation. As a result, many liver transplant candidates will develop life-threatening complications of their liver disease and not survive the pretransplant waiting period. Recent studies have demonstrated that hepatic lidocaine metaboli...

journal_title：Transplantation

authors： Shiffman ML,Fisher RA,Sanyal AJ,Edinboro LE,Luketic VA,Purdum PP 3rd,Raymond P,Posner MP

更新日期：1993-04-01 00:00:00

abstract：BACKGROUND:Liver transplantation from donation after cardiac death (DCD) donors is an increasingly common approach for expansion of the donor organ supply. However, transplantation with DCD livers results in inferior graft survival. In this study, we examined donor and recipient characteristics that are associated with...

journal_title：Transplantation

authors： Lee KW,Simpkins CE,Montgomery RA,Locke JE,Segev DL,Maley WR

更新日期：2006-12-27 00:00:00

abstract：:To determine the impact of different flush and reperfusion techniques on postreperfusion syndrome (PRS) and postoperative graft function, 100 transplants were randomly assigned into four groups as follows: group 1 (n=31), portal vein flush, no vena caval venting; group 2 (n=21), hepatic arterial flush, no vena caval v...

journal_title：Transplantation

authors： Millis JM,Melinek J,Csete M,Imagawa DK,Olthoff KM,Neelankanta G,Braunfeld MY,Sopher MJ,Chan SM,Pregler JL,Yersiz H,Busuttil AA,Shackleton CR,Shaked A,Busuttil RW

更新日期：1997-02-15 00:00:00

abstract：:Spontaneous rupture of the liver has been described in association with many benign and malignant conditions. We report, to our knowledge, the first case of spontaneous rupture of the liver upon revascularization, requiring total hepatectomy and portocaval shunt, followed by successful retransplantation. Routine patho...

journal_title：Transplantation

authors： Mistry BM,Solomon H,Garvin PJ,Durham RM,Turnage S,Bacon BR,Galvin N,Varma CR

更新日期：2000-05-27 00:00:00

abstract：:Frozen sections of lymph nodes from normal mice were examined by immunofluorescence with anti-T lymphocyte and anti-Ig reagents and by autoradiography following [3H]TdR administration. The scattered T lymphocytes present among B lymphocytes of primary follicles were found to be mostly nonproliferating; the few prolife...

journal_title：Transplantation

authors： Berman MA,Rafiei S,Gutman GA

更新日期：1981-11-01 00:00:00

abstract：:Acute graft-versus-host-disease is classically described as reactivity of donor lymphocytes to recipient alloantigens. To date there is debate as to whether GVHD can be induced across a species barrier. We recently reported the induction of stable xenogeneic chimerism (rat-->mouse) and donor-specific transplantation t...

journal_title：Transplantation

authors： Cooper MH,Nalesnik MA,Watkins SC,Hoffman RA,Ildstad ST

更新日期：1993-10-01 00:00:00

abstract：:To evaluate the pharmacokinetic properties of the new microemulsion formulation of cyclosporine (Sandimmun Neoral), a double-blind, prospective study in stable renal transplant recipients was performed. The patients were randomized on a 4:1 basis either to receive Sandimmun Neoral (n = 45) or continue on regular Sandi...

journal_title：Transplantation

authors： Wahlberg J,Wilczek HE,Fauchald P,Nordal KP,Heaf JG,Olgaard K,Hansen JM,Lokkegaard H,Mueller EA,Kovarik JM

更新日期：1995-10-15 00:00:00

abstract：BACKGROUND:The aim of this study was to investigate the population pharmacokinetics of tacrolimus in pediatric liver transplant recipients and to identify factors that may explain pharmacokinetic variability. METHODS:Data were collected retrospectively from 35 children who received oral immunosuppressant therapy with ...

journal_title：Transplantation

authors： Staatz CE,Taylor PJ,Lynch SV,Willis C,Charles BG,Tett SE

更新日期：2001-09-27 00:00:00

abstract：INTRODUCTION:We investigated the putative candidate biomarkers of graft rejection in peripheral blood of intestinal transplant patients. MATERIALS AND METHODS:Peripheral blood gene expression analysis was performed in intestinal transplant patients. The results were matched with concurrent graft biopsies using bioinfo...

journal_title：Transplantation

authors： Andreev VP,Tryphonopoulos P,Blomberg BB,Tsinoremas N,Weppler D,Neuman DR,Volsky A,Nishida S,Tekin A,Selvaggi G,Levi DM,Tzakis AG,Ruiz P

更新日期：2011-12-27 00:00:00

abstract：:We have analyzed HLA data from the UNOS registry on 20,230 patients on the renal waiting list in 1991 and 18,708 donors from 1988-1992. Significant differences were found in the distribution of HLA antigens for comparisons of the total donor pool and the various racial groups of patients as well as for inter- and intr...

journal_title：Transplantation

authors： Leffell MS,Steinberg AG,Bias WB,Machan CH,Zachary AA

更新日期：1994-11-27 00:00:00

abstract：BACKGROUND:We are presently investigating the therapeutic potential of herpes simplex-thymidine kinase-expressing donor T cells in the setting of a T cell-depleted allogeneic bone marrow transplantation. The generation, expansion, and selection of the gene-modified T cells require a 12-day ex vivo culture period in hig...

journal_title：Transplantation

authors： Contassot E,Murphy W,Angonin R,Pavy JJ,Bittencourt MC,Robinet E,Reynolds CW,Cahn JY,Hervé P,Tiberghien P

更新日期：1998-05-27 00:00:00

abstract：:Hepatic venoocclusive disease is a frequent lethal complication of bone marrow transplantation. It has also been associated with hepatic irradiation and administration of chemotherapeutic agents without BMT. The pathogenesis and therapy of VOD are unclear. The present studies were directed at developing a canine model...

journal_title：Transplantation

authors： Epstein RB,Min KW,Anderson SL,Syzek L

更新日期：1992-07-01 00:00:00