Alemtuzumab.

abstract：:A 22-year-old previously nonsensitized female patient (HLA-A2,28; B7,14; DR1,2) received a kidney from her HLA-identical brother. She irreversibly rejected the graft 2 1/2 weeks later. In vitro tests performed 6 weeks after the graft loss, using recipient responding and donor-stimulating and target cells, revealed a w...

journal_title：Transplantation

authors： Pfeffer PF,Thorsby E

更新日期：1982-01-01 00:00:00

abstract：BACKGROUND:Recent data show the efficacy of embryonic stem cells (ESC) to engraft in allogeneic recipients without host pretreatment. This property is due to their low expression of major histocompatibility complex (MHC) class I antigens and lack of MHC class II expression. Here, we tested the hypothesis that the const...

journal_title：Transplantation

authors： Fabricius D,Bonde S,Zavazava N

更新日期：2005-05-15 00:00:00

abstract：:The effect of the tritiated thymidine (3H-TdR) suicide technique on the ability of donor cells to induce fatal graft-versus-host disease (GVHD) was studied. C57BL/6 (H-2b) spleen cells were stimulated in vitro with irradiated BALB/c (H-2d) Moloney lymphoma cells in mixed culture and 3H-TdR of high-specific activity ad...

journal_title：Transplantation

authors： Cheever MA,Einstein AB Jr,Kempf RA,Fefer A

更新日期：1977-04-01 00:00:00

abstract：:The histopathological features of chronic rejection and its initiation were assessed using rat heterotopic heart transplantation and retransplantation models. Fully allogeneic or minor, non-MHC antigen-mismatch heart grafts transplanted into recipient rats treated with a short course of FK506 showed long-term survival...

journal_title：Transplantation

authors： Izutani H,Miyagawa S,Shirakura R,Matsumiya G,Nakata S,Shimazaki Y,Matsuda H

更新日期：1995-11-27 00:00:00

abstract：:Methods are described for preparing large amounts of horse anti-human thymocyte globulin (ATG, ATGAM; The Upjohn Company) for clinical use. These methods have been used since 1968 to provide material for clinical trials. Characteristics of 40 lots of ATG are summarized. ...

journal_title：Transplantation

authors： Wechter WJ,Nelson JW,Perper RJ,Parcells AJ,Riebe KW,Evans JS,Satoh PS,Ko H

更新日期：1979-10-01 00:00:00

abstract：:Over the last decade there have been major advances in all aspects of liver transplantation with the consequence that the number of patients who could benefit from the procedure is increasing. As a result, the number of patients listed for liver transplantation is growing while the donor pool is remaining constant or ...

journal_title：Transplantation

authors： Neuberger J,Ubel PA

更新日期：2000-11-27 00:00:00

abstract：:Natural killer (NK) lymphocytes are powerful effector cells of the peripheral immune system. NK cell functions are controlled by the expression of a variety of cell surface receptors with either inhibitory or activating roles. The genetic and functional diversity of this repertoire of receptors and the role of human l...

journal_title：Transplantation

authors： Young NT

更新日期：2004-07-15 00:00:00

abstract：:Cyclosporine prevents the development of diabetes in spontaneously diabetic BB rats and NOD mice. However, islet transplants have been shown to be subject to immunologic destruction in hosts treated with CsA and anti-CD4 antibody or those rendered tolerant to donor antigens. This study determines whether the minimum d...

journal_title：Transplantation

authors： Dugoni WE Jr,Bartlett ST

更新日期：1990-05-01 00:00:00

abstract：BACKGROUND:The effective use of new steroid-sparing immunosuppressive regimens may lower cumulative glucocorticoid use among renal transplant recipients. However, it is unknown what effect this therapeutic trend has had on bone disease. METHODS:Unselected newly transplanted inpatients (n=45) were identified and compre...

journal_title：Transplantation

authors： Mikuls TR,Julian BA,Bartolucci A,Saag KG

更新日期：2003-01-15 00:00:00

abstract：BACKGROUND:Infectious complications still represent a major cause of morbidity and mortality in patients with organ transplantation. In particular, small bowel or multivisceral transplantation is complicated to a greater extent than other grafts as a consequence of infectious complications including sepsis. METHODS:Th...

journal_title：Transplantation

authors： Guaraldi G,Cocchi S,Codeluppi M,Di Benedetto F,De Ruvo N,Masetti M,Venturelli C,Pecorari M,Pinna AD,Esposito R

更新日期：2005-12-27 00:00:00

abstract：:The class II region of major histocompatibility complex of the rat. Rattus norvegicus (RT1) consists of RT1.B, RT1.D, and RT1.H subregions. The gene order around the H subregion was determined as RT1.A--H beta-H alpha--B by RFLP analysis of naturally occurring intra-RT1 recombinant rats with HLA DP probes. A unique re...

journal_title：Transplantation

authors： Fujii H,Kakinuma M,Yoshiki T,Natori T

更新日期：1991-08-01 00:00:00

abstract：:We had previously shown in a canine model that the administration of anti-MHC class II monoclonal antibody (MAB) immediately after autologous marrow transplantation prevented hemopoietic reconstitution. Since MHC class II expression in mice differs from that in dogs we were interested in determining the effect of MHC ...

journal_title：Transplantation

authors： Huss R,Beckham C,Storb R,Deeg HJ

更新日期：1994-12-27 00:00:00

abstract：BACKGROUND:To define whether immunosuppressive agents that block the interleukin (IL)-2 pathway could prevent activation-induced cell death of activated T cells in the graft, we measured expression of IL-2, IL-2 receptor alpha chain (CD25), IL-15, Fas, and Fas ligand by real time reverse transcription-polymerase chain ...

journal_title：Transplantation

authors： Baan CC,Balk AH,van Riemsdijk IC,Vantrimpont PJ,Maat AP,Niesters HG,Zondervan PE,van Gelder T,Weimar W

更新日期：2003-05-27 00:00:00

abstract：:We have previously demonstrated that streptozotocin-induced diabetic rats have decreased guanylate cyclase (EC 4.6.1.2) activity in liver and other tissues which was returned to normal by the administration of exogenous insulin. Since successful pancreatic islet transplants have been shown to lower basal hepatic gluco...

journal_title：Transplantation

authors： Vesely DL,Selawry H,Levey GS

更新日期：1979-06-01 00:00:00

abstract：:Acute rejection is a frequent cause of early graft dysfunction in renal transplantation, and serum creatinine is the most important measure of clinical response. However, there is little information on serum creatinine during rejection episodes. In this study, the determinants that might influence the clinical respons...

journal_title：Transplantation

authors： Nankivell BJ,Allen RD,O'Connell PJ,Chapman JR

更新日期：1995-07-15 00:00:00

abstract：BACKGROUND:Uterus transplantation is a treatment for absolute uterine infertility and can be performed with living and deceased donors. Given the safety and increased utilization of robotic assistance with other gynecologic and transplant donor operations, we adopted a robot-assisted approach to donor hysterectomy. Thi...

journal_title：Transplantation

authors： Johannesson L,Koon EC,Bayer J,McKenna GJ,Wall A,Fernandez H,Martinez EJ,Gupta A,Ruiz R,Onaca N,Testa G

更新日期：2021-01-01 00:00:00

abstract：:Second-set rejection is generally considered to be mediated by cytotoxic humoral antibodies. A few discordant data have been reported, however. To address this question, we have taken advantage of a model in which specific cytotoxic alloantibodies are not produced although transplantation cellular immunity develops. F...

journal_title：Transplantation

authors： Aitouche A,Touraine JL

更新日期：1993-09-01 00:00:00

abstract：BACKGROUND:CD4+ T cells play an essential role in allograft rejection. The monoclonal anti-rat CD4 antibody, RIB 5/2, has been shown to modulate the CD4 glycoprotein without eliminating the recipient T cells. We have successfully induced tolerance to rat heart allografts by recipient pretreatment with a single dose of ...

journal_title：Transplantation

authors： Motoyama K,Arima T,Yu S,Lehmann M,Flye MW

更新日期：2000-01-27 00:00:00

abstract：BACKGROUND:Reconstitution of hematopoiesis after hematopoietic stem cell transplantation (HSCT) occurs through a reservoir of donor CD34+ HSC. CD34+/VEGFR-2+ is a primitive, quiescent subpopulation of HSC known to generate hematopoietic or endothelial progeny in vitro and in vivo. We hypothesized that donor-specific an...

journal_title：Transplantation

authors： Nordlander A,Mattsson J,Sundberg B,Sumitran-Holgersson S

更新日期：2008-09-15 00:00:00

abstract：:Extrinsic denervation and lymphatic disruption impair nutrient absorption after small bowel transplantation. The present study was undertaken to determine whether adding the ileocecal valve with or without the ascending colon would improve the function of a segmental intestinal graft. Five groups of Lewis rats (n = 10...

journal_title：Transplantation

authors： Black RT,Hashimoto T,Zhong RZ,Behme RJ,Garcia BM,Duff JH,Grant DR

更新日期：1994-04-15 00:00:00

abstract：BACKGROUND:Umbilical cord blood transplantation (UCBT) is increasingly used and produces similar results to matched unrelated donor transplantation. METHODS:We performed a retrospective single-center analysis of 50 umbilical cord blood transplantations UCBTs performed from 2001 to 2010, including 37 single and 13 doub...

journal_title：Transplantation

authors： Berglund S,Le Blanc K,Remberger M,Gertow J,Uzunel M,Svenberg P,Winiarski J,Ljungman P,Ringdén O,Uhlin M,Mattsson J

更新日期：2012-11-27 00:00:00

abstract：BACKGROUND:In a pilot trial we evaluated the toxicity and efficacy of sirolimus (rapamycin) as second-line therapy for the treatment of acute graft-versus-host disease (GVHD) in 21 patients (1-46 years of age) after allogeneic hematopoietic stem cell transplantation (HSCT). METHODS:All patients were treated with methy...

journal_title：Transplantation

authors： Benito AI,Furlong T,Martin PJ,Anasetti C,Appelbaum FR,Doney K,Nash RA,Papayannopoulou T,Storb R,Sullivan KM,Witherspoon R,Deeg HJ

更新日期：2001-12-27 00:00:00

abstract：BACKGROUND:Apoptosis is a well-documented pathway for islet cell death. One potential mechanism is overexpression of death-promoting Bax compared with antiapoptotic Bcl-2 in islets. METHODS:We isolated islets from 10 human pancreata and measured the expression of Bax mRNA and Bcl-2 mRNA by real-time quantitative polym...

journal_title：Transplantation

authors： Thomas D,Yang H,Boffa DJ,Ding R,Sharma VK,Lagman M,Li B,Hering B,Mohanakumar T,Lakey J,Kapur S,Hancock WW,Suthanthiran M

更新日期：2002-12-15 00:00:00

abstract：BACKGROUND:CTLA4 immunoglobulin (Ig)G that binds to B7 effectively inhibits the signaling of CD28/CTLA4-B7 pathway and induces antigen specific T cell unresponsiveness in vitro and in vivo. Using CTLA4IgG, we examined induction of long-term graft survival and the mechanism of maintenance of tolerance in rat allogeneic ...

journal_title：Transplantation

authors： Tarumi K,Murakami M,Yagihashi A,Nakagawa I,Hirata K,Uede T

更新日期：1999-02-27 00:00:00

abstract：BACKGROUND:Mixed lymphohematopoietic chimerism can provide an effective means of inducing longterm immunological tolerance and has been documented in a monkey allograft model. A conditioning regimen including nonmyeloablative or myeloablative irradiation and splenectomy has been used to induce chimerism in a pig-to-pri...

journal_title：Transplantation

authors： Kozlowski T,Monroy R,Xu Y,Glaser R,Awwad M,Cooper DK,Sachs DH

更新日期：1998-07-27 00:00:00

abstract：BACKGROUND:Finding the best combination of immunosuppression is an important challenge in kidney transplantation. Current short-term (1- and 3-year) allograft survival is quite good, making it difficult to determine differences in therapeutic regimens without large sample sizes. Using data from the United Network for O...

journal_title：Transplantation

authors： Cherikh WS,Myron Kauffman H,Maghirang J,Bleyer AJ,Johnson CP

更新日期：2003-08-15 00:00:00

abstract：:Immunosuppression with sirolimus and low-dose tacrolimus has facilitated successful clinical islet transplantation (CIT). Because the long-term effects on the kidney are unknown and immunosuppressant drugs can be nephrotoxic, CIT is currently restricted to patients with preserved renal function or a functioning renal ...

journal_title：Transplantation

authors： Senior PA,Shapiro AM,Ackerman TE,Ryan EA,Paty BW,Bhargava R

更新日期：2004-09-27 00:00:00

abstract：BACKGROUND:The maturation of dendritic cells (DC) is influenced by various factors, in particular cytokine-mediated signaling events. These include modulation of the activation of nuclear factor kappa B (NF-kappaB), which controls the transcription of genes encoding major histocompatibility complex (MHC) antigens, and ...

journal_title：Transplantation

authors： Lee JI,Ganster RW,Geller DA,Burckart GJ,Thomson AW,Lu L

更新日期：1999-11-15 00:00:00

abstract：:Various autoantibodies were screened in 53 long-term survivors after allogeneic bone marrow transplantation. Among them, 40 displayed chronic graft-versus-host disease, with clinical features reminiscent of collagen diseases, especially scleroderma, Sjögren's syndrome, and autoimmune hepatitis. Antinuclear, anti-smoot...

journal_title：Transplantation

authors： Rouquette-Gally AM,Boyeldieu D,Prost AC,Gluckman E

更新日期：1988-08-01 00:00:00

abstract：:To determine the impact of different flush and reperfusion techniques on postreperfusion syndrome (PRS) and postoperative graft function, 100 transplants were randomly assigned into four groups as follows: group 1 (n=31), portal vein flush, no vena caval venting; group 2 (n=21), hepatic arterial flush, no vena caval v...

journal_title：Transplantation

authors： Millis JM,Melinek J,Csete M,Imagawa DK,Olthoff KM,Neelankanta G,Braunfeld MY,Sopher MJ,Chan SM,Pregler JL,Yersiz H,Busuttil AA,Shackleton CR,Shaked A,Busuttil RW

更新日期：1997-02-15 00:00:00