Orthotopic bone transplantation in mice. I. Technique and assessment of healing.

abstract：:Liver transplantation is currently the only established treatment of end-stage liver disease, but it is limited by a severe shortage of viable donor livers. Donors after cardiac death (DCD) are an untapped source that could significantly increase the pool of available livers. Preservation of these DCD livers by conven...

journal_title：Transplantation

authors： Tolboom H,Pouw RE,Izamis ML,Milwid JM,Sharma N,Soto-Gutierrez A,Nahmias Y,Uygun K,Berthiaume F,Yarmush ML

更新日期：2009-01-27 00:00:00

abstract：BACKGROUND:Histologic evaluation of small bowel allograft biopsies is important for the diagnosis of acute rejection. However, a standard histologic schema to grade the severity of intestinal acute rejection is not currently available. The primary goal of this study was to develop a histologic grading system for the di...

journal_title：Transplantation

authors： Wu T,Abu-Elmagd K,Bond G,Nalesnik MA,Randhawa P,Demetris AJ

更新日期：2003-04-27 00:00:00

abstract：BACKGROUND:Graft-versus-host disease (GVHD) is a major complication after bone marrow transplantation, which may be refractory to immunosuppressive drugs. As preliminary case reports suggested that extracorporeal photochemotherapy (ECP) using a Therakos device might be beneficial, we conducted a pilot study to assess t...

journal_title：Transplantation

authors： Besnier DP,Chabannes D,Mahé B,Mussini JM,Baranger TA,Muller JY,Milpied N,Esnault VL

更新日期：1997-07-15 00:00:00

abstract：:Antihuman lymphocyte rabbit (or horse) gamma globulins used in recipients of organ transplantation are prepared against thymocytes or immortalized cell lines, the only two sources so far allowing enough antigen preparation. These cells lack, however, the surface determinants characteristic of alloreactive blasts invol...

journal_title：Transplantation

authors： Bonneville M,Carcagne J,Vie H,Moreau JF,Chevalier S,Latour M,Carosella E,Soulillou JP

更新日期：1989-08-01 00:00:00

abstract：:Pregnancy in inbred mice is associated with long-term accceptance of H-Y-incompatible skin grafts (in some "rejector" strain females) and with the formation of cytotoxic and agglutinating H-Y antibodies (in females generally). Yet there is no evident correlation between the two phenomena; postpartum females of nonreje...

journal_title：Transplantation

authors： Krupen-Brown K,Wachtel SS

更新日期：1979-06-01 00:00:00

abstract：BACKGROUND:Human cytomegalovirus (CMV) uses different strategies to escape from human host defense reactions. Previously we have observed that infection of endothelial cells with CMV in vitro leads to enhanced activity of endothelial ectonucleotidases. These ectoenzymes are responsible for hydrolysis of extracellular a...

journal_title：Transplantation

authors： Zandberg M,van Son WJ,Harmsen MC,Bakker WW

更新日期：2007-11-27 00:00:00

abstract：:Cytomegalovirus remains a significant source of morbidity and mortality in immunocompromised hosts. The increased sensitivity of molecular diagnostic techniques (PCR, antigenemia) has resulted in our ability to detect viral replication earlier in the posttransplant period, before the onset of symptoms. With the advent...

journal_title：Transplantation

authors： Abecassis MM,Koffron AJ,Kaplan B,Buckingham M,Muldoon JP,Cribbins AJ,Kaufman DB,Fryer JP,Stuart J,Stuart FP

更新日期：1997-01-27 00:00:00

abstract：BACKGROUND:Preexisting IgG antibodies to donor human leukocyte antigens (HLA) are a risk factor for rapid allograft rejection. However, non-HLA antibodies, of the IgM class, also called autoreactive antibodies, are not believed to affect graft survival. The aim of this study was to determine the incidence and clinical ...

journal_title：Transplantation

authors： Smith JD,Hamour IM,Burke MM,Mahesh B,Stanford RE,Haj-Yahia S,Robinson DR,Kaul P,Yacoub MH,Banner NR,Rose ML

更新日期：2009-03-27 00:00:00

abstract：BACKGROUND:This study is designed to examine a possible association of cardiopulmonary bypass (CPB) support and outcome of lung transplantation in a well-balanced group of emphysema patients. METHODS:We performed a retrospective analysis of 62 consecutive primary bilateral lung transplantations for emphysema. Risk fac...

journal_title：Transplantation

authors： de Boer WJ,Hepkema BG,Loef BG,van der Bij W,Verschuuren EA,de Vries HJ,Lems SP,Ebels T

更新日期：2002-05-27 00:00:00

abstract：:Genetic manipulation of pancreatic islets before transplantation has the potential to alter cellular immunity as well as islet function. The purpose of this study was to examine the feasibility of gene transfer to islets, using replication-defective adenoviral vectors. Newborn mouse islets were infected with AdHCMVsp1...

journal_title：Transplantation

authors： Csete ME,Benhamou PY,Drazan KE,Wu L,McIntee DF,Afra R,Mullen Y,Busuttil RW,Shaked A

更新日期：1995-01-27 00:00:00

abstract：:To investigate the causes of impaired liver function (LF)* after BMT, 88 patients were included for analysis of hepatitis B virus (HBV) and hepatitis C virus (HCV) infections, transplant methods, preconditioning regimens, and graft-versus-host disease (GVHD). Fifty of them (56.8%) developed abnormal LF after BMT and a...

journal_title：Transplantation

authors： Chen PM,Liu JH,Fan FS,Hsieh RK,Wei CH,Liu RS,Tzeng CH

更新日期：1995-04-27 00:00:00

abstract：BACKGROUND:Connective tissue growth factor (CTGF) is a key mediator of tissue fibrogenesis in kidney disease. Its involvement in renal allograft fibrosis was recently demonstrated in a mouse model. METHODS:We prospectively studied the association between urinary CTGF (CTGFu) levels and renal allograft fibrosis during ...

journal_title：Transplantation

authors： Metalidis C,van Vuuren SH,Broekhuizen R,Lerut E,Naesens M,Bakker SJ,Wetzels JF,Goldschmeding R,Kuypers DR

更新日期：2013-09-15 00:00:00

abstract：BACKGROUND:Recent evidence has suggested that inconsistencies in human-islet yields after collagenase digestion are attributed to the activation of endogenous enzymes of the cadaveric donor pancreas. Inhibition of protease activity by Pefabloc (0.4 mM; Roche Biochemicals Inc., Indianapolis, IN) has recently been shown ...

journal_title：Transplantation

authors： Rose NL,Palcic MM,Helms LM,Lakey JR

更新日期：2003-02-27 00:00:00

abstract：BACKGROUND:Registry databases offer the statistical power to analyze differences in graft survival rates that may not be detected in randomized clinical trials. This study analyses 2-year graft survival using tacrolimus (tac) or cyclosporine (CsA) with mycophenolate mofetil (MMF) and steroids. METHODS:Data reported to...

journal_title：Transplantation

authors： Bunnapradist S,Daswani A,Takemoto SK

更新日期：2003-07-15 00:00:00

abstract：:The United Network for Organ Sharing is poised to resolve geographic disparity in liver transplantation and promote allocation based on medical urgency. At the time of writing, United Network for Organ Sharing is considering redistricting the organ procurement and transplantation network so that patient model for end-...

journal_title：Transplantation

authors： Mehrotra S,Kilambi V,Gilroy R,Ladner DP,Klintmalm GB,Kaplan B

更新日期：2015-02-01 00:00:00

abstract：BACKGROUND:Post-lung transplant infection is one of the leading causes of morbidity and mortality. The cause and incidence are similar in many series; however, infections such as Mycobacterium tuberculosis are influenced by the epidemiologic situation. The authors present a prospective and observational study to define...

journal_title：Transplantation

authors： Bravo C,Roldán J,Roman A,Degracia J,Majo J,Guerra J,Monforte V,Vidal R,Morell F

更新日期：2005-01-15 00:00:00

abstract：BACKGROUND:Deoxyspergualin (DSG), a potent immunosuppressive drug, has been clinically used as a rescue therapy for acute graft rejection. However, DSG has severe adverse effects that limits its use. Here, we examined the optimized therapeutic protocol for DSG using chronopharmacological profiles of it. METHODS:First,...

journal_title：Transplantation

authors： Uchida H,Kobayashi E,Matsuda K,Mizuta K,Sugimoto K,Kawarasaki H,Hashizume K,Fujimura A

更新日期：1999-05-15 00:00:00

abstract：:MHC expression on endothelial cells after cytomegalovirus infection was investigated using double antibody radioimmunoassays and immunofluorescence flow cytometry. After CMV infection there was an increase in class I and beta 2 microglobulin expression. This increase corresponds to the percentage of cells that are inf...

journal_title：Transplantation

authors： van Dorp WT,Jonges E,Bruggeman CA,Daha MR,van Es LA,van Der Woude FJ

更新日期：1989-09-01 00:00:00

abstract：:To examine whether cyclosporine (CsA) has mutagenic potential against human cells, we analyzed sister chromatid exchange (SCE) induction by CsA using human lymphocytes in vitro. SCE frequencies increased significantly in the lymphocytes treated with 1 microgram/ml and 5 micrograms/ml CsA, though the frequencies seemed...

journal_title：Transplantation

authors： Yuzawa K,Kondo I,Fukao K,Iwasaki Y,Hamaguchi H

更新日期：1986-07-01 00:00:00

abstract：BACKGROUND:The incidence of stroke and risk factors for different subtypes of cerebrovascular (CBV) events in renal transplant recipients have not been examined in any large prospective controlled trial. METHODS:The Assessment of Lescol in Renal Transplantation was a randomized, double-blind, placebo-controlled study ...

journal_title：Transplantation

authors： Abedini S,Holme I,Fellström B,Jardine A,Cole E,Maes B,Holdaas H,ALERT Study Group.

更新日期：2009-01-15 00:00:00

abstract：:In a canine model of acute ischemic lung injury, a hypertonic citrate solution (HTC) widely used for renal preservation in the United Kingdom, was compared with modified Euro-Collins' solution (ECS) currently the most widely clinically used pulmonary perfusate. Ten beagle dogs underwent left thoracotomy and exclusion ...

journal_title：Transplantation

authors： Hooper TL,Jones MT,Thomson DS,Cook L,Owen S,Wilkes S,Woodcock A,Webster AH,Hasleton P,McGregor CG

更新日期：1991-05-01 00:00:00

abstract：BACKGROUND:To identify factors related with successful pregnancy in renal transplant recipients and the effect of pregnancy on long-term graft outcome. METHODS:The study group consisted of 48 women who conceived after undergoing renal transplantation (total pregnancies 74). The control group consisted of 187 nonpregna...

journal_title：Transplantation

authors： Kim HW,Seok HJ,Kim TH,Han DJ,Yang WS,Park SK

更新日期：2008-05-27 00:00:00

abstract：INTRODUCTION:We investigated the putative candidate biomarkers of graft rejection in peripheral blood of intestinal transplant patients. MATERIALS AND METHODS:Peripheral blood gene expression analysis was performed in intestinal transplant patients. The results were matched with concurrent graft biopsies using bioinfo...

journal_title：Transplantation

authors： Andreev VP,Tryphonopoulos P,Blomberg BB,Tsinoremas N,Weppler D,Neuman DR,Volsky A,Nishida S,Tekin A,Selvaggi G,Levi DM,Tzakis AG,Ruiz P

更新日期：2011-12-27 00:00:00

abstract：:Preventing hyperacute rejection (HAR) is a difficult and unsolved problem in xenotransplantation. This may be due, in part, to a lack of therapies that can suppress production of natural antibodies (NA), which are thought to be critical mediators of HAR. This study examined the effect of 15-deoxyspergualin (DSPG) and ...

journal_title：Transplantation

authors： Leventhal JR,Flores HC,Gruber SA,Figueroa J,Platt JL,Manivel JC,Bach FH,Matas AJ,Bolman RM 3rd

更新日期：1992-07-01 00:00:00

abstract：BACKGROUND:Innate immunity plays a role in controlling adaptive immune responses. METHODS:We investigated the clinical relevance of single nucleotide polymorphisms in 22 genes encoding innate, secreted, and signaling pattern recognition receptors in a total of 520 donor-recipient pairs of postmortem, human leukocyte a...

journal_title：Transplantation

authors： Eikmans M,de Canck I,van der Pol P,Baan CC,Haasnoot GW,Mallat MJ,Vergunst M,de Meester E,Roodnat JI,Anholts JD,van Thielen M,Doxiadis II,de Fijter JW,van der Linden PJ,van Beelen E,van Kooten C,Kal-van Gestel JA,Peeters

更新日期：2012-09-15 00:00:00

abstract：BACKGROUND:In an effort to define reliable assays that might predict postimmunosuppressant-withdrawal development of chronic rejection (CR), despite conditioning for tolerance induction, we evaluated various immunological responses in nonhuman primate renal allograft recipients. METHODS:Fourteen Cynomolgus monkeys rec...

journal_title：Transplantation

authors： Boskovic S,Kawai T,Smith RN,Wee SL,Nadazdin O,Koyama I,Saidman S,Cardarelli F,Elias N,Sykes M,Strom T,Colvin RB,Sachs DH,Cosimi AB

更新日期：2006-09-27 00:00:00

abstract：BACKGROUND:Recipients of simultaneous kidney-pancreas transplantation receive a combination of polyclonal antithymocyte globulin (ATG), cyclosporin or tacrolimus, mycophenolate mofetil (MMF) and corticosteroids (Cs). To avoid the side effects and adverse events associated with Cs, we investigated a new immunosuppressiv...

journal_title：Transplantation

authors： Cantarovich D,Giral-Classe M,Hourmant M,Dantal J,Blancho G,Karam G,Soulillou JP

更新日期：2000-04-15 00:00:00

abstract：BACKGROUND:Kidneys from older donors are likely to have a lower nephron mass. Nevertheless they constitute a valuable source of kidney allografts. Long cold ischemic time (CIT), with or without delayed graft function (DGF), has been associated with reduced graft survival. The aim of this study was to review the experie...

journal_title：Transplantation

authors： Asderakis A,Dyer P,Augustine T,Worthington J,Campbell B,Johnson RW

更新日期：2001-08-27 00:00:00

abstract：BACKGROUND:In patients with cytomegalovirus (CMV) disease, regular monitoring of viral loads and treatment until negative are recommended. However, with more sensitive polymerase chain reaction (PCR) assays and cellular peripheral sample types, detection of low-level viremia is achievable. We compared a whole blood rea...

journal_title：Transplantation

authors： Lisboa LF,Asberg A,Kumar D,Pang X,Hartmann A,Preiksaitis JK,Pescovitz MD,Rollag H,Jardine AG,Humar A

更新日期：2011-01-27 00:00:00

abstract：:Little is known of the host immune mechanisms responsible for initiation and progression of chronic rejection. We describe immunopathologic features associated with progressively deteriorating function of kidney allografts in the F344-to-Lewis rat strain combination, which differ at MHC and non-MHC loci. Initial rejec...

journal_title：Transplantation

authors： Hancock WH,Whitley WD,Tullius SG,Heemann UW,Wasowska B,Baldwin WM 3rd,Tilney NL

更新日期：1993-09-01 00:00:00