Ontogeny of suppressor cells. II. Suppression of graft-versus-host and mixed leukocyte culture responses by embryonic cells.

abstract：BACKGROUND:Recently, peptides derived from the heavy chain of HLA-B2702 have been shown to modulate immune responses. In this study, we examined the use of these peptides for immunosuppression in a pig to mouse islet xenograft model. METHODS:Purified porcine islets were transplanted in autoimmune (non-obese diabetic) ...

journal_title：Transplantation

authors： Squiers EC,Hodell M,Tice D,Buelow R

更新日期：1998-12-15 00:00:00

abstract：BACKGROUND:Survival after lung transplantation is mainly limited by the development of chronic lung allograft dysfunction (CLAD). The aim of this study was to investigate if platelet inhibition by clopidogrel has a functionally relevant influence on the microvascular integrity of orthotopic tracheal allografts as an an...

journal_title：Transplantation

authors： Heim C,Khan MA,von Silva-Tarouca B,Kuckhahn A,Stamminger T,Ramsperger-Gleixner M,Nicolls MR,Weyand M,Ensminger SM

更新日期：2019-05-01 00:00:00

abstract：:To examine whether cyclosporine (CsA) has mutagenic potential against human cells, we analyzed sister chromatid exchange (SCE) induction by CsA using human lymphocytes in vitro. SCE frequencies increased significantly in the lymphocytes treated with 1 microgram/ml and 5 micrograms/ml CsA, though the frequencies seemed...

journal_title：Transplantation

authors： Yuzawa K,Kondo I,Fukao K,Iwasaki Y,Hamaguchi H

更新日期：1986-07-01 00:00:00

abstract：:LEW rats with long-surviving (> 100 days) (DA x LEW)F1 kidney allografts were generated by treating the recipients with cyclosporine for 14 days after grafting. All rats were monitored after transplantation for the development of antibodies to intact donor class I MHC molecules. Cyclosporine completely suppressed the ...

journal_title：Transplantation

authors： Benham Am,Sawyer GJ,Fabre JW

更新日期：1996-05-27 00:00:00

abstract：:Second clinical kidney grafts often survive longer than first grafts. Using a rat cardiac allograft model, we examined the conditions under which survival of a second graft can be longer than first graft survival. In the BUF-to-LEW combination, following rejection of the first transplant, second cardiac allografts fro...

journal_title：Transplantation

authors： Yanagiya A,Terasaki PI,Iwaki Y,Ho BB,Drinkwater DC,Laks H

更新日期：1992-10-01 00:00:00

abstract：:The effect of cyclosporine on hepatic ischemia was investigated. Hepatic ischemia was produced for 90 min in mongrel dogs. Experimental dogs were divided into three groups as follows: group A (control group), group B (CsA pretreatment group), group C (CsA posttreatment group). CsA was administered at a dose of 10 mg/k...

journal_title：Transplantation

authors： Hayashi T,Nagasue N,Kohno H,Chang YC,Nakamura T

更新日期：1991-07-01 00:00:00

abstract：:Phenotype, donor-specific cytolytic activity, and helper activity to release cytokines of cells infiltrating within renal allografts of hosts rendered unresponsive by perioperative administration of donor lymphocytes via the portal vein (p.v.) were investigated in order to analyze the mechanism of prolongation of allo...

journal_title：Transplantation

authors： Hamashima T,Yoshimura N,Matsui S,Lee CJ,Ohsaka Y,Oka T

更新日期：1990-01-01 00:00:00

abstract：:The overall incidence of malignancy in renal transplant recipients is 100-fold higher compared with age matched controls. Routine clinical evaluation therefore often includes the determination of serum tumor markers AFP, CA19-9, CEA, CA125, CA15-3, PSA, and calcitonin. We evaluated the specificity and the sensitivity ...

journal_title：Transplantation

authors： Oberbauer R,Banyai S,Schmidt A,Kornek G,Scheithauer W,Mayer G

更新日期：1996-11-27 00:00:00

abstract：:Allograft rejection results from a complex process involving both the innate and acquired immune systems. The innate immune system predominates in the early phase of the allogeneic response, during which chemokines and cell adhesion play essential roles, not only for leukocyte migration into the graft but also for fac...

journal_title：Transplantation

authors： Le Moine A,Goldman M,Abramowicz D

更新日期：2002-05-15 00:00:00

abstract：BACKGROUND:Calcineurin inhibitor-induced renal dysfunction is a major problem in liver transplantation. Interleukin-2 receptor antagonist induction followed by delayed tacrolimus (Tac) administration may minimize the renal insult without compromising immunoprotection. METHODS:This open, randomized, multicenter trial e...

journal_title：Transplantation

authors： Calmus Y,Kamar N,Gugenheim J,Duvoux C,Ducerf C,Wolf P,Samuel D,Vanlemmens C,Neau-Cransac M,Salamé E,Chazouillères O,Declerck N,Pageaux GP,Dubel L,Rostaing L

更新日期：2010-06-27 00:00:00

abstract：BACKGROUND:Patient-level risk factors for delayed graft function (DGF) have been well described. However, the Organ Procurement and Transplantation Network definition of DGF is based on dialysis in the first week, which is subject to center-level practice patterns. It remains unclear if there are center-level differenc...

journal_title：Transplantation

authors： Orandi BJ,James NT,Hall EC,Van Arendonk KJ,Garonzik-Wang JM,Gupta N,Montgomery RA,Desai NM,Segev DL

更新日期：2015-05-01 00:00:00

abstract：:We developed a multiplex, quantitative, real-time, polymerase chain reaction assay for cytomegalovirus (CMV) and used it to measure the CMV viral load in weekly blood specimens from 43 lung transplant recipients. The median viral load in blood samples immediately preceding bronchoscopy was 1150 copies/microg human DNA...

journal_title：Transplantation

authors： Sanchez JL,Kruger RM,Paranjothi S,Trulock EP,Lynch JP,Hicks C,Shannon WD,Storch GA

更新日期：2001-08-27 00:00:00

abstract：:Interferon gamma and tumor necrosis factor alpha play a significant role in the upregulation of host immunity and inflammation, for example by induction and enhancement of the expression of major histocompatibility complex class I and II antigens on a wide variety of cell types, both in vitro and in vivo. In this stud...

journal_title：Transplantation

authors： Stevens HP,van der Kwast TH,van der Meide PH,Vuzevski VD,Buurman WA,Jonker M

更新日期：1990-11-01 00:00:00

abstract：BACKGROUND:The role of combined liver-kidney transplantation (CLKT) for cirrhotic patients with renal failure (RF) is controversial. Since the model for end-stage liver disease era, there has been a rise in the number of CLKT. Using the Organ Procurement Transplant Network/United Network for Organ Sharing database, thi...

journal_title：Transplantation

authors： Fong TL,Khemichian S,Shah T,Hutchinson IV,Cho YW

更新日期：2012-08-27 00:00:00

abstract：:T cell receptor (TCR) beta-chain usage by HLA-DR1 alloreactive T cell lines was examined to determine whether common TCR gene segments were used preferentially. We have demonstrated previously that a DR1-specific, human renal allograft-derived T cell line and replicate, anti-DR1 mixed lymphocyte reactions (MLR), estab...

journal_title：Transplantation

authors： Hand SL,Alter MD,Finn OJ

更新日期：1996-04-15 00:00:00

abstract：BACKGROUND:Liver transplantation is a widely accepted treatment for end-stage liver disease. The aim of our study was to investigate the imbalance between T helper type 17 (Th17) and CD4(+) CD25(+) Foxp3(+) regulatory T (Treg) cells during hepatic allograft rejection in a rodent grafts model because their roles in live...

journal_title：Transplantation

authors： Zhou Y,Yang X,Zhang H,Jiang J

更新日期：2015-06-01 00:00:00

abstract：BACKGROUND:Kidneys from older donors are likely to have a lower nephron mass. Nevertheless they constitute a valuable source of kidney allografts. Long cold ischemic time (CIT), with or without delayed graft function (DGF), has been associated with reduced graft survival. The aim of this study was to review the experie...

journal_title：Transplantation

authors： Asderakis A,Dyer P,Augustine T,Worthington J,Campbell B,Johnson RW

更新日期：2001-08-27 00:00:00

abstract：BACKGROUND:Focal segmental glomerulosclerosis (FSGS) recurs after kidney transplantation in more than 30% of cases and can lead to allograft loss. Serum soluble urokinase-type plasminogen activator receptor (suPAR) is implicated in the pathogenesis of native and recurrent FSGS. METHODS:We conducted a retrospective stu...

journal_title：Transplantation

authors： Alachkar N,Wei C,Arend LJ,Jackson AM,Racusen LC,Fornoni A,Burke G,Rabb H,Kakkad K,Reiser J,Estrella MM

更新日期：2013-10-15 00:00:00

abstract：BACKGROUND:The influence of the graft composition on the clinical outcome after allogeneic peripheral blood stem cell (PBSC) transplantation is not well established. METHODS:The cellular composition of the apheretic products obtained from 63 human leukocyte antigen-identical siblings was prospectively correlated with ...

journal_title：Transplantation

authors： Iori AP,Torelli GF,De Propris MS,Milano F,Pupella S,Gozzer M,Mancini F,Milani ML,Intoppa S,Cerretti R,Lucarelli B,Valle V,Malandruccolo L,Iannella E,Arleo E,Guarini A,Foà R

更新日期：2008-02-15 00:00:00

abstract：:Serologic evidence of resolved hepatitis B virus (HBV) infection (HBV surface antigen negative, anti-HBV core antibody [HBc] positive) in a liver donor can be regarded as an occult infection with episomal HBV in the liver. The purpose of this study was to evaluate the safety of anti-HBc-positive living donors. Between...

journal_title：Transplantation

authors： Hwang S,Moon DB,Lee SG,Park KM,Kim KH,Ahn CS,Lee YJ,Chu CW,Yang HS,Cho SH,Oh KB,Ha TY,Min PC

更新日期：2003-02-15 00:00:00

abstract：BACKGROUND:Renal warm ischemic injury and immunosuppression with cyclosporin A (CsA) may contribute to chronic allograft nephropathy after cadaveric transplantation. This study establishes whether CsA can sensitize the kidney to injury and fibrosis induced by renal warm ischemia (RWI). METHODS:The left kidney of Sprag...

journal_title：Transplantation

authors： Ahmed A,Huang L,Raftery AT,Ahmed AK,Fahmy H,El Nahas AM,Haylor JL

更新日期：2004-03-15 00:00:00

abstract：:Sprague-Dawley rats were treated for 14 days with rapamycin (RAP; 1.5 mg/kg/day i.p.), cyclosporine (15 mg/kg/day by gavage), both drugs in combination, or appropriate drug vehicles. Hematological parameters and biochemical indices of renal and hepatic function were determined throughout the experimental period, at th...

journal_title：Transplantation

authors： Whiting PH,Woo J,Adam BJ,Hasan NU,Davidson RJ,Thomson AW

更新日期：1991-08-01 00:00:00

abstract：:MHC expression on endothelial cells after cytomegalovirus infection was investigated using double antibody radioimmunoassays and immunofluorescence flow cytometry. After CMV infection there was an increase in class I and beta 2 microglobulin expression. This increase corresponds to the percentage of cells that are inf...

journal_title：Transplantation

authors： van Dorp WT,Jonges E,Bruggeman CA,Daha MR,van Es LA,van Der Woude FJ

更新日期：1989-09-01 00:00:00

abstract：:The class II region of major histocompatibility complex of the rat. Rattus norvegicus (RT1) consists of RT1.B, RT1.D, and RT1.H subregions. The gene order around the H subregion was determined as RT1.A--H beta-H alpha--B by RFLP analysis of naturally occurring intra-RT1 recombinant rats with HLA DP probes. A unique re...

journal_title：Transplantation

authors： Fujii H,Kakinuma M,Yoshiki T,Natori T

更新日期：1991-08-01 00:00:00

abstract：BACKGROUND:There is growing interest in new therapeutic options for the treatment of end-stage liver diseases. In addition to mechanical devices supporting liver function, such as bioreactors, the transplantation of hepatocyte-like cells derived from (adult) stem cells offer great perspectives. We have generated hepato...

journal_title：Transplantation

authors： Ruhnke M,Nussler AK,Ungefroren H,Hengstler JG,Kremer B,Hoeckh W,Gottwald T,Heeckt P,Fandrich F

更新日期：2005-05-15 00:00:00

abstract：:A technique of orthotopic renal transplantation in rabbits is described. The technique has been evolved in an experience of over 400 grafts, and difficulties encountered in producing satisfactory anaesthesia and techniques of anastomosis and in obtaining reliable graft function postoperatively have been defined and ov...

journal_title：Transplantation

authors： Dunn DC

更新日期：1976-11-01 00:00:00

abstract：BACKGROUND:Apoptosis has been identified after ischemia-reperfusion (IR) injury to the brain, heart, kidney, retina, and the adrenals. Intestinal IR injury causes villous and crypt damage, which has so far been attributed to cellular necrosis. This study was undertaken to investigate the possible role of apoptosis afte...

journal_title：Transplantation

authors： Shah KA,Shurey S,Green CJ

更新日期：1997-11-27 00:00:00

abstract：:The glycosaminoglycan hyaluronan is not only involved in cellular differentiation and migration but may also play a role in several inflammatory diseases. We have previously demonstrated an increased local production of hyaluronan in chronically rejected kidneys and the correspondingly affected renal vessels. In this ...

journal_title：Transplantation

authors： Wells A,Larsson E,Hanás E,Laurent T,Hällgren R,Tufveson G

更新日期：1993-06-01 00:00:00

abstract：:If transplantation of endocrine tissue is to become a therapy for a significant number of insulin-dependent diabetic individuals, tissue sources other than adult human islets will be required. Because human fetal pancreatic cells may offer that alternative, we have tried to find the optimal combination of tissue cultu...

journal_title：Transplantation

authors： Beattie GM,Otonkoski T,Lopez AD,Hayek A

更新日期：1993-12-01 00:00:00

abstract：BACKGROUND:The long-term outcome of lung transplantation is impeded by the development of obliterative bronchiolitis (OB). We sought to investigate the relationship between the apoptosis of tracheal epithelial cells and bone marrow-derived myofibroblasts in the process of OB. METHODS:The mouse orthotopic tracheal tran...

journal_title：Transplantation

authors： Wang C,Xia T,Jiang K,Qiao X,Zhang X,Li J,Wang J,Nie J

更新日期：2016-09-01 00:00:00