Pathophysiological Trends During Withdrawal of Life Support: Implications for Organ Donation After Circulatory Death.

abstract：:The effect of cyclosporine on lymphocyte intracellular free calcium [( Ca2+]i) is controversial, and potential age-related differences in lymphocyte CsA sensitivity have not been studied. We measured the mitogen-induced change in [Ca2+]i in peripheral blood lymphocytes (PBLs) following intravenous CsA infusion (5 mg/k...

journal_title：Transplantation

authors： Tsao PW,Diaz RJ,Radde IC,Wong PY,Martell MF,Augustine JM,Wilson GJ,Coles JG

更新日期：1991-08-01 00:00:00

abstract：:We have used a polymerase chain reaction-based assay measuring polymorphic (CA)n repeats, a class of simple sequence repeats, to assess the success of allogeneic canine marrow transplants. Results were compared with those obtained with karyotype analysis of dividing cells in recipients that were sex mismatched with th...

journal_title：Transplantation

authors： Yu C,Ostrander E,Bryant E,Burnett R,Storb R

更新日期：1994-09-27 00:00:00

abstract：:The effect of cyclosporine and metabolite 17 (M17) as well as other CsA-related compounds (CsG, dihydro-CsC, dihydro-CsD, CsH, B5.49, and H7.94) was tested on T lymphocyte clone proliferation. In these experiments, antigen and interleukin 2 (IL-2) dependent long-term T lymphocyte clones derived from a rejected human k...

journal_title：Transplantation

authors： Chabannes D,Moreau JF,Soulillou JP

更新日期：1987-12-01 00:00:00

abstract：:KM2210, a conjugate of estradiol and chlorambucil (CBL), which was originally developed as an anti-breast cancer agent, inhibits proliferative response of human mononuclear cells to alloantigens in mixed lymphocyte culture in a dose-dependent manner, but has no effect on their response to phytohemagglutinin. Neither e...

journal_title：Transplantation

authors： Matsudaira T,Kodo H,Okamoto S,Tani K,Tojo A,Ozawa K,Asano K,Asano S

更新日期：1992-10-01 00:00:00

abstract：BACKGROUND:The clinical significance of HLA-directed antibodies newly detected after transplantation (HT) is controversial. METHODS:Seventy-one HT recipients consented to enroll. Mean follow-up time was 28 months (range 6-48). Panel reactive antibody (PRA) analysis was performed on posttransplant sera (2 weeks, 1, 2, ...

journal_title：Transplantation

authors： Tambur AR,Pamboukian SV,Costanzo MR,Herrera ND,Dunlap S,Montpetit M,Heroux A

更新日期：2005-10-27 00:00:00

abstract：:The methodology of the conventional mixed lymphocyte culture test has been simplified and miniaturized by developing a micromethod employing Terasaki trays with a final culture volume of 20 mul containing between 10,000 and 20,000 responding and stimulating cells each/culture. This represents one-tenth the cell concen...

journal_title：Transplantation

authors： Péna-Martinez J,Festenstein H

更新日期：1975-07-01 00:00:00

abstract：:The addition of prostaglandin to the single-flush technique of lung preservation is considered to enhance subsequent graft function. We have evaluated the use of the prostacyclin analog, Iloprost, in an animal model of unilateral lung transplantation. Group 1 (n = 5) received Iloprost as a pretreatment intravenously (...

journal_title：Transplantation

authors： Hooper TL,Fetherston GJ,Flecknell PA,Dark JH,McGregor CG

更新日期：1990-03-01 00:00:00

abstract：:The aim of this study was to analyze the possible protective effects of a glutamine and arginine precursor (ornithine-alpha-ketoglutarate [OKG]) on the mucosa of a transplanted intestine when administered with either a defined formula oral diet (DFD) or a standard chow. Isogenic male Lewis rats (250 g) were submitted ...

journal_title：Transplantation

authors： de Oca J,Bettonica C,Cuadrado S,Vallet J,Martín E,Garcia A,Montañés T,Jaurrieta E

更新日期：1997-03-15 00:00:00

abstract：:This study focuses upon two discrete components of posttransplant hepatic reticuloendothelial system (RES) function-phagocytosis and killing of bacteria-under various conditions of ischemic preservation. We had previously reported that, following intravenous injection of rats with 51Cr and 125I double-labeled Escheric...

journal_title：Transplantation

authors： Klein AS,Zhadkevich M,Wang D,Margolick JB,Winkelstein JA,Bulkley GB

更新日期：1996-04-27 00:00:00

abstract：BACKGROUND:The infiltration of epithelium by CD8+ T lymphocytes in human renal or liver allografts is a critical feature of acute rejection. CD103 expression can be acquired in vitro by CD8+ cytotoxic T lymphocytes in response to allogeneic renal epithelial cells and promotes their adhesion to epithelium and subsequent...

journal_title：Transplantation

authors： Leteurtre E,Copin MC,Labalette M,Noel C,Roumilhac D,Pruvot FR,Lecomte-Houcke M,Gosselin B,Dessaint JP

更新日期：2000-07-15 00:00:00

abstract：:The generation of Gal knockout (KO) pigs is likely to be an important advance in xenotransplantation. However, recent reports suggesting that expression of Gal may not be completely eliminated raise the possibility of a continuing anti-Gal immune response. The authors used a Gal-mismatched skin graft model to study ce...

journal_title：Transplantation

authors： Gock H,Murray-Segal L,Salvaris E,Cowan P,D'Apice AJ

更新日期：2004-03-15 00:00:00

abstract：BACKGROUND:IgG antibodies to HLA class I antigens can cause hyperacute rejection of renal allografts. Screening of sera from such transplant candidates is laborious, time-consuming, and expensive when performed by sensitive antihuman globulin-augmented lymphocytotoxicity (AHG-CDC). METHODS:Because 60-70% of our transp...

journal_title：Transplantation

authors： Moore SB,Ploeger NA,DeGoey SR

更新日期：1997-12-15 00:00:00

abstract：BACKGROUND:Inhibition of complement in small animal models of xenotransplantation has demonstrated graft infiltration with natural killer (NK) cells and monocytes associated with endothelial cell (EC) activation. We have previously demonstrated that human NK cells activate porcine EC in vitro, which results in adhesion...

journal_title：Transplantation

authors： von Albertini M,Ferran C,Brostjan C,Bach FH,Goodman DJ

更新日期：1998-11-15 00:00:00

abstract：BACKGROUND:In the acute rejection of allografts, the interaction between Fas (CD95) and its ligand (FasL; CD95L) has been shown to be involved in mediating apoptotic cell death. The role, however, of these molecules in the pathogenesis of transplant vascular sclerosis is as yet undetermined. The present study was there...

journal_title：Transplantation

authors： Subbotin V,Sun H,Aitouche A,Salam A,Valdivia LA,Fung JJ,Starzl TE,Rao AS

更新日期：1999-05-27 00:00:00

abstract：:We have analyzed PBL from 7 children exposed to CsA in utero and 4 children exposed to AZA in utero. Expression of CD3, CD4, CD8, and CD20 were normal for both groups of children; however, significant differences were detected in the expression of CD45RA, CD45R0, and CD29. While CsA-exposed children had higher density...

journal_title：Transplantation

authors： Pilarski LM,Yacyshyn BR,Lazarovits AI

更新日期：1994-01-01 00:00:00

abstract：:BK polyoma virus causes allograft dysfunction as a result of tubulo-interstitial nephritis in 2% to 5% of renal transplant recipients. The incidence of BK virus infection among renal transplant recipients in India is unknown. We used routine histologic examination, immunohistochemistry, and electron microscopy to retr...

journal_title：Transplantation

authors： Sachdeva MS,Nada R,Jha V,Sakhuja V,Joshi K

更新日期：2004-02-15 00:00:00

abstract：:The effect of the spleen cells and thymus cells from Corynebacterium liquefaciens-treated (C57BL/6 x BALB/c)F1 hybrid mice on graft-versus-host (GVH) reaction, initiated in the parental to newborn F1 hybrid strain combination, was studied by using Simonsen's spleen assay. The combined inocula of 5 x 10(6) normal BALB/...

journal_title：Transplantation

authors： Kobayashi M,Kawashima K,Yamada K

更新日期：1980-01-01 00:00:00

abstract：BACKGROUND:The polymorphic family of killer-cell immunoglobulin-like receptors (KIRs) consists of activating and inhibitory receptors expressed by natural killer (NK) cells and effector T cells that recognize human leukocyte antigen (HLA) class I ligands. It has been suggested that KIR/HLA incompatibility exerts benefi...

journal_title：Transplantation

authors： Kunert K,Seiler M,Mashreghi MF,Klippert K,Schönemann C,Neumann K,Pratschke J,Reinke P,Volk HD,Kotsch K

更新日期：2007-12-15 00:00:00

abstract：BACKGROUND:There are limited data on the outcome of transplant recipients with familial Mediterranean fever (FMF)-associated AA amyloidosis. The aim of the present study is to evaluate demographic, clinical, laboratory, and prognostic characteristics and outcome measures of these patients. METHODS:Eighty-one renal tra...

journal_title：Transplantation

authors： Sarihan I,Caliskan Y,Mirioglu S,Ozluk Y,Senates B,Seyahi N,Basturk T,Yildiz A,Kilicaslan I,Sever MS

更新日期：2020-08-01 00:00:00

abstract：:Athymic PVG-rnu/rnu (RT1c) rats were grafted with skin bearing isolated MHC disparities 7-14 days in advance of cell transfer. The ability of naive CD4+ or CD8+ thoracic duct lymphocytes to induce rejection was assessed by adoptive transfer of one or both T cell subsets into nude recipients bearing congenic PVG.r1 (MH...

journal_title：Transplantation

authors： Bell EB,Rejali D,Whitby EH,Sparshott SM,Yang CP

更新日期：1990-10-01 00:00:00

abstract：BACKGROUND:Liver transplantation is a widely accepted treatment for end-stage liver disease. The aim of our study was to investigate the imbalance between T helper type 17 (Th17) and CD4(+) CD25(+) Foxp3(+) regulatory T (Treg) cells during hepatic allograft rejection in a rodent grafts model because their roles in live...

journal_title：Transplantation

authors： Zhou Y,Yang X,Zhang H,Jiang J

更新日期：2015-06-01 00:00:00

abstract：BACKGROUND:In previous studies of cynomolgus monkey lung allograft recipients, we demonstrated significant immunosuppressive efficacy but reduced tolerability after combined treatment with high doses of microemulsion cyclosporine (CsA) and SDZ RAD (40-O-(2-hydroxyethyl)-rapamycin). The current study was designed to com...

journal_title：Transplantation

authors： Hausen B,Gummert J,Berry GJ,Christians U,Serkova N,Ikonen T,Hook L,Legay F,Schuler W,Schreier MH,Morris RE

更新日期：2000-02-27 00:00:00

abstract：BACKGROUND:There is an increasing appreciation of the deleterious effects of antibody and B cells on acute and chronic transplant outcomes. Many effector functions of antibody are mediated by a family of receptors (FcγRs) that are expressed on most immune cells, including neutrophils, natural killer cells, and B cells....

journal_title：Transplantation

authors： Clatworthy MR,Matthews RJ,Doehler B,Willcocks LC,Opelz G,Smith KGC

更新日期：2014-08-15 00:00:00

abstract：BACKGROUND:Kidney donors and transplant recipients may be at risk of complications from glomerular hyperfiltration of the single kidney. It has been assumed that tests of the existence of renal functional reserve [delta glomerular filtration rate (deltaGFR), delta effective renal plasma flow (deltaERPF)] can be used to...

journal_title：Transplantation

authors： Englund M,Berg U

更新日期：2000-11-15 00:00:00

abstract：:To determine the degree of graft versus host disease (GVHD) prophylaxis that might be necessary if cord blood (CB) transplantation is more widely applied, we compared human cord blood mononuclear cell (CBMC) and adult peripheral blood mononuclear cell (PBMC) proliferative responses and stimulatory capabilities; to exa...

journal_title：Transplantation

authors： Greenfeld JI,Noizat-Pirenne F,Hardy MA,Oluwole SF,Hesdorffer CA,Preti RA,De Groote D,Franchimont P

更新日期：1994-08-27 00:00:00

abstract：:Since the earliest days of transplantation, immunobiologists have sought means to prevent recognition and rejection of foreign tissue. The goal of these strategies is the retention of recipient immune function while selectively avoiding graft injury. Although considerable theoretical and technical problems remain, an ...

journal_title：Transplantation

authors： Lynch RJ,Platt JL

更新日期：2009-12-15 00:00:00

abstract：BACKGROUND:Current histological methods cannot accurately determine the survival rate of human pancreatic islets following portal vein infusion. This is due, in part, to the low number of infused islets relative to the whole liver. In this study, we assessed the ability of confocal laser scanning microscopy (CLSM) to t...

journal_title：Transplantation

authors： Sui F,Tang W,Karunananthan J,Qi C,Li J,He N,Kandeel F,Li J

更新日期：2020-06-01 00:00:00

abstract：BACKGROUND:The current shortage of organ donors has led many centers to use marginal and nonheart-beating donors (NHBDs). Recent research has implicated the infiltration of lymphocytes as an important mediator of ischemia-reperfusion injury (IRI). FTY720 is an immunosuppressant that promotes lymphocyte sequestration in...

journal_title：Transplantation

authors： Delbridge MS,Shrestha BM,Raftery AT,El Nahas AM,Haylor JL

更新日期：2007-07-27 00:00:00

abstract：:The mammalian target of rapamycin inhibitors (mTOR-I), drugs widely used in transplant medicine and oncology, exert their function by inhibiting a serine/threonine kinase with a pivotal role in cellular metabolism and in a wide range of eukaryotic biological/cellular functions and signaling networks. Additionally, as ...

journal_title：Transplantation

authors： Zaza G,Granata S,Caletti C,Signorini L,Stallone G,Lupo A

更新日期：2018-02-01 00:00:00

abstract：:Transplantation tolerance can be induced in the adult mouse by the selective manipulation of the CD4+ T cell subset. C3H/He recipients with prolonged survival (> 120 days) of C57BL/10 cardiac allografts induced by treatment, at the time of transplantation, with the anti-CD4 mAb, YTS 191.1, were skin grafted simultaneo...

journal_title：Transplantation

authors： Pearson TC,Darby CR,Bushell AR,West LJ,Morris PJ,Wood KJ

更新日期：1993-02-01 00:00:00