Immunobiology of natural killer lymphocytes in transplantation.

Abstract:

:Natural killer (NK) lymphocytes are powerful effector cells of the peripheral immune system. NK cell functions are controlled by the expression of a variety of cell surface receptors with either inhibitory or activating roles. The genetic and functional diversity of this repertoire of receptors and the role of human leukocyte antigen class I histocompatibility molecules as a major group of NK receptor ligands endows NK cells with an innate alloreactive capacity. Early studies of experimental bone marrow transplantation revealed an important role for NK cells in the rejection of allogeneic grafts and contributed significantly to our understanding of NK cell behavior. Both animal models and in vitro studies have since implicated NK cells as contributors to the pathology of clinical transplantation. However, recent clinical studies have demonstrated the potential benefits of exploiting NK cell alloreactivity in mismatched hematopoietic stem cell transplantation for particular types of acute leukemia. Future investigations of NK cell alloreactive functions will undoubtedly reveal additional roles and potential therapeutic applications of this fundamental cell type in clinical transplantation.

journal_name

Transplantation

journal_title

Transplantation

authors

Young NT

doi

10.1097/01.tp.0000123764.10461.4c

subject

Has Abstract

pub_date

2004-07-15 00:00:00

pages

1-6

issue

1

eissn

0041-1337

issn

1534-6080

pii

00007890-200407150-00001

journal_volume

78

pub_type

杂志文章,评审
  • Nosocomial Legionnaires' disease following renal transplantation.

    abstract::A cluster of five cases of Legionnaires' disease in renal transplant patients is described. They were treated with erythromycin and rifampicin, and all five survived. Two of them had rejected their grafts prior to their Legionella pneumonia; two rejected their transplants after reduction of immunosuppressive therapy t...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:

    authors: Wilczek H,Kallings I,Nyström B,Hoffner S

    更新日期:1987-06-01 00:00:00

  • The prevalence of coronary artery disease in liver transplant candidates over age 50.

    abstract::The prevalence of angiographically proven coronary artery disease (CAD) in adults with end-stage liver disease who undergo evaluation for liver transplantation is unknown; also it is unclear if cholestatic liver disease represents an independent risk factor. Patients with end-stage liver disease over age 50 having liv...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:

    authors: Carey WD,Dumot JA,Pimentel RR,Barnes DS,Hobbs RE,Henderson JM,Vogt DP,Mayes JT,Westveer MK,Easley KA

    更新日期:1995-03-27 00:00:00

  • Chronopharmacology for deoxyspergualin: toxicity and efficacy in the rat.

    abstract:BACKGROUND:Deoxyspergualin (DSG), a potent immunosuppressive drug, has been clinically used as a rescue therapy for acute graft rejection. However, DSG has severe adverse effects that limits its use. Here, we examined the optimized therapeutic protocol for DSG using chronopharmacological profiles of it. METHODS:First,...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199905150-00012

    authors: Uchida H,Kobayashi E,Matsuda K,Mizuta K,Sugimoto K,Kawarasaki H,Hashizume K,Fujimura A

    更新日期:1999-05-15 00:00:00

  • Langerhans cell homeostasis and turnover after nonmyeloablative and myeloablative allogeneic hematopoietic cell transplantation.

    abstract:BACKGROUND:Langerhans cells (LCs) are self-renewing epidermal myeloid cells that can migrate and mature into dendritic cells. Recipient LCs that survive cytotoxic therapy given in preparation for allogeneic hematopoietic cell transplantation may prime donor T cells to mediate cutaneous graft-versus-host disease (GVHD)....

    journal_title:Transplantation

    pub_type: 临床试验,杂志文章

    doi:10.1097/TP.0000000000000097

    authors: Mielcarek M,Kirkorian AY,Hackman RC,Price J,Storer BE,Wood BL,Leboeuf M,Bogunovic M,Storb R,Inamoto Y,Flowers ME,Martin PJ,Collin M,Merad M

    更新日期:2014-09-15 00:00:00

  • The vanishing importance of age in renal transplantation.

    abstract:BACKGROUND:The growing number of patients awaiting a kidney transplant raises questions about allocation of kidneys to the elderly and about the use of elderly donors. In all reported studies analyzing the influence of age on the outcome after renal transplantation, age is investigated as a categorical variable. METHO...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199902270-00015

    authors: Roodnat JI,Zietse R,Mulder PG,Rischen-Vos J,van Gelder T,IJzermans JN,Weimar W

    更新日期:1999-02-27 00:00:00

  • Increased incidence of acute myeloid leukemia after liver transplantation? Description of three new cases and review of the literature.

    abstract:BACKGROUND:Acute myeloid leukemia (AML) after solid organ transplantation is rare, with only six AML cases after liver transplantation (LT) being reported. METHODS:Characteristics of three AML cases observed among 799 recipients of LT in the authors' institution and estimation of the standardized incidence ratio (SIR)...

    journal_title:Transplantation

    pub_type: 杂志文章,评审

    doi:10.1097/01.TP.0000102549.40531.13

    authors: Camós M,Esteve J,Rimola A,Grande L,Rozman M,Colomer D,Villamor N,Costa D,Montserrat E

    更新日期:2004-01-27 00:00:00

  • Effect of cold ischemic time and HLA matching in kidneys coming from "young" and "old" donors: do not leave for tomorrow what you can do tonight.

    abstract:BACKGROUND:Kidneys from older donors are likely to have a lower nephron mass. Nevertheless they constitute a valuable source of kidney allografts. Long cold ischemic time (CIT), with or without delayed graft function (DGF), has been associated with reduced graft survival. The aim of this study was to review the experie...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-200108270-00020

    authors: Asderakis A,Dyer P,Augustine T,Worthington J,Campbell B,Johnson RW

    更新日期:2001-08-27 00:00:00

  • Evaluation of pretransplant immunologic status in kidney-transplant recipients by panel reactive antibody and soluble CD30 determinations.

    abstract:OBJECTIVES:To retrospectively compare the accuracy of pretransplant panel of reactivity antibodies (PRA) and serum level of soluble CD30 (sCD30) in predicting early (< 6 months) acute rejection (AR) in living-donor and deceased-donor kidney-transplant (KT) patients. METHODS:Pretransplant sera of 24 KT recipients were ...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:

    authors: Cinti P,Pretagostini R,Arpino A,Tamburro ML,Mengasini S,Lattanzi R,De Simone P,Berloco P,Molajoni ER

    更新日期:2005-03-15 00:00:00

  • Indirect allorecognition of major histocompatibility complex allopeptides in human renal transplant recipients with chronic graft dysfunction.

    abstract:BACKGROUND:It has been suggested that T cells primed by processed donor major histocompatibility complex antigen (the "indirect" pathway of allorecognition) may be responsible for mediating chronic allograft rejection. The purpose of this study was to develop a clinically useful assay to study the occurrence of indirec...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199709270-00001

    authors: Vella JP,Spadafora-Ferreira M,Murphy B,Alexander SI,Harmon W,Carpenter CB,Sayegh MH

    更新日期:1997-09-27 00:00:00

  • Advances in small-intestine transplantation.

    abstract::Intestinal transplantation has become the treatment of choice for patients who are experiencing life-threatening complications of intestinal failure. Early attempts with intestinal transplantation were unsuccessful as a consequence of both technical and immunologic failures. The introduction of tacrolimus provided the...

    journal_title:Transplantation

    pub_type: 杂志文章,评审

    doi:10.1097/01.tp.0000126931.23349.15

    authors: Langnas AN

    更新日期:2004-05-15 00:00:00

  • Racial Differences in Survival of Incident Home Hemodialysis and Kidney Transplant Patients.

    abstract:BACKGROUND:Previous studies have indicated that patients on maintenance hemodialysis have worse survival compared with kidney transplant (KTx) recipients. However, none of these studies have compared mortality of the US patients using alternative dialysis modalities such as home hemodialysis (HHD) with KTx recipients. ...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0000000000001005

    authors: Molnar MZ,Ravel V,Streja E,Kovesdy CP,Mehrotra R,Kalantar-Zadeh K

    更新日期:2016-10-01 00:00:00

  • Improved metabolic control and quality of life in seven patients with type 1 diabetes following islet after kidney transplantation.

    abstract:BACKGROUND:The beneficial effects of glycemic control on both survival and function of transplanted kidneys in patients with type 1 diabetes mellitus (T1DM) and end-stage renal disease (ESRD) have been recognized. METHODS:Herein, we present the clinical outcome of a single-center pilot trial of islet after kidney (IAK...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0b013e318166a27b

    authors: Cure P,Pileggi A,Froud T,Messinger S,Faradji RN,Baidal DA,Cardani R,Curry A,Poggioli R,Pugliese A,Betancourt A,Esquenazi V,Ciancio G,Selvaggi G,Burke GW 3rd,Ricordi C,Alejandro R

    更新日期:2008-03-27 00:00:00

  • Human leukocyte antigen class II DQ alpha and beta epitopes identified from sera of kidney allograft recipients.

    abstract:BACKGROUND:Epitopes are the sites to which antibodies bind. Both alpha and beta peptide chains of the human leukocyte antigen-DQ heterodimers (DQA1 and DQB1, respectively) contain polymorphic regions. We can identify DQA1 and DQB1 epitopes by DQ single antigen beads assay of the antibodies, correlating the beads' react...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0b013e3181804cd2

    authors: Deng CT,El-Awar N,Ozawa M,Cai J,Lachmann N,Terasaki PI

    更新日期:2008-08-15 00:00:00

  • Epidemiology of BK virus in renal allograft recipients: independent risk factors for BK virus replication.

    abstract:BACKGROUND:Identification of risk factors for BK virus (BKV) replication may improve transplant outcome. We investigated the impact of immunosuppressive drugs on the prevalence of BKV replication in recipients of human renal allografts. METHODS:One hundred twenty renal allograft recipients were studied prospectively a...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0b013e31817c6447

    authors: Dadhania D,Snopkowski C,Ding R,Muthukumar T,Chang C,Aull M,Lee J,Sharma VK,Kapur S,Suthanthiran M

    更新日期:2008-08-27 00:00:00

  • Effect of timing of administration and quantity of blood transfusion on cadaver renal transplant survival.

    abstract::Graft and patient survival rates were analyzed in 239 consecutive first cadaver renal transplants as a function of time of administration of blood transfusion and the number of units given. There was no statistically significant difference in patient survival in comparing patients who were never transfused, patients n...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-198012000-00008

    authors: Corry RJ,West JC,Hunsicker LG,Schanbacher BA,Lachenbruch PA

    更新日期:1980-12-01 00:00:00

  • Rejection responses to allogeneic hepatocytes by reconstituted SCID mice, CD4, KO, and CD8 KO mice.

    abstract:INTRODUCTION:The purpose of the current study was to investigate the capacity of CD4+, CD8+, or non-T cells to independently initiate acute rejection of allogeneic hepatocytes using reconstituted SCID, CD4 or CD8 knockout (KO) recipient mice. METHODS:Allogeneic hepatocytes (FVB/N, H-2q) were transplanted into C57BL/6....

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-200012270-00017

    authors: Bumgardner GL,Gao D,Li J,Baskin JH,Heininger M,Orosz CG

    更新日期:2000-12-27 00:00:00

  • The economic benefit of allocation of kidneys based on cross-reactive group matching.

    abstract:BACKGROUND:Recently the United Network for Organ Sharing (UNOS) began a pilot study to evaluate prospectively the merits of an allocation of cadaveric kidneys based on broader classes of HLA antigens, called cross-reactive groups (CREG). The objectives of the pilot study consider patient outcomes, but not the potential...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-200008150-00024

    authors: Hollenbeak CS,Woodward RS,Cohen DS,Lowell JA,Singer GG,Tesi RJ,Howard TK,Mohanakumar T,Brennan DC,Schnitzler MA

    更新日期:2000-08-15 00:00:00

  • Twenty-four-hour hypothermic preservation of rat liver with Euro-Collins and UW solutions. A comparative evaluation by 31P NMR spectroscopy, biochemical assays, and light microscopy.

    abstract::A comparative study of 24 hr preservation at 4 degrees C of excised rat livers with Euro-Collins and hydroxyethyl starch-free University of Wisconsin (UWm) solutions has been conducted based on the assessment of (1) the cellular energy status determined by 31P NMR spectroscopy and (2) cellular injury estimated from th...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199210000-00006

    authors: Gulian JM,Dalmasso C,Desmoulin F,Scheiner C,Cozzone PJ

    更新日期:1992-10-01 00:00:00

  • Factors affecting graft survival after liver transplantation from donation after cardiac death donors.

    abstract:BACKGROUND:Liver transplantation from donation after cardiac death (DCD) donors is an increasingly common approach for expansion of the donor organ supply. However, transplantation with DCD livers results in inferior graft survival. In this study, we examined donor and recipient characteristics that are associated with...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/01.tp.0000250936.73034.98

    authors: Lee KW,Simpkins CE,Montgomery RA,Locke JE,Segev DL,Maley WR

    更新日期:2006-12-27 00:00:00

  • Levosimendan treatment after primary organ failure in heart transplantation: a direct way to recovery?

    abstract::Heart transplantation is considered nowadays the gold standard in the therapy of chronic and terminal heart insufficiency. Primary organ failure after heart transplantation is a severe complication generally related to prolonged ischemia time, poor quality of the organ, or acute rejection. All these factors can potent...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/01.tp.0000233845.15508.89

    authors: Beiras-Fernandez A,Weis FC,Fuchs H,Meiser BM,Reichart B,Weis M

    更新日期:2006-10-27 00:00:00

  • Hemostatic complications in bone marrow transplantation: a retrospective analysis of 447 patients.

    abstract:BACKGROUND:Hemostatic complications are not uncommon after bone marrow transplantation (BMT). However, little is known about the frequency, localization, determinants, and outcome of hemostatic events in autologous and allogeneic BMT. METHODS:Four hundred forty-seven patients (364 allogeneic, 83 autologous transplants...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-200211150-00018

    authors: Pihusch R,Salat C,Schmidt E,Göhring P,Pihusch M,Hiller E,Holler E,Kolb HJ

    更新日期:2002-11-15 00:00:00

  • The impact of transforming growth factor-beta1 gene polymorphism on end-stage renal failure after heart transplantation.

    abstract:BACKGROUND:Nephrotoxicity is a major side effect of calcineurin inhibitors (CNI). Earlier we reported 8% of our heart transplant recipients reaching end-stage renal failure (ESRF). Now, with an extended follow up of 20 years, we re-evaluated the development of ESRF and studied its influence on survival and the impact o...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/01.tp.0000250360.78553.5e

    authors: van de Wetering J,Weimar CH,Balk AH,Roodnat JI,Holweg CT,Baan CC,van Domburg RT,Weimar W

    更新日期:2006-12-27 00:00:00

  • Male-restricted expression of H-Y antigen on preimplantation mouse embryos.

    abstract::The H-Y (male) antigen is detectable on 50% of eight-cell mouse embryos. We show that 82% of the offspring resulting from the transfer of (C57BL/6 X A/J)F1 embryos surviving treatment with H-Y antibody and complement to the uteruses of pseudopregnant mice are female. The increased ratio of female-to-male births indica...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-198401000-00004

    authors: Shelton JA,Goldberg EH

    更新日期:1984-01-01 00:00:00

  • Comparison of pulsatile perfusion and cold storage for paired kidney allografts.

    abstract::Use of pulsatile perfusion to optimize outcomes in deceased donor kidney transplantation remains controversial. This study is a retrospective analysis of all cadaveric renal allografts procured locally by our center over a 3-year period. Kidney pairs were identified in which one kidney underwent pulsatile perfusion an...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0b013e318187b978

    authors: Shah AP,Milgrom DP,Mangus RS,Powelson JA,Goggins WC,Milgrom ML

    更新日期:2008-10-15 00:00:00

  • The effect of verapamil in reducing the severity of acute tubular necrosis in canine renal autotransplants.

    abstract::Calcium channel blockade has been shown to prevent warm renal ischemic damage. The ability of verapamil to decrease the severity of acute tubular necrosis (ATN) after 24-hr cold storage and autotransplantation was studied in a randomized paired study of 12 dogs. Experimental animals pretreated with intraarterial verap...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-198709000-00006

    authors: Agatstein EH,Farrer JH,Kaplan LM,Randazzo RF,Glassock RJ,Kaufman JJ

    更新日期:1987-09-01 00:00:00

  • Outcomes After Declining Increased Infectious Risk Kidney Offers for Pediatric Candidates in the United States.

    abstract:BACKGROUND:Kidneys from infectious risk donors (IRD) confer substantial survival benefit in adults, yet the benefit of IRD kidneys to pediatric candidates remains unclear in the context of high waitlist prioritization. METHODS:Using 2010-2016 Scientific Registry of Transplant Recipients data, we studied 2417 pediatric...

    journal_title:Transplantation

    pub_type: 杂志文章,多中心研究

    doi:10.1097/TP.0000000000002674

    authors: Bowring MG,Jackson KR,Wasik H,Neu A,Garonzik-Wang J,Durand C,Desai N,Massie AB,Segev DL

    更新日期:2019-12-01 00:00:00

  • Graft-versus-host disease in the absence of the spleen after allogeneic bone marrow transplantation.

    abstract:BACKGROUND:The spleen is considered to be an important secondary lymphoid organ where acute graft-versus-host disease (GVHD) is initiated by donor T cells that recognize host alloantigens after allogeneic bone-marrow transplantation (BMT). The influence of splenectomy on the development of GVHD prior to BMT has yet to ...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-200205270-00027

    authors: Clouthier SG,Ferrara JL,Teshima T

    更新日期:2002-05-27 00:00:00

  • Low pretransplant bone-mineral density and rapid bone loss do not increase risk for avascular osteonecrosis after allogeneic hematopoietic stem cell transplantation.

    abstract:BACKGROUND:Avascular osteonecrosis (AVN) is a serious complication of allogeneic stem cell transplantation (SCT). Graft-versus-host disease and its treatment with steroids are the main risk factors; underlying diagnosis, age and gender are further risk factors. It has been speculated that low baseline bone mineral dens...

    journal_title:Transplantation

    pub_type: 临床试验,杂志文章

    doi:10.1097/01.tp.0000164353.86447.db

    authors: Schulte CM,Beelen DW

    更新日期:2005-06-27 00:00:00

  • Cell and extracellular matrix rejection in arterial concordant and discordant xenografts in the rat.

    abstract::Vascularized xenografts are rejected acutely and hyperacutely in concordant or discordant combinations, respectively. We investigated the impact of the donor-recipient combination on the rejection of arterial xenografts, analyzing the cellular and extracellular matricial compartments. Aortic xenografts were performed ...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199609270-00017

    authors: Allaire E,Mandet C,Bruneval P,Bensenane S,Becquemin JP,Michel JB

    更新日期:1996-09-27 00:00:00

  • Long-term graft outcome with mycophenolate mofetil and azathioprine: A paired kidney analysis.

    abstract:BACKGROUND:Randomized controlled trials and U.S. Registry data have demonstrated that mycophenolate mofetil (MMF) reduces acute rejection rates and improves graft survival. We undertook the first paired kidney analysis comparing the effects of MMF and azathioprine on graft outcome in the United Kingdom. METHODS:In all...

    journal_title:Transplantation

    pub_type: 杂志文章,meta分析

    doi:10.1097/01.tp.0000250713.65004.35

    authors: Shah S,Collett D,Johnson R,Thuraisingham RC,Raftery MJ,Rudge CJ,Yaqoob MM

    更新日期:2006-12-27 00:00:00