Immunobiology of natural killer lymphocytes in transplantation.


:Natural killer (NK) lymphocytes are powerful effector cells of the peripheral immune system. NK cell functions are controlled by the expression of a variety of cell surface receptors with either inhibitory or activating roles. The genetic and functional diversity of this repertoire of receptors and the role of human leukocyte antigen class I histocompatibility molecules as a major group of NK receptor ligands endows NK cells with an innate alloreactive capacity. Early studies of experimental bone marrow transplantation revealed an important role for NK cells in the rejection of allogeneic grafts and contributed significantly to our understanding of NK cell behavior. Both animal models and in vitro studies have since implicated NK cells as contributors to the pathology of clinical transplantation. However, recent clinical studies have demonstrated the potential benefits of exploiting NK cell alloreactivity in mismatched hematopoietic stem cell transplantation for particular types of acute leukemia. Future investigations of NK cell alloreactive functions will undoubtedly reveal additional roles and potential therapeutic applications of this fundamental cell type in clinical transplantation.






Young NT




Has Abstract


2004-07-15 00:00:00














  • Ganciclovir transiently attenuates murine cytomegalovirus-associated renal allograft inflammation.

    abstract:BACKGROUND:Prophylactic ganciclovir (GCV) is used in high-risk renal transplant patients to prevent acute cytomegalovirus (CMV) disease, but its impact on inflammation within the allograft itself remains undefined. METHODS:To study the effect of GCV prophylaxis on allograft inflammation, murine CMV (MCMV)-infected all...


    pub_type: 杂志文章


    authors: Shimamura M,Saunders U,Rha B,Guo L,Cassady KA,George JF,Britt WJ

    更新日期:2011-10-15 00:00:00

  • Recipient treatment with L-arginine attenuates donor lung injury associated with hemorrhagic shock.

    abstract:BACKGROUND:Organ donors are frequently trauma victims, but the impact of donor hemorrhagic shock and resuscitation (HSR) on pulmonary graft function has not been assessed. L-arginine treatment during reperfusion increases the production of endothelial nitric oxide and thus ameliorates ischemia-reperfusion injury. Objec...


    pub_type: 杂志文章


    authors: Preissler G,Löhe F,Ebersberger U,Huff I,Bittmann I,Messmer K,Jauch KW,Angele MK

    更新日期:2009-06-15 00:00:00

  • Pubertal Development in Pediatric Kidney Transplant Patients Receiving Mammalian Target of Rapamycin Inhibitors or Conventional Immunosuppression.

    abstract:BACKGROUND:Data regarding the onset of puberty in children receiving mammalian target of rapamycin (mTOR) inhibitors are limited. METHODS:Kidney transplant patients aged <14 years were analyzed retrospectively to a maximum age of 18 years, with a minimal observation period of 1 year. Immunosuppression comprised (1) st...


    pub_type: 杂志文章


    authors: Förster J,Ahlenstiel-Grunow T,Zapf A,Mynarek M,Pape L

    更新日期:2016-11-01 00:00:00

  • Comparison of University of Wisconsin and St Thomas' Hospital solutions on endothelium-derived hyperpolarizing factor-mediated function in coronary micro-arteries.

    abstract:BACKGROUND:It is controversial whether coronary endothelial function is impaired after cold exposure to University of Wisconsin (UW) or St. Thomas' Hospital (ST) solution during heart transplantation. We therefore examined the effects of cold storage of coronary micro-arteries with UW or ST solution on endothelium-deri...


    pub_type: 杂志文章


    authors: Ge ZD,He GW

    更新日期:2000-07-15 00:00:00

  • Comparing Glycaemic Benefits of Active Versus Passive Lifestyle Intervention in Kidney Allograft Recipients: A Randomized Controlled Trial.

    abstract:BACKGROUND:New-onset diabetes is common after kidney transplantation, but the benefit of lifestyle intervention to improve glucose metabolism posttransplantation is unproven. METHODS:We conducted a single-center, randomized controlled trial involving 130 nondiabetic kidney transplant recipients with stable function be...


    pub_type: 杂志文章,随机对照试验


    authors: Kuningas K,Driscoll J,Mair R,Smith H,Dutton M,Day E,Sharif AA

    更新日期:2020-07-01 00:00:00

  • Apoptosis and chemokine induction after renal ischemia-reperfusion.

    abstract:BACKGROUND:One of the earliest prerequisites for the development of inflammation after ischemia-reperfusion (I/R) is local chemokine expression. We recently demonstrated that apoptosis, characterized by intracellular caspase-activation, contributes to the development of inflammation after I/R. METHODS:The contribution...


    pub_type: 杂志文章


    authors: Daemen MA,de Vries B,van't Veer C,Wolfs TG,Buurman WA

    更新日期:2001-04-15 00:00:00

  • Temporal trends in lung transplant center volume and outcomes in the United States.

    abstract::Publicly available program-specific data from the scientific registry of transplant recipients were used to determine the association between adult lung transplant center volume and 1-year recipient mortality from 2000 to 2007. We found a significant inverse association between the center volume of adult lung transpla...


    pub_type: 杂志文章


    authors: Scarborough JE,Bennett KM,Davis RD,Lin SS,Tracy ET,Kuo PC,Pappas TN

    更新日期:2010-03-27 00:00:00

  • Focal acute tubular necrosis in a renal allograft.

    abstract::Nuclear imaging is used to evaluate renal allografts demonstrating delayed function after transplantation. Interpretation of the nuclear scan in the context of clinical data, provides helpful information in the management of the transplant recipient. The better quality of images obtained with technetium-99m mercaptoac...


    pub_type: 杂志文章


    authors: Mange KC,Scheff A,Brayman K,Mozley D,Grossman RA,Naji A,Aradhye S

    更新日期:1997-11-27 00:00:00

  • Mycobacterium haemophilum infections in bone marrow transplant recipients.

    abstract::The purpose of this study was to describe the clinical presentation, treatment, and outcome of Mycobacterium haemophilum infection in patients undergoing bone marrow transplantation at a cancer center. Bone marrow transplant recipients with M haemophilum infection were identified upon culture of the organism by implem...


    pub_type: 杂志文章


    authors: White MH,Papadopoulos EB,Small TN,Kiehn TE,Armstrong D

    更新日期:1995-11-15 00:00:00

  • The asystolic donor syndrome: transaminitis and thrombocytopenia after non-heartbeating renal transplantation.

    abstract:BACKGROUND:The use of kidneys from non-heartbeating donors (NHB) remains controversial. An increased incidence of delayed primary function and primary nonfunction is common. We report a characteristic syndrome of transaminitis and thrombocytopenia after NHB renal transplantation, which may be predictive of graft outcom...


    pub_type: 杂志文章


    authors: Andrews PA,Denton MD,Compton FC,Koffman CG

    更新日期:1997-05-27 00:00:00

  • Strategies to minimize immunological and nonimmunological risk factors in the renal transplant population.

    abstract::To improve long-term outcome after renal transplantation, attention should be placed on the tailored use of immunosuppressive regimens that have a more favorable impact on the immunological and nonimmunological risk profiles of an individual recipient. Tacrolimus is widely used for maintenance and rejection immunosupp...


    pub_type: 杂志文章


    authors: First MR

    更新日期:2001-09-27 00:00:00

  • Comparison of arterialized and nonarterialized orthotopic liver transplantation in mice: prowess or relevant model?

    abstract:BACKGROUND:New insights into mechanisms of injury in orthotopic liver transplantation (OLT) often come from experiments in small animal models. Mice are particularly suitable because of the growing availability of gene-altered animals and specific antibodies. A validated model of OLT in mice is not available and, in pa...


    pub_type: 杂志文章


    authors: Tian Y,Rüdiger HA,Jochum W,Clavien PA

    更新日期:2002-11-15 00:00:00

  • Blood citrulline level is an exclusionary marker for significant acute rejection after intestinal transplantation.

    abstract:BACKGROUND:Serum citrulline is a marker for acute cellular rejection (ACR) after intestinal transplantation; however, its clinical utility has not yet been established. The goal of this study was to determine clearcut serum levels beyond which the diagnosis of acute rejection could be supported or refuted, and predicto...


    pub_type: 杂志文章


    authors: David AI,Selvaggi G,Ruiz P,Gaynor JJ,Tryphonopoulos P,Kleiner GI,Moon JI,Nishida S,Pappas PA,Conanan L,Weppler D,Esquenazi V,Levi DM,Kato T,Tzakis AG

    更新日期:2007-11-15 00:00:00

  • Therapeutic Hypothermia in Organ Donors: Follow-up and Safety Analysis.

    abstract:BACKGROUND:In a recent trial, targeted mild hypothermia in brain-dead organ donors significantly reduced the incidence of delayed graft function after kidney transplantation. This trial was stopped early for efficacy. Here, we report long-term graft survival for all organs along with donor critical care end points. ME...


    pub_type: 杂志文章,随机对照试验


    authors: Malinoski D,Patel MS,Axelrod DA,Broglio K,Lewis RJ,Groat T,Niemann CU

    更新日期:2019-11-01 00:00:00

  • The risks, benefits, and costs of expanding donor criteria. A collaborative prospective three-year study.

    abstract::The study purpose was to identify risks, benefits and costs associated with an expanded donor protocol. The protocol design evaluated organs rescued using expanded donor criteria and weighed all costs associated with doing so. Costs were measured against conditions experienced with expanded and traditional criteria an...


    pub_type: 杂志文章


    authors: Jacobbi LM,McBride VA,Etheredge EE,McDonald JC,Cooper ES,Frey D,Boudreaux JP,Gonzalez F,Van Meter C,McMillan R

    更新日期:1995-12-27 00:00:00

  • Detection of Complement-binding Donor-specific Antibodies, Not IgG-antibody Strength Nor C4d Status, at Antibody-mediated Rejection Diagnosis Is an Independent Predictor of Kidney Graft Failure.

    abstract:BACKGROUND:Antibody-mediated rejection (AMR) remains associated with reduced kidney graft survival and no clear prognostic marker is available. METHODS:We investigated whether donor-specific antibodies (DSA) ability to bind C1q in comparison with AMR C4d status, both indirect signs of complement activation, improve ri...


    pub_type: 杂志文章


    authors: Malheiro J,Santos S,Tafulo S,Dias L,Martins S,Fonseca I,Almeida M,Pedroso S,Beirão I,Castro-Henriques A,Cabrita A

    更新日期:2018-11-01 00:00:00

  • A randomized multicenter trial of the anti-ICAM-1 monoclonal antibody (enlimomab) for the prevention of acute rejection and delayed onset of graft function in cadaveric renal transplantation: a report of the European Anti-ICAM-1 Renal Transplant Study Gro

    abstract:BACKGROUND:T-cell activation through T-cell receptor engagement requires co-stimulatory molecules and also adhesion molecules such as ICAM-1. Moreover ICAM-1 mediates leukocyte invasion from the blood into tissue during inflammatory processes. In animal studies using mouse monoclonal antibodies against ICAM-1 (enlimoma...


    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Salmela K,Wramner L,Ekberg H,Hauser I,Bentdal O,Lins LE,Isoniemi H,Bäckman L,Persson N,Neumayer HH,Jørgensen PF,Spieker C,Hendry B,Nicholls A,Kirste G,Hasche G

    更新日期:1999-03-15 00:00:00

  • The clinical utility of whole blood versus plasma cytomegalovirus viral load assays for monitoring therapeutic response.

    abstract:BACKGROUND:In patients with cytomegalovirus (CMV) disease, regular monitoring of viral loads and treatment until negative are recommended. However, with more sensitive polymerase chain reaction (PCR) assays and cellular peripheral sample types, detection of low-level viremia is achievable. We compared a whole blood rea...


    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Lisboa LF,Asberg A,Kumar D,Pang X,Hartmann A,Preiksaitis JK,Pescovitz MD,Rollag H,Jardine AG,Humar A

    更新日期:2011-01-27 00:00:00

  • Control of organ transplant-associated graft-versus-host disease by activated host lymphocyte infusions.

    abstract:BACKGROUND:Prolonged persistence of donor-derived T cells after organ transplantation has been proposed to improve long-term allograft survival. However, surviving transplant-derived T cells are also able to mediate devastating graft-versus-host disease (GvHD). Currently, GvHD after organ transplantation is usually ref...


    pub_type: 杂志文章


    authors: Kuball J,Theobald M,Ferreira EA,Hess G,Burg J,Maccagno G,Barreiros AP,Lüth S,Schimanski CC,Schuchmann M,Schwarting A,Neurath M,Otto G,Galle PR,Lohse AW

    更新日期:2004-12-27 00:00:00

  • Recurrence of focal-segmental glomerulosclerosis in children after renal transplantation: clinical and genetic aspects.

    abstract::Focal segmental glomerulosclerosis (FSGS) is the primary renal disease in approximately one-tenth of pediatric patients receiving a renal allograft. Recurrence of proteinuria after renal transplantation is observed in approximately 30% of patients and negatively impacts graft survival. Risk factors for recurrence are ...


    pub_type: 杂志文章,评审


    authors: Weber S,Tönshoff B

    更新日期:2005-09-27 00:00:00

  • A reevaluation of the role of IgM Non-HLA antibodies in cardiac transplantation.

    abstract:BACKGROUND:Preexisting IgG antibodies to donor human leukocyte antigens (HLA) are a risk factor for rapid allograft rejection. However, non-HLA antibodies, of the IgM class, also called autoreactive antibodies, are not believed to affect graft survival. The aim of this study was to determine the incidence and clinical ...


    pub_type: 杂志文章


    authors: Smith JD,Hamour IM,Burke MM,Mahesh B,Stanford RE,Haj-Yahia S,Robinson DR,Kaul P,Yacoub MH,Banner NR,Rose ML

    更新日期:2009-03-27 00:00:00

  • Pattern of liver, kidney, heart, and intestine allograft rejection in different mouse strain combinations.

    abstract::With advances in microsurgery and molecular biology, the mouse model for organ transplantation has become increasingly popular. However, knowledge about these models is limited, as only a small number of centers have experience with murine models. In this study, we compared the rejection pattern after liver, kidney, h...


    pub_type: 杂志文章


    authors: Zhang Z,Zhu L,Quan D,Garcia B,Ozcay N,Duff J,Stiller C,Lazarovits A,Grant D,Zhong R

    更新日期:1996-11-15 00:00:00

  • Time course of glomerular endothelial injury related to pulsatile perfusion preservation.

    abstract::To elucidate the time course of glomerular and arterial endothelial injury resulting from pulsatile perfusion preservation of human kidneys, we examined two kidneys, one at 16 and the other at 42 hr, for which no suitable recipient could be found. The scanning electron microscope revealed subtle changes at 16 hr in th...


    pub_type: 杂志文章


    authors: Gattone VH 2nd,Filo RS,Evan AP,Leapman SB,Smith EJ,Luft FC

    更新日期:1985-04-01 00:00:00

  • Insulin-heparin infusions peritransplant substantially improve single-donor clinical islet transplant success.

    abstract:BACKGROUND:Successful islet transplantation can result in insulin independence in many patients with type 1 diabetes mellitus, but it often requires more than one islet infusion. The ability to achieve insulin independence with a single donor is an important goal in clinical islet transplantation due to the limited org...


    pub_type: 杂志文章


    authors: Koh A,Senior P,Salam A,Kin T,Imes S,Dinyari P,Malcolm A,Toso C,Nilsson B,Korsgren O,Shapiro AM

    更新日期:2010-02-27 00:00:00

  • Calcineurin inhibitors, but not rapamycin, reduce percentages of CD4+CD25+FOXP3+ regulatory T cells in renal transplant recipients.

    abstract:BACKGROUND:Immunosuppression in renal transplantation, although manageable in the short-term, is a major hurdle for long-term graft survival. Recently, increased frequencies of CD4CD25 regulatory T cells (Tregs) have been described as an additional mechanism that induces alloimmune tolerance. METHODS:We assessed 64 re...


    pub_type: 杂志文章


    authors: Segundo DS,Ruiz JC,Izquierdo M,Fernández-Fresnedo G,Gómez-Alamillo C,Merino R,Benito MJ,Cacho E,Rodrigo E,Palomar R,López-Hoyos M,Arias M

    更新日期:2006-08-27 00:00:00

  • The development and specificity of antiidiotypic antibodies in renal transplant recipients receiving single-donor blood transfusions.

    abstract::Multiple pretransplant sera obtained from alloimmunized renal transplant recipients were tested for the presence of antiidiotypic-like antibodies (AB2) that inhibit donor-specific HLA antibodies in the microlymphocytotoxicity assay. Fourteen patients received repetitive single-donor blood transfusions (SDT). In this p...


    pub_type: 杂志文章


    authors: Phelan DL,Rodey GE,Anderson CB

    更新日期:1989-07-01 00:00:00

  • Long-term functions of encapsulated islets grafted in nonhuman primates without immunosuppression.

    abstract:BACKGROUND:Long-term survival and functions of encapsulated islet grafts need to be evaluated in the absence of immunosuppression. The present study aimed to assess the viability and functions of macroencapsulated islets grafted in nonhuman primates without immunosuppression for 1 year. METHODS:Islet transplantations ...


    pub_type: 杂志文章


    authors: Sasikala M,Rao GV,Vijayalakshmi V,Pradeep R,Pothani S,Kumar PP,Gaddipati R,Sirisha G,Cheemalakonda R,Tandan M,Subramanyam C,Vasudevan S,Reddy DN

    更新日期:2013-10-15 00:00:00

  • Long-term duct-occluded segmental pancreatic autografts: absence of microvascular diabetic complications.

    abstract:BACKGROUND:Current insulin therapies for control of glucose metabolism in patients with type I diabetes mellitus prevent major metabolic consequences of insulin deficiency, but none prevents or arrests long-term complications. In experimental models of canine diabetes, retinopathy, neuropathy, and nephropathy have been...


    pub_type: 杂志文章


    authors: Hawthorne WJ,Wilson TG,Williamson P,Stewart GJ,Allen RD,Little JM,Deane SA,Ekberg H

    更新日期:1997-10-15 00:00:00

  • Noninvasive prognostication of polyomavirus BK virus-associated nephropathy.

    abstract:BACKGROUND:BK virus-associated nephropathy (BKVN) is associated with an increased risk of graft failure. METHODS:Levels of mRNAs encoding proteins implicated in inflammation and fibrosis were measured in urine collected at the time of biopsy diagnosis of BKVN in 29 kidney graft recipients and analyzed for prognosticat...


    pub_type: 杂志文章


    authors: Dadhania D,Snopkowski C,Muthukumar T,Lee J,Ding R,Sharma VK,Christos P,Bang H,Kapur S,Seshan SV,Suthanthiran M

    更新日期:2013-07-27 00:00:00

  • Alloreactive anti-HLA-B7 cytolytic T cell clones use restricted T cell receptor genes.

    abstract::Most alloreactive T cells specifically recognize peptides bound to donor MHC molecules. In addition to peptides, solvent accessible MHC residues also may stimulate alloreactive T cells. We studied T cell receptor (TCR) usage by 16 independent anti-HLA-B7 alloreactive cytolytic T lymphocyte (CTL) clones. Most or all of...


    pub_type: 杂志文章


    authors: Li YY,Smith KD,Shi Y,Lutz CT

    更新日期:1996-10-15 00:00:00