The distribution of HLA antigens and phenotypes among donors and patients in the UNOS registry.

abstract：:Ontogenic development of suppressor cells was studied in mouse embryos. It was found that liver cells of embryos at various stages of gestation were capable of interfering with the mixed leukocyte culture (MLC) reaction. The MLC reaction was also inhibited by embryonic spleen and thymus cells. However, the latter were...

journal_title：Transplantation

authors： Globerson A,Umiel T

更新日期：1978-12-01 00:00:00

abstract：BACKGROUND:Remote ischemic preconditioning (RIPC) protects against liver ischemia reperfusion (IR) injury. An essential circulating mediator of this protection is nitric oxide (NO) induced by lower limb RIPC. One of the mechanisms through which NO generally acts is the soluble guanylyl cyclase-cyclic GMP (sGC-cGMP) pat...

journal_title：Transplantation

authors： Abu-Amara M,Yang SY,Quaglia A,Rowley P,Tapuria N,Fuller B,Davidson B,Seifalian A

更新日期：2012-05-15 00:00:00

abstract：BACKGROUND:The rate of acute rejection (AR) has decreased significantly, but whether this is associated with improvement in long-term graft survival is controversial. METHODS:We analyzed 1445 consecutive adult deceased donor kidney transplant recipients from 1985 to 2005, over two periods (1985-1995 vs. 1996-2005) to ...

journal_title：Transplantation

authors： Sola E,Gonzalez-Molina M,Cabello M,Burgos D,Ramos J,Gutierrez C,Lopez V,Soler J,de la Vega E,Hernandez D

更新日期：2010-03-27 00:00:00

abstract：BACKGROUND:We previously reported the novel activity of alloprimed CD8 T cells that suppress posttransplant alloantibody production. The purpose of the study is to investigate the expression and role of CXCR5 on antibody-suppressor CD8 T-cell function. METHODS:C57BL/6 mice were transplanted with FVB/N hepatocytes. All...

journal_title：Transplantation

authors： Zimmerer JM,Ringwald BA,Elzein SM,Avila CL,Warren RT,Abdel-Rasoul M,Bumgardner GL

更新日期：2019-09-01 00:00:00

abstract：BACKGROUND:Small-for-size grafts often cause persistent conjugated hyperbilirubinemia in the recipient after adult-to-adult living donor liver transplantation, but the cause has not yet been clarified. In physiologic status, bilirubin is excreted from hepatocytes to the bile canaliculus by means of multidrug resistance...

journal_title：Transplantation

authors： Chang TH,Hakamada K,Toyoki Y,Tsuchida S,Sasaki M

更新日期：2004-01-15 00:00:00

abstract：:Mandatory continuous monitoring of early transplant outcome with centralized oversight was introduced in 2004 for all 23 UK adult kidney transplant units. Risk-adjusted cumulative sum charts are used to assess 30-day graft and patient survival against past performance for each center, and change in transplant center p...

journal_title：Transplantation

authors： Collett D,Sibanda N,Pioli S,Bradley JA,Rudge C

更新日期：2009-10-27 00:00:00

abstract：:Portal vein thrombosis is the most common cause of portal hypertension in noncirrhotic patients. Variceal bleeding is difficult to treat in these patients, especially those with prehepatic diffuse portal mesenteric thrombosis. In a patient with refractory esophagogastroduodenal variceal bleeding as a result of diffuse...

journal_title：Transplantation

authors： Vianna R,Giovanardi RO,Fridell JA,Tector AJ

更新日期：2005-08-27 00:00:00

abstract：BACKGROUND:Although islet xenotransplantation is a promising therapy for type 1 diabetes, its clinical application has been hampered by cellular rejection and the requirement for high levels of immunosuppression. The aim of this study was to determine the role of Foxp3 regulatory T (Treg) cells in costimulation blockad...

journal_title：Transplantation

authors： Wu J,Hu M,Qian YW,Hawthorne WJ,Burns H,Liuwantara D,Alexander SI,Yi S,O'Connell PJ

更新日期：2017-07-01 00:00:00

abstract：:Programmed cell death (PCD) is currently one of the most intensively studied areas in cell biology. Substantial evidence now exists demonstrating the integral role of PCD in many fundamental immunologic processes; therefore, understanding the mechanisms of PCD may provide advances with broad implications in immunobiol...

journal_title：Transplantation

authors： Woodle ES,Kulkarni S

更新日期：1998-09-27 00:00:00

abstract：:There is increasing evidence that various maturational stages of B-cells infiltrate various solid organ transplants undergoing acute rejection. The presence of immature CD20 and mature CD138 plasma cells associate with more aggressive and steroid-recalcitrant graft rejection and portend poor graft outcomes. Though ass...

journal_title：Transplantation

authors： Zarkhin V,Li L,Sarwal M

更新日期：2008-06-27 00:00:00

abstract：BACKGROUND:MicroRNA-155 (miR-155) is known to be involved in autoimmune diseases, inflammation, and transplantation. However, its role in a warm hepatic ischemia-reperfusion (IR) model has not been fully elucidated. METHODS:Partial hepatic IR was performed in wild-type and miR-155-deficient mice treated with or withou...

journal_title：Transplantation

authors： Li Y,Ma D,Wang Z,Yang J

更新日期：2017-07-01 00:00:00

abstract：:Created by the US National Organ Transplant Act in 1984, the Scientific Registry of Transplant Recipients (SRTR) is obligated to publicly report data on transplant program and organ procurement organization performance in the United States. These reports include risk-adjusted assessments of graft and patient survival,...

journal_title：Transplantation

authors： Snyder JJ,Salkowski N,Kim SJ,Zaun D,Xiong H,Israni AK,Kasiske BL

更新日期：2016-02-01 00:00:00

abstract：:T cells must be activated before they can elicit damage to allografts, through interaction of their T cell receptor (TCR) with peptide-MHC complex and through accessory molecules. Signaling through accessory molecules or costimulatory molecules is a critical way for the immune system to fine tune T cell activation. An...

journal_title：Transplantation

authors： Kinnear G,Jones ND,Wood KJ

更新日期：2013-02-27 00:00:00

abstract：:Distribution of cadaveric donor kidneys, based upon the donor-recipient HLA match grade, remains one of the major controversies in transplantation. To determine whether matching results in fewer rejection episodes and better graft survival, we retrospectively studied our single-center patient population of 683 cyclosp...

journal_title：Transplantation

authors： Kerman RH,Kimball PM,Lindholm A,Van Buren CT,Katz SM,Lewis RM,McClain J,Podbielski J,Williams J,Kahan BD

更新日期：1993-11-01 00:00:00

abstract：:To determine if cold preservation time continues to affect renal transplant outcome, prospectively collected data from 17,937 cadaveric renal transplants performed between 1982 and 1991 were analyzed. Cold preservation intervals of 1-16, 16-32, 32-48, and greater than 48 hr were studied by multi- and univariate method...

journal_title：Transplantation

authors： Peters TG,Shaver TR,Ames JE 4th,Santiago-Delpin EA,Jones KW,Blanton JW

更新日期：1995-01-27 00:00:00

abstract：BACKGROUND:There is growing interest in new therapeutic options for the treatment of end-stage liver diseases. In addition to mechanical devices supporting liver function, such as bioreactors, the transplantation of hepatocyte-like cells derived from (adult) stem cells offer great perspectives. We have generated hepato...

journal_title：Transplantation

authors： Ruhnke M,Nussler AK,Ungefroren H,Hengstler JG,Kremer B,Hoeckh W,Gottwald T,Heeckt P,Fandrich F

更新日期：2005-05-15 00:00:00

abstract：:The humanization of animals is a powerful tool for the exploration of human disease pathogenesis in biomedical research, as well as for the development of therapeutic interventions with enhanced translational potential. Humanized models enable us to overcome biologic differences that exist between humans and other spe...

journal_title：Transplantation

authors： Adigbli G,Ménoret S,Cross AR,Hester J,Issa F,Anegon I

更新日期：2020-11-01 00:00:00

abstract：BACKGROUND:Metabolic syndrome (MS) is a known cardiovascular risk factor in the general population. We explored the influence of MS on the occurrence of atherosclerotic events (AEs) after renal transplantation. METHODS:Three hundred thirty-seven renal transplant recipients were included in the study. Various parameter...

journal_title：Transplantation

authors： Courivaud C,Kazory A,Simula-Faivre D,Chalopin JM,Ducloux D

更新日期：2007-06-27 00:00:00

abstract：:ABO-incompatible (ABOi) kidney transplantation has gained a renewed interest during the past years. In 2001, a protocol for ABOi kidney transplantation based on antigen-specific immunoadsorption and rituximab was introduced at our center. In this study long-term graft function using this protocol was assessed. All ABO...

journal_title：Transplantation

authors： Genberg H,Kumlien G,Wennberg L,Tydén G

更新日期：2007-12-27 00:00:00

abstract：BACKGROUND:Lower liver transplant success is observed when the donor is female. Intracellular acidosis during ischemia is proposed to contribute to the injury sustained by the transplanted organ and its role in livers obtained from nonheartbeating donors is unclear. Research has shown that livers of female rats develop...

journal_title：Transplantation

authors： Soric S,Belanger MP,Askin N,Wittnich C

更新日期：2007-09-27 00:00:00

abstract：BACKGROUND:The need to find a safe, effective liver support system for patients with fulminant hepatic failure (FHF) continues to be unmet. A system using immortalized human hepatocytes was originally developed in the early 1990s. A modified version of the initial extracorporeal liver-assist device (ELAD) was recently ...

journal_title：Transplantation

authors： Millis JM,Cronin DC,Johnson R,Conjeevaram H,Conlin C,Trevino S,Maguire P

更新日期：2002-12-27 00:00:00

abstract：:Graft and patient survival rates were analyzed in 239 consecutive first cadaver renal transplants as a function of time of administration of blood transfusion and the number of units given. There was no statistically significant difference in patient survival in comparing patients who were never transfused, patients n...

journal_title：Transplantation

authors： Corry RJ,West JC,Hunsicker LG,Schanbacher BA,Lachenbruch PA

更新日期：1980-12-01 00:00:00

abstract：:We retrospectively compared the clinical and financial impact of a final cross-match by T cell flow cytometry (FXM) versus conventional complement-dependent cytotoxicity (CXM) in consecutive primary cadaveric kidney (K) and primary simultaneous cadaveric pancreas-kidney (SPK) transplant recipients. Mean follow-up was ...

journal_title：Transplantation

authors： Pelletier RP,Orosz CG,Adams PW,Bumgardner GL,Davies EA,Elkhammas EA,Henry ML,Ferguson RM

更新日期：1997-06-15 00:00:00

abstract：:By means of double diffusion in gel reactions, "heterophile" antibodies were demonstrated in human renal transplantation sera. Of thirty-two recipients of renal allografts, 12 (37 per cent) had antibodies to extract of bovine erythrocyte stromata, and 5 (19 per cent) of 26 recipients produced antibodies to extract of ...

journal_title：Transplantation

authors： Kano K,Loza U,Gerbasi JR,Milgrom F

更新日期：1975-01-01 00:00:00

abstract：:The fate of cell surface I-Ak and H-2Kk antigens shed by murine spleen cells in culture was studied by incubation of nonlabeled spleen cells or splenic T or B cells with culture fluids containing shed radiolabeled alloantigens. Approximately 30 to 40% of the shed alloantigens could be absorbed by syngeneic or allogene...

journal_title：Transplantation

authors： Emerson SG,Cone RE

更新日期：1982-01-01 00:00:00

abstract：BACKGROUND:Patients with long-term functioning organ allografts may have developed different mechanisms that explain the lack of graft rejection. However, it is not known how these mechanisms interplay or whether one of them predominates in such situations. METHODS:The authors analyzed the expression of T-cell surface...

journal_title：Transplantation

authors： Alvarez CM,Paris SC,Arango L,Arbelaez M,Garcia LF,RAD B201 study group.

更新日期：2004-11-27 00:00:00

abstract：BACKGROUND:Clinical and hematological profile of chronic anemia in children after orthotopic liver transplantation (OLT) is unknown. METHODS:We prospectively studied children after orthotopic liver transplantation (OLT) with hemoglobin levels < 2 standard deviation of age appropriate mean for > 6 months. Investigation...

journal_title：Transplantation

authors： Misra S,Moore TB,Ament ME,Vargas JH,Busutill RW,McDiarmid SV

更新日期：2000-11-27 00:00:00

abstract：:The immunosuppressive effects of leflunomide and cyclosporine were evaluated in a rat neurovascularized myocutaneous allograft model. Inbred Brown-Norway and Lewis rats were served as donors and recipients, respectively. All recipients were observed for 60 days or until allograft rejection occurred. All isograft contr...

journal_title：Transplantation

authors： Yeh LS,Gregory CR,Griffey SM,Lecouteur RA,Morris RE

更新日期：1996-09-27 00:00:00

abstract：BACKGROUND:Two patients underwent cadaver transplantation with kidneys from a donor with a history of World Health Organization Class IV/V lupus nephritis, and we report their clinical and pathological outcome. METHODS:The donor had a diagnosis of lupus nephritis made by renal biopsy 5 years before donation. At the ti...

journal_title：Transplantation

authors： Lipkowitz GS,Madden RL,Kurbanov A,Mulhern JG,O'Shea MH,Germain MJ,Freeman J,Braden GL

更新日期：2000-03-27 00:00:00

abstract：BACKGROUND:Donor T cells are primarily responsible for graft-versus-host disease (GVHD). Three effector pathways have been described for T-cell cytotoxicity: granzyme B/perforin, Fas/Fas ligand (FasL), and secreted molecules such as tumor necrosis factor (TNF)-alpha. Therefore, this study evaluates the gene expression ...

journal_title：Transplantation

authors： Jaksch M,Remberger M,Mattsson J

更新日期：2004-01-27 00:00:00