Recovery of warm ischemic rat liver grafts by normothermic extracorporeal perfusion.

abstract：BACKGROUND:Calcineurin inhibitor (CI)-based immunosuppression has prolonged the survival of heart transplant recipients. However, CI-induced renal injury remains as a major problem in these patients. Sirolimus is an immunosuppressant with no significant impact on renal function. A limited number of recent papers have s...

journal_title：Transplantation

authors： Bestetti R,Theodoropoulos TA,Burdmann EA,Filho MA,Cordeiro JA,Villafanha D

更新日期：2006-03-15 00:00:00

abstract：BACKGROUND:Infectious diseases are a major source of morbidity and mortality for immunosuppressed transplant recipients and the antimicrobial chemotherapy can be often less effective in these individuals, because the contribution of underlying host defenses is absent. METHODS:The influence of co-amoxiclav on the funct...

journal_title：Transplantation

authors： Cuffini AM,Tullio V,Giacchino F,Bonino A,Mandras N,Bianchi N,Roana J,Scalas D,Bonello F,Carlone NA

更新日期：2001-02-27 00:00:00

abstract：:Hepatic tolerance to hypotension was assessed by changes in arterial ketone body ratio (KBR) and hepatic energy charge levels in experimental brain death induced by epidural ballooning in dogs, and compared with the hemorrhagic shock model. Systolic arterial blood pressure was significantly decreased from 182 mmHg to ...

journal_title：Transplantation

authors： Lin H,Okamoto R,Yamamoto Y,Maki A,Ueda J,Tokunaga Y,Yamamoto S,Mori K,Tanaka K,Yamaoka Y

更新日期：1989-03-01 00:00:00

abstract：:Frozen sections of lymph nodes from normal mice were examined by immunofluorescence with anti-T lymphocyte and anti-Ig reagents and by autoradiography following [3H]TdR administration. The scattered T lymphocytes present among B lymphocytes of primary follicles were found to be mostly nonproliferating; the few prolife...

journal_title：Transplantation

authors： Berman MA,Rafiei S,Gutman GA

更新日期：1981-11-01 00:00:00

abstract：:Since 1989, the U.S. Food and Drug Administration (FDA) has encouraged the study of new drug and therapeutic products in elderly patients. However, despite the aging population in the United States, elderly patients continue to be underrepresented in clinical trials across a variety of therapeutic areas, including tra...

journal_title：Transplantation

authors： Meyer JM,Archdeacon P,Albrecht R

更新日期：2013-04-15 00:00:00

abstract：BACKGROUND:In a recent trial, targeted mild hypothermia in brain-dead organ donors significantly reduced the incidence of delayed graft function after kidney transplantation. This trial was stopped early for efficacy. Here, we report long-term graft survival for all organs along with donor critical care end points. ME...

journal_title：Transplantation

authors： Malinoski D,Patel MS,Axelrod DA,Broglio K,Lewis RJ,Groat T,Niemann CU

更新日期：2019-11-01 00:00:00

abstract：BACKGROUND:The polymorphic family of killer-cell immunoglobulin-like receptors (KIRs) consists of activating and inhibitory receptors expressed by natural killer (NK) cells and effector T cells that recognize human leukocyte antigen (HLA) class I ligands. It has been suggested that KIR/HLA incompatibility exerts benefi...

journal_title：Transplantation

authors： Kunert K,Seiler M,Mashreghi MF,Klippert K,Schönemann C,Neumann K,Pratschke J,Reinke P,Volk HD,Kotsch K

更新日期：2007-12-15 00:00:00

abstract：:A study was designed to determine if cold preservation induces an increase in lymphocyte adherence to liver sinusoids on reperfusion. Rat livers were stored at 1 degree C in University of Wisconsin solution for 45 min, 8 hr, or 30 hr, and then reperfused for 90 min at 37 degrees C in an isolated perfused rat liver app...

journal_title：Transplantation

authors： Clavien PA,Morgan GR,Sanabria JR,Petrunka C,Levy GA,Robert P,Harvey C,Strasberg SM

更新日期：1991-09-01 00:00:00

abstract：BACKGROUND:Human herpesvirus 6 (HHV-6) is susceptible to latency and reactivation in hematopoietic stem cell transplant (HSCT) recipients. We investigated the incidence of HHV-6 DNAemia and factors related to HHV-6 DNAemia and death after allogeneic stem cell transplantations. We also explored the relationship between ...

journal_title：Transplantation

authors： Jeulin H,Agrinier N,Guery M,Salmon A,Clément L,Bordigoni P,Venard V

更新日期：2013-05-27 00:00:00

abstract：BACKGROUND:Cidofovir (CDV) is a nucleotide analogue with proven in vitro effects against cytomegalovirus (CMV) and adenovirus and has been successfully used in the treatment of CMV retinitis in AIDS patients. METHODS:We performed a prospective study to evaluate the efficacy of CDV in 17 patients with hematological mal...

journal_title：Transplantation

authors： Platzbecker U,Bandt D,Thiede C,Helwig A,Freiberg-Richter J,Schuler U,Plettig R,Geissler G,Rethwilm A,Ehninger G,Bornhäuser M

更新日期：2001-04-15 00:00:00

abstract：BACKGROUND:Natural antibodies that react with galactose-alpha(1,3)galactose [galalpha(1,3)gal] carbohydrate epitopes exist in humans and Old World primates because of the inactivation of the alpha1,3-galactosyltransferase (alpha1,3GT) gene in these species and the subsequent production of antibodies to environmental mi...

journal_title：Transplantation

authors： Nozawa S,Xing PX,Wu GD,Gochi E,Kearns-Jonker M,Swensson J,Starnes VA,Sandrin MS,McKenzie IF,Cramer DV

更新日期：2001-07-15 00:00:00

abstract：:Increased blood loss is a major contributory factor to postoperative short- and longterm outcome in orthotopic liver transplantation (OLT). Hyperfibrinolysis, occurring mainly in the anhepatic phase, and disseminated intravascular coagulation (DIC), starting immediately after reperfusion, have been observed to paralle...

journal_title：Transplantation

authors： Himmelreich G,Hundt K,Neuhaus P,Roissant R,Riess H

更新日期：1992-03-01 00:00:00

abstract：:Active regulation or suppression of donor reactive cells is emerging as a key mechanism for inducing and maintaining unresponsiveness to donor alloantigens. Accumulating evidence suggests that a balance between immunoregulation and deletion of donor alloantigen reactive T cells can provide effective control of immune ...

journal_title：Transplantation

authors： Wood KJ,Luo S,Akl A

更新日期：2004-01-15 00:00:00

abstract：:Humoral or antibody-mediated rejection in cardiac transplant recipients is mediated by donor-specific cytotoxic antibodies and is histologically defined by linear deposits of immunoglobulin and complement in the myocardial capillaries. Antibody-mediated rejection often is accompanied by hemodynamic compromise and is a...

journal_title：Transplantation

authors： Aranda JM Jr,Scornik JC,Normann SJ,Lottenberg R,Schofield RS,Pauly DF,Miles M,Hill JA,Sleasman JW,Skoda-Smith S

更新日期：2002-03-27 00:00:00

abstract：:In liver allograft rejection, interlobular bile ducts are thought to be the main target of rejection. In contrast, in other organ allografts the capillary bed of the graft appears to be the primary target. To determine whether portal tract microvasculature is destroyed in liver allografts during rejection, we have ide...

journal_title：Transplantation

authors： Matsumoto Y,McCaughan GW,Painter DM,Bishop GA

更新日期：1993-07-01 00:00:00

abstract：BACKGROUND:In France, the need for continuous monitoring of transplant center performance has recently become apparent. Cumulative sum (CUSUM) monitoring of transplantation is already been used to monitor transplant outcomes in the United Kingdom and in the United States. Because CUSUM monitoring can be applied by diff...

journal_title：Transplantation

authors： Alexandrine B,Savoye E,Pessione F,Cantrelle C,Jasseron C,Santin G,Bastien O,Legeai C

更新日期：2019-09-01 00:00:00

abstract：:The in-vitro amino acid (AA) and alpha-keto acid (KA) metabolism of bioreactors initially seeded with 2.5 x 10(9) pig hepatocytes was investigated with a perfusion technique. Considerable changes in the culture medium concentrations of AA and KA were measured during the first days in culture. This is indicative of dyn...

journal_title：Transplantation

authors： Gerlach JC,Fuchs M,Smith MD,Bornemann R,Encke J,Neuhaus P,Riedel E

更新日期：1996-07-27 00:00:00

abstract：:The applicability of laparoscopic donor nephrectomy (LDN) has not been assessed in the obese donor. We hypothesized that obesity is not a technical contraindication to LDN. From May 1998 to February 1999, 40 patients underwent LDN at the Georgetown Transplant Institute with the transperitoneal technique. Prophylaxis a...

journal_title：Transplantation

authors： Kuo PC,Plotkin JS,Stevens S,Cribbs A,Johnson LB

更新日期：2000-01-15 00:00:00

abstract：BACKGROUND:Human leukocyte antigen (HLA) antibodies, especially those that fix complement, are associated with antibody-mediated rejection and graft failure. The C1q assay on single antigen beads detects a subset of HLA antibodies that can fix complement and precede C4d deposition. The aim of this study was to determin...

journal_title：Transplantation

authors： Yabu JM,Higgins JP,Chen G,Sequeira F,Busque S,Tyan DB

更新日期：2011-02-15 00:00:00

abstract：BACKGROUND:Bronchiolitis obliterans syndrome (BOS) is the major problem after lung and heart-lung transplantation (LTx/HLTx). Sirolimus (Sir) and Mycophenolate (MMF) showed a promising efficacy in the treatment of BOS in animal models. The first clinical experience in converting LTx/HLTx-recipients with BOS from calcin...

journal_title：Transplantation

authors： Groetzner J,Wittwer T,Kaczmarek I,Ueberfuhr P,Strauch J,Nagib R,Meiser B,Franke U,Reichart B,Wahlers T

更新日期：2006-02-15 00:00:00

abstract：BACKGROUND:It has been suggested that T cells primed by processed donor major histocompatibility complex antigen (the "indirect" pathway of allorecognition) may be responsible for mediating chronic allograft rejection. The purpose of this study was to develop a clinically useful assay to study the occurrence of indirec...

journal_title：Transplantation

authors： Vella JP,Spadafora-Ferreira M,Murphy B,Alexander SI,Harmon W,Carpenter CB,Sayegh MH

更新日期：1997-09-27 00:00:00

abstract：:Pulmonary complications are often lethal components of acute graft-vs.-host disease (GVHD). Although interstitial pneumonitis and lymphocytic bronchitis have been implicated as elements of acute GVHD, previous studies have not determined a correlation between the onset of these histopathologies or their contribution t...

journal_title：Transplantation

authors： Workman DL,Clancy J Jr

更新日期：1994-07-27 00:00:00

abstract：:Cytomegalovirus disease is an important cause of morbidity following liver transplantation. To date there has not been an effective prophylaxis for CMV disease after liver transplantation. One hundred forty-three patients were randomized to receive either high dose oral acyclovir (800 mg 4 times a day) alone for 3 mon...

journal_title：Transplantation

authors： Martin M,Mañez R,Linden P,Estores D,Torre-Cisneros J,Kusne S,Ondick L,Ptachcinski R,Irish W,Kisor D

更新日期：1994-10-15 00:00:00

abstract：:The prevalence of angiographically proven coronary artery disease (CAD) in adults with end-stage liver disease who undergo evaluation for liver transplantation is unknown; also it is unclear if cholestatic liver disease represents an independent risk factor. Patients with end-stage liver disease over age 50 having liv...

journal_title：Transplantation

authors： Carey WD,Dumot JA,Pimentel RR,Barnes DS,Hobbs RE,Henderson JM,Vogt DP,Mayes JT,Westveer MK,Easley KA

更新日期：1995-03-27 00:00:00

abstract：:The interactions of rapamycin (Rapa), CsA, and donor-specific transfusion (DST) were examined in an ACI to Lewis rat heterotopic cardiac allograft model. Survival data were truncated at 175 days for the purpose of statistical comparisons. Vehicle (Veh)-treated animals rejected at a mean of 7.3 +/- 0.2 days. Treatment ...

journal_title：Transplantation

authors： Davies CB,Madden RL,Alexander JW,Cofer BR,Fisher RA,Anderson P

更新日期：1993-05-01 00:00:00

abstract：:Mice given a pretransplant i.v. infusion of spleen cells from donors incompatible with the recipients with respect to individual minor H antigens exhibit a delayed rejection of skin grafts from these incompatible donors. Attempts were made to detect suppressor T cells, possibly induced by the i.v. infusion of donor ce...

journal_title：Transplantation

authors： Johnson LL

更新日期：1990-01-01 00:00:00

abstract：BACKGROUND:Although it is generally considered that livers with moderate steatosis can be safely used in the setting of living-donor liver transplantation, the effect of the regenerative process of such a graft on postoperative liver function is incompletely understood. We assessed the morphologic and functional altera...

journal_title：Transplantation

authors： Ninomiya M,Shimada M,Terashi T,Ijichi H,Yonemura Y,Harada N,Soejima Y,Suehiro T,Maehara Y

更新日期：2004-02-15 00:00:00

abstract：BACKGROUND:Pneumocystis jirovecii pneumonia (PJP) is an important infection-related complication, whose mode of transmission remains uncertain. METHODS:We investigated a nosocomial cluster of 14 PJP cases (11 confirmed and 3 probable) in kidney transplant recipients using epidemiological and genotyping methods. RESUL...

journal_title：Transplantation

authors： Phipps LM,Chen SC,Kable K,Halliday CL,Firacative C,Meyer W,Wong G,Nankivell BJ

更新日期：2011-12-27 00:00:00

abstract：BACKGROUND:Early and late complications related to the pancreas after simultaneous kidney-pancreas transplantation (SKPT) frequently result in graft loss. The authors describe a surgical rescue technique that allows salvage of the pancreatic graft when surgical complications appear after the transplant. METHODS:Of 158...

journal_title：Transplantation

authors： Orsenigo E,Cristallo M,Socci C,Castoldi R,Fiorina P,Invernizzi L,Caldara R,Secchi A,Di Carlo V

更新日期：2003-01-27 00:00:00

abstract：BACKGROUND:In patients with acute liver failure (ALF) of unknown cause, viral infections are believed to be involved. This study investigates the involvement of human herpesvirus-6 (HHV-6). METHODS:Thirty-two patients with ALF who underwent transplantations during a 6-year period were studied for viruses in biopsies f...

journal_title：Transplantation

authors： Härmä M,Höckerstedt K,Lautenschlager I

更新日期：2003-08-15 00:00:00