Humanization of Immunodeficient Animals for the Modeling of Transplantation, Graft Versus Host Disease, and Regenerative Medicine.

Abstract:

:The humanization of animals is a powerful tool for the exploration of human disease pathogenesis in biomedical research, as well as for the development of therapeutic interventions with enhanced translational potential. Humanized models enable us to overcome biologic differences that exist between humans and other species, while giving us a platform to study human processes in vivo. To become humanized, an immune-deficient recipient is engrafted with cells, tissues, or organoids. The mouse is the most well studied of these hosts, with a variety of immunodeficient strains available for various specific uses. More recently, efforts have turned to the humanization of other animal species such as the rat, which offers some technical and immunologic advantages over mice. These advances, together with ongoing developments in the incorporation of human transgenes and additional mutations in humanized mouse models, have expanded our opportunities to replicate aspects of human allotransplantation and to assist in the development of immunotherapies. In this review, the immune and tissue humanization of various species is presented with an emphasis on their potential for use as models for allotransplantation, graft versus host disease, and regenerative medicine.

journal_name

Transplantation

journal_title

Transplantation

authors

Adigbli G,Ménoret S,Cross AR,Hester J,Issa F,Anegon I

doi

10.1097/TP.0000000000003177

subject

Has Abstract

pub_date

2020-11-01 00:00:00

pages

2290-2306

issue

11

eissn

0041-1337

issn

1534-6080

pii

00007890-202011000-00017

journal_volume

104

pub_type

杂志文章
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  • Factors Associated With Changes in Body Composition Shortly After Orthotopic Liver Transplantation: The Potential Influence of Immunosuppressive Agents.

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    更新日期:1993-09-01 00:00:00

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    更新日期:2002-08-15 00:00:00

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    更新日期:2006-06-27 00:00:00

  • The effect of verapamil on renal function after warm and cold ischemia in the isolated perfused rat kidney.

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    authors: Shapiro JI,Cheung C,Itabashi A,Chan L,Schrier RW

    更新日期:1985-12-01 00:00:00

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    pub_type: 杂志文章

    doi:10.1097/00007890-199504150-00011

    authors: Mor E,Skerrett D,Manzarbeitia C,Sheiner PA,Schwartz ME,Emre S,Thung SN,Miller CM

    更新日期:1995-04-15 00:00:00

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    pub_type: 杂志文章

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    更新日期:1980-05-01 00:00:00

  • Impaired revascularization of transplanted mouse pancreatic islets is chronic and glucose-independent.

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    authors: Mattsson G,Jansson L,Nordin A,Carlsson PO

    更新日期:2003-03-15 00:00:00

  • The graft-versus-host reaction and immune function. II. Recruitment of pre-T-cells in vivo by graft-versus-host-induced dysplastic thymuses following irradiation and bone marrow treatment.

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    doi:

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    更新日期:1984-03-01 00:00:00

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    更新日期:1986-05-01 00:00:00

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    更新日期:1992-07-01 00:00:00

  • Low serum IGF-1 is a risk factor for cardiac allograft vasculopathy in cardiac transplant recipients.

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    doi:10.1097/TP.0b013e31823ec10d

    authors: Aharinejad S,Salama M,Rödler S,Ehrlich M,Zuckermann A,Laufer G

    更新日期:2012-02-15 00:00:00

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  • Renal transplantation from elderly living donors.

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    更新日期:1991-02-01 00:00:00

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    pub_type: 杂志文章,评审

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    pub_type: 临床试验,杂志文章

    doi:10.1097/00007890-199807150-00007

    authors: Zanker B,Schneeberger H,Rothenpieler U,Hillebrand G,Illner WD,Theodorakis I,Stangl M,Land W

    更新日期:1998-07-15 00:00:00

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    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199207000-00015

    authors: Faltin DL,Jeannet M,Suter PM

    更新日期:1992-07-01 00:00:00