Liver Transplantation of HCV-Viremic Donors into HCV-Negative Recipients in the USA: Increasing Frequency with Profound Geographic Variation.

abstract：BACKGROUND:Posttransplant lymphoproliferative disease (PTLD) is a major complication after bone marrow and solid organ transplantation. The disease encompasses a spectrum of abnormal, Epstein-Barr virus (EBV)-associated B-cell proliferations. We have previously shown that EBV-infected, spontaneous lymphoblastoid cell l...

journal_title：Transplantation

authors： Nepomuceno RR,Snow AL,Robert Beatty P,Krams SM,Martinez OM

更新日期：2002-08-15 00:00:00

abstract：BACKGROUND:Human intravenous immunoglobulin G delayed xenogeneic hyperacute rejection (HAR) in the guinea pig-to-rat combination. We investigated the respective roles of the Fc and Fab fragments of the IgG molecule in this inhibitory effect. METHODS:By using a guinea pig-to-rat heart transplantation model, the efficie...

journal_title：Transplantation

authors： Urbani L,Fabre M,Cardoso J,Lambin P,Devillier P,Soubrane O,Houssin D,Gautreau C

更新日期：1998-08-15 00:00:00

abstract：BACKGROUND:The effect of height and sex on liver transplantation (LT) for hepatocellular carcinoma (HCC) remains unclear. METHODS:Using United Network for Organ Sharing (UNOS) data, 14 844 HCC patients listed for LT from 2005 to 2015 were identified. Cumulative incidence of waitlist events (LT and dropout for death or...

journal_title：Transplantation

authors： Lee E,Sarkar M,Dodge J,Kohi M,Mehta N

更新日期：2020-05-01 00:00:00

abstract：:The new class of immunosuppressants--inhibitors of the mammalian target of rapamycin--has no nephrotoxicity and the capacity to inhibit vascular smooth cell proliferation. These characteristics may afford considerable clinical advantages in the transplantation of kidneys from expanded criteria donors (ECD). Six clinic...

journal_title：Transplantation

authors： Rigotti P,Kahan BD

更新日期：2009-04-27 00:00:00

abstract：BACKGROUND:Monocarboxylate transporter (MCT)-1, a member of a family of molecules, transports monocarboxylates such as lactate. Inhibiting MCT-1 leads to long-term graft survival in rodent heart transplantation and induces tolerance. We evaluated an MCT-1 inhibitor, AS2495674, in a rat heart transplant model and analyz...

journal_title：Transplantation

authors： Cho KS,Yamada T,Wynn C,Behanna HA,Hong IC,Manaves V,Nakanishi T,Hirose J,Abe Y,Jiang H,Tamura K,Saita Y

更新日期：2010-12-27 00:00:00

abstract：:The overall incidence of malignancy in renal transplant recipients is 100-fold higher compared with age matched controls. Routine clinical evaluation therefore often includes the determination of serum tumor markers AFP, CA19-9, CEA, CA125, CA15-3, PSA, and calcitonin. We evaluated the specificity and the sensitivity ...

journal_title：Transplantation

authors： Oberbauer R,Banyai S,Schmidt A,Kornek G,Scheithauer W,Mayer G

更新日期：1996-11-27 00:00:00

abstract：:Cold-storage preservation of the canine pancreas prior to islet isolation has previously been noted to reduce the intrasplenic islet autograft success rate; but the mechanism of this deleterious effect has not been determined. We undertook a study in both outbred dogs and Lewis (RT1-1) rats to determine the influence ...

journal_title：Transplantation

authors： Munn SR,Kaufman DB,Field MJ,Viste AB,Sutherland DE

更新日期：1989-01-01 00:00:00

abstract：BACKGROUND:Solitary pancreas transplants, both pancreas transplant alone (PTA) and pancreas after kidney (PAK), have higher rejection rates and lower graft survivals than simultaneous pancreas-kidney transplants (SPK). The aim of this study is to compare three different antibody induction regimens in solitary pancreas ...

journal_title：Transplantation

authors： Stegall MD,Kim DY,Prieto M,Cohen AJ,Griffin MD,Schwab TR,Nyberg SL,Velosa JA,Gloor JM,Innocenti F,Bohorquez H,Dean PG,Carpenter HA,Leontovich ON,Sterioff S,Larson TS

更新日期：2001-11-27 00:00:00

abstract：BACKGROUND:Auxiliary partial orthotopic liver transplantation (APOLT) has been an effective alternative in acute liver failure (ALF), but clinically several problems remain to be resolved. Thus, we attempt to establish an APOLT model for ALF using a large animal and demonstrate the validity of our model. METHODS:In ex...

journal_title：Transplantation

authors： Fukueda M,Ishizaki N,Hamada N,Kadono J,Kaieda M,Nakamura N,Komokata T,Sakata R

更新日期：2006-11-27 00:00:00

abstract：BACKGROUND:In experimental brain death models, autonomic storm (AS) triggers severe myocardial dysfunction, which can be attenuated by pharmacologic treatment. The aim of this study was to determine the incidence of AS in a cohort of human organ donors and to evaluate the potential interest of AS treatment on myocardia...

journal_title：Transplantation

authors： Audibert G,Charpentier C,Seguin-Devaux C,Charretier PA,Grégoire H,Devaux Y,Perrier JF,Longrois D,Mertes PM

更新日期：2006-10-27 00:00:00

abstract：BACKGROUND:We developed a nonviral gene transfer method using rapid injection of naked DNA targeting the liver and applied it in a rat model of liver transplantation. METHODS:Inbred Dark Agouti and Lewis rats were used. To test the efficacy and adverse effects of systemic or local (catheter-based) injection, different...

journal_title：Transplantation

authors： Inoue S,Hakamata Y,Kaneko M,Kobayashi E

更新日期：2004-04-15 00:00:00

abstract：BACKGROUND:Whether kidney transplant recipients who were treated for a malignant tumor before transplantation are at an increased risk of developing a tumor posttransplantation has not been adequately quantified and characterized. METHODS:We studied more than 270 000 patients on whom pretransplant and posttransplant m...

journal_title：Transplantation

authors： Unterrainer C,Opelz G,Döhler B,Süsal C,Collaborative Transplant Study.

更新日期：2019-03-01 00:00:00

abstract：BACKGROUND:It is unclear if the category of acute rejection with intimal arteritis (ARV) is relevant to short- and long-term clinical outcomes and if the graft outcomes are affected by the severity of intimal arteritis. METHODS:One hundred forty-eight ARV episodes were reviewed and categorized according to the 2013 Ba...

journal_title：Transplantation

authors： Wu K,Budde K,Schmidt D,Neumayer HH,Rudolph B

更新日期：2015-08-01 00:00:00

abstract：:The cytotoxicity of tumour-bearer serum against a transplanted aminoazodye-induced rat hepatoma was revealed using normal rat serum as the source of complement as assessed using a short-term 51Cr release test. The tumour-bearing rat was not deficient in a functional complement system and direct cytolysis against hepat...

journal_title：Transplantation

authors： Price MR,Höffken K,Baldwin RW

更新日期：1979-08-01 00:00:00

abstract：BACKGROUND:Post-lung transplant infection is one of the leading causes of morbidity and mortality. The cause and incidence are similar in many series; however, infections such as Mycobacterium tuberculosis are influenced by the epidemiologic situation. The authors present a prospective and observational study to define...

journal_title：Transplantation

authors： Bravo C,Roldán J,Roman A,Degracia J,Majo J,Guerra J,Monforte V,Vidal R,Morell F

更新日期：2005-01-15 00:00:00

abstract：:Class I molecules of the MHC affect target cell sensitivity to NK cell repertoire. In the mouse, absence of MHC class I molecules on target cells is associated with an increased susceptibility to NK cell-mediated lysis, while syngeneic class I molecules confer protection. In contrast to the protective role of syngenei...

journal_title：Transplantation

authors： Salcedo M,Höglund P,Ljunggren HG

更新日期：1995-08-15 00:00:00

abstract：BACKGROUND:Recurrent hepatitis C virus (HCV) after liver transplantation (OLT) is a major cause of graft loss in HCV-positive patients. In this study, we evaluated the efficacy and safety of pegylated interferon alfa-2b (peginterferon) and ribavirin treatment for recurrent HCV after OLT and analyzed the influence of an...

journal_title：Transplantation

authors： Neumann U,Puhl G,Bahra M,Berg T,Langrehr JM,Neuhaus R,Neuhaus P

更新日期：2006-07-15 00:00:00

abstract：BACKGROUND:Finding the best combination of immunosuppression is an important challenge in kidney transplantation. Current short-term (1- and 3-year) allograft survival is quite good, making it difficult to determine differences in therapeutic regimens without large sample sizes. Using data from the United Network for O...

journal_title：Transplantation

authors： Cherikh WS,Myron Kauffman H,Maghirang J,Bleyer AJ,Johnson CP

更新日期：2003-08-15 00:00:00

abstract：:The effects of dietary (10% calories) safflower (SAF), evening primrose (EPO), and fish oil (F) as sources of linoleic acid (control), gamma-linolenic acid, and long-chain n-3 fatty acids, respectively, on cardiovascular and renal responses to chronic (5 weeks) cyclosporine administration were studied in male borderli...

journal_title：Transplantation

authors： Mills DE,Ward RP,McCutcheon D,Dixon H,Ly H,Scholey J

更新日期：1992-03-01 00:00:00

abstract：BACKGROUND:The aim of this study was to analyze humoral xenoreactivity of various Old World primate species sera against pig islets and the effects of these sera on pig islet viability and function after culture. METHODS:Freshly isolated or cultured adult pig islets were analyzed by immunohistology or by cytofluorimet...

journal_title：Transplantation

authors： Mirenda V,Le Mauff B,Boeffard F,Cassard A,Jugeau N,Soulillou JP,Anegon I

更新日期：1998-12-15 00:00:00

abstract：BACKGROUND:Epitopes are the sites to which antibodies bind. Both alpha and beta peptide chains of the human leukocyte antigen-DQ heterodimers (DQA1 and DQB1, respectively) contain polymorphic regions. We can identify DQA1 and DQB1 epitopes by DQ single antigen beads assay of the antibodies, correlating the beads' react...

journal_title：Transplantation

authors： Deng CT,El-Awar N,Ozawa M,Cai J,Lachmann N,Terasaki PI

更新日期：2008-08-15 00:00:00

abstract：:Pancreas transplantation utilizing portal venous and enteric exocrine drainage has potential benefits over the standard systemic venous and bladder exocrine drainage method. Unfortunately, technical difficulties are often experienced with the arterial anastomosis after the portal venous anastomosis is completed. We ha...

journal_title：Transplantation

authors： Bigam DL,Hemming AW,Sanabria JR,Cattral MS

更新日期：1999-07-27 00:00:00

abstract：:OKT3 is considered to be effective in the prophylaxis and treatment of rejection. However, anti-OKT3 immunization is still a major side-effect. Only the IgG antiidiotypic component of the response is responsible for neutralization of OKT3 therapeutic activity by inhibiting OKT3's binding to T cells (i.e., blocking ant...

journal_title：Transplantation

authors： Legendre C,Kreis H,Bach JF,Chatenoud L

更新日期：1992-01-01 00:00:00

abstract：:Renal allografts were performed in miniature swine that were identical at their major histocompatibility locus and were presensitized by skin grafts from their prospective renal donors. All of these renal grafts were rejected in a hyperacute or markedly accelerated manner compared to the survival of comparable grafts ...

journal_title：Transplantation

authors： Kirkman RL,Colvin RB,Flye MW,Williams GM,Sachs DH

更新日期：1979-07-01 00:00:00

abstract：BACKGROUND:Motexafin lutetium (Lu-Tex) is a photodynamic therapy (PDT) agent that localizes in atheromatous plaque in which it can be activated by far-red light. Lu-Tex biolocalization was examined in graft coronary artery disease (GCAD) with a rodent allograft model. After photoactivation, the effect on intimal prolif...

journal_title：Transplantation

authors： Yamaguchi A,Woodburn KW,Hayase M,Hoyt G,Robbins RC

更新日期：2001-06-15 00:00:00

abstract：BACKGROUND:The detection of acute rejection in heart transplantation remains an important feature of transplant management, especially in the early phase. Frequent surveillance with endomyocardial biopsy is necessary, even though it is an invasive procedure and carries a certain risk. Hence, noninvasive biomarkers able...

journal_title：Transplantation

authors： Crescioli C,Buonamano A,Scolletta S,Sottili M,Francalanci M,Giomarelli P,Biagioli B,Lisi G,Pradella F,Serio M,Romagnani P,Maccherini M

更新日期：2009-01-27 00:00:00

abstract：:Alemtuzumab is a humanized CD52-specific monoclonal antibody that is increasingly used off-label as an induction agent in solid organ transplantation, particularly in the setting of maintenance immunosuppression minimization protocols. In this review, we briefly discuss this agent's mechanisms of action and summarize ...

journal_title：Transplantation

authors： Weaver TA,Kirk AD

更新日期：2007-12-27 00:00:00

abstract：BACKGROUND:Host macrophages are abundant within fetal pig pancreas xenografts undergoing rejection, but their role is unknown. Therefore, we examined the effect of host macrophage depletion on xenograft rejection. METHODS:Nonobese diabetic (NOD) mice were given clodronate-loaded liposomes intravenously to deplete macr...

journal_title：Transplantation

authors： Fox A,Koulmanda M,Mandel TE,van Rooijen N,Harrison LC

更新日期：1998-12-15 00:00:00

abstract：:Osteopetrotic microphthalmic mice (mi/mi) were treated by injections of suspensions of myeloid tissue, newborns i.p., and weanlings i.v. Donated syngeneic material effected permanent cure of oteopetrosis provided that the dose was large enough (10(8) cells of bone marrow). H-2-compatible allogeneic bone marrow was ini...

journal_title：Transplantation

authors： Nisbet NW,Menage J,Loutit JF

更新日期：1979-10-01 00:00:00

abstract：BACKGROUND:Kidney transplantation (KT) of human immunodeficiency virus (HIV)-positive patients has transformed the management of end-stage kidney disease in this population. Although favourable outcomes have been reported, patients experience high rates of acute allograft rejection (AR). We examined factors associated ...

journal_title：Transplantation

authors： Gathogo E,Harber M,Bhagani S,Levy J,Jones R,Hilton R,Davies G,Post FA,UK HIV Kidney Transplantation Study Group.

更新日期：2016-04-01 00:00:00