Evidence that cyclosporine prevents rejection and recurrent diabetes in pancreatic transplants in the BB rat.

abstract：BACKGROUND:Recipient antidonor cytotoxic T-cell activity has been associated with graft loss and acute rejection in renal allograft recipients. The role of immunologic mechanisms in the development of chronic graft rejection is controversial. We analyzed all living related renal transplants performed at Children's Hosp...

journal_title：Transplantation

authors： Alexander SI,Younes SB,Yunis JJ,Zurakowski D,Mirza N,Dubey D,Drew MP,Harmon WE,Yunis EJ

更新日期：1997-06-27 00:00:00

abstract：BACKGROUND:The National Marrow Donor Program (NMDP) has approximately 5 million registered potential donors and continues to add more than 30,000 new recruits to the registry monthly. However, more than 30% of potential donors are not available or decline to donate at key decision points in the donation process. Althou...

journal_title：Transplantation

authors： Myaskovsky L,Switzer GE,Dew MA,Goycoolea JM,Confer DL,Abress L

更新日期：2004-03-27 00:00:00

abstract：BACKGROUND:Imported pancreata accumulate cold ischemia time (CIT), limiting utilization and worsening outcomes. Flow cytometric crossmatching (FXM) is a standard method to assess recipient and donor compatibility, but can prolong CIT. Single-antigen bead assays allow for detection of recipient donor-specific HLA antibo...

journal_title：Transplantation

authors： Eby BC,Redfield RR,Ellis TM,Leverson GE,Schenian AR,Odorico JS

更新日期：2016-05-01 00:00:00

abstract：BACKGROUND:The novel agent sirolimus (SRL; Rapamune; rapamycin) inhibits the immune response by a mechanism distinct from those of calcineurin antagonists or antimetabolites. This randomized, controlled, multicenter, single blind, phase II trial examined the combination of SRL, steroids, and full versus reduced doses o...

journal_title：Transplantation

authors： Kahan BD,Julian BA,Pescovitz MD,Vanrenterghem Y,Neylan J

更新日期：1999-11-27 00:00:00

abstract：:The effect of cyclosporin A was tested in a heterotopic cardiac xenograft model, in which hamster hearts were implanted into LEW rats. Despite the presence of low titers of rat anti-hamster lymphocytotoxic antibodies immediate rejection of the hamster hearts did not occur, suggesting that this model represented a xeno...

journal_title：Transplantation

authors： Homan WP,Williams KA,Fabre JW,Millard PR,Morris PJ

更新日期：1981-03-01 00:00:00

abstract：:Four skin graft models are created which vary in the rates of lymphatic and vascular reconstitution. Rat allografts (Brown Norway or (L times BN)F1 hybrid) transplanted to Lewis recipients by conventional (immediate lymphatic, delayed vascular), surgical anastomosis (immediate lymphatic, immediate vascular) or isolate...

journal_title：Transplantation

authors： Wustrack KO,Gruber RP,Lucas ZJ

更新日期：1975-02-01 00:00:00

abstract：BACKGROUND:Infants (<12 months) who require liver transplantation (LTx) represent a particularly challenging and understudied group of patients. METHODS:This retrospective study aimed to describe a large single-center experience of infants who received isolated LTx, illustrate important differences in infants versus o...

journal_title：Transplantation

authors： Venick RS,Farmer DG,McDiarmid SV,Duffy JP,Gordon SA,Yersiz H,Hong JC,Vargas JH,Ament ME,Busuttil RW

更新日期：2010-03-15 00:00:00

abstract：BACKGROUND:In the present study we examined the effect of the timing of marrow infusion on engraftment in nonmyeloablatively conditioned mice. METHODS:B10 mice were conditioned with decreasing doses of total body irradiation (TBI) and reconstituted with bone marrow cells (BMCs) from major histocompatibility complex-di...

journal_title：Transplantation

authors： Xu H,Exner BG,Chilton PM,Tanner MK,Mueller YM,Rezzoug F,Ildstad ST

更新日期：2004-03-27 00:00:00

abstract：BACKGROUND:Solid organ xenograft rejection is associated with vascular injury resulting at least in part in platelet activation, and rejected xenografts invariably demonstrate intravascular thrombosis and interstitial hemorrhage. Complement activation plays a prominent role in platelet-endothelial interaction. We teste...

journal_title：Transplantation

authors： Brandl U,Jöckle H,Erhardt M,Michel S,Burdorf L,Brenner P,Bittmann I,Rössle M,Mordstein V,Hammer C,Thein E,Reichart B,Schmoeckel M

更新日期：2007-12-27 00:00:00

abstract：:Cyclosporine treatment of BALB/c mice (at a dose of 20 mg/kg every other day for 3 weeks) caused a remarkable reduction in the PNA-, L3T4+Lyt-2- subset of thymocytes. A significant reduction of the L3T4+Lyt-2-subset was also observed in both the lymph node and spleen cells of CsA-treated mice, though the degree of the...

journal_title：Transplantation

authors： Hiramine C,Hojo K,Matsumoto H,Koseto M,Itoh M

更新日期：1989-03-01 00:00:00

abstract：BACKGROUND:Currently, the severity of veno-occlusive disease (VOD) is graded retrospectively on the basis of the evolution of clinical and biological criteria. The objective of this study was to describe a noninvasive method capable of predicting the severity of this disease at the time of the diagnosis. METHODS:Seven...

journal_title：Transplantation

authors： Lassau N,Auperin A,Leclere J,Bennaceur A,Valteau-Couanet D,Hartmann O

更新日期：2002-07-15 00:00:00

abstract：BACKGROUND:The purpose of this study is to examine the effects of the coronavirus disease 2019 (COVID-19) pandemic on adult lung transplants and report practice changes in the United States. METHODS:A retrospective analysis of a public dataset from the United Network for Organ Sharing was performed regarding adult lun...

journal_title：Transplantation

authors： Chan EG,Chan PG,Harano T,Ryan JP,Morrell MR,Sanchez PG

更新日期：2021-01-01 00:00:00

abstract：:We have previously demonstrated that subclinical chronic rejection (CR) induces structural and functional alterations in enteric smooth muscle and nerves in a rat model of small intestinal transplantation. This study was designed to investigate the effect of prolonged FK506 rescue therapy on these sequelae of CR. Immu...

journal_title：Transplantation

authors： Heeckt PF,Lee KK,Halfter WM,Schraut WH,Bauer AJ

更新日期：1995-01-27 00:00:00

abstract：BACKGROUND:We previously reported that posttransplant lymphoproliferative disorders (PTLD) occurred more frequently in non-African American (AF) kidney transplant recipients. An in-depth analysis of racial differences in the development of PTLD has not been reported. METHODS:We assessed Medicare claims for PTLD in a r...

journal_title：Transplantation

authors： Nee R,Hurst FP,Dharnidharka VR,Jindal RM,Agodoa LY,Abbott KC

更新日期：2011-07-27 00:00:00

abstract：:In three patients with end-stage renal failure due to primary hyperoxaluria type 1, successful combined liver-kidney transplantation enabled us to assess the insoluble oxalate pool, which was compared with the histopathological changes observed in iliac crest biopsy specimens. Good correlation was observed between the...

journal_title：Transplantation

authors： Toussaint C,Vienne A,De Pauw L,Gelin M,Janssen F,Hall M,Schurmans T,Pasteels JL

更新日期：1995-06-27 00:00:00

abstract：BACKGROUND:To evaluate the long-term outcome of renal transplant patients with membranoproliferative glomerulonephritis (MPGN) type I and the impact of recurrence. METHODS:The outcomes of 68 renal transplants performed between 1976 and 2009 in 63 patients with MPGN were compared with those of 136 controls matched for ...

journal_title：Transplantation

authors： Moroni G,Casati C,Quaglini S,Gallelli B,Banfi G,Montagnino G,Messa P

更新日期：2011-06-15 00:00:00

abstract：:The intestinal phase of the graft-versus-host reaction (GVHR) has been investigated in adult F1 mice bearing grafts of fetal gut using an H-2-incompatible and an H-2-compatible, Mls-incompatible combination. The results indicate that the mitotic activity of the intestinal crypts and the number of intraepithelial lymph...

journal_title：Transplantation

authors： Mowat AM,Ferguson A

更新日期：1981-09-01 00:00:00

abstract：:The monoclonal antibodies (MoAb) CR11-351 and KS1 are secreted by hybridomas generated with splenocytes from BALB/c mice immunized with the cultured human B lymphoid cells LG-2 (HLA-A2,A2,B27,B27). The 2 monoclonal antibodies immunoprecipitated components with a superimposable 2-dimensional gel electrophoretic profile...

journal_title：Transplantation

authors： Tsujisaki M,Sakaguchi K,Igarashi M,Richiardi P,Perosa F,Ferrone S

更新日期：1988-03-01 00:00:00

abstract：:Single amino acid disparities in MHC class I molecules can elicit transplantation responses. Since beta 2 microglobulin (beta 2m) is noncovalently associated with class I antigens on the cell membrane we investigated whether the single amino acid polymorphism at position 85 (Asp-->Ala) in the mouse beta 2m molecule ca...

journal_title：Transplantation

authors： Hederer RA,Chandler PR,Dyson PJ,Antoniou AN,Millrain MM,Mellor AL,Simpson E,Robinson PJ

更新日期：1996-01-27 00:00:00

abstract：:High levels of tumor necrosis factor-alpha, interleukin-2, and gamma-interferon appeared in the circulation of kidney transplant recipients after the first injection of the monoclonal antibody OKT3. This initial injection was systematically followed by fever. The three cytokines were released in all patients (n = 9), ...

journal_title：Transplantation

authors： Abramowicz D,Schandene L,Goldman M,Crusiaux A,Vereerstraeten P,De Pauw L,Wybran J,Kinnaert P,Dupont E,Toussaint C

更新日期：1989-04-01 00:00:00

abstract：BACKGROUND:De novo donor HLA-specific (dnDSA) and non-HLA antibodies including antiangiotensin type 1 receptor antibodies (AT1R-abs) have been associated with antibody-mediated rejection (AMR) and decreased graft survival as well as cellular-mediated rejection (CMR) and early onset of microvasculopathy in heart transpl...

journal_title：Transplantation

authors： Reinsmoen NL,Lai CH,Mirocha J,Cao K,Ong G,Naim M,Wang Q,Haas M,Rafiei M,Czer L,Patel J,Kobashigawa J

更新日期：2014-03-15 00:00:00

abstract：:Temperature is a key parameter in organ preservation that has been consistently linked to primary nonfunction (PNF). In this communication, and for the first time anywhere, continued and direct measurements of human liver intraparenchymal temperatures are reported in six clinical cases of orthotopic liver transplantat...

journal_title：Transplantation

authors： Villa R,Fondevila C,Erill I,Guimerà A,Bombuy E,Gómez-Suárez C,Sacristán JC,García-Valdecasas JC

更新日期：2006-02-15 00:00:00

abstract：BACKGROUND:Waiting time to deceased donor kidney transplant varies greatly across the United States. This variation violates the final rule, a federal mandate, which demands geographic equity in organ allocation for transplantation. METHODS:Retrospective analysis of the United States Renal Data System and United Netwo...

journal_title：Transplantation

authors： Davis AE,Mehrotra S,McElroy LM,Friedewald JJ,Skaro AI,Lapin B,Kang R,Holl JL,Abecassis MM,Ladner DP

更新日期：2014-05-27 00:00:00

abstract：BACKGROUND:Diarrhea is a frequent complication of solid organ transplantation. Cryptosporidiosis is classically reported in patients with acquired immunodeficiency syndrome and emerged as a cause of persistent diarrhea in solid organ transplant patients. METHODS:Through the ANOFEL Cryptosporidium National Network and ...

journal_title：Transplantation

authors： Lanternier F,Amazzough K,Favennec L,Mamzer-Bruneel MF,Abdoul H,Tourret J,Decramer S,Zuber J,Scemla A,Legendre C,Lortholary O,Bougnoux ME,ANOFEL Cryptosporidium National Network and Transplant Cryptosporidium Study Group.

更新日期：2017-04-01 00:00:00

abstract：OBJECTIVE:The purpose of this study was to identify pretransplantation and posttransplantation indicators for the development of diabetes mellitus in the first 2 months after renal transplantation and to examine the influence of a cyclosporine A (CsA)-based versus a tacrolimus-based immunosuppressive regimen on these r...

journal_title：Transplantation

authors： Sato T,Inagaki A,Uchida K,Ueki T,Goto N,Matsuoka S,Katayama A,Haba T,Tominaga Y,Okajima Y,Ohta K,Suga H,Taguchi S,Kakiya S,Itatsu T,Kobayashi T,Nakao A

更新日期：2003-11-15 00:00:00

abstract：BACKGROUND:DBA/2J kidney allografts, but not heart allografts, are spontaneously accepted indefinitely in C57BL/6 (B6) mice, through regulatory tolerance mechanism dependent on Foxp3 cells. In contrast, B6 kidneys are rejected within a week in DBA/2J recipients. We hypothesized that the tolerogenic difference of the ki...

journal_title：Transplantation

authors： Oh NA,O'Shea T,Ndishabandi DK,Yuan Q,Hong S,Gans J,Ge J,Gibney S,Chase C,Yang C,Rosales I,Shinoda K,Drew B,Kojima L,Russell PS,Madsen JC,Colvin RB,Alessandrini A

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Lung transplant recipients are among those with the highest risk of influenza infection and complications each year. A few studies show adequate responses after influenza immunization; no studies examined the season-long protection. METHODS:Influenza antibody concentrations were measured using hemagglutinat...

journal_title：Transplantation

authors： Long AJ,Worzella SL,Moran JJ,Hayney MS

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND:Two side effects of irradiation are premature ovarian failure (POF) and osteoporosis, both of which are concerns not only clinically, for patients, but also experimentally, for animals. We examine whether bone marrow transplantation (BMT) can correct the POF induced by radiation and also address whether allo...

journal_title：Transplantation

authors： Feng W,Cui Y,Zhan H,Shi M,Cui W,Guo K,Li Q,Song C,Zhang Y,Mori T,Gershwin ME,Abraham NG,Ikehara S

更新日期：2010-02-27 00:00:00

abstract：BACKGROUND:Prophylactic administration of anti-HBs intravenous immunoglobulins (IVIg) in hepatitis B infected-liver transplant patients protects against acute rejection. To explore the suitability of intravenous immunoglobulins (IVIg) as prophylaxis of acute rejection and graft-versus-host disease (GVHD) after allograf...

journal_title：Transplantation

authors： Tha-In T,Metselaar HJ,Tilanus HW,Boor PP,Mancham S,Kuipers EJ,de Man RA,Kwekkeboom J

更新日期：2006-06-27 00:00:00

abstract：BACKGROUND:Postoperative damage of the urethral rhabdosphincter and nerve-vascular networks is a major complication of radical prostatectomy and generally causes incontinence and/or erectile dysfunction. The human skeletal muscle-derived stem cells, which have a synchronized reconstitution capacity of muscle-nerve-bloo...

journal_title：Transplantation

authors： Nakajima N,Tamaki T,Hirata M,Soeda S,Nitta M,Hoshi A,Terachi T

更新日期：2017-10-01 00:00:00