The association of donor center characteristics with attrition from the national marrow donor registry.

abstract：:A study was designed to determine if cold preservation induces an increase in lymphocyte adherence to liver sinusoids on reperfusion. Rat livers were stored at 1 degree C in University of Wisconsin solution for 45 min, 8 hr, or 30 hr, and then reperfused for 90 min at 37 degrees C in an isolated perfused rat liver app...

journal_title：Transplantation

authors： Clavien PA,Morgan GR,Sanabria JR,Petrunka C,Levy GA,Robert P,Harvey C,Strasberg SM

更新日期：1991-09-01 00:00:00

abstract：BACKGROUND:The incidence and impact of cytomegalovirus (CMV) disease that occurs despite CMV prophylaxis among liver transplant recipients have been incompletely defined. METHODS:The incidence and risk factors for CMV disease during the first posttransplant year in a cohort of liver transplant recipients who received ...

journal_title：Transplantation

authors： Limaye AP,Bakthavatsalam R,Kim HW,Kuhr CS,Halldorson JB,Healey PJ,Boeckh M

更新日期：2004-11-15 00:00:00

abstract：:Although cyclosporine has high specificity for the immune system, immunosuppressive therapy with CsA is often complicated by nephrotoxicity. The main morphologic targets of CsA nephrotoxicity include the tubular epithelial and endothelial cells. These cells were investigated in vitro. CsA caused a dose- and time-depen...

journal_title：Transplantation

authors： Ryffel B,Foxwell BM,Gee A,Greiner B,Woerly G,Mihatsch MJ

更新日期：1988-08-01 00:00:00

abstract：:Recent reports have demonstrated that humoral factors, especially antibodies elicited by xenoantigens, play an important role in the rejection of concordant cardiac xenografts. These induced antibodies, however, have not been well characterized. Therefore, we investigated the rejection mechanism, especially the role o...

journal_title：Transplantation

authors： Matsumiya G,Shirakura R,Miyagawa S,Izutani H,Sawa Y,Nakata S,Matsuda H

更新日期：1994-06-15 00:00:00

abstract：BACKGROUND:One of the main concerns after living donor liver transplantation is the risk of morbidity and/or mortality that it imposes on the donors. Respiratory postoperative complications in living liver donors have already been reported but their frequency seems to be underestimated. We designed a prospective study ...

journal_title：Transplantation

authors： Dondero F,Taillé C,Mal H,Sommacale D,Sauvanet A,Farges O,Francoz C,Durand F,Delefosse D,Denninger MH,Vilgrain V,Marrash-Chahla R,Fournier M,Belghiti J

更新日期：2006-01-27 00:00:00

abstract：BACKGROUND:A combined liver and kidney transplantation (CLKT) is advocated for selected individuals with chronic kidney disease undergoing liver transplantation (LT). The aim was to develop a risk score to identify the patients whose estimated glomerular filtration rate (eGFR) would decline during the year post-LT to a...

journal_title：Transplantation

authors： O'Riordan A,Donaldson N,Cairns H,Wendon J,O'Grady JG,Heaton N,Hendry BM

更新日期：2010-06-15 00:00:00

abstract：BACKGROUND:New-onset diabetes is common after kidney transplantation, but the benefit of lifestyle intervention to improve glucose metabolism posttransplantation is unproven. METHODS:We conducted a single-center, randomized controlled trial involving 130 nondiabetic kidney transplant recipients with stable function be...

journal_title：Transplantation

authors： Kuningas K,Driscoll J,Mair R,Smith H,Dutton M,Day E,Sharif AA

更新日期：2020-07-01 00:00:00

abstract：:We have previously demonstrated that subclinical chronic rejection (CR) induces structural and functional alterations in enteric smooth muscle and nerves in a rat model of small intestinal transplantation. This study was designed to investigate the effect of prolonged FK506 rescue therapy on these sequelae of CR. Immu...

journal_title：Transplantation

authors： Heeckt PF,Lee KK,Halfter WM,Schraut WH,Bauer AJ

更新日期：1995-01-27 00:00:00

abstract：:Of 213 renal allgraft recipients suspected to have had pulmonary tuberculosis, 132 had sputum examinations and 14 showed acid-fast bacilli. Of the remaining 118 patients, 25 had gastric aspirations, 18 had bronchoalveolar lavage, and 75 did not require further investigation because of spontaneous improvement or confir...

journal_title：Transplantation

authors： John GT,Juneja R,Mukundan U,Date A,Vincent L,Jacob CK,Shastry JC

更新日期：1996-03-27 00:00:00

abstract：:The number of patients awaiting hepatic transplantation continues to exceed organ donation. As a result, many liver transplant candidates will develop life-threatening complications of their liver disease and not survive the pretransplant waiting period. Recent studies have demonstrated that hepatic lidocaine metaboli...

journal_title：Transplantation

authors： Shiffman ML,Fisher RA,Sanyal AJ,Edinboro LE,Luketic VA,Purdum PP 3rd,Raymond P,Posner MP

更新日期：1993-04-01 00:00:00

abstract：:The humoral theory states that antibodies cause the rejection of allografts. From 1917 to 1929, extensive efforts were made to produce antibodies against tumors. It was finally realized that the antibodies were produced against the transplant antigens present on transplantable tumors, not against the tumor-specific an...

journal_title：Transplantation

authors： Terasaki PI

更新日期：2012-04-27 00:00:00

abstract：:Children who experience acute liver failure following liver transplantation will have multiple organ failure and a high rate of mortality unless emergency retransplantation can be performed. Transplant hepatectomy with portocaval shunting has been described as a bridge to transplantation in the most severe cases, as w...

journal_title：Transplantation

authors： Hammer GB,So SK,Al-Uzri A,Conley SB,Concepcion W,Cox KL,Berquist WE,Esquivel CO

更新日期：1996-07-15 00:00:00

abstract：BACKGROUND:Pneumocystis jiroveci pneumonia may be a life-threatening opportunistic infection in immunosuppressed solid organ transplant recipients. Despite effective treatment with high-dose trimethoprim-sulfamethoxazole and steroids, morbidity is often severe and lethality remains high. New therapeutic approaches are ...

journal_title：Transplantation

authors： Utili R,Durante-Mangoni E,Basilico C,Mattei A,Ragone E,Grossi P

更新日期：2007-09-27 00:00:00

abstract：BACKGROUND:Combined transplantation of the lungs and liver is indicated for patients who would not be expected to survive transplantation of either organ alone. No single center has accumulated a significant experience, and as a result the expectations for this operation in the current era are unknown. METHODS:Patient...

journal_title：Transplantation

authors： Barshes NR,DiBardino DJ,McKenzie ED,Lee TC,Stayer SA,Mallory GB,Karpen SJ,Quiros-Tejeira RE,Carter BA,Fraser CD Jr,Goss JA

更新日期：2005-11-15 00:00:00

abstract：:A quantitative absorption-blocking assay was used to measure the levels of antibody in immune rabbit sera that react with the serologically defined HLA molecular complex on the cell surface. Quantitation was determined by comparing the number of xenoantibody-treated cells with the number of untreated control cells nee...

journal_title：Transplantation

authors： Wilson LA,Gallaspy GT

更新日期：1978-07-01 00:00:00

abstract：:Adult male B6AF1 (H-2KIb/kDb/d) mice were given skin allografts from adult male C3H (H-2k) mice, with and without contralateral cotransplants. The cotransplants were of either adult or neonatal (less than 24 hr) C3H skin. In recipient mice treated peritransplantation with antilymphocyte serum and posttransplantation w...

journal_title：Transplantation

authors： Markees TG,De Fazio SR,Gozzo JJ

更新日期：1990-12-01 00:00:00

abstract：BACKGROUND:Goal tacrolimus concentrations for the prevention of rejection in sensitized renal transplant recipients are not well established. METHODS:We evaluated the association between discharge tacrolimus trough concentration and the incidence of biopsy-proven acute rejection (BPAR) in 216 moderately sensitized ren...

journal_title：Transplantation

authors： Richards KR,Hager D,Muth B,Astor BC,Kaufman D,Djamali A

更新日期：2014-05-27 00:00:00

abstract：BACKGROUND:Chronic lung disease and pulmonary failure are complications that can occur after bone marrow transplantation (BMT) and are associated with severe morbidity and mortality. METHODS:We report on four patients who developed chronic, progressive, and irreversible lung disease 1 to 3 years after allogeneic BMT i...

journal_title：Transplantation

authors： Heath JA,Kurland G,Spray TL,Kernan NA,Small TN,Brochstein JA,Gillio AP,Boklan J,O'Reilly RJ,Boulad F

更新日期：2001-12-27 00:00:00

abstract：BACKGROUND:Cold preservation is the most practical method to maintain the viability of isolated lungs. However, rapid cooling may affect pulmonary endothelial function. We examined the effects of microtubule stabilization with paclitaxel on pulmonary endothelial barrier integrity under cold temperature. METHODS:Human ...

journal_title：Transplantation

authors： Suzuki S,Bing H,Sugawara T,Matsuda Y,Tabata T,Hoshikawa Y,Saijo Y,Kondo T

更新日期：2004-08-27 00:00:00

abstract：:Despite major advances in immunopharmacology, virtually all patients receive the same center-specific immunosuppressive regimen following orthotopic liver transplantation (OLT). The present analysis was performed on the hypothesis that the original disease representing the indication for OLT leads to a different initi...

journal_title：Transplantation

authors： Berlakovich GA,Imhof M,Karner-Hanusch J,Gotzinger P,Gollackner B,Gnant M,Hanelt S,Laufer G,Muhlbacher F,Steininger R

更新日期：1996-02-27 00:00:00

abstract：BACKGROUND:Intracellular concentration of reactive oxygen species is held within tight physiological limits by enzymes with scavenging and repair functions. Under extreme conditions such as prolonged cold ischemia, these enzymes may be unable to adequately protect the organ, resulting in reperfusion injury that renders...

journal_title：Transplantation

authors： St Peter SD,Imber CJ,Jones DC,Fuggle SV,Watson CJ,Friend PJ,Marshall SE

更新日期：2002-09-27 00:00:00

abstract：BACKGROUND:Although islet xenotransplantation is a promising therapy for type 1 diabetes, its clinical application has been hampered by cellular rejection and the requirement for high levels of immunosuppression. The aim of this study was to determine the role of Foxp3 regulatory T (Treg) cells in costimulation blockad...

journal_title：Transplantation

authors： Wu J,Hu M,Qian YW,Hawthorne WJ,Burns H,Liuwantara D,Alexander SI,Yi S,O'Connell PJ

更新日期：2017-07-01 00:00:00

abstract：BACKGROUND:Apoptosis is a well-documented pathway for islet cell death. One potential mechanism is overexpression of death-promoting Bax compared with antiapoptotic Bcl-2 in islets. METHODS:We isolated islets from 10 human pancreata and measured the expression of Bax mRNA and Bcl-2 mRNA by real-time quantitative polym...

journal_title：Transplantation

authors： Thomas D,Yang H,Boffa DJ,Ding R,Sharma VK,Lagman M,Li B,Hering B,Mohanakumar T,Lakey J,Kapur S,Hancock WW,Suthanthiran M

更新日期：2002-12-15 00:00:00

abstract：:One major limitation in pancreatic islet transplantation is availability of donor tissue. Donor shortage is exacerbated by islet apoptosis from the stresses of islet isolation and transplantation. Furthermore, the side effects of immunosuppressive drugs preclude transplants into patients whose diabetes is controlled b...

journal_title：Transplantation

authors： Sutherland RM,Allison J,Thomas HE,Brady JL,Kay TW,Lew AM

更新日期：2004-05-27 00:00:00

abstract：BACKGROUND:The rate of acute rejection (AR) has decreased significantly, but whether this is associated with improvement in long-term graft survival is controversial. METHODS:We analyzed 1445 consecutive adult deceased donor kidney transplant recipients from 1985 to 2005, over two periods (1985-1995 vs. 1996-2005) to ...

journal_title：Transplantation

authors： Sola E,Gonzalez-Molina M,Cabello M,Burgos D,Ramos J,Gutierrez C,Lopez V,Soler J,de la Vega E,Hernandez D

更新日期：2010-03-27 00:00:00

abstract：BACKGROUND:Chronic renal allograft failure remains a major challenge to overcome. Factors such as donor quality, delayed graft function (DGF), acute rejection, and immunosuppression are known to affect long-term outcome, but their relationship to histological damage to graft outcome is unclear. METHODS:Protocol kidney...

journal_title：Transplantation

authors： Nankivell BJ,Fenton-Lee CA,Kuypers DR,Cheung E,Allen RD,O'Connell PJ,Chapman JR

更新日期：2001-02-27 00:00:00

abstract：OBJECTIVE:We compared the enzyme release from preserved and ex vivo reperfused livers after acute injury or inflammatory stimulus with organ function. METHODS:Acute injury was induced by carbon tetrachloride and inflammation was induced by turpentine oil treatments. Livers were exsanguinated and preserved for 8 or 24 ...

journal_title：Transplantation

authors： Gioli-Pereira L,Coradin K,Nagaoka MR,Borges DR,Kouyoumdjian M

更新日期：2002-10-27 00:00:00

abstract：:This study investigates the possibility that the active enhancing properties of bone marrow (BM) cells may be related to Ia-like determinants on their surface membranes. Less chromium was released on a cell per cell basis from nucleated baboon BM cells used as targets in complement-dependent cytotoxicity than from lab...

journal_title：Transplantation

authors： Smit JA,Myburgh JA,Gaillard VJ

更新日期：1978-08-01 00:00:00

abstract：BACKGROUND:Dendritic cells (DC) can exert powerful immune stimulatory as well as regulatory functions and are therefore important tools for therapeutic strategies. Dexamethasone (Dex) was previously shown to inhibit DC maturation and to induce regulatory properties both in vitro and in vivo. Here, we investigated the i...

journal_title：Transplantation

authors： Stax AM,Gelderman KA,Schlagwein N,Essers MC,Kamerling SW,Woltman AM,van Kooten C

更新日期：2008-11-15 00:00:00

abstract：:The success of kidney transplants is limited by the lack of robust improvements in long-term survival. It is now recognized that alloimmune responses are responsible for the majority of allograft failures. Development of novel therapies to decrease allosensitization is critical. The lack of new drug development in kid...

journal_title：Transplantation

authors： Jordan SC,Choi J,Kim I,Wu G,Toyoda M,Shin B,Vo A

更新日期：2017-01-01 00:00:00