Hepatitis C infection, time in renal-replacement therapy, and outcome after kidney transplantation.

Abstract:

BACKGROUND:Hepatitis C virus (HCV) infection is common in kidney transplantation and is known to affect long-term patient and graft survival, as is time in renal-replacement therapy (RRT). The aim of this study was to investigate HCV in relation to time in RRT and its impact on outcome after transplantation. METHODS:A follow-up cohort study using Kaplan-Meier analysis and Cox proportional hazards model was performed in 545 kidney and 26 kidney-pancreas transplant recipients receiving transplants between 1989 and 1997, with last follow-up on December 31, 2002. HCV status at transplantation and time in RRT were analyzed. RESULTS:Time in RRT was significantly longer (P<0.0001), and previous transplantations were more common (P=0.04) in the HCV-positive group. HCV significantly reduced patient (P=0.0012) and graft survival (P=0.0003) after transplantation. Adjustment for age, sex, diabetes, previous transplantations, type of transplant, and time in RRT resulted in a relative risk (RR) for death of 2.23, 1.92, and 1.07 for HCV, diabetes, and age, respectively. The RR for graft loss was 1.96 and 1.03 for HCV and age. Sex, previous transplants, and time in RRT did not affect HCV as an independent risk factor for patient or graft survival. The leading cause of death was cardiovascular disease in both groups. CONCLUSIONS:HCV was, in our series, more important than time in RRT for patient death and graft loss posttransplant. Successful pretransplant antiviral therapy could be more beneficial for HCV-infected patients rather than early transplantation for long-term outcome, but this needs to be studied prospectively.

journal_name

Transplantation

journal_title

Transplantation

authors

Bruchfeld A,Wilczek H,Elinder CG

doi

10.1097/01.tp.0000131948.29742.24

subject

Has Abstract

pub_date

2004-09-15 00:00:00

pages

745-50

issue

5

eissn

0041-1337

issn

1534-6080

pii

00007890-200409150-00020

journal_volume

78

pub_type

杂志文章
  • Differentiation of class I- and class II-directed donor-specific alloreactivity in bronchoalveolar lavage lymphocytes from lung transplant recipients.

    abstract::Previous studies have demonstrated that donor antigen-specific primed-lymphocyte-test (PLT) reactivity of bronchoalveolar lavage lymphocytes is strongly associated with acute pulmonary rejection and with obliterative bronchiolitis (OB); however, a systematic analysis of PLT reactivity as being class I-or II-directed h...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199201000-00036

    authors: Reinsmoen NL,Bolman RM,Savik K,Butters K,Hertz M

    更新日期:1992-01-01 00:00:00

  • Xenogeneic skin and kidney transplants in a closely related canine system, fox-dog.

    abstract::Fox kidney and skin grafts were transplanted into dog recipients. Fox kidneys, transplanted en bloc into untreated dogs, survived 6.2 +/- 0.4 days. The skin transplants survived 5.9 +/- 1.4 days. The grafted kidneys showed almost normal function before rejection. Both skin and kidney rejection were mediated through a ...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-197508000-00009

    authors: Chaussy C,Hammer C,von Scheel J,Pielsticker K,Sollinger HW,Pfeifer KJ,Pongratz H,Brender W

    更新日期:1975-08-01 00:00:00

  • Cytomegalovirus disease is not a major risk factor for ischemic heart disease after renal transplantation.

    abstract:BACKGROUND:It has been suggested that cytomegalovirus infection increases the risk of ischemic heart disease. Both cytomegalovirus and ischemic heart disease are common after renal transplantation, suggesting a possible causal association in this population. METHODS AND PATIENTS:We studied 1004 consecutive renal trans...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-200110270-00011

    authors: Hernández D,Hanson E,Kasiske MK,Danielson B,Roel J,Kasiske BL

    更新日期:2001-10-27 00:00:00

  • Clinical and histologic patterns of early graft failure due to recurrnet hepatitis C in four patients after liver transplantation.

    abstract::Hepatitis C viral recurrence after orthotopic liver transplantation is almost universal. Hepatitis C induced graft failure may occur, but the clinical and histologic profiles are not well defined. The aim of this study was to describe the pattern of early graft failure in patients with recurrent hepatitis C after live...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199603150-00005

    authors: Dickson RC,Caldwell SH,Ishitani MB,Lau JY,Driscoll CJ,Stevenson WC,McCullough CS,Pruett TL

    更新日期:1996-03-15 00:00:00

  • The kinetics of tolerance induction by nondepleting anti-CD4 monoclonal antibody (RIB 5/2) plus intravenous donor alloantigen administration.

    abstract:BACKGROUND:CD4+ T cells play an essential role in allograft rejection. The monoclonal anti-rat CD4 antibody, RIB 5/2, has been shown to modulate the CD4 glycoprotein without eliminating the recipient T cells. We have successfully induced tolerance to rat heart allografts by recipient pretreatment with a single dose of ...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-200001270-00015

    authors: Motoyama K,Arima T,Yu S,Lehmann M,Flye MW

    更新日期:2000-01-27 00:00:00

  • ISHLT Primary Graft Dysfunction Incidence, Risk Factors, and Outcome: A UK National Study.

    abstract:BACKGROUND:Heart transplantation (HTx) remains the most effective long-term treatment for advanced heart failure. Primary graft dysfunction (PGD) continues to be a potentially life-threatening early complication. In 2014, a consensus statement released by International Society for Heart and Lung Transplantation (ISHLT)...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0000000000002220

    authors: Avtaar Singh SS,Banner NR,Rushton S,Simon AR,Berry C,Al-Attar N

    更新日期:2019-02-01 00:00:00

  • Intrasplenic hepatocyte allotransplantation in dalmation dogs with and without cyclosporine immunosuppression.

    abstract::Hepatocyte allotransplantation has been performed successfully in several small animal models for the amelioration of inborn metabolic errors. Before a human clinical trial of hepatocyte allotransplantation can be attempted, preliminary experience in a large animal model is needed. We transplanted isolated mongrel hep...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199705150-00003

    authors: Benedetti E,Kirby JP,Asolati M,Blanchard J,Ward MG,Williams R,Hewett TA,Fontaine M,Pollak R

    更新日期:1997-05-15 00:00:00

  • Safety of blood group A2-to-O liver transplantation: an analysis of the United Network of Organ Sharing database.

    abstract:BACKGROUND:ABO-incompatible organ transplantation typically induces hyperacute rejection. A2-to-O liver transplantations have been successful. This study compared overall and graft survival in O recipients of A2 and O grafts based on Organ Procurement and Transplantation Network data. METHODS:Scientific Registry of Tr...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0b013e31825c591e

    authors: Kluger MD,Guarrera JV,Olsen SK,Brown RS Jr,Emond JC,Cherqui D

    更新日期:2012-09-15 00:00:00

  • Amyloid A Amyloidosis After Renal Transplantation: An Important Cause of Mortality.

    abstract:BACKGROUND:There are limited data on the outcome of transplant recipients with familial Mediterranean fever (FMF)-associated AA amyloidosis. The aim of the present study is to evaluate demographic, clinical, laboratory, and prognostic characteristics and outcome measures of these patients. METHODS:Eighty-one renal tra...

    journal_title:Transplantation

    pub_type: 杂志文章,多中心研究

    doi:10.1097/TP.0000000000003043

    authors: Sarihan I,Caliskan Y,Mirioglu S,Ozluk Y,Senates B,Seyahi N,Basturk T,Yildiz A,Kilicaslan I,Sever MS

    更新日期:2020-08-01 00:00:00

  • Plasma polymerase chain reaction for cytomegalovirus DNA after allogeneic marrow transplantation: comparison with polymerase chain reaction using peripheral blood leukocytes, pp65 antigenemia, and viral culture.

    abstract::In a prospective longitudinal study, detection of cytomegalovirus (CMV) DNA in plasma (plasma polymerase chain reaction [PCR]) was compared with PCR of CMV DNA in peripheral blood leukocytes (PBL PCR), the CMV pp65 antigenemia assay, and viral cultures from blood, urine, and throat of 29 patients, 14 of whom received ...

    journal_title:Transplantation

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00007890-199707150-00020

    authors: Boeckh M,Gallez-Hawkins GM,Myerson D,Zaia JA,Bowden RA

    更新日期:1997-07-15 00:00:00

  • Prevalence and correlates of self-reported pretransplant nonadherence with medication in heart, liver, and lung transplant candidates.

    abstract:BACKGROUND:Evidence on prevalence and correlates of pretransplant medication nonadherence (MNA) is limited. The present study explored self-reported prevalence and correlates of MNA before heart, liver, and lung transplantation. METHODS:This cross-sectional descriptive study included 174 patients: 69 lung, 33 heart, a...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/01.tp.0000158430.06507.87

    authors: Dobbels F,Vanhaecke J,Desmyttere A,Dupont L,Nevens F,De Geest S

    更新日期:2005-06-15 00:00:00

  • In vivo bioluminescence imaging of transplanted islets and early detection of graft rejection.

    abstract:BACKGROUND:Bioluminescence imaging (BLI) modalities are being developed to monitor islet transplant mass and function in vivo. The aim of this study was to use the BLI system to determine how the change in functional islet mass correlated to metabolic abnormalities during the course of alloimmune rejection in a murine ...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/01.tp.0000206109.71181.bf

    authors: Chen X,Zhang X,Larson CS,Baker MS,Kaufman DB

    更新日期:2006-05-27 00:00:00

  • Normothermic Ex Vivo Kidney Perfusion Improves Early DCD Graft Function Compared With Hypothermic Machine Perfusion and Static Cold Storage.

    abstract:BACKGROUND:Better preservation strategies for the storage of donation after circulatory death grafts are essential to improve graft function and to increase the kidney donor pool. We compared continuous normothermic ex vivo kidney perfusion (NEVKP) with hypothermic anoxic machine perfusion (HAMP) and static cold storag...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0000000000003066

    authors: Urbanellis P,Hamar M,Kaths JM,Kollmann D,Linares I,Mazilescu L,Ganesh S,Wiebe A,Yip PM,John R,Konvalinka A,Mucsi I,Ghanekar A,Bagli DJ,Robinson LA,Selzner M

    更新日期:2020-05-01 00:00:00

  • Immunobiology of xenogeneic cornea grafts in mouse eyes. II. Immunogenicity of xenogeneic cornea tissue grafts implanted in anterior chamber of mouse eyes.

    abstract:BACKGROUND:Xenogeneic corneal fragments (guinea pig) are highly resistant to immune rejection in the anterior chamber of mouse eyes. Because guinea pigs and mice are discordant (i.e., mouse serum normally contains guinea pig reactive xenoantibodies), we wished to determine the extent to which xenogeneic corneal fragmen...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-200002270-00025

    authors: Tanaka K,Streilein JW

    更新日期:2000-02-27 00:00:00

  • Immunosuppression with a combination of the leflunomide analog, FK778, and microemulsified cyclosporine for renal transplantation in mongrel dogs.

    abstract:BACKGROUND:The leflunomide analog, FK778, is a selective pyrimidine synthesis inhibitor. In rodent models, FK778 is efficacious in the prevention of allograft and xenograft rejection, and a combination of FK778 and cyclosporine has synergistic immunosuppressive efficacy. METHODS:Heterotopic renal transplantation was p...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/01.TP.0000061789.97072.12

    authors: Kyles AE,Gregory CR,Griffey SM,Bernsteen L,Pierce J,Lilja HS,Morris RE

    更新日期:2003-04-27 00:00:00

  • Early up-regulation of macrophages and myofibroblasts: a new marker for development of chronic renal allograft rejection.

    abstract:BACKGROUND:Increased numbers of macrophages and myofibroblasts are observed to occur in chronic renal allograft rejection (CR). The aim of this study was to examine the expression of cellular markers for the macrophage and myofibroblast in early renal transplant biopsy specimens and correlate these findings with allogr...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-200006270-00028

    authors: Pilmore HL,Painter DM,Bishop GA,McCaughan GW,Eris JM

    更新日期:2000-06-27 00:00:00

  • Thymoglobulin induction decreases rejection in solitary pancreas transplantation.

    abstract:BACKGROUND:Solitary pancreas transplants, both pancreas transplant alone (PTA) and pancreas after kidney (PAK), have higher rejection rates and lower graft survivals than simultaneous pancreas-kidney transplants (SPK). The aim of this study is to compare three different antibody induction regimens in solitary pancreas ...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-200111270-00017

    authors: Stegall MD,Kim DY,Prieto M,Cohen AJ,Griffin MD,Schwab TR,Nyberg SL,Velosa JA,Gloor JM,Innocenti F,Bohorquez H,Dean PG,Carpenter HA,Leontovich ON,Sterioff S,Larson TS

    更新日期:2001-11-27 00:00:00

  • Induction of transplantation tolerance in rats by spleen allografts. II. Evidence that W3/25+ T suppressor/inducer and OX8+ T suppressor/effector cells are required to mediate specific unresponsiveness.

    abstract::The results presented in this report demonstrate that T cells, isolated from AGUS rats bearing long-term (WAG X AGUS)F1 spleen allografts adoptively transferred to irradiated AGUS recipients could not mediate the rejection of WAG hearts but rejected PVG. A hearts in acute fashion. Further, unresponsive T cells were ab...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-198709000-00024

    authors: Stepkowski SM,Bitter-Suermann H,Duncan WR

    更新日期:1987-09-01 00:00:00

  • Nosocomial Legionnaires' disease following renal transplantation.

    abstract::A cluster of five cases of Legionnaires' disease in renal transplant patients is described. They were treated with erythromycin and rifampicin, and all five survived. Two of them had rejected their grafts prior to their Legionella pneumonia; two rejected their transplants after reduction of immunosuppressive therapy t...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:

    authors: Wilczek H,Kallings I,Nyström B,Hoffner S

    更新日期:1987-06-01 00:00:00

  • Active enhancement in the primate by bone marrow I. Ia-like determinants on nucleated bone marrow cells.

    abstract::This study investigates the possibility that the active enhancing properties of bone marrow (BM) cells may be related to Ia-like determinants on their surface membranes. Less chromium was released on a cell per cell basis from nucleated baboon BM cells used as targets in complement-dependent cytotoxicity than from lab...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-197808000-00001

    authors: Smit JA,Myburgh JA,Gaillard VJ

    更新日期:1978-08-01 00:00:00

  • C1q-fixing human leukocyte antigen antibodies are specific for predicting transplant glomerulopathy and late graft failure after kidney transplantation.

    abstract:BACKGROUND:Human leukocyte antigen (HLA) antibodies, especially those that fix complement, are associated with antibody-mediated rejection and graft failure. The C1q assay on single antigen beads detects a subset of HLA antibodies that can fix complement and precede C4d deposition. The aim of this study was to determin...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0b013e318203fd26

    authors: Yabu JM,Higgins JP,Chen G,Sequeira F,Busque S,Tyan DB

    更新日期:2011-02-15 00:00:00

  • Surgical site infection in liver transplant recipients: impact of the type of perioperative prophylaxis.

    abstract::Surgical site infection (SSI) is an important cause of morbidity after orthotopic liver transplantation (OLT). Perioperative antibiotic prophylaxis is one of the main modifiable risk factors. We prospectively investigated the epidemiology, risk factors, and prognosis of SSI in a cohort of 167 OLT. Two different schedu...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0b013e3181735407

    authors: García Prado ME,Matia EC,Ciuro FP,Díez-Canedo JS,Sousa Martín JM,Porras López FM,de la Casa AC,Cisneros Herreros JM

    更新日期:2008-06-27 00:00:00

  • Impact of Acuity Circles on Outcomes for Pediatric Liver Transplant Candidates.

    abstract:BACKGROUND:In December 2018, United Network for Organ Sharing approved an allocation scheme based on recipients' geographic distance from a deceased donor (acuity circles [ACs]). Previous analyses suggested that ACs would reduce waitlist mortality overall, but their impact on pediatric subgroups was not considered. ME...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0000000000003079

    authors: Mogul DB,Perito ER,Wood N,Mazariegos GV,VanDerwerken D,Ibrahim SH,Mohammad S,Valentino PL,Gentry S,Hsu E

    更新日期:2020-08-01 00:00:00

  • Acute renal injury in the interferon-gamma gene knockout mouse: effect on cytokine gene expression.

    abstract::We studied major histocompatibility complex (MHC) and cytokine mRNA induction after renal injury in the absence of interferon-gamma (IFN-gamma) using IFN-gamma gene knockout (GKO) mice. The left renal pedicle of normal (wild-type) and GKO BALB/c mice was clamped for 60 minutes; cytokine and MHC mRNA expression were mo...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199560120-00031

    authors: Goes N,Urmson J,Vincent D,Halloran PF

    更新日期:1995-12-27 00:00:00

  • Infection of human endothelium in vitro by cytomegalovirus causes enhanced expression of purinergic receptors: a potential virus escape mechanism?

    abstract:BACKGROUND:Human cytomegalovirus (CMV) uses different strategies to escape from human host defense reactions. Previously we have observed that infection of endothelial cells with CMV in vitro leads to enhanced activity of endothelial ectonucleotidases. These ectoenzymes are responsible for hydrolysis of extracellular a...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/01.tp.0000287598.25493.a5

    authors: Zandberg M,van Son WJ,Harmsen MC,Bakker WW

    更新日期:2007-11-27 00:00:00

  • Depletion of hepatitis C virus from procured kidneys using pulsatile perfusion preservation.

    abstract::The safety of the use of kidneys procured from a hepatitis C virus (HCV)-positive cadaver donors in transplantation has recently been the subject of controversy. One factor that is important in determining the transmission of the virus and/or viral liver disease is the total viral inoculum to which the renal allograft...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199403270-00011

    authors: Zucker K,Cirocco R,Roth D,Olson L,Burke GW,Nery J,Esquenazi V,Miller J

    更新日期:1994-03-27 00:00:00

  • Diarrhea after kidney transplantation: a new look at a frequent symptom.

    abstract::Diarrhea is a frequent but overlooked complication of kidney transplantation. Diarrhea is repeatedly neglected, often considered by patients and clinicians an unavoidable side effect of immunosuppressive regimens. It is, however, associated with a significant impairment in life quality. Severe and chronic posttranspla...

    journal_title:Transplantation

    pub_type: 杂志文章,评审

    doi:10.1097/TP.0000000000000335

    authors: Aulagnon F,Scemla A,DeWolf S,Legendre C,Zuber J

    更新日期:2014-10-27 00:00:00

  • Favorable Kidney Function in Pediatric Liver Transplant Recipients: Results of a Single-center Cohort Study.

    abstract:BACKGROUND:Although chronic kidney disease (CKD) is still a common complication, the prognosis of kidney function after liver transplantation (LT) is not well known. Moreover, kidney function after LT in children with renal involvement is unknown. METHODS:We retrospectively analyzed patients aged <20 years who underwe...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0000000000002548

    authors: Sato M,Kaneko T,Ogura M,Kamei K,Ito S,Fukuda A,Sakamoto S,Kasahara M,Ishikura K

    更新日期:2019-08-01 00:00:00

  • Telomerase activity in rat liver allografts.

    abstract:BACKGROUND:Telomerase activity in grafts may be involved in the alteration of cellular senescence after transplantation or its relevant immunological events. METHODS:At the age of 20 weeks, donor livers harvested from DA (RT1a) were orthotopically transplanted into PVG (RT1c) or LEW (RT1(1)) rats. Rats having undergon...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-200003150-00062

    authors: Goto S,Lin YC,Lai CY,Lee CM,Pan TL,Lord R,Chiang KC,Tseng HP,Lin CL,Cheng YF,Yokoyama H,Kitano S,Chen CL

    更新日期:2000-03-15 00:00:00

  • The role of self-expandable metallic stents for the treatment of airway complications after lung transplantation.

    abstract:BACKGROUND:Airway complications continue to be an important source of morbidity and mortality after lung transplantation (LTx). Different approaches have been used for their nonsurgical management. We describe our experience using self-expandable metallic stents (SEMSs) in patients with airway complications post-LTx. ...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/01.TP.0000061229.83500.A0

    authors: Saad CP,Ghamande SA,Minai OA,Murthy S,Pettersson G,DeCamp M,Mehta AC

    更新日期:2003-05-15 00:00:00