Xenoantibody directed against molecular components of the HLA system. Quantitation of antibody to serologically defined HLA complexes on the cell surface.

abstract：BACKGROUND:Circulation of leukocytes via blood, tissue and lymph is integral to adaptive immunity. Afferent lymphatics form CCL21 gradients to guide dendritic cells and T cells to lymphatics and then to draining lymph nodes (dLN). Vascular endothelial growth factor C and vascular endothelial growth factor receptor 3 (V...

journal_title：Transplantation

authors： Iwami D,Brinkman CC,Bromberg JS

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND:Allogeneic bone marrow transplantation is under investigation for a range of nonmalignant indications, including tolerance induction through mixed chimerism. This strategy has so far been tested experimentally only in young recipients. Due to immunosenescence, older patients have an increase in memory T cell...

journal_title：Transplantation

authors： Hock K,Oberhuber R,Lee YL,Wrba F,Wekerle T,Tullius SG

更新日期：2013-06-27 00:00:00

abstract：:A murine monoclonal antihuman T cell antibody is described that is pan-T in that it reacts with all T cells, including those from thymus, but not with B cells or other cells, except for a small subpopulation of null cells. Biochemical analysis demonstrated that the antigen detected is a glycoprotein, Mr 50,000 daltons...

journal_title：Transplantation

authors： Thurlow PJ,Lovering E,d'Apice AJ,McKenzie IF

更新日期：1983-09-01 00:00:00

abstract：BACKGROUND:Infants (<12 months) who require liver transplantation (LTx) represent a particularly challenging and understudied group of patients. METHODS:This retrospective study aimed to describe a large single-center experience of infants who received isolated LTx, illustrate important differences in infants versus o...

journal_title：Transplantation

authors： Venick RS,Farmer DG,McDiarmid SV,Duffy JP,Gordon SA,Yersiz H,Hong JC,Vargas JH,Ament ME,Busuttil RW

更新日期：2010-03-15 00:00:00

abstract：BACKGROUND:Ischemia-reperfusion (I/R) injury after lung transplantation causes alveolar damage, lung edema, and acute rejection. Poly(adenosine diphosphate-ribose) polymerase (PARP) is a single-stranded DNA repair enzyme that induces apoptosis and necrosis after DNA damage caused by reactive oxygen species. We evaluate...

journal_title：Transplantation

authors： Hatachi G,Tsuchiya T,Miyazaki T,Matsumoto K,Yamasaki N,Okita N,Nanashima A,Higami Y,Nagayasu T

更新日期：2014-09-27 00:00:00

abstract：BACKGROUND:We investigated the hypothesis that Foxp3+ cells are an integral component of antiallograft immunity but are dominated by pathogenic effectors. METHODS:Wild-type H-2b C57BL/6 (B6) mice or B6 mice with a targeted disruption of c-Rel gene (c-Rel-/-) were used as recipients of islet grafts from allogeneic DBA/...

journal_title：Transplantation

authors： Yang H,Ding R,Sharma VK,Hilaire FS,Lagman M,Li B,Thomas DA,Luo X,Song P,Stauffer C,August P,Suthanthiran M

更新日期：2007-06-27 00:00:00

abstract：BACKGROUND:Umbilical cord blood transplantation (UCBT) is increasingly used and produces similar results to matched unrelated donor transplantation. METHODS:We performed a retrospective single-center analysis of 50 umbilical cord blood transplantations UCBTs performed from 2001 to 2010, including 37 single and 13 doub...

journal_title：Transplantation

authors： Berglund S,Le Blanc K,Remberger M,Gertow J,Uzunel M,Svenberg P,Winiarski J,Ljungman P,Ringdén O,Uhlin M,Mattsson J

更新日期：2012-11-27 00:00:00

abstract：:Because of the inherent difficulties in allele assignment with HLA-DR serological typing, in 1993 our organ procurement organization-based HLA laboratory replaced serology with the molecular method of polymerase chain reaction using sequence-specific primer mixes (PCR-SSP) to type for DR and DQ at a resolution level e...

journal_title：Transplantation

authors： Bryan CF,Harrell KM,Nelson PW,Pierce GE,Ross G,Shield CF 3rd,Warady BA,Aeder MI,Helling TS,Landreneau MD,Luger AM

更新日期：1996-12-27 00:00:00

abstract：BACKGROUND:We developed a nonviral gene transfer method using rapid injection of naked DNA targeting the liver and applied it in a rat model of liver transplantation. METHODS:Inbred Dark Agouti and Lewis rats were used. To test the efficacy and adverse effects of systemic or local (catheter-based) injection, different...

journal_title：Transplantation

authors： Inoue S,Hakamata Y,Kaneko M,Kobayashi E

更新日期：2004-04-15 00:00:00

abstract：BACKGROUND:We previously reported that no cytotoxic T-lymphocyte precursor frequencies (CTLpf) were found in 60% of patients on azathioprine or mycophenolate mofetil+Pred long after kidney transplantation. We questioned whether the absence of donor-specific CTLpf was associated with low levels of stimulatory Th1 (tumor...

journal_title：Transplantation

authors： van Besouw NM,de Kuiper R,van der Mast BJ,van de Wetering J,Baan CC,Weimar W

更新日期：2009-05-27 00:00:00

abstract：BACKGROUND:Both T and B cells have been shown to be implicated in the pathogenesis of bronchiolitis obliterans syndrome, which is considered to represent chronic lung allograft rejection. However, the relative contributions of T cells and alloantibodies in the pathogenesis of the disease are still unknown. In this stud...

journal_title：Transplantation

authors： Higuchi T,Jaramillo A,Kaleem Z,Patterson GA,Mohanakumar T

更新日期：2002-09-15 00:00:00

abstract：:Following liver transplantation bile formation may be influenced by hepatic denervation and cyclosporine therapy. To better establish any effect of liver transplantation on bile secretion, 6 mongrel dogs were studied: 3 underwent liver denervation by a modified autotransplantation procedure and insertion of a Thomas c...

journal_title：Transplantation

authors： Sutherland FR,Preshaw RM,Shaffer EA

更新日期：1993-02-01 00:00:00

abstract：BACKGROUND:The results of the transplantation of marginal donor kidneys remain controversial. This study aimed to investigate the impact of donor risk factors as predictors of kidney-graft outcome. METHODS:Allograft failure risk factors were studied in 7,209 cadaveric kidney-transplant recipients reporting to the Etab...

journal_title：Transplantation

authors： Pessione F,Cohen S,Durand D,Hourmant M,Kessler M,Legendre C,Mourad G,Noël C,Peraldi MN,Pouteil-Noble C,Tuppin P,Hiesse C

更新日期：2003-02-15 00:00:00

abstract：BACKGROUND:Gene targeting in large animals has the potential to be useful in medicine as well as in agriculture. Previously, we reported the first successful targeting of the bovine alpha1,3-galactosyltransferase (alpha1,3GT) gene and establishment of a heterozygous knockout cell line. In this report, we generated both...

journal_title：Transplantation

authors： Sendai Y,Sawada T,Urakawa M,Shinkai Y,Kubota K,Hoshi H,Aoyagi Y

更新日期：2006-03-15 00:00:00

abstract：BACKGROUND:The effect of height and sex on liver transplantation (LT) for hepatocellular carcinoma (HCC) remains unclear. METHODS:Using United Network for Organ Sharing (UNOS) data, 14 844 HCC patients listed for LT from 2005 to 2015 were identified. Cumulative incidence of waitlist events (LT and dropout for death or...

journal_title：Transplantation

authors： Lee E,Sarkar M,Dodge J,Kohi M,Mehta N

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND:Extracorporeal membrane oxygenation (ECMO) can be used to maintain oxygen delivery and provide hemodynamic support in case of circulatory and/or respiratory failure. Although the role of ECMO has emerged in the setting of adult liver transplantation (LT), data in children are limited. We aimed to describe th...

journal_title：Transplantation

authors： Ziogas IA,Johnson WR,Matsuoka LK,Rauf MA,Thurm C,Hall M,Bacchetta M,Godown J,Alexopoulos SP

更新日期：2020-08-13 00:00:00

abstract：:Significant extended survival of C3H/He skin grafts in antilymphocyte serum (ALS)-treated B6AF1 mice can be brought about by the injection of donor-strain bone marrow on day 6 or 7 after grafting. In the present study, survival of the active graft-prolonging bone marrow cells under several storage conditions was inves...

journal_title：Transplantation

authors： De Fazio SR,Hartner WC,Monaco AP,Gozzo JJ

更新日期：1986-01-01 00:00:00

abstract：:A technique for orthotopic bone transplantation in mice has been developed. A section of recipient tibia was removed and replaced by a similar section from the donor animal. The graft was held in place by internal fixation. Bone healing was assessed clinically, histologically, radiologically, and by torsion testing. T...

journal_title：Transplantation

authors： Halloran PF,Ziv I,Lee EH,Langer F,Pritzker KP,Gross AE

更新日期：1979-06-01 00:00:00

abstract：BACKGROUND:Patient-level risk factors for delayed graft function (DGF) have been well described. However, the Organ Procurement and Transplantation Network definition of DGF is based on dialysis in the first week, which is subject to center-level practice patterns. It remains unclear if there are center-level differenc...

journal_title：Transplantation

authors： Orandi BJ,James NT,Hall EC,Van Arendonk KJ,Garonzik-Wang JM,Gupta N,Montgomery RA,Desai NM,Segev DL

更新日期：2015-05-01 00:00:00

abstract：BACKGROUND:The first generic tacrolimus product gained Food and Drug Administration approval in August 2009. This prospective, observational trial sought to determine the need for dose titrations and measure drug cost savings on conversion to generic tacrolimus. METHODS:Transplant recipients on stable tacrolimus doses...

journal_title：Transplantation

authors： McDevitt-Potter LM,Sadaka B,Tichy EM,Rogers CC,Gabardi S

更新日期：2011-09-27 00:00:00

abstract：BACKGROUND:There is a lack of information about survival after dropout from the liver transplant waiting list. Therefore, we aimed to assess the overall survival, and risk factors for death, after waiting list dropout due to hepatocellular carcinoma (HCC) progression. METHODS:We assessed patients who dropped out of th...

journal_title：Transplantation

authors： Gorgen A,Rosales R,Sadler E,Beecroft R,Knox J,Dawson LA,Ghanekar A,Grant D,Greig PD,Sapisochin G

更新日期：2019-10-01 00:00:00

abstract：:Beta cell replacement has the potential to restore euglycemia in patients with insulin-dependent diabetes. Although great progress has been made in establishing allogeneic islet transplantation from deceased donors as the standard of care for those with the most labile diabetes, it is also clear that the deceased dono...

journal_title：Transplantation

authors： Odorico J,Markmann J,Melton D,Greenstein J,Hwa A,Nostro C,Rezania A,Oberholzer J,Pipeleers D,Yang L,Cowan C,Huangfu D,Egli D,Ben-David U,Vallier L,Grey ST,Tang Q,Roep B,Ricordi C,Naji A,Orlando G,Anderson DG,P

更新日期：2018-08-01 00:00:00

abstract：:We report the observation that the major sources of variation in cadaver renal allograft survival rates are not related to the technique of donor organ preservation but are related solely to other factors including pretransplant blood transfusion of the recipient, antilymphocyte serum (ALS) treatment of the recipient,...

journal_title：Transplantation

authors： Vaughn WK,Mendez-Picon G,Humphries AL,Spees EK

更新日期：1981-12-01 00:00:00

abstract：BACKGROUND:Immunosuppressive drugs that target T cells are useful for prolonging allograft survival. The anti-CD3 immunotoxin FN18-CRM9 has been shown to effectively prolong renal allograft survival in a rhesus monkey model of transplantation. However, immunotoxin-treated monkeys showed increased levels of inflammatory...

journal_title：Transplantation

authors： Hamawy MM,Tsuchida M,Manthei ER,Dong Y,Fechner JE,Knechtle JS

更新日期：1999-09-15 00:00:00

abstract：:We studied major histocompatibility complex (MHC) and cytokine mRNA induction after renal injury in the absence of interferon-gamma (IFN-gamma) using IFN-gamma gene knockout (GKO) mice. The left renal pedicle of normal (wild-type) and GKO BALB/c mice was clamped for 60 minutes; cytokine and MHC mRNA expression were mo...

journal_title：Transplantation

authors： Goes N,Urmson J,Vincent D,Halloran PF

更新日期：1995-12-27 00:00:00

abstract：:The aim of this study was to investigate excretion of urinary and pancreatic juice neopterin in patients after combined pancreas-kidney transplantation and to relate it to the clinical course. The study design was a prospective observation study. Thirty consecutive patients with end-stage diabetic disease received a s...

journal_title：Transplantation

authors： Tilg H,Königsrainer A,Krausler R,Aulitzky WE,Margreiter R,Reibnegger G,Wachter H,Huber C

更新日期：1992-04-01 00:00:00

abstract：:The addition of prostaglandin to the single-flush technique of lung preservation is considered to enhance subsequent graft function. We have evaluated the use of the prostacyclin analog, Iloprost, in an animal model of unilateral lung transplantation. Group 1 (n = 5) received Iloprost as a pretreatment intravenously (...

journal_title：Transplantation

authors： Hooper TL,Fetherston GJ,Flecknell PA,Dark JH,McGregor CG

更新日期：1990-03-01 00:00:00

abstract：BACKGROUND:Composite tissue allotransplantation (CTA) is a recently introduced option for limb replacement and reconstruction of other nonreconstructible tissue defects. As with recipients of other allotransplants, CTA recipients can experience rejection episodes that are presumed to be mediated by immune mechanisms si...

journal_title：Transplantation

authors： Cendales LC,Kirk AD,Moresi JM,Ruiz P,Kleiner DE

更新日期：2005-12-27 00:00:00

abstract：BACKGROUND:Patients with pretransplantation strong donor-specific anti-human leukocyte antigen (HLA) antibodies (DSA) are at higher risk for rejection. We aimed to study the safety of kidney transplantation in patients with lower strength DSAs in a prospective cohort study. METHODS:Three hundred and seventy-three cons...

journal_title：Transplantation

authors： Marfo K,Ajaimy M,Colovai A,Kayler L,Greenstein S,Lubetzky M,Gupta A,Kamal L,de Boccardo G,Masiakos P,Kinkhabwala M,Akalin E

更新日期：2014-11-27 00:00:00

abstract：:To elucidate the time course of glomerular and arterial endothelial injury resulting from pulsatile perfusion preservation of human kidneys, we examined two kidneys, one at 16 and the other at 42 hr, for which no suitable recipient could be found. The scanning electron microscope revealed subtle changes at 16 hr in th...

journal_title：Transplantation

authors： Gattone VH 2nd,Filo RS,Evan AP,Leapman SB,Smith EJ,Luft FC

更新日期：1985-04-01 00:00:00