Abstract:
:Natural killer (NK) lymphocytes are powerful effector cells of the peripheral immune system. NK cell functions are controlled by the expression of a variety of cell surface receptors with either inhibitory or activating roles. The genetic and functional diversity of this repertoire of receptors and the role of human leukocyte antigen class I histocompatibility molecules as a major group of NK receptor ligands endows NK cells with an innate alloreactive capacity. Early studies of experimental bone marrow transplantation revealed an important role for NK cells in the rejection of allogeneic grafts and contributed significantly to our understanding of NK cell behavior. Both animal models and in vitro studies have since implicated NK cells as contributors to the pathology of clinical transplantation. However, recent clinical studies have demonstrated the potential benefits of exploiting NK cell alloreactivity in mismatched hematopoietic stem cell transplantation for particular types of acute leukemia. Future investigations of NK cell alloreactive functions will undoubtedly reveal additional roles and potential therapeutic applications of this fundamental cell type in clinical transplantation.
journal_name
Transplantationjournal_title
Transplantationauthors
Young NTdoi
10.1097/01.tp.0000123764.10461.4csubject
Has Abstractpub_date
2004-07-15 00:00:00pages
1-6issue
1eissn
0041-1337issn
1534-6080pii
00007890-200407150-00001journal_volume
78pub_type
杂志文章,评审相关文献
TRANSPLANTATION文献大全abstract::A cluster of five cases of Legionnaires' disease in renal transplant patients is described. They were treated with erythromycin and rifampicin, and all five survived. Two of them had rejected their grafts prior to their Legionella pneumonia; two rejected their transplants after reduction of immunosuppressive therapy t...
journal_title:Transplantation
pub_type: 杂志文章
doi:
更新日期:1987-06-01 00:00:00
abstract::The prevalence of angiographically proven coronary artery disease (CAD) in adults with end-stage liver disease who undergo evaluation for liver transplantation is unknown; also it is unclear if cholestatic liver disease represents an independent risk factor. Patients with end-stage liver disease over age 50 having liv...
journal_title:Transplantation
pub_type: 杂志文章
doi:
更新日期:1995-03-27 00:00:00
abstract:BACKGROUND:Deoxyspergualin (DSG), a potent immunosuppressive drug, has been clinically used as a rescue therapy for acute graft rejection. However, DSG has severe adverse effects that limits its use. Here, we examined the optimized therapeutic protocol for DSG using chronopharmacological profiles of it. METHODS:First,...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199905150-00012
更新日期:1999-05-15 00:00:00
abstract:BACKGROUND:Langerhans cells (LCs) are self-renewing epidermal myeloid cells that can migrate and mature into dendritic cells. Recipient LCs that survive cytotoxic therapy given in preparation for allogeneic hematopoietic cell transplantation may prime donor T cells to mediate cutaneous graft-versus-host disease (GVHD)....
journal_title:Transplantation
pub_type: 临床试验,杂志文章
doi:10.1097/TP.0000000000000097
更新日期:2014-09-15 00:00:00
abstract:BACKGROUND:The growing number of patients awaiting a kidney transplant raises questions about allocation of kidneys to the elderly and about the use of elderly donors. In all reported studies analyzing the influence of age on the outcome after renal transplantation, age is investigated as a categorical variable. METHO...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199902270-00015
更新日期:1999-02-27 00:00:00
abstract:BACKGROUND:Acute myeloid leukemia (AML) after solid organ transplantation is rare, with only six AML cases after liver transplantation (LT) being reported. METHODS:Characteristics of three AML cases observed among 799 recipients of LT in the authors' institution and estimation of the standardized incidence ratio (SIR)...
journal_title:Transplantation
pub_type: 杂志文章,评审
doi:10.1097/01.TP.0000102549.40531.13
更新日期:2004-01-27 00:00:00
abstract:BACKGROUND:Kidneys from older donors are likely to have a lower nephron mass. Nevertheless they constitute a valuable source of kidney allografts. Long cold ischemic time (CIT), with or without delayed graft function (DGF), has been associated with reduced graft survival. The aim of this study was to review the experie...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200108270-00020
更新日期:2001-08-27 00:00:00
abstract:OBJECTIVES:To retrospectively compare the accuracy of pretransplant panel of reactivity antibodies (PRA) and serum level of soluble CD30 (sCD30) in predicting early (< 6 months) acute rejection (AR) in living-donor and deceased-donor kidney-transplant (KT) patients. METHODS:Pretransplant sera of 24 KT recipients were ...
journal_title:Transplantation
pub_type: 杂志文章
doi:
更新日期:2005-03-15 00:00:00
abstract:BACKGROUND:It has been suggested that T cells primed by processed donor major histocompatibility complex antigen (the "indirect" pathway of allorecognition) may be responsible for mediating chronic allograft rejection. The purpose of this study was to develop a clinically useful assay to study the occurrence of indirec...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199709270-00001
更新日期:1997-09-27 00:00:00
abstract::Intestinal transplantation has become the treatment of choice for patients who are experiencing life-threatening complications of intestinal failure. Early attempts with intestinal transplantation were unsuccessful as a consequence of both technical and immunologic failures. The introduction of tacrolimus provided the...
journal_title:Transplantation
pub_type: 杂志文章,评审
doi:10.1097/01.tp.0000126931.23349.15
更新日期:2004-05-15 00:00:00
abstract:BACKGROUND:Previous studies have indicated that patients on maintenance hemodialysis have worse survival compared with kidney transplant (KTx) recipients. However, none of these studies have compared mortality of the US patients using alternative dialysis modalities such as home hemodialysis (HHD) with KTx recipients. ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000001005
更新日期:2016-10-01 00:00:00
abstract:BACKGROUND:The beneficial effects of glycemic control on both survival and function of transplanted kidneys in patients with type 1 diabetes mellitus (T1DM) and end-stage renal disease (ESRD) have been recognized. METHODS:Herein, we present the clinical outcome of a single-center pilot trial of islet after kidney (IAK...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e318166a27b
更新日期:2008-03-27 00:00:00
abstract:BACKGROUND:Epitopes are the sites to which antibodies bind. Both alpha and beta peptide chains of the human leukocyte antigen-DQ heterodimers (DQA1 and DQB1, respectively) contain polymorphic regions. We can identify DQA1 and DQB1 epitopes by DQ single antigen beads assay of the antibodies, correlating the beads' react...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3181804cd2
更新日期:2008-08-15 00:00:00
abstract:BACKGROUND:Identification of risk factors for BK virus (BKV) replication may improve transplant outcome. We investigated the impact of immunosuppressive drugs on the prevalence of BKV replication in recipients of human renal allografts. METHODS:One hundred twenty renal allograft recipients were studied prospectively a...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31817c6447
更新日期:2008-08-27 00:00:00
abstract::Graft and patient survival rates were analyzed in 239 consecutive first cadaver renal transplants as a function of time of administration of blood transfusion and the number of units given. There was no statistically significant difference in patient survival in comparing patients who were never transfused, patients n...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198012000-00008
更新日期:1980-12-01 00:00:00
abstract:INTRODUCTION:The purpose of the current study was to investigate the capacity of CD4+, CD8+, or non-T cells to independently initiate acute rejection of allogeneic hepatocytes using reconstituted SCID, CD4 or CD8 knockout (KO) recipient mice. METHODS:Allogeneic hepatocytes (FVB/N, H-2q) were transplanted into C57BL/6....
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200012270-00017
更新日期:2000-12-27 00:00:00
abstract:BACKGROUND:Recently the United Network for Organ Sharing (UNOS) began a pilot study to evaluate prospectively the merits of an allocation of cadaveric kidneys based on broader classes of HLA antigens, called cross-reactive groups (CREG). The objectives of the pilot study consider patient outcomes, but not the potential...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200008150-00024
更新日期:2000-08-15 00:00:00
abstract::A comparative study of 24 hr preservation at 4 degrees C of excised rat livers with Euro-Collins and hydroxyethyl starch-free University of Wisconsin (UWm) solutions has been conducted based on the assessment of (1) the cellular energy status determined by 31P NMR spectroscopy and (2) cellular injury estimated from th...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199210000-00006
更新日期:1992-10-01 00:00:00
abstract:BACKGROUND:Liver transplantation from donation after cardiac death (DCD) donors is an increasingly common approach for expansion of the donor organ supply. However, transplantation with DCD livers results in inferior graft survival. In this study, we examined donor and recipient characteristics that are associated with...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000250936.73034.98
更新日期:2006-12-27 00:00:00
abstract::Heart transplantation is considered nowadays the gold standard in the therapy of chronic and terminal heart insufficiency. Primary organ failure after heart transplantation is a severe complication generally related to prolonged ischemia time, poor quality of the organ, or acute rejection. All these factors can potent...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000233845.15508.89
更新日期:2006-10-27 00:00:00
abstract:BACKGROUND:Hemostatic complications are not uncommon after bone marrow transplantation (BMT). However, little is known about the frequency, localization, determinants, and outcome of hemostatic events in autologous and allogeneic BMT. METHODS:Four hundred forty-seven patients (364 allogeneic, 83 autologous transplants...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200211150-00018
更新日期:2002-11-15 00:00:00
abstract:BACKGROUND:Nephrotoxicity is a major side effect of calcineurin inhibitors (CNI). Earlier we reported 8% of our heart transplant recipients reaching end-stage renal failure (ESRF). Now, with an extended follow up of 20 years, we re-evaluated the development of ESRF and studied its influence on survival and the impact o...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000250360.78553.5e
更新日期:2006-12-27 00:00:00
abstract::The H-Y (male) antigen is detectable on 50% of eight-cell mouse embryos. We show that 82% of the offspring resulting from the transfer of (C57BL/6 X A/J)F1 embryos surviving treatment with H-Y antibody and complement to the uteruses of pseudopregnant mice are female. The increased ratio of female-to-male births indica...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198401000-00004
更新日期:1984-01-01 00:00:00
abstract::Use of pulsatile perfusion to optimize outcomes in deceased donor kidney transplantation remains controversial. This study is a retrospective analysis of all cadaveric renal allografts procured locally by our center over a 3-year period. Kidney pairs were identified in which one kidney underwent pulsatile perfusion an...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e318187b978
更新日期:2008-10-15 00:00:00
abstract::Calcium channel blockade has been shown to prevent warm renal ischemic damage. The ability of verapamil to decrease the severity of acute tubular necrosis (ATN) after 24-hr cold storage and autotransplantation was studied in a randomized paired study of 12 dogs. Experimental animals pretreated with intraarterial verap...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198709000-00006
更新日期:1987-09-01 00:00:00
abstract:BACKGROUND:Kidneys from infectious risk donors (IRD) confer substantial survival benefit in adults, yet the benefit of IRD kidneys to pediatric candidates remains unclear in the context of high waitlist prioritization. METHODS:Using 2010-2016 Scientific Registry of Transplant Recipients data, we studied 2417 pediatric...
journal_title:Transplantation
pub_type: 杂志文章,多中心研究
doi:10.1097/TP.0000000000002674
更新日期:2019-12-01 00:00:00
abstract:BACKGROUND:The spleen is considered to be an important secondary lymphoid organ where acute graft-versus-host disease (GVHD) is initiated by donor T cells that recognize host alloantigens after allogeneic bone-marrow transplantation (BMT). The influence of splenectomy on the development of GVHD prior to BMT has yet to ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200205270-00027
更新日期:2002-05-27 00:00:00
abstract:BACKGROUND:Avascular osteonecrosis (AVN) is a serious complication of allogeneic stem cell transplantation (SCT). Graft-versus-host disease and its treatment with steroids are the main risk factors; underlying diagnosis, age and gender are further risk factors. It has been speculated that low baseline bone mineral dens...
journal_title:Transplantation
pub_type: 临床试验,杂志文章
doi:10.1097/01.tp.0000164353.86447.db
更新日期:2005-06-27 00:00:00
abstract::Vascularized xenografts are rejected acutely and hyperacutely in concordant or discordant combinations, respectively. We investigated the impact of the donor-recipient combination on the rejection of arterial xenografts, analyzing the cellular and extracellular matricial compartments. Aortic xenografts were performed ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199609270-00017
更新日期:1996-09-27 00:00:00
abstract:BACKGROUND:Randomized controlled trials and U.S. Registry data have demonstrated that mycophenolate mofetil (MMF) reduces acute rejection rates and improves graft survival. We undertook the first paired kidney analysis comparing the effects of MMF and azathioprine on graft outcome in the United Kingdom. METHODS:In all...
journal_title:Transplantation
pub_type: 杂志文章,meta分析
doi:10.1097/01.tp.0000250713.65004.35
更新日期:2006-12-27 00:00:00