Abstract:
BACKGROUND:The rate of acute rejection (AR) has decreased significantly, but whether this is associated with improvement in long-term graft survival is controversial. METHODS:We analyzed 1445 consecutive adult deceased donor kidney transplant recipients from 1985 to 2005, over two periods (1985-1995 vs. 1996-2005) to compare long-term graft survival. RESULTS:The second period was associated with older donors and recipients and a reduction in AR. A significant increase of 10.1 months at 11 years was seen in death-censored graft survival in 1996 to 2005. For this posttransplant time, graft half-life was 10.8 years in 1985 to 1995, while at this point in the second period 62% of recipients had a functioning graft. The yearly increase in serum creatinine was less pronounced in the latter period (0.05 mg/dL vs. 0.02 mg/dL, P<0.01). No difference was found in patient survival. Cox analysis showed that donor age (HR 1.02, P<0.001), AR (HR 1.72, P<0.001), panel-reactive antibody at transplantation (HR 1.01, P<0.001), and serum creatinine at 1 year (HR 2.01, P<0.001) had a negative impact on graft outcome. By contrast, the use of mycophenolate mofetil was associated with a 24% reduction in graft loss rate (HR 0.76, P<0.05). CONCLUSION:Long-term graft survival and renal function have improved in renal transplant recipients since 1996.
journal_name
Transplantationjournal_title
Transplantationauthors
Sola E,Gonzalez-Molina M,Cabello M,Burgos D,Ramos J,Gutierrez C,Lopez V,Soler J,de la Vega E,Hernandez Ddoi
10.1097/TP.0b013e3181c892ddsubject
Has Abstractpub_date
2010-03-27 00:00:00pages
714-20issue
6eissn
0041-1337issn
1534-6080journal_volume
89pub_type
杂志文章相关文献
TRANSPLANTATION文献大全abstract::To gain insight into the contribution of immunologic and hemodynamic factors in the progressive demise of structure and function in chronic renal allograft dysfunction, we studied the histological changes, the immunostainable glomerular anionic sites, and glomerular capillary hydrostatic pressures of rat renal allogra...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199612150-00018
更新日期:1996-12-15 00:00:00
abstract::A technique for simplified heterotopic rat heart transplantation having only aorto-aortic anastomosis is presented. The heterotopic rt heart survives and functions well when one lung lobe is attached t the transplantation and functions as a reservoir. Iso- and allotransplants are compared by electrocardiogram (ECG) de...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198204000-00020
更新日期:1982-04-01 00:00:00
abstract:BACKGROUND:Recent data indicate that factors other than erythropoietin (EPO), such as insulin-like growth factor 1 (IGF-1), can promote erythropoiesis in vitro and correct the anemia of chronic renal failure in vivo. IGF-1 is produced by the liver under growth hormone control, as well as by other sources, including the...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199709270-00021
更新日期:1997-09-27 00:00:00
abstract::Cyclosporine (CsA) administration and nitric oxide (NO) blockade promote similar chronic renal hemodynamic alterations in rats. We evaluated various clinical CsA doses under conditions of NO blockade using L-NAME (N-nitro L-arginine methyl ester). Groups of Sprague-Dawley rats kept on a normal salt (+NaCl) or low-salt...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199605270-00017
更新日期:1996-05-27 00:00:00
abstract:BACKGROUND:In response to a longstanding Federal mandate to minimize the role of geography in access to transplant in the United States, we assessed whether patient travel distance was associated with lung transplant outcomes. We focused on the posttransplant time period, when the majority of patient visits to a transp...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000003129
更新日期:2020-11-01 00:00:00
abstract:BACKGROUND:After pancreas transplantation, endocrine function is determined by the insulin secretory capacity of the transplanted pancreas. The authors evaluated the predictive value of postoperative oral glucose tolerance test (OGTT) and stimulated insulin secretion on long-term endocrine function. METHODS:Forty-one ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000098821.26466.DE
更新日期:2003-11-27 00:00:00
abstract::In this study we examined the functional capacity of unseparated, IL-2R positive and IL-2R negative leukocytes infiltrating BN rat hearts or kidneys grafted into allogeneic LEW rats. Upon adoptive transfer into syngeneic LEW recipients, splenocytes or day-3 graft infiltrate cells of either cardiac or renal transplants...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199007000-00019
更新日期:1990-07-01 00:00:00
abstract::The expression of some genes has been comparatively studied in transplanted rat liver and in liver reperfused after ischemia in situ. Experiments on protein synthesis by tissue slices from cold-stored or transplanted livers show that rat livers that retain a good capacity for protein synthesis during storage undergo a...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199305000-00004
更新日期:1993-05-01 00:00:00
abstract::Nippostrongylus infection strongly stimulates TH2 activity in vivo. Given the evidence of cross regulation between TH2 and TH1 cells, and the link between TH1 activity and graft rejection, we examined the effects of Nippostrongylus infection on the fate of kidney allografts in rats. Both prior Nippostrongylus infectio...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199601270-00003
更新日期:1996-01-27 00:00:00
abstract::The term "accommodation" was invoked to describe endothelial cell resistance to antibody-mediated rejection after ABO-incompatible kidney or experimental xenograft transplantation. Currently, there is much interest in how to achieve successful human leukocyte antigen (HLA)-incompatible allograft transplantation in HLA...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31823f468c
更新日期:2012-02-15 00:00:00
abstract::Hemorrhagic cystitis (HC) is a major cause of morbidity after BMT; we have analyzed its incidence, risk factors, and complications in 977 patients undergoing BMT between 1974 and 1988. Despite vigorous hydration and frequent voiding in all patients receiving cyclophosphamide, 135/977 (15% by Kaplan-Meier projection) d...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199310000-00020
更新日期:1993-10-01 00:00:00
abstract:BACKGROUND:There are limited experimental data on the nature of the humoral response elicited in humans against pig antigens. In this study, we have examined the xenoantibody (XAb) response in eight patients with acute liver failure exposed to pig hepatocytes after treatment with the bioartificial liver (BAL). METHODS...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199901150-00003
更新日期:1999-01-15 00:00:00
abstract:BACKGROUND:Although chronic kidney disease (CKD) is still a common complication, the prognosis of kidney function after liver transplantation (LT) is not well known. Moreover, kidney function after LT in children with renal involvement is unknown. METHODS:We retrospectively analyzed patients aged <20 years who underwe...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000002548
更新日期:2019-08-01 00:00:00
abstract:BACKGROUND:This study evaluated zoom endoscopic findings according to four components in comparison with the histologic findings of acute cellular rejection (ACR) in a living-related small bowel transplantation (SBTx) patient. METHODS:A 16-year-old boy with microvillus inclusion disease underwent SBTx with a 150-cm-lo...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200202270-00013
更新日期:2002-02-27 00:00:00
abstract:BACKGROUND:If pancreas transplantation is a validated alternative for type 1 diabetic patients with end-stage renal disease, the management of patients who have lost their primary graft is poorly defined. This study aims at evaluating pancreas retransplantation outcome. METHODS:Between 1976 and 2008, 569 pancreas tran...
journal_title:Transplantation
pub_type: 杂志文章,多中心研究
doi:10.1097/TP.0b013e318271d795
更新日期:2013-01-27 00:00:00
abstract::Lamivudine combined with hepatitis B immune globulin (HBIg) is the standard of care for preventing the recurrence hepatitis B virus after liver transplant. To determine the risk of hepatitis B virus (HBV) recurrence after early withdrawal of HBIg in patients receiving lamivudine maintenance therapy, 20 patients receiv...
journal_title:Transplantation
pub_type: 杂志文章,随机对照试验
doi:10.1097/01.tp.0000277289.23677.0a
更新日期:2007-09-15 00:00:00
abstract:BACKGROUND:Prognostic models, which estimate survival probabilities, enable the survival benefit from a procedure to be assessed and allow the comparison of outcomes between centers. We therefore compared three models that estimate survival in the absence of transplantation for patients with alcoholic liver disease (AL...
journal_title:Transplantation
pub_type: 杂志文章,多中心研究
doi:10.1097/01.TP.0000089236.78772.57
更新日期:2003-11-27 00:00:00
abstract:BACKGROUND:Antibody-mediated rejection (AMR) is a leading cause of morbidity and mortality after kidney transplantation. Early diagnosis and treatment of subclinical AMR based on the donor-specific antibody (DSA) testing may result in better outcomes. METHODS:We tested this hypothesis in 220 kidney transplant recipien...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000002566
更新日期:2019-08-01 00:00:00
abstract:BACKGROUND:CD4+ T cells play an essential role in allograft rejection. The monoclonal anti-rat CD4 antibody, RIB 5/2, has been shown to modulate the CD4 glycoprotein without eliminating the recipient T cells. We have successfully induced tolerance to rat heart allografts by recipient pretreatment with a single dose of ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200001270-00015
更新日期:2000-01-27 00:00:00
abstract:BACKGROUND:Current insulin therapies for control of glucose metabolism in patients with type I diabetes mellitus prevent major metabolic consequences of insulin deficiency, but none prevents or arrests long-term complications. In experimental models of canine diabetes, retinopathy, neuropathy, and nephropathy have been...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199710150-00003
更新日期:1997-10-15 00:00:00
abstract:BACKGROUND:Increasing use of kidney grafts for simultaneous liver and kidney (SLK) transplants is causing concern about the most effective utilization of scarce kidney graft resources. This study evaluated the impact of implementing the proposed United Network for Organ Sharing SLK transplant policy on outcomes for end...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000000270
更新日期:2015-02-01 00:00:00
abstract:BACKGROUND:The currently used macrolide immunosuppressants, i.e., cyclosporine and tacrolimus, exert considerable nephrotoxicity. We aimed to avoid the nephrotoxic effects by applying a cyclosporine-free regimen for the induction as well as for the maintenance treatment of renal allograft recipients using mycophenolate...
journal_title:Transplantation
pub_type: 临床试验,杂志文章
doi:10.1097/00007890-199807150-00007
更新日期:1998-07-15 00:00:00
abstract:BACKGROUND:Intrahepatic bile duct strictures are a serious complication after non-heart-beating (NHB) liver transplantation. Bile salt toxicity has been identified as an important factor in the pathogenesis of bile duct injury and cholangiopathies. The role of bile salt toxicity in the development of biliary strictures...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e318170f5f7
更新日期:2008-06-15 00:00:00
abstract:BACKGROUND:Cell-based insulin therapies can potentially improve glycemic regulation in insulin-dependent diabetic patients. Enteroendocrine cells engineered to secrete recombinant insulin have exhibited glycemic efficacy, but have been primarily studied as uncontrollable growth systems in immune incompetent mice. Furth...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000000247
更新日期:2014-09-15 00:00:00
abstract:BACKGROUND:We hypothesized that tissue-engineered contractile cardiomyocyte sheets without a scaffold would show histological and electrical integration with impaired myocardium, leading to the regeneration of infarcted myocardium. METHODS:Neonatal rat cardiomyocytes were cultured on Poly(N-isopropylacrylamide)-grafte...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000181163.69108.dd
更新日期:2005-12-15 00:00:00
abstract:BACKGROUND:Early detection of rejection after lung transplantation may prevent allograft failure. This study determines if mRNA from the cell adhesion molecules intercellular adhesion molecule-1, vascular cell adhesion molecule (VCAM)-1, and E-selectin in pulmonary endovascular tissue samples could be markers of early ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000057530.32397.6D
更新日期:2003-04-15 00:00:00
abstract::Sera from 56 recipients of liver or heart transplants were investigated for monoclonal immunoglobulins (mIg) by immunofixation electrophoresis (IFE) at different times during 4 years after transplantation. Transient, changing, or stable mIgs were found in 18 patients. A significantly increased mIg incidence was observ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198809000-00011
更新日期:1988-09-01 00:00:00
abstract:BACKGROUND:Mixed allogeneic hematopoietic chimerism has previously been reliably achieved and shown to induce tolerance to fully MHC-mismatched allografts in mice and monkeys. However, the establishment of hematopoietic chimerism has been difficult to achieve in the discordant pig-to-primate xenogeneic model. METHODS:...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199904150-00007
更新日期:1999-04-15 00:00:00
abstract::To investigate the role of natural killer (NK) cells in the induction and pathogenesis of graft-versus-host (GVH) disease, +/beige (+/bg; normal NK cell activity) and beige/beige (bg/bg; deficient NK cell activity) parental C57BL/6 (B6) lymphoid cells were used to induce GVH reactions in either B6 X C3H/Hej +/bg (+/bg...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198708000-00017
更新日期:1987-08-01 00:00:00
abstract::Orthotopic liver allografts from BN donors to LEW recipients are spontaneously accepted, and the recipients develop donor-specific immunological unresponsiveness. This unresponsiveness may be mediated by suppressor T cells. Immunomagnetically purified splenic T cells from LEW rats bearing BN liver grafts were shown to...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199212000-00019
更新日期:1992-12-01 00:00:00