Abstract:
:We have previously demonstrated that streptozotocin-induced diabetic rats have decreased guanylate cyclase (EC 4.6.1.2) activity in liver and other tissues which was returned to normal by the administration of exogenous insulin. Since successful pancreatic islet transplants have been shown to lower basal hepatic glucose output, gluconeogenesis, and urea production, pancreatic islet transplants seemed to be a more physiological model to test the in vivo effects of insulin on guanylate cyclase activity in diabetic animals. The present investigation demonstrates that pancreatic islet transplants into two different species of streptozotocin-induced diabetic rats increased the lowered activity of guanylate cyclase activity found in diabetic animals to the level of guanylate cyclase activity present in control animals.
journal_name
Transplantationjournal_title
Transplantationauthors
Vesely DL,Selawry H,Levey GSsubject
Has Abstractpub_date
1979-06-01 00:00:00pages
403-5issue
6eissn
0041-1337issn
1534-6080journal_volume
27pub_type
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