Abstract:
:The humanization of animals is a powerful tool for the exploration of human disease pathogenesis in biomedical research, as well as for the development of therapeutic interventions with enhanced translational potential. Humanized models enable us to overcome biologic differences that exist between humans and other species, while giving us a platform to study human processes in vivo. To become humanized, an immune-deficient recipient is engrafted with cells, tissues, or organoids. The mouse is the most well studied of these hosts, with a variety of immunodeficient strains available for various specific uses. More recently, efforts have turned to the humanization of other animal species such as the rat, which offers some technical and immunologic advantages over mice. These advances, together with ongoing developments in the incorporation of human transgenes and additional mutations in humanized mouse models, have expanded our opportunities to replicate aspects of human allotransplantation and to assist in the development of immunotherapies. In this review, the immune and tissue humanization of various species is presented with an emphasis on their potential for use as models for allotransplantation, graft versus host disease, and regenerative medicine.
journal_name
Transplantationjournal_title
Transplantationauthors
Adigbli G,Ménoret S,Cross AR,Hester J,Issa F,Anegon Idoi
10.1097/TP.0000000000003177subject
Has Abstractpub_date
2020-11-01 00:00:00pages
2290-2306issue
11eissn
0041-1337issn
1534-6080pii
00007890-202011000-00017journal_volume
104pub_type
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