Abstract:
BACKGROUND:In a randomized, controlled study we investigated the clinical efficacy of the microemulsion formulation of cyclosporine (Neoral) in comparison with Sandimmune (SIM) in the treatment of patients who underwent primary orthotopic liver transplantation (OLT). METHODS:In total, 33 patients were randomized in a double-blind fashion before undergoing primary OLT to receive either Neoral or SIM. All 33 patients initially received intravenous cyclosporine, but as soon as it was tolerated, the oral study drug was initiated (median time, 3.6 days) and 17 patients received Neoral and 16 SIM (for both drugs, 10 mg/kg/day). Both groups were comparable with regard to age, sex, etiology of chronic liver disease, and hepatic biochemical profile. Episodes of rejection were diagnosed histologically and characterized as mild, moderate, or severe using criteria from the National Institute of Diabetes and Digestive and Kidney Diseases. RESULTS:Patients were followed for 1 year. Four patients in each group were discontinued prematurely. The reason for discontinuation of cyclosporine was drug-related complications in two of the NEO patients and in three of the SIM group; the other three were non-drug-related. Rejection episodes occurred in 9 of 17 patients (52.90%) in the Neoral group and in 9 of 16 patients (56.3%) in the SIM group. The total number of rejection episodes in each group was 14. However, in evaluating the severity of rejection histologically, nine episodes of rejection were characterized as moderate/ severe in the SIM group compared with only three in the Neoral group (P=0.027). Five of the nine moderate/severe rejection episodes in the SIM group occurred within the first 2 weeks after transplant. In contrast, moderate/severe rejection did not occur in the Neoral group in this early period. Two patients in the SIM group and no patients in the Neoral group required treatment with OKT3 for steroid-resistant rejection. There were no differences in mean doses or trough levels when comparing the two study groups. The incidence of adverse effects was similar in the two groups. CONCLUSIONS:Neoral is a safe and efficacious drug in the treatment of primary OLT patients. Given comparable doses of cyclosporine in each group over 1 year, there was no significant difference in the total number of rejection episodes between study groups. However, patients treated with Neoral had a lower incidence of moderate/severe histologic rejection and were free of steroid-resistant rejection when compared with SIM-treated patients.
journal_name
Transplantationjournal_title
Transplantationauthors
Graziadei IW,Wiesner RH,Marotta PJ,Porayko MK,Dahlke LJ,Wilson SM,Steers JL,Krom RAdoi
10.1097/00007890-199709150-00011subject
Has Abstractpub_date
1997-09-15 00:00:00pages
726-31issue
5eissn
0041-1337issn
1534-6080journal_volume
64pub_type
临床试验,杂志文章,随机对照试验相关文献
TRANSPLANTATION文献大全abstract::Idarubicin was conjugated to anti-Ly-2.1 and anti-L3T4 monoclonal antibodies. These conjugates were used to investigate their effects on skin graft survival in mice. Several donor and recipient combinations were used so that the effect of individual or mixtures of conjugates on class I and class II antigenic differenc...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198907000-00018
更新日期:1989-07-01 00:00:00
abstract::In the literature, varying terminology for living organ donation can be found. However, there seems to be a need for a new classification to avoid confusion. Therefore, we assessed existing terminology in the light of current living organ donation practices and suggest a more straightforward classification. We propose...
journal_title:Transplantation
pub_type: 社论
doi:10.1097/TP.0b013e3182129236
更新日期:2011-05-15 00:00:00
abstract::We performed a multicenter study to investigate the problem of cadaver kidney transplants that never achieve function, or that recover after a period of delayed function, and we used multivariate techniques to model the results. Sixty-nine patients who received cadaver kidney transplants that never functioned (NF) wer...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198801000-00027
更新日期:1988-01-01 00:00:00
abstract:BACKGROUND:Selective inhibition of lymphocyte activation through abrogation of signal 3-cytokine transduction emerges as a new strategy for immunosuppression. This is the first report on the novel Janus kinase (JAK)1/3 inhibitors R507 and R545 for prevention of acute allograft rejection. METHODS:Pharmacokinetic and in...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3182660496
更新日期:2012-10-15 00:00:00
abstract:BACKGROUND:Liver transplantation (LT) represents a curative treatment for small hepatocellular carcinoma (HCC). Potentially curable higher-stage HCC patients are denied LT due to the lack of cancer markers that predict progression and recurrence. METHODS:Thirty-eight candidates for LT with hepatitis C virus (HCV) cirr...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000258643.05294.0b
更新日期:2007-04-15 00:00:00
abstract:BACKGROUND:Interspecies differences create important shortcomings in existing animal models used to describe in vivo events responsible for allograft rejection. Alloimmune destruction of human dermal microvessels, histologically consistent with rejection, has been demonstrated in human skin-grafted severe combined immu...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199903270-00018
更新日期:1999-03-27 00:00:00
abstract:BACKGROUND:Frequencies of alloreactive T cells determined by limiting dilution assays (LDA) may not adequately reflect the donor-reactive immune status in transplant recipients. To reevaluate LDA frequencies, we developed a flow cytometry test for direct determination of alloreactive T-cell frequencies and compared the...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200208270-00023
更新日期:2002-08-27 00:00:00
abstract::Spontaneous rupture of the liver has been described in association with many benign and malignant conditions. We report, to our knowledge, the first case of spontaneous rupture of the liver upon revascularization, requiring total hepatectomy and portocaval shunt, followed by successful retransplantation. Routine patho...
journal_title:Transplantation
pub_type: 杂志文章,评审
doi:10.1097/00007890-200005270-00048
更新日期:2000-05-27 00:00:00
abstract::A laparoscopic live-donor nephrectomy was performed on a 40-year-old man. The kidney was removed intact via a 9-cm infraumbilical midline incision. Warm ischemia was limited to less than 5 min. Immediately upon revascularization, the allograft produced urine. By the second postoperative day, the recipient's serum crea...
journal_title:Transplantation
pub_type: 杂志文章
doi:
更新日期:1995-11-15 00:00:00
abstract::Cell-mediated cytotoxicity directed toward pancreatic islets plays a significant role in the pathogenesis of type 1 diabetes mellitus. Histologically, autoimmune insulitis appears as mononuclear infiltrates that precede actual beta cell loss. Experimental studies by Bartlett et al. on the BB rat model suggest that who...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199612270-00014
更新日期:1996-12-27 00:00:00
abstract::For maximum use of left liver plus caudate lobe grafts, the short hepatic vein draining the caudate lobe should be reconstructed. We devised a new venoplasty technique. On the graft side, a wide venous orifice with a long cuff was formed by gathering the left, middle, and short hepatic veins using a conduit vein graft...
journal_title:Transplantation
pub_type: 临床试验,杂志文章
doi:10.1097/01.tp.0000244729.39485.7c
更新日期:2007-01-27 00:00:00
abstract::Invasive aspergillosis and mucormycosis are life-threatening infections in solid organ and hematopoietic cell transplant recipients. Despite medical advancements in the care of these patients and the availability of new mold-active drugs, the outcomes remain suboptimal. Therefore, there has been increased interest in ...
journal_title:Transplantation
pub_type: 杂志文章,评审
doi:10.1097/TP.0000000000002353
更新日期:2018-11-01 00:00:00
abstract::Clearance studies were performed in 32 transplanted children treated with CsA in combination with low-dose prednisolone (CsA group), and the results were compared with those of 29 children transplanted earlier and treated with azathioprine and prednisolone (CIS group). Serum creatinine and urea levels 6 weeks and 1 ye...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198704000-00006
更新日期:1987-04-01 00:00:00
abstract::Plasma levels of main granulocyte components of patients after cadaveric renal transplantation were compared 9 days postoperative with the plasma levels of patients undergoing aortofemoral and iliacofemoral bypass operation or abdominal surgery. Lactoferrin values were significantly lower in patients under immunosuppr...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198901000-00032
更新日期:1989-01-01 00:00:00
abstract:BACKGROUND:The aim of this study was to investigate familial amyloidotic polyneuropathy, Portuguese type patients' endocrine cell content in the stomach and duodenum before and after liver transplantation, and to relate the findings to the patients' gastrointestinal disturbances. METHODS:Ten liver-transplanted familia...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200009150-00015
更新日期:2000-09-15 00:00:00
abstract::Incompatibility for DBA/2 (D2) minor histocompatibility antigens (MiHA) alone leads to a severe lethal graft-versus-host reaction (GVHR) in irradiated (D2 X B10.D2)F1 mice receiving a bone-marrow-plus-spleen-cell graft from B10.D2 donors. This mortality is abrogated when the donors are preimmunized simultaneously agai...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198309000-00016
更新日期:1983-09-01 00:00:00
abstract::The value of percutaneous core needle biopsy in the immunohistological evaluation of renal allograft dysfunction was studied in 72 consecutive biopsies performed in 42 patients. The phenotypes of infiltrating cells mediating graft destruction were identified with monoclonal antibodies and immunoperoxidase staining tec...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198701000-00022
更新日期:1987-01-01 00:00:00
abstract:BACKGROUND:Cardiac allograft vasculopathy (CAV) is a major limitation in long-term graft survival after heart transplantation (HTx). Its prediction and detection at an early stage is a challenge because an accurate, minimally invasive blood test is lacking. The aim of this study was to analyze the relationship of Tact ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000000493
更新日期:2015-07-01 00:00:00
abstract::To determine the degree of graft versus host disease (GVHD) prophylaxis that might be necessary if cord blood (CB) transplantation is more widely applied, we compared human cord blood mononuclear cell (CBMC) and adult peripheral blood mononuclear cell (PBMC) proliferative responses and stimulatory capabilities; to exa...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199408270-00018
更新日期:1994-08-27 00:00:00
abstract:BACKGROUND:Uterus transplantation is a treatment for absolute uterine infertility and can be performed with living and deceased donors. Given the safety and increased utilization of robotic assistance with other gynecologic and transplant donor operations, we adopted a robot-assisted approach to donor hysterectomy. Thi...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000003211
更新日期:2021-01-01 00:00:00
abstract::Intestinal transplant is an established treatment of irreversible intestinal failure, unless complicated by advanced intestinal failure-associated liver disease, when liver-bowel transplant may be necessary. Finding at least moderate hepatic fibrosis or gastroesophageal varices (GOV) at oesophago-gastroduodenoscopy (O...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3181891d63
更新日期:2008-11-27 00:00:00
abstract::Histoincompatible-complete radiation chimeras, after resolving acute graft-versus-host disease (GVHD), establish specific tolerance to host and donor alloantigens. This tolerance can be perturbed with immunosuppressive agents and infusions of small numbers of donor-type cells, with infusions of massive numbers of dono...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198109000-00005
更新日期:1981-09-01 00:00:00
abstract:BACKGROUND:The incidence and impact of cytomegalovirus (CMV) disease that occurs despite CMV prophylaxis among liver transplant recipients have been incompletely defined. METHODS:The incidence and risk factors for CMV disease during the first posttransplant year in a cohort of liver transplant recipients who received ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000145989.22373.03
更新日期:2004-11-15 00:00:00
abstract::Pretreatment of LEW rats with cyclosporin A (10 mg/kg/day orally for 14 days) plus 10(8) DA or (DA X LEW)F1 spleen lymphocytes on two occasions markedly prolonged the survival of subsequent DA renal allografts. The lymphocytotoxic antibody response was suppressed completely and renal biopsies showed a marked mononucle...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198106000-00004
更新日期:1981-06-01 00:00:00
abstract:BACKGROUND:Osteoporosis is a well-documented complication of organ transplantation. Bisphosphonates have been shown to be effective in preventing corticosteroid-induced osteoporosis in renal transplant recipients, but data are lacking for treatment of established osteoporosis. This study reports our clinical experience...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200103150-00017
更新日期:2001-03-15 00:00:00
abstract::Isolator-maintained CBH/Ola (Rtlc) rats were lethally irradiated and reconstituted with spleen and bone marrow cells from fully allogeneic WAG or Wistar (Rtlu) donors. Hematopoietically reconstituted rats were treated with cyclosporine (CsA)4 as prophylaxis for graft-versus-host disease (GVHD) for periods ranging from...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198511000-00002
更新日期:1985-11-01 00:00:00
abstract:BACKGROUND & AIMS:Direct-acting antiviral (DAA) therapy made possible the novel practice of utilizing HCV-viremic (HCV-RNA-positive) donors into HCV-negative recipients in the United States. Although initial reports of outcomes have been satisfactory, higher-quality longer-term outcomes remain to be elucidated. METHOD...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000003382
更新日期:2020-06-29 00:00:00
abstract::T lymphocyte subsets, mitogenic response, and immunoglobulin levels were studied in peripheral blood from 95 thalassemic patients before and at different times after bone marrow transplantation. With the exception of patients receiving more than 100 transfusion units before transplant, who showed an increased percenta...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198809000-00012
更新日期:1988-09-01 00:00:00
abstract:BACKGROUND:Because CD4CD25Foxp3 regulatory T cells (Tregs) are essential for the maintenance of self-tolerance, significant interest surrounds the developmental cues for thymic-derived natural Tregs (nTregs) and periphery-generated adaptive Tregs (aTregs). In the transplant setting, the allograft may play a role in the...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31820e50b3
更新日期:2011-04-15 00:00:00
abstract:BACKGROUND:Immunosuppressive therapy is a risk factor for the increased incidence and metastatic progression of malignancies in organ graft recipients. Transforming growth factor (TGF)-beta(1) has been associated with tumor invasion and metastasis, and we have implicated cyclosporine-associated TGF-beta(1) hyperexpress...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000081399.75231.3B
更新日期:2003-08-15 00:00:00