Abstract:
:We recently reported that reconstitution of lethally irradiated B10 mouse recipients with 40 x 10(6) untreated WF rat bone marrow cells resulted in stable fully xenogeneic chimerism (WF rat----B10 mouse). In these animals, the tolerance induced for skin xenografts was highly MHC specific in that donor-specific WF rat skin grafts were significantly prolonged while MHC-disparate third-party xenografts were rapidly rejected (median survival time [MST] = 9 days). We have now examined whether islet cell xenografts placed under the renal capsule of chimeras rendered diabetic with streptozotocin would be accepted and remain functional to maintain euglycemia. Animals were prepared, typed for chimerism at 6 weeks, and diabetes induced with streptozotocin. Donor-specific WF (Rt1Au) islet cell xenografts were significantly prolonged (MST greater than 180 days) in WF----B10 chimeras, while MHC-disparate third-party F344 rat (Rt1A1) grafts were rejected with a time course similar to unmanipulated B10 mice (MST = 8 days). The transplanted donor-specific islet cells were functional to maintain euglycemia, since removal of the grafts at from 100 to 180 days in selected individual chimeras uniformly resulted in return of the diabetic state. These data suggest that donor-specific islet cell xenografts are accepted and remain functional in mice rendered tolerant to rat xenoantigens following bone marrow transplantation.
journal_name
Transplantationjournal_title
Transplantationauthors
Zeng YJ,Ricordi C,Tzakis A,Rilo HL,Carroll PB,Starzl TE,Ildstad STdoi
10.1097/00007890-199202010-00005subject
Has Abstractpub_date
1992-02-01 00:00:00pages
277-83issue
2eissn
0041-1337issn
1534-6080journal_volume
53pub_type
杂志文章相关文献
TRANSPLANTATION文献大全abstract::Spodoptera frugiperda (Sf9) insect cells secreted a class I MHC RT1.Aa heavy chain protein when infected with baculovirus that bore a construct that contained a honeybee melittin secretion (ms) signal attached to RT1.Aa cDNA. The RT1.Aa heavy chain protein in the culture supernatant and cell lysate immunoprecipitated ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199602150-00024
更新日期:1996-02-15 00:00:00
abstract:BACKGROUND:Organs for transplantation are a scarce community resource but community preferences and how they are incorporated into allocation policies are unclear. This systematic review aimed to ascertain community preferences for organ allocation and the principles underpinning these preferences. METHODS:Medline, Em...
journal_title:Transplantation
pub_type: 杂志文章,评审
doi:10.1097/TP.0b013e3181cf1ee1
更新日期:2010-04-15 00:00:00
abstract::Two patients with Fanconi's anemia treated for 5 years with oxymetholone developed hepatic function abnormalities in association with hepatic tumors demonstrated by isotope liver-spleen scan or abdominal echogram. The lesions resolved over a period of 26 months after allogeneic marrow transplantation, and the patients...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198405000-00006
更新日期:1984-05-01 00:00:00
abstract:BACKGROUND:T-cell receptor transgenic (TCR-tg) mouse models with direct CD4 alloreactivity will help elucidate mechanisms of transplant rejection and tolerance in vivo. Although such models exist, they are limited by unusual strain combinations or are based on model antigens. METHODS:A TCR-tg mouse with direct CD4 spe...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31815e883e
更新日期:2008-01-27 00:00:00
abstract::Murine lymphoid cells sensitized against allografts express two types of cytotoxicity measured in vitro in short-term assays of 2 to 3 hr by 51Cr release. One type of cytotoxicity is specific against target cells carrying the sensitizing alloantigens, and the other type is nonspecific against both syngeneic and unrela...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-197602000-00002
更新日期:1976-02-01 00:00:00
abstract:BACKGROUND:Targeting 2-hr postdose cyclosporine (C2) levels to 1,000 to 1,700 mg/dL during the first 6 months after renal transplantation is recommended for triple immunosuppressive regimens. This trial determines whether lower C2 levels could be targeted safely in de novo kidney transplant recipients under a quadruple...
journal_title:Transplantation
pub_type: 临床试验,杂志文章
doi:10.1097/01.tp.0000137423.01887.7d
更新日期:2004-10-27 00:00:00
abstract:BACKGROUND:Cardiac allograft vasculopathy (CAV) is a major limitation in long-term graft survival after heart transplantation (HTx). Its prediction and detection at an early stage is a challenge because an accurate, minimally invasive blood test is lacking. The aim of this study was to analyze the relationship of Tact ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000000493
更新日期:2015-07-01 00:00:00
abstract::MHC expression on endothelial cells after cytomegalovirus infection was investigated using double antibody radioimmunoassays and immunofluorescence flow cytometry. After CMV infection there was an increase in class I and beta 2 microglobulin expression. This increase corresponds to the percentage of cells that are inf...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198909000-00024
更新日期:1989-09-01 00:00:00
abstract:BACKGROUND:Host macrophages are abundant within fetal pig pancreas xenografts undergoing rejection, but their role is unknown. Therefore, we examined the effect of host macrophage depletion on xenograft rejection. METHODS:Nonobese diabetic (NOD) mice were given clodronate-loaded liposomes intravenously to deplete macr...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199812150-00002
更新日期:1998-12-15 00:00:00
abstract:BACKGROUND:To investigate the transparency, biocompatibility, and safety of human-derived acellular dermal matrix for application in corneal stromal transplantation. METHODS:Twenty-four patients (24 eyes) with pellucid marginal corneal degeneration were enrolled, and intrastromal keratoplasty was performed with human-...
journal_title:Transplantation
pub_type: 临床试验,杂志文章
doi:10.1097/TP.0000000000002681
更新日期:2019-06-01 00:00:00
abstract::One of the most powerful influences on cadaveric renal graft survival is the enhancing effect of blood transfusions from unrelated individuals (1, 2). However, the optimum number of transfusions required to achieve this effect remains controversial. Enhanced graft survival following only one or two transfusions has be...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198503000-00008
更新日期:1985-03-01 00:00:00
abstract::Rat liver transplantation was utilized to study the effect of hepatic iron on the control of iron absorption. Six iron-loaded and six normal livers were transplanted into normal or iron-loaded animals. Iron absorption was measured pretransplant and 10 days posttransplant by total-body counting (59Fe). The animals were...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198907000-00005
更新日期:1989-07-01 00:00:00
abstract:BACKGROUND:Human intravenous immunoglobulin G delayed xenogeneic hyperacute rejection (HAR) in the guinea pig-to-rat combination. We investigated the respective roles of the Fc and Fab fragments of the IgG molecule in this inhibitory effect. METHODS:By using a guinea pig-to-rat heart transplantation model, the efficie...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199808150-00018
更新日期:1998-08-15 00:00:00
abstract:BACKGROUND:Hepatitis C virus (HCV) infection is common in kidney transplantation and is known to affect long-term patient and graft survival, as is time in renal-replacement therapy (RRT). The aim of this study was to investigate HCV in relation to time in RRT and its impact on outcome after transplantation. METHODS:A...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000131948.29742.24
更新日期:2004-09-15 00:00:00
abstract:BACKGROUND:The purpose of this study was to determine whether screening for anti-human leukocyte antigen (HLA) antibodies (Abs) could predict development of acute rejection (AR) before clinical evidence of kidney allograft dysfunction in nonsensitized recipients. METHODS:Eighty-four non-HLA identical kidney transplant...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3181c3503e
更新日期:2010-01-27 00:00:00
abstract:BACKGROUND:Although clinical data suggest its existence, little is known about the effect of rapamycin derivatives on wound repair. This study aims to delineate the influence of the mammalian target of rapamycin inhibitor everolimus on wound healing in the rat intestine. METHODS:Four groups of 26 male Wistar rats rece...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000246078.09845.9c
更新日期:2006-12-15 00:00:00
abstract:BACKGROUND:Ischemia-reperfusion syndrome has been recognized as an important pathogenic factor in renal transplantation, not only in the development of delayed graft function but also in the development of acute and chronic rejection. Hypoxia-inducible factor (HIF)-1 activates transcription of several genes implicated ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000063128.86981.B2
更新日期:2003-05-27 00:00:00
abstract::The NOD mouse develops immune-mediated diabetes mellitus characterized by T cell infiltration and destruction of pancreatic islet tissue. We wished to determine whether one contributing factor was an abnormality of the NOD pancreas that caused it to elicit an attack by NOD T cells. Therefore we constructed mice that h...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199206000-00032
更新日期:1992-06-01 00:00:00
abstract::Teratoma 402 AX is an embryo-like tumor cell line originally derived from the testicles of strain 129/J mice. This teratocarcinoma grows well in males and pregnant females but poorly in virgin females when given in small doses. Induction of growth of this tumor is syngeneic and allogeneic virgin females was achieved b...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-197510000-00005
更新日期:1975-10-01 00:00:00
abstract:BACKGROUND:Fatty livers are more prone to primary nonfunction after transplantation. It is known that cell injury is strongly associated with alterations in the content and composition of membrane lipids. We assumed that plasma membrane (PM) fluidity, which is the most important property of the membrane, differed betwe...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199901270-00002
更新日期:1999-01-27 00:00:00
abstract:BACKGROUND:Donation after circulatory death (DCD) provides an alternative pathway to deceased organ transplantation. Although clinical DCD lung, liver, and kidney transplantation are well established, transplantation of hearts retrieved from DCD donors has reached clinical translation only recently. Progress has been l...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000001396
更新日期:2016-12-01 00:00:00
abstract:BACKGROUND:Over 85% of US centers adhere to practice guidelines that consider morbid obesity to be a contraindication to liver transplantation (LT). The relationship of morbid obesity with LT outcomes and survival benefit in the current era is unknown. METHODS:We investigated the association of body mass index with wa...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000001461
更新日期:2016-12-01 00:00:00
abstract:BACKGROUND:Strong alloreactive T cell responses are a menace in transplantation surgery and their menagement requires understanding the basis of alloreactivity. Alloantigen recognition can be peptide independent, peptide specific, or peptide dependent. The mechanisms influencing each recognition pattern are largely unk...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200203150-00024
更新日期:2002-03-15 00:00:00
abstract::Human herpesvirus type 6 (HHV-6) causes roseola infantum (exanthema subitum) upon primary infection in young children. Thereafter it persists lifelong in the organism. Like other herpesviruses, HHV-6 can be reactivated in periods of immunosuppression - e.g., after organ transplantation. In order to study the incidence...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199602270-00027
更新日期:1996-02-27 00:00:00
abstract::The aim of this study was to investigate excretion of urinary and pancreatic juice neopterin in patients after combined pancreas-kidney transplantation and to relate it to the clinical course. The study design was a prospective observation study. Thirty consecutive patients with end-stage diabetic disease received a s...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199204000-00020
更新日期:1992-04-01 00:00:00
abstract::The influence of continuous immunosuppression on the immune system of 2 neonates born to heart-lung transplant recipients was analyzed. T cells, T cell subpopulations, B cells and cyclosporine levels were measured in maternal and cord blood at the time of delivery. Cyclosporine, both parent compound, and metabolites w...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198908000-00008
更新日期:1989-08-01 00:00:00
abstract:BACKGROUND:Endomyocardial biopsy (EMB) remains the gold standard for acute cellular rejection (ACR) diagnosis in cardiac transplantation yet is subject to interobserver variability. A method that could avoid discordant EMB analysis would be desirable. The apoptosis rate in EMB correlates with ACR severity. Apollon inhi...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3181c3c690
更新日期:2010-01-27 00:00:00
abstract::Published data on the guinea pig-to-rat hepatic xenotransplant model describe problems concerning poor graft reperfusion. To further investigate this phenomenon, orthotopic liver xenotransplantation between weight-matched guinea pigs and rats were performed using Kamada's technique. On reperfusion, all cases had porta...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199807150-00017
更新日期:1998-07-15 00:00:00
abstract::Blood transfusions are common in patients with end-stage liver disease (ESLD), and their effects on sensitization, rejection, and liver graft survival are not well known. These effects were examined in 121 recipients of primary liver grafts, surviving > or = 30 days. Ninety-six (79%) patients received transfusions bef...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199706150-00008
更新日期:1997-06-15 00:00:00
abstract::Renal vasoconstriction has been implicated as a major contributing factor for the nephrotoxic effects of cyclosporine. In an attempt to assess the relative contribution of thromboxane (Tx), the effects of coadministering CsA with the selective Tx synthetase inhibitor, Dazmegrel (DAZ) (Pfizer, Inc.), were determined. R...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199111000-00016
更新日期:1991-11-01 00:00:00