Is a clinical application of hybrid liver support systems limited by an initial disorder in cellular amino acid and alpha-keto acid metabolism, rather than by later gradual loss of primary hepatocyte function?

abstract：BACKGROUND:The role of natural killer (NK) cells and macrophages (Møs) in the absence of T cell immunity in discordant xenograft (xg) rejection was investigated. METHODS:Guinea pig hearts were transplanted into athymic nude rats receiving no treatment or antixenoantibody (xAb), anticomplement (C), antinatural killer (...

journal_title：Transplantation

authors： Xia G,Ji P,Rutgeerts O,Waer M

更新日期：2000-07-15 00:00:00

abstract：BACKGROUND:It has been postulated that chimerism after transplantation might promote graft acceptance. In the present study, we prospectively assessed blood chimerism in 10 lung transplant recipients during the first posttransplant year and investigated whether chimerism was associated with an immunologically stable si...

journal_title：Transplantation

authors： Knoop C,Andrien M,Defleur V,Antoine M,de Francquen P,Goldman M,Estenne M

更新日期：1997-07-15 00:00:00

abstract：BACKGROUND:The significance of late urinary tract infections (UTIs) after renal transplantation and their association with scarring and graft dysfunction remains controversial. We sought to define the prevalence of renal scarring in allograft recipients with a history of late recurrent UTIs, to determine whether the pr...

journal_title：Transplantation

authors： Dupont PJ,Psimenou E,Lord R,Buscombe JR,Hilson AJ,Sweny P

更新日期：2007-08-15 00:00:00

abstract：BACKGROUND:Small bowel transplantation in children weighing less than 10 kg is hindered by the lack of size-matched donors. The ability to create reduced size small bowel grafts from adult cadaveric donors suitable for use in young children has been studied. METHODS:Volumetric assessment of computed tomography scans w...

journal_title：Transplantation

authors： Delrivière L,Muiesan P,Marshall M,Davenport M,Dhawan A,Kane P,Karani J,Rela M,Heaton N

更新日期：2000-04-15 00:00:00

abstract：BACKGROUND:Encapsulation of islets has been widely investigated as a treatment for diabetes. The characteristics and dynamics of insulin secretion by encapsulated islets in response to glucose and other secretagogues are not well understood. METHODS:In our study, macroencapsulated syngeneic islets at 3-4 wk after tran...

journal_title：Transplantation

authors： Trivedi N,Keegan M,Steil GM,Hollister-Lock J,Hasenkamp WM,Colton CK,Bonner-Weir S,Weir GC

更新日期：2001-01-27 00:00:00

abstract：:Skin grafts can be significantly prolonged in ALS-treated mice by the injection of 25 x 10(6) donor bone marrow cells or 50 x 10(6) spleen cells. Lymph node cells and thymocytes are only minimally effective in prolonging grafts. The effect of a hematopoietic growth factor, granulocyte-macrophage colony stimulating fac...

journal_title：Transplantation

authors： Monaco AP,Wood ML,Gottschalk R,Seiler FR

更新日期：1991-01-01 00:00:00

abstract：:The potential usefulness of verapamil, a calcium channel blocker to renal allograft preservation, was investigated using the isolated perfused rat kidney. Two models of ischemic injury were used. In the first model, rat kidneys were exposed to 40 min of 37 degrees C ischemia on the perfusion circuit. Addition of verap...

journal_title：Transplantation

authors： Shapiro JI,Cheung C,Itabashi A,Chan L,Schrier RW

更新日期：1985-12-01 00:00:00

abstract：:We have tested the predictive model for risk of sensitization by donor-specific transfusions developed at the University of California, San Francisco for its applicability to the DST experience at UW/Madison. Patient sample sizes between the two groups were similar (n = 249 for UW/Madison, n = 261 for UCSF) and the tw...

journal_title：Transplantation

authors： Burlingham WJ,Stratta R,Mason B,Lorentzen D,Feyzi J,Sollinger HW,Belzer FO

更新日期：1989-01-01 00:00:00

abstract：BACKGROUND:Microvascular endothelial cells (ECs) are central to an allograft's immunogenicity. Cold ischemia and reperfusion injury associated with static cold storage and warm reperfusion activates ECs and increases the immunogenicity of the allograft. After reperfusion, mitochondrial permeability transition pore (mPT...

journal_title：Transplantation

authors： Tran DT,Esckilsen S,Mulligan J,Mehrotra S,Atkinson C,Nadig SN

更新日期：2018-06-01 00:00:00

abstract：:A model for immediate vascularization of skin was devised to examine one of the possible explanations for the differential survival rates of transplants of freely grafted skin and organs, i.e., the increased vulnerability of skin to early ischemic necrosis prior to revascularization. Female Fischer (F) rat skin was tr...

journal_title：Transplantation

authors： Perloff LJ,Barker CF

更新日期：1979-08-01 00:00:00

abstract：:Most alloreactive T cells specifically recognize peptides bound to donor MHC molecules. In addition to peptides, solvent accessible MHC residues also may stimulate alloreactive T cells. We studied T cell receptor (TCR) usage by 16 independent anti-HLA-B7 alloreactive cytolytic T lymphocyte (CTL) clones. Most or all of...

journal_title：Transplantation

authors： Li YY,Smith KD,Shi Y,Lutz CT

更新日期：1996-10-15 00:00:00

abstract：BACKGROUND:CTLA4 immunoglobulin (Ig)G that binds to B7 effectively inhibits the signaling of CD28/CTLA4-B7 pathway and induces antigen specific T cell unresponsiveness in vitro and in vivo. Using CTLA4IgG, we examined induction of long-term graft survival and the mechanism of maintenance of tolerance in rat allogeneic ...

journal_title：Transplantation

authors： Tarumi K,Murakami M,Yagihashi A,Nakagawa I,Hirata K,Uede T

更新日期：1999-02-27 00:00:00

abstract：:Graft-versus-host disease (GvHD), a life-threatening complication of bone marrow transplantation, is initiated by donor T cells reacting to recipient dendritic cells (DC). GvHD can be controlled by attenuating donor T cells, but few strategies exist to target DC, particularly resident tissue DC, despite recent evidenc...

journal_title：Transplantation

authors： Collin MP,Munster D,Clark G,Wang XN,Dickinson AM,Hart DN

更新日期：2005-03-27 00:00:00

abstract：:Antihuman lymphocyte rabbit (or horse) gamma globulins used in recipients of organ transplantation are prepared against thymocytes or immortalized cell lines, the only two sources so far allowing enough antigen preparation. These cells lack, however, the surface determinants characteristic of alloreactive blasts invol...

journal_title：Transplantation

authors： Bonneville M,Carcagne J,Vie H,Moreau JF,Chevalier S,Latour M,Carosella E,Soulillou JP

更新日期：1989-08-01 00:00:00

abstract：BACKGROUND:Human leukocyte antigen (HLA) antibodies were normally not found in subjects who have not been immunized by pregnancies, transfusions, or transplants. But with new methodology, we now see that HLA antibodies are often found in nonalloimmunized males. METHODS:The sera of 424 healthy male donors were tested w...

journal_title：Transplantation

authors： Morales-Buenrostro LE,Terasaki PI,Marino-Vázquez LA,Lee JH,El-Awar N,Alberú J

更新日期：2008-10-27 00:00:00

abstract：:The development of allospecific cellular immunity during acute rat renal allograft rejection parallels alterations occurring in arachidonic acid metabolism, including increased production of the vasoconstrictor eicosanoid thromboxane A2 (TxA2). We have previously demonstrated that chronic inhibition of thromboxane syn...

journal_title：Transplantation

authors： Ruiz P,Coffman TM,Klotman PE,Sanfilippo F

更新日期：1989-10-01 00:00:00

abstract：BACKGROUND:Immunosuppressive regimens for kidney transplantation which reduce the long-term burden of immunosuppression are attractive, but little data are available to judge the safety and efficacy of the different strategies used. We tested the hypothesis that the simple, cheap, regimen of alemtuzumab induction combi...

journal_title：Transplantation

authors： Chan K,Taube D,Roufosse C,Cook T,Brookes P,Goodall D,Galliford J,Cairns T,Dorling A,Duncan N,Hakim N,Palmer A,Papalois V,Warrens AN,Willicombe M,McLean AG

更新日期：2011-10-15 00:00:00

abstract：:Despite major advances in immunopharmacology, virtually all patients receive the same center-specific immunosuppressive regimen following orthotopic liver transplantation (OLT). The present analysis was performed on the hypothesis that the original disease representing the indication for OLT leads to a different initi...

journal_title：Transplantation

authors： Berlakovich GA,Imhof M,Karner-Hanusch J,Gotzinger P,Gollackner B,Gnant M,Hanelt S,Laufer G,Muhlbacher F,Steininger R

更新日期：1996-02-27 00:00:00

abstract：BACKGROUND:To confirm the results of a number of studies conducted in Europe, the United States, and Japan, this multicenter, randomized trial compared the 12-month efficacy and safety of tacrolimus- and cyclosporine-based immunosuppressive regimens in the prevention of renal allograft rejection. METHODS:A total of 44...

journal_title：Transplantation

authors： Mayer AD,Dmitrewski J,Squifflet JP,Besse T,Grabensee B,Klein B,Eigler FW,Heemann U,Pichlmayr R,Behrend M,Vanrenterghem Y,Donck J,van Hooff J,Christiaans M,Morales JM,Andres A,Johnson RW,Short C,Buchholz B,Rehmert N

更新日期：1997-08-15 00:00:00

abstract：BACKGROUND:HLAMatchmaker is a computer algorithm that determines human leukocyte antigen (HLA) compatibility at the level of polymorphic amino acid triplets in antibody-accessible sequence positions. Recent studies have shown that HLA-DR-matched kidney transplant recipients with zero to two triplet mismatches had almos...

journal_title：Transplantation

authors： Duquesnoy RJ,Howe J,Takemoto S

更新日期：2003-03-27 00:00:00

abstract：BACKGROUND:Long-term acceptance of semi-identical orthotopic liver transplants (OLTs) in inbred swine is induced by a 12-day course of FK506. To study whether acceptance is attributable to central or peripheral immune mechanisms, the effect of complete thymectomy was determined. METHODS:Total thymectomy was performed ...

journal_title：Transplantation

authors： Uryuhara K,Ambiru S,Dehoux JP,Oike F,Talpe S,Gianello P

更新日期：2004-04-27 00:00:00

abstract：BACKGROUND:Transjugular intrahepatic portosystemic shunt (TIPS) is used in the management of refractory ascites (RA) and variceal bleeds. Little data exist on TIPS safety, efficacy, and survival after liver transplantation (LT). METHODS:We conducted a retrospective analysis of patients who underwent TIPS placement aft...

journal_title：Transplantation

authors： Feyssa E,Ortiz J,Grewal K,Azhar A,Parsikia A,Tufail K,Hashemi N,Brady P,Araya V

更新日期：2011-04-15 00:00:00

abstract：:Since calcium channel blocking agents and CsA exert an antiproliferative effect upon T cell mitogenesis, we have compared and characterized their immunosuppressive properties at the level of gene activation. Verapamil (greater than or equal to 30 microM), which blocks T cell mitogenesis and a rise in cytosolic calcium...

journal_title：Transplantation

authors： Walz G,Zanker B,Wieder K,Hadro E,Moscovitch-Lopatin M,Smith BR,Strom TB

更新日期：1989-02-01 00:00:00

abstract：:Pancreatic transplantation is intended to normalize carbohydrate metabolism in insulin-dependent diabetics by restoring endogenous insulin release, and it is usually performed together with kidney transplantation in patients with end-stage renal failure. A major problem in these patients is the daily control of the gr...

journal_title：Transplantation

authors： Secchi A,Pontiroli AE,Traeger J,Dubernard JM,Touraine JL,Ruitton A,Blanc N,Pozza G

更新日期：1983-04-01 00:00:00

abstract：BACKGROUND:The aim of this study was to determine the efficacy of cariporide (a sodium-hydrogen exchanger inhibitor), BMS180448 (a pharmacologic ischemic preconditioning agent), and the combination thereof, as adjuvant therapies for extended cardiac allograft preservation. METHODS:A porcine model of donor brain death ...

journal_title：Transplantation

authors： Ryan JB,Hicks M,Cropper JR,Garlick SR,Kesteven SH,Wilson MK,Feneley MP,Macdonald PS

更新日期：2003-09-15 00:00:00

abstract：BACKGROUND:Although the elderly represents a rapidly growing population among transplant recipients, age-specific aspects have not been considered sufficiently in clinical trials. Moreover, age-specific effects of immunosuppressive therapies remain poorly understood. METHODS:Here, we assessed the impact of rapamycin o...

journal_title：Transplantation

authors： Quante M,Heinbokel T,Edtinger K,Minami K,Uehara H,Nian Y,Azuma H,Abdi R,Elkhal A,Tullius SG

更新日期：2018-01-01 00:00:00

abstract：:Graft-versus-host disease is a potential problem following small bowel transplantation. We have previously shown that a two-day intraperitoneal course of polyclonal antilymphocyte serum completely prevents GVHD without impairing allograft function in a unidirectional rat small bowel transplant model. In the present st...

journal_title：Transplantation

authors： Shaffer D,Ubhi CS,Simpson MA,Gottschalk R,Milford EL,Maki T,Monaco AP

更新日期：1991-12-01 00:00:00

abstract：BACKGROUND:Endothelial dysfunction (ED) has a major role in the cardiovascular outcome of patients with chronic kidney disease (CKD). The aim of this study was to investigate the relation between fetuin A levels and ED in kidney transplant recipients. METHODS:Forty-two living donor kidney transplant recipients, 21 (11...

journal_title：Transplantation

authors： Caglar K,Yilmaz MI,Saglam M,Cakir E,Kilic S,Eyileten T,Sonmez A,Oguz Y,Oner K,Ors F,Vural A,Yenicesu M

更新日期：2007-02-27 00:00:00

abstract：BACKGROUND:Although graft local infusion (GLI) treatment via the portal vein or the hepatic artery has been the pivotal strategy in ABO incompatible (ABOi) living donor liver transplantation (LDLT) in Japan, the procedure is associated with a high rate of catheter-associated complications. METHODS:A new ABOi-LDLT prot...

journal_title：Transplantation

authors： Ikegami T,Taketomi A,Soejima Y,Yoshizumi T,Uchiyama H,Harada N,Iguchi T,Hashimoto N,Maehara Y

更新日期：2009-08-15 00:00:00

abstract：:The response to IL-2 and IL-4 of several functionally defined lymphoid cell types was assessed at the individual responding cell level in limiting dilution experiments in which exogenous IL-2 or IL-4 was used to promote cellular activation and expansion. Splenic precursors that give rise to alloreactive CTL in LDA sup...

journal_title：Transplantation

authors： Widmer MB,Voice RF,Conlon PJ,Grabstein KH

更新日期：1990-04-01 00:00:00