Abstract:
:MHC expression on endothelial cells after cytomegalovirus infection was investigated using double antibody radioimmunoassays and immunofluorescence flow cytometry. After CMV infection there was an increase in class I and beta 2 microglobulin expression. This increase corresponds to the percentage of cells that are infected with CMV. There was no evidence that the increased class I expression was due to soluble factors produced by the infected cells. Although CMV only affects approximately 10% of the endothelial cells, class I and beta 2 microglobulin expression on the cell population exceeds that induced by an optimal dose of alpha-interferon. Class II expression is not increased after CMV infection. However, when gamma-interferon was added to the medium after CMV infection a normal increase in class II expression was found, suggesting that CMV infection does not inhibit the gamma-interferon-induced expression of these molecules.
journal_name
Transplantationjournal_title
Transplantationauthors
van Dorp WT,Jonges E,Bruggeman CA,Daha MR,van Es LA,van Der Woude FJdoi
10.1097/00007890-198909000-00024subject
Has Abstractpub_date
1989-09-01 00:00:00pages
469-72issue
3eissn
0041-1337issn
1534-6080journal_volume
48pub_type
杂志文章相关文献
TRANSPLANTATION文献大全abstract:BACKGROUND:Ischemia-reperfusion injury (IRI) plays key roles in graft viability and posttransplantation function. Caspase-3 associated with apoptosis and inflammation is up-regulated by IRI. We propose that naked small interfering RNA (siRNA) targeting caspase-3 may prevent IRI and improve kidney preservation. METHODS...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e318207949f
更新日期:2011-03-15 00:00:00
abstract:BACKGROUND:Currently, the severity of veno-occlusive disease (VOD) is graded retrospectively on the basis of the evolution of clinical and biological criteria. The objective of this study was to describe a noninvasive method capable of predicting the severity of this disease at the time of the diagnosis. METHODS:Seven...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200207150-00011
更新日期:2002-07-15 00:00:00
abstract:BACKGROUND:Goal tacrolimus concentrations for the prevention of rejection in sensitized renal transplant recipients are not well established. METHODS:We evaluated the association between discharge tacrolimus trough concentration and the incidence of biopsy-proven acute rejection (BPAR) in 216 moderately sensitized ren...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000000149
更新日期:2014-05-27 00:00:00
abstract:BACKGROUND:Long-term follow-up and management of donors was undertaken in a specialist kidney transplant unit in Pakistan to identify risk and prevent adverse outcomes in living related kidney donors. METHODS:In an observation cohort study between 1985 and 2012, 3748 donors were offered free medical follow-up and trea...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000001075
更新日期:2016-06-01 00:00:00
abstract::Infection remains one of the major complications of nonspecific immunosuppression in renal transplant patients and accounts for significant morbidity and mortality. The incidence of infectious complications has been shown to be related to the degree of immunosuppression and correlated with the total steroid dosage, us...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199701150-00030
更新日期:1997-01-15 00:00:00
abstract:BACKGROUND:Elastase released from activated neutrophils is an important mediator of inflammatory tissue damage. We investigated the effect of human neutrophil elastase (NE) inhibitor (ONO-5046) on reperfusion injury after pancreaticoduodenal transplantation in rats by measuring the expression of intercellular adhesion ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199806270-00014
更新日期:1998-06-27 00:00:00
abstract:BACKGROUND:Rat lung allograft rejection is mediated by collagen type V (col(V)) specific T-helper-cell 17 (Th17) cells. Adoptive transfer of these cells is sufficient to induce rejection pathology in isografts, whereas tolerance to col(V) suppresses allograft rejection. Therefore, we tested whether regulatory T cells f...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3181bcde7b
更新日期:2009-12-27 00:00:00
abstract:BACKGROUND:Previous studies have demonstrated that long-term tolerance of class I mismatched renal allografts in miniature swine is induced by a short course of cyclosporine (CyA), and that a total thymectomy 21 days before transplantation abrogates the induction of stable tolerance. We have now examined the effects of...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199904270-00005
更新日期:1999-04-27 00:00:00
abstract:BACKGROUND:After cold ischemia, electrons transferred in the electron transport chain may leak out of the mitochondria in proportion to the deterioration of mitochondrial oxidative phosphorylation. This seems to be one major cause of the lipid peroxidation that occurs mainly in the hepatocytes at reperfusion in liver t...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199904270-00015
更新日期:1999-04-27 00:00:00
abstract::In mice, "helper/inducer" T cells can be depleted by treatment with a rat monoclonal antibody to the cell surface antigen, L3T4, which is homologous to the human antigen T4 (CD4). In order to examine the contribution of "helper/inducer" T cells to cellular immunity, C57BL/6 (H-2b) mice were treated weekly with 1 mg i....
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198612000-00012
更新日期:1986-12-01 00:00:00
abstract:BACKGROUND:A widely held view is that any increase in the potency of an immunosuppressive agent will lead to an increase in infection and malignancy, such as life-threatening Epstein-Barr virus (EBV) induced posttransplant lymphoproliferative disorders (PTLD). We tested this paradigm by studying the effect of adding mo...
journal_title:Transplantation
pub_type: 临床试验,杂志文章
doi:10.1097/00007890-199905150-00002
更新日期:1999-05-15 00:00:00
abstract::Islet transplantation is currently being explored as a treatment for patients with type 1 diabetes. At present, the number of patients becoming insulin-independent is rapidly increasing world-wide applying the transplantation protocol originally described by the group in Edmonton. A hallmark in this procedure is repea...
journal_title:Transplantation
pub_type: 杂志文章,评审
doi:10.1097/01.tp.0000157273.60147.7c
更新日期:2005-05-27 00:00:00
abstract:BACKGROUND:DBA/2J kidney allografts, but not heart allografts, are spontaneously accepted indefinitely in C57BL/6 (B6) mice, through regulatory tolerance mechanism dependent on Foxp3 cells. In contrast, B6 kidneys are rejected within a week in DBA/2J recipients. We hypothesized that the tolerogenic difference of the ki...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000002867
更新日期:2020-01-01 00:00:00
abstract::The participation of an immunologically compatible donor-intended recipient pair in a kidney exchange that is unnecessary for them can significantly increase the number of kidneys available for transplantation. Despite their utilitarian value transplant ethicists have condemned this type of organ exchange as morally i...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3182047554
更新日期:2011-02-15 00:00:00
abstract:BACKGROUND:More than 30% of potential kidney transplant recipients have pre-existing anti-human leukocyte antigen antibodies. This subgroup has significantly lower transplant rates and increased mortality. Desensitization has become an important tool to overcome this immunological barrier. However, limited data is avai...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000442782.98131.7c
更新日期:2014-06-27 00:00:00
abstract:BACKGROUND:Proteinuria is associated with endothelial dysfunction (ED) and increased mortality. We investigated whether urinary protein excretion (UPE) is correlated with markers of ED and whether these markers affect the association of proteinuria with mortality in renal transplant recipients (RTR). METHODS:Six hundr...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3181903d25
更新日期:2008-12-27 00:00:00
abstract:BACKGROUND:To date, the outcomes of transplant tourism have not been reported extensively. In addition, data about the accuracy of urine cytology for the detection and the role of the BK virus (BKV) in the carcinogenesis of urothelial carcinoma (UC) after renal transplantation are lacking. METHODS:Three hundred seven ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000000023
更新日期:2014-07-15 00:00:00
abstract:BACKGROUND AND METHODS:To investigate the frequency of apoptosis and the expression of Fas/Fas ligand (FasL) in liver allografts, we examined 97 biopsy specimens from 62 patients after orthotopic liver transplantation. The results of the biopsies were as follows: acute allograft rejection (n=32); hepatitis C virus (HCV...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199904150-00027
更新日期:1999-04-15 00:00:00
abstract::The aim of this study was to assess directly the function of isolated hepatocytes 1 year after transplantation into the spleen, using an original model of isolated rat-spleen perfusion. Three specific liver functions, albumin synthesis, indocyanine-green clearance, and antipyrine oxidation, were studied. Five x 10(6) ...
journal_title:Transplantation
pub_type: 杂志文章
doi:
更新日期:1990-04-01 00:00:00
abstract:BACKGROUND:The organ donor shortage has led to a reconsideration of the use of non-heart-beating donors (NHBDs). However, graft injury due to warm ischemia in NHBD livers strongly affects posttransplant outcome. The present study was aimed at investigating the role of the cellular cyclic (c)AMP second messenger signal ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199810270-00004
更新日期:1998-10-27 00:00:00
abstract::T cell receptor (TCR) beta-chain usage by HLA-DR1 alloreactive T cell lines was examined to determine whether common TCR gene segments were used preferentially. We have demonstrated previously that a DR1-specific, human renal allograft-derived T cell line and replicate, anti-DR1 mixed lymphocyte reactions (MLR), estab...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199604150-00017
更新日期:1996-04-15 00:00:00
abstract:BACKGROUND:Deoxyspergualin (DSG), a potent immunosuppressive drug, has been clinically used as a rescue therapy for acute graft rejection. However, DSG has severe adverse effects that limits its use. Here, we examined the optimized therapeutic protocol for DSG using chronopharmacological profiles of it. METHODS:First,...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199905150-00012
更新日期:1999-05-15 00:00:00
abstract:BACKGROUND:Despite the success rate of solitary pancreas transplantation in type 1 diabetes with preserved kidney function has greatly improved in recent years, a residual proportion of failures persists. METHODS:With the aim of investigating autoimmunity as an unrecognized cause of graft failure, we measured autoanti...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31822ae65f
更新日期:2011-09-27 00:00:00
abstract::Multiple variations of the basic lymphocytotoxicity test have been reported to increase test sensitivity. Although these modifications are used routinely in crossmatch tests, as required by federal regulation, there has been no methodical assessment of the relative sensitivities and specificities of these techniques w...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199509000-00016
更新日期:1995-09-15 00:00:00
abstract::We developed a multiplex, quantitative, real-time, polymerase chain reaction assay for cytomegalovirus (CMV) and used it to measure the CMV viral load in weekly blood specimens from 43 lung transplant recipients. The median viral load in blood samples immediately preceding bronchoscopy was 1150 copies/microg human DNA...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200108270-00030
更新日期:2001-08-27 00:00:00
abstract:BACKGROUND:In a randomized, controlled study we investigated the clinical efficacy of the microemulsion formulation of cyclosporine (Neoral) in comparison with Sandimmune (SIM) in the treatment of patients who underwent primary orthotopic liver transplantation (OLT). METHODS:In total, 33 patients were randomized in a ...
journal_title:Transplantation
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00007890-199709150-00011
更新日期:1997-09-15 00:00:00
abstract:BACKGROUND:In previous studies of cynomolgus monkey lung allograft recipients, we demonstrated significant immunosuppressive efficacy but reduced tolerability after combined treatment with high doses of microemulsion cyclosporine (CsA) and SDZ RAD (40-O-(2-hydroxyethyl)-rapamycin). The current study was designed to com...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200002270-00005
更新日期:2000-02-27 00:00:00
abstract:BACKGROUND:Innate immunity plays a role in controlling adaptive immune responses. METHODS:We investigated the clinical relevance of single nucleotide polymorphisms in 22 genes encoding innate, secreted, and signaling pattern recognition receptors in a total of 520 donor-recipient pairs of postmortem, human leukocyte a...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31825c5967
更新日期:2012-09-15 00:00:00
abstract::To examine whether cyclosporine (CsA) has mutagenic potential against human cells, we analyzed sister chromatid exchange (SCE) induction by CsA using human lymphocytes in vitro. SCE frequencies increased significantly in the lymphocytes treated with 1 microgram/ml and 5 micrograms/ml CsA, though the frequencies seemed...
journal_title:Transplantation
pub_type: 杂志文章
doi:
更新日期:1986-07-01 00:00:00
abstract::Deposition of the C4d complement degradation product has been shown to be a marker of antibody-mediated rejection of solid organ allografts, including kidney, heart, liver, and lung. We investigated whether C4d deposition also would be useful in monitoring rejection in human composite tissue allografts. A total of 60 ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000266899.93315.52
更新日期:2007-07-27 00:00:00