Multiple pathways to allograft rejection.

abstract：BACKGROUND:The development of kidney dysfunction is one of the most important after liver transplantation (LT). Genetic variants of pathogenetically relevant cytokines may influence the development and course of the disease. The aim of our study was to evaluate the role of transforming growth factor-β1 (TGF-β1) polymor...

journal_title：Transplantation

authors： Eurich D,Neumann UP,Boas-Knoop S,Neuhaus R,Bahra M,Neuhaus P,Schmitz V

更新日期：2012-03-15 00:00:00

abstract：BACKGROUND:Donor T cells are primarily responsible for graft-versus-host disease (GVHD). Three effector pathways have been described for T-cell cytotoxicity: granzyme B/perforin, Fas/Fas ligand (FasL), and secreted molecules such as tumor necrosis factor (TNF)-alpha. Therefore, this study evaluates the gene expression ...

journal_title：Transplantation

authors： Jaksch M,Remberger M,Mattsson J

更新日期：2004-01-27 00:00:00

abstract：BACKGROUND:Liver transplantation (LT) represents a curative treatment for small hepatocellular carcinoma (HCC). Potentially curable higher-stage HCC patients are denied LT due to the lack of cancer markers that predict progression and recurrence. METHODS:Thirty-eight candidates for LT with hepatitis C virus (HCV) cirr...

journal_title：Transplantation

authors： Mas VR,Fisher RA,Archer KJ,Yanek KC,Williams B,Dumur CI,Maluf DG

更新日期：2007-04-15 00:00:00

abstract：:Renal transplant recipients are at risk of severe morbidity and mortality from CMV disease. We have undertaken routine surveillance for CMV shedding on 133 transplant recipients, using a rapid culture technique, in order to assess the incidence of CMV infection and disease in these patients and to assess the prognosti...

journal_title：Transplantation

authors： Pillay D,Ali AA,Liu SF,Kops E,Sweny P,Griffiths PD

更新日期：1993-07-01 00:00:00

abstract：BACKGROUND:The need to find a safe, effective liver support system for patients with fulminant hepatic failure (FHF) continues to be unmet. A system using immortalized human hepatocytes was originally developed in the early 1990s. A modified version of the initial extracorporeal liver-assist device (ELAD) was recently ...

journal_title：Transplantation

authors： Millis JM,Cronin DC,Johnson R,Conjeevaram H,Conlin C,Trevino S,Maguire P

更新日期：2002-12-27 00:00:00

abstract：BACKGROUND:Patient-level risk factors for delayed graft function (DGF) have been well described. However, the Organ Procurement and Transplantation Network definition of DGF is based on dialysis in the first week, which is subject to center-level practice patterns. It remains unclear if there are center-level differenc...

journal_title：Transplantation

authors： Orandi BJ,James NT,Hall EC,Van Arendonk KJ,Garonzik-Wang JM,Gupta N,Montgomery RA,Desai NM,Segev DL

更新日期：2015-05-01 00:00:00

abstract：:The optimal timing of administration of free radical scavengers in lung preservation has yet to be determined. In previous studies, the oxygen free radical scavenger dimethylthiourea (DMTU) has improved pulmonary function when added to Eurocollins flush solution at the time of lung harvest and infused at the time of l...

journal_title：Transplantation

authors： Lambert CJ Jr,Egan TM

更新日期：1992-08-01 00:00:00

abstract：:The aim of this study was to analyze the possible protective effects of a glutamine and arginine precursor (ornithine-alpha-ketoglutarate [OKG]) on the mucosa of a transplanted intestine when administered with either a defined formula oral diet (DFD) or a standard chow. Isogenic male Lewis rats (250 g) were submitted ...

journal_title：Transplantation

authors： de Oca J,Bettonica C,Cuadrado S,Vallet J,Martín E,Garcia A,Montañés T,Jaurrieta E

更新日期：1997-03-15 00:00:00

abstract：BACKGROUND:Most transplant centers in the United States, including our own, use creatinine clearance (Ccr) to estimate glomerular filtration rate (GFR) in potential living kidney donors. The purpose of this study was to evaluate our experience with estimation of donor GFR by Ccr and to explore other potential strategie...

journal_title：Transplantation

authors： Bertolatus JA,Goddard L

更新日期：2001-01-27 00:00:00

abstract：:Electrolytic lesions were produced in the tuberal hypothalamus and amygdala of male Fischer and female BNLF1 rats, and in male Fischer and female BNLF1 rats that had received antecedent hypophysectomies. Skin grafts from Lewis rats survived less well on tuberal-lesioned male Fischer rats than similar grafts on sham-op...

journal_title：Transplantation

authors： Dann JA,Wachtel SS,Rubin AL

更新日期：1979-04-01 00:00:00

abstract：:Fox kidney and skin grafts were transplanted into dog recipients. Fox kidneys, transplanted en bloc into untreated dogs, survived 6.2 +/- 0.4 days. The skin transplants survived 5.9 +/- 1.4 days. The grafted kidneys showed almost normal function before rejection. Both skin and kidney rejection were mediated through a ...

journal_title：Transplantation

authors： Chaussy C,Hammer C,von Scheel J,Pielsticker K,Sollinger HW,Pfeifer KJ,Pongratz H,Brender W

更新日期：1975-08-01 00:00:00

abstract：:Donor graft major histocompatibility complex class I antigens are targets for both allogeneic and xenogeneic rejection. Mice homozygous for beta 2-microglobulin gene disruption express reduced amounts of surface MHC class I antigens. Liver cells from such mutant mice were transplanted into isogeneic, allogeneic, and x...

journal_title：Transplantation

authors： Li X,Faustman D

更新日期：1993-04-01 00:00:00

abstract：:The interactions of steroid hormones and human peripheral blood lymphocytes (PBLs) have been investigated following glass-wool column separation of PBLs and incubation in a serum-free medium in the presence of phytohemagglutinin (PHA). Addition of hydrocortisone or progesterone above physiological concentrations resul...

journal_title：Transplantation

authors： Neifeld JP,Tormey DC

更新日期：1979-05-01 00:00:00

abstract：:We recently reported that reconstitution of lethally irradiated B10 mouse recipients with 40 x 10(6) untreated WF rat bone marrow cells resulted in stable fully xenogeneic chimerism (WF rat----B10 mouse). In these animals, the tolerance induced for skin xenografts was highly MHC specific in that donor-specific WF rat ...

journal_title：Transplantation

authors： Zeng YJ,Ricordi C,Tzakis A,Rilo HL,Carroll PB,Starzl TE,Ildstad ST

更新日期：1992-02-01 00:00:00

abstract：BACKGROUND:A 35-year period of clinical development resulted in orthotopic liver transplantation (OLT) becoming a standardized surgical procedure. Despite this progress, the rate of technical complications is still high. Although the main problem in most analyses is vascular or bile duct failure, we observed a remarkab...

journal_title：Transplantation

authors： Soliman T,Langer F,Puhalla H,Pokorny H,Grunberger T,Berlakovich GA,Langle F,Muhlbacher F,Steininger R

更新日期：2000-05-27 00:00:00

abstract：:Recent reports have demonstrated that humoral factors, especially antibodies elicited by xenoantigens, play an important role in the rejection of concordant cardiac xenografts. These induced antibodies, however, have not been well characterized. Therefore, we investigated the rejection mechanism, especially the role o...

journal_title：Transplantation

authors： Matsumiya G,Shirakura R,Miyagawa S,Izutani H,Sawa Y,Nakata S,Matsuda H

更新日期：1994-06-15 00:00:00

abstract：:This study compares two recently introduced radioimmunoassay kits involving specific monoclonal antibodies to cyclosporine. One kit (Sandimmun) involved 3H-labeled CsA (3H-CsA) as tracer and the other (CY-CLO-Trac-SP) involved a 125I-labeled conjugated derivative of CsA. The kits were nearly equivalent in method perfo...

journal_title：Transplantation

authors： Sgoutas DS,Hammarstrom M

更新日期：1989-04-01 00:00:00

abstract：:We developed a new and simplified donor-specific blood transfusion (DSBT) protocol for prospective kidney transplant recipients from one-haplotype-mismatched related donors. Prospective kidney donors gave 450 ml of blood in a quad-pack unit, and the blood was stored in a blood bank. Twenty-five patients were transfuse...

journal_title：Transplantation

authors： Cheigh JS,Suthanthiran M,Kaplan M,Evelyn M,Riggio RR,Fotino M,Schechter N,Wolf CF,Stubenbord WT,Stenzel KH

更新日期：1984-11-01 00:00:00

abstract：BACKGROUND:This study addresses the question of the mechanism for maintaining tolerance to donor alloantigen in the absence of antigen and the role of secondary lymphoid tissues. METHODS:Depleting anti-CD4 antibody administration in conjunction with allogeneic heart transplantation generates donor-specific operational...

journal_title：Transplantation

authors： Chosa E,Hara M,Watanabe A,Matsuzaki Y,Nakamura K,Hamano K,Wood KJ,Onitsuka T

更新日期：2007-05-15 00:00:00

abstract：:A panel of ethicists, organ procurement organization executives, physicians, and surgeons was convened by the sponsorship of the American Society of Transplant Surgeons to determine whether an ethically acceptable pilot trial could be proposed to provide a financial incentive for a family to consent to the donation of...

journal_title：Transplantation

authors： Arnold R,Bartlett S,Bernat J,Colonna J,Dafoe D,Dubler N,Gruber S,Kahn J,Luskin R,Nathan H,Orloff S,Prottas J,Shapiro R,Ricordi C,Youngner S,Delmonico FL

更新日期：2002-04-27 00:00:00

abstract：:Islet transplantation may be optimized by islet immunoisolation to prevent direct contact between the islet graft and the host tissue. In this study, we examined the glycemia and insulin secretion in streptozotocin-diabetic rats transplanted with islets subjected to immunoisolation with Algire diffusion chamber or wit...

journal_title：Transplantation

authors： Ar'Rajab A,Bengmark S,Ahrén B

更新日期：1991-03-01 00:00:00

abstract：:The aim of this study was to analyze, in heart transplant patients, if renal function improvement after cyclosporine replacement by everolimus persists at the middle term and its predictors. We studied prospectively 56 patients in whom conversion was consecutively made. Forty-five patients completed the follow-up peri...

journal_title：Transplantation

authors： Moro López JA,Almenar L,Martínez-Dolz L,Sánchez-Lázaro I,Agüero J,Buendía F,Ortiz V,Salvador A

更新日期：2009-02-27 00:00:00

abstract：:A patient with short gut syndrome presented with end-stage liver disease. She underwent an isolated liver transplantation at the age of 3.5 years. Parenteral nutrition was discontinued 1.5 years after surgery. At 7 years of age, the patient has maintained normal nutritional indices and growth while on a normal oral di...

journal_title：Transplantation

authors： Gottrand F,Michaud L,Bonnevalle M,Dubar G,Pruvot FR,Turck D

更新日期：1999-02-27 00:00:00

abstract：BACKGROUND:Arterial hypertension (HT) is common in renal transplant recipients (RTRs). Control of HT is not optimal in this high-risk population despite recommendations for target blood pressure levels under 130/80 mm Hg. METHODS:We performed a cross-sectional analysis of the prevalence of uncontrolled HT, and using a...

journal_title：Transplantation

authors： Vetromile F,Pernin V,Szwarc I,Garrigue V,Delmas S,Mourad G,Fesler P

更新日期：2015-05-01 00:00:00

abstract：BACKGROUND:Isolated transient elevation of alkaline phosphatase (ALP) in the absence of bone or liver disease has been reported in children including liver transplant patients. Specific isoenzyme patterns have been associated with this phenomenon in healthy children but have not been reported after liver transplantatio...

journal_title：Transplantation

authors： O'Riordan S,Baker AJ,Sherwood RA

更新日期：2002-10-15 00:00:00

abstract：BACKGROUND:Vitamin D deficiency has been reported in different chronic pulmonary diseases like asthma and chronic obstructive pulmonary disease, but little is known in lung transplant recipients. METHODS:Serum 25-hydroxyvitamin D (25-OHD) levels and pulmonary function (forced expiratory volume in 1 sec [FEV(1)] %predi...

journal_title：Transplantation

authors： Verleden SE,Vos R,Geenens R,Ruttens D,Vaneylen A,Dupont LJ,Verleden GM,van Raemdonck DE,Vanaudenaerde BM

更新日期：2012-01-27 00:00:00

abstract：BACKGROUND:Recently, methylxanthines such as pentoxifylline (PTX) were shown to be immunosuppressive in vitro. Unfortunately, when used in transplant patients, PTX was poorly active as an immunosuppressant. Here we report that the new methylxanthine derivative A802715 not only is more active than PTX, it also suppresse...

journal_title：Transplantation

authors： Lin Y,Goebels J,Rutgeerts O,Kasran A,Van Gool S,Ceuppens J,Schönharting M,Waer M

更新日期：1997-06-27 00:00:00

abstract：:Renal function was observed retrospectively in a population of 228 adults who underwent a cardiac allograft at the University of Pittsburgh from June 1980 through June 1987, survived a minimum of one year, and received cyclosporine. Renal function was determined by serial measurement of serum creatinine concentration....

journal_title：Transplantation

authors： Greenberg A,Thompson ME,Griffith BJ,Hardesty RL,Kormos RL,el-Shahawy MA,Janosky JE,Puschett JB

更新日期：1990-10-01 00:00:00

abstract：BACKGROUND:Urothelial carcinoma (UC) is a common complication after renal replacement therapy (RRT) among Chinese end-stage renal disease (ESRD) patients. It is unclear whether there are any differences in the clinicopathologic characteristics of UC between renal transplantation (RT) and dialysis patients; such differe...

journal_title：Transplantation

authors： Zhang B,Shen C,Han WK,Yu W

更新日期：2014-09-15 00:00:00

abstract：:Mus caroli blastocysts transferred to pseudopregnant Mus musculus implant but die about midgestation. Death of the M caroli embryos is associated with infiltration of the fetoplacental units by M musculus lymphocytes, including functional cytotoxic T lymphocytes (CTL). To determine if specific maternal antifetal immun...

journal_title：Transplantation

authors： Crepeau MA,Croy BA

更新日期：1988-06-01 00:00:00