Lung rejection occurs in lung transplant recipients with blood chimerism.

abstract：BACKGROUND:Black kidney transplant recipients experience disproportionately high rates of graft loss. This disparity has persisted for 40 years, and improvements may be impeded based on the current public reporting of overall graft loss by US regulatory organizations for transplantation. METHODS:Longitudinal cohort st...

journal_title：Transplantation

authors： Taber DJ,Gebregziabher M,Payne EH,Srinivas T,Baliga PK,Egede LE

更新日期：2017-02-01 00:00:00

abstract：:Antibody-mediated injury is a major cause of allograft dysfunction and loss. Antibodies to ABH(O) blood group antigens are classic mediators of ABO-incompatible graft rejection, whereas donor-specific anti-HLA antibodies and, more recently, autoantibodies are appreciated as important contributors to allograft inflamma...

journal_title：Transplantation

authors： Dieudé M,West LJ,Muruve DA,Gunaratnam L,Mohanakumar T,Zorn E,Cairo CW,Freed DH,Schultz KR,Fairchild RL,Hébert MJ

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND:Human leukocyte antigen (HLA) antibodies, especially those that fix complement, are associated with antibody-mediated rejection and graft failure. The C1q assay on single antigen beads detects a subset of HLA antibodies that can fix complement and precede C4d deposition. The aim of this study was to determin...

journal_title：Transplantation

authors： Yabu JM,Higgins JP,Chen G,Sequeira F,Busque S,Tyan DB

更新日期：2011-02-15 00:00:00

abstract：BACKGROUND:Despite early skepticism, the field of vascularized composite allotransplantation (VCA) has demonstrated feasibility. The ethics of VCA have moved past doubts about the morality of attempting such transplants to how to conduct them ethically. METHODS:Leaders of each program performing and/or evaluating VCA ...

journal_title：Transplantation

authors： Caplan AL,Parent B,Kahn J,Dean W,Kimberly LL,Lee WPA,Rodriguez ED

更新日期：2019-06-01 00:00:00

abstract：:Methods are described for preparing large amounts of horse anti-human thymocyte globulin (ATG, ATGAM; The Upjohn Company) for clinical use. These methods have been used since 1968 to provide material for clinical trials. Characteristics of 40 lots of ATG are summarized. ...

journal_title：Transplantation

authors： Wechter WJ,Nelson JW,Perper RJ,Parcells AJ,Riebe KW,Evans JS,Satoh PS,Ko H

更新日期：1979-10-01 00:00:00

abstract：:To determine the extent to which pretransplant immunity resulting from natural infection protects against cytomegalovirus (CMV) disease, we analyzed CMV serology on 153 kidney donor and recipient pairs and followed transplant patients to determine incidence and severity of CMV disease. The overall incidence of CMV dis...

journal_title：Transplantation

authors： Smiley ML,Wlodaver CG,Grossman RA,Barker CF,Perloff LJ,Tustin NB,Starr SE,Plotkin SA,Friedman HM

更新日期：1985-08-01 00:00:00

abstract：:Renal function was observed retrospectively in a population of 228 adults who underwent a cardiac allograft at the University of Pittsburgh from June 1980 through June 1987, survived a minimum of one year, and received cyclosporine. Renal function was determined by serial measurement of serum creatinine concentration....

journal_title：Transplantation

authors： Greenberg A,Thompson ME,Griffith BJ,Hardesty RL,Kormos RL,el-Shahawy MA,Janosky JE,Puschett JB

更新日期：1990-10-01 00:00:00

abstract：:The aim of our study was to sensitize cells in vitro, follow their proliferative and cytotoxic responses, and determine their ability to cause lethal graft-versus-host disease (GVHD). C57BL/6 (H2b) spleen cells were incubated with irradiated BALB/C (H2d) Moloney lymphoma cells (LSTRA) in mixed leukocyte culture condit...

journal_title：Transplantation

authors： Einstein AB Jr,Cheever MA,Fefer A

更新日期：1976-12-01 00:00:00

abstract：BACKGROUND:Recently the United Network for Organ Sharing (UNOS) began a pilot study to evaluate prospectively the merits of an allocation of cadaveric kidneys based on broader classes of HLA antigens, called cross-reactive groups (CREG). The objectives of the pilot study consider patient outcomes, but not the potential...

journal_title：Transplantation

authors： Hollenbeak CS,Woodward RS,Cohen DS,Lowell JA,Singer GG,Tesi RJ,Howard TK,Mohanakumar T,Brennan DC,Schnitzler MA

更新日期：2000-08-15 00:00:00

abstract：BACKGROUND:Donation after circulatory death (DCD) provides an alternative pathway to deceased organ transplantation. Although clinical DCD lung, liver, and kidney transplantation are well established, transplantation of hearts retrieved from DCD donors has reached clinical translation only recently. Progress has been l...

journal_title：Transplantation

authors： Iyer A,Chew HC,Gao L,Villanueva J,Hicks M,Doyle A,Kumarasinghe G,Jabbour A,Jansz PC,Feneley MP,Harvey RP,Graham RM,Dhital KK,Macdonald PS

更新日期：2016-12-01 00:00:00

abstract：:In vivo cell-mediated effector mechanisms of allograft destruction were investigated in a canine single-lung transplantation model. This large animal model permits direct longitudinal studies of immune effector cells from the grafts of individual recipients by bronchoalveolar lavage (BAL). Evidence was obtained that t...

journal_title：Transplantation

authors： Norin AJ,Kamholz SL

更新日期：1989-11-01 00:00:00

abstract：BACKGROUND:Neutrophilic tubulitis accompanied by intratubular neutrophil clusters in the renal allograft is a surrogate marker for urinary tract infection (UTI). Overlapping histologic findings can occur in antibody-mediated rejection, which is characterized by peritubular capillary (PTC) deposition of C4d. This study ...

journal_title：Transplantation

authors： Gupta G,Shapiro R,Girnita A,Batal I,McCauley J,Basu A,Tan H,Randhawa P

更新日期：2009-04-15 00:00:00

abstract：:Long-term graft survival is mainly influenced by early graft rejection and posttransplant graft function. The ability of both complement-dependent cytotoxicity cross-match (CDC) and flow cytometry cross-match (FCXM) to predict acute rejection episodes has been evaluated by cross-matching 40 patients who received cadav...

journal_title：Transplantation

authors： Utzig MJ,Blümke M,Wolff-Vorbeck G,Lang H,Kirste G

更新日期：1997-02-27 00:00:00

abstract：:To determine the impact of different flush and reperfusion techniques on postreperfusion syndrome (PRS) and postoperative graft function, 100 transplants were randomly assigned into four groups as follows: group 1 (n=31), portal vein flush, no vena caval venting; group 2 (n=21), hepatic arterial flush, no vena caval v...

journal_title：Transplantation

authors： Millis JM,Melinek J,Csete M,Imagawa DK,Olthoff KM,Neelankanta G,Braunfeld MY,Sopher MJ,Chan SM,Pregler JL,Yersiz H,Busuttil AA,Shackleton CR,Shaked A,Busuttil RW

更新日期：1997-02-15 00:00:00

abstract：:Cross sensitization between the products of the H-2K and H-2D loci has been demonstrated by an experimental design in which recipients were sensitized with tissue bearing determinants controlled by one locus (e.g., H-2K), and then challenged with skin grafts expressing determinants controlled by the other locus (e.g.,...

journal_title：Transplantation

authors： Murphy DB,Shreffler DC

更新日期：1975-07-01 00:00:00

abstract：:The mammalian target of rapamycin inhibitors (mTOR-I), drugs widely used in transplant medicine and oncology, exert their function by inhibiting a serine/threonine kinase with a pivotal role in cellular metabolism and in a wide range of eukaryotic biological/cellular functions and signaling networks. Additionally, as ...

journal_title：Transplantation

authors： Zaza G,Granata S,Caletti C,Signorini L,Stallone G,Lupo A

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND:More than 60% children with small bowel transplantation (SBTx) experience acute cellular rejection. PURPOSE/METHODS:To identify children at risk of rejection, donor- and third-party-induced proliferation of T-helper and T cytotoxic (Tc) cells, and their naïve and memory (M) subsets was evaluated simultaneou...

journal_title：Transplantation

authors： Ashokkumar C,Gupta A,Sun Q,Higgs BW,Ningappa M,Snyder S,Johnson M,Mazariegos G,Soltys K,Bond G,Abu-Elmagd K,Sindhi R

更新日期：2010-06-15 00:00:00

abstract：:In a cross-sectional survey of the quality of life of 45 liver transplant recipients, physical and psychological status, physical complaints, capability to participate in daily life, social support, and global quality of life were assessed. The average time of follow-up was 9 months after transplantation. Nine patient...

journal_title：Transplantation

authors： Leyendecker B,Bartholomew U,Neuhaus R,Hörhold M,Blumhardt G,Neuhaus P,Klapp BF

更新日期：1993-09-01 00:00:00

abstract：:Hepatic artery thrombosis is a continuing source of morbidity and mortality following orthotopic liver transplantation. The cornerstone of therapy has been urgent retransplantation that is limited by organ availability. For this reason we developed a policy of urgent revascularization for allograft rescue. Hepatic art...

journal_title：Transplantation

authors： Langnas AN,Marujo W,Stratta RJ,Wood RP,Li SJ,Shaw BW

更新日期：1991-01-01 00:00:00

abstract：:During anesthesia 5 mg of muromonab CD3 (OKT3), an anti-CD3 monoclonal antibody, was administered prophylactically to twelve patients undergoing cadaveric renal transplantation. Preoperatively, all patients were at or near their dry body weights. Methylprednisolone 500 mg on call to or in the operating room, azathiopr...

journal_title：Transplantation

authors： Robinson ST,Barry JM,Norman DJ

更新日期：1993-08-01 00:00:00

abstract：:A comparative study of 24 hr preservation at 4 degrees C of excised rat livers with Euro-Collins and hydroxyethyl starch-free University of Wisconsin (UWm) solutions has been conducted based on the assessment of (1) the cellular energy status determined by 31P NMR spectroscopy and (2) cellular injury estimated from th...

journal_title：Transplantation

authors： Gulian JM,Dalmasso C,Desmoulin F,Scheiner C,Cozzone PJ

更新日期：1992-10-01 00:00:00

abstract：:Uncontrolled donation after circulatory death (uDCD) refers to donation from persons who die following an unexpected and unsuccessfully resuscitated cardiac arrest. Despite the large potential for uDCD, programs of this kind only exist in a reduced number of countries with a limited activity. Barriers to uDCD are of a...

journal_title：Transplantation

authors： Coll E,Miñambres E,Sánchez-Fructuoso A,Fondevila C,Campo-Cañaveral de la Cruz JL,Domínguez-Gil B

更新日期：2020-08-01 00:00:00

abstract：BACKGROUND:Malnutrition is common in patients with end-stage liver disease considered for transplantation, but it is unclear whether this affects the outcome after transplantation. AIM.: To determine whether the severity of malnutrition in liver transplant candidates affects outcome after transplantation. METHODS:We d...

journal_title：Transplantation

authors： Shahid M,Johnson J,Nightingale P,Neuberger J

更新日期：2005-02-15 00:00:00

abstract：BACKGROUND:Cold preservation is the most practical method to maintain the viability of isolated lungs. However, rapid cooling may affect pulmonary endothelial function. We examined the effects of microtubule stabilization with paclitaxel on pulmonary endothelial barrier integrity under cold temperature. METHODS:Human ...

journal_title：Transplantation

authors： Suzuki S,Bing H,Sugawara T,Matsuda Y,Tabata T,Hoshikawa Y,Saijo Y,Kondo T

更新日期：2004-08-27 00:00:00

abstract：BACKGROUND:To optimize the methods used for human islet isolation for transplantation, it is important to improve our understanding of the structure of the islet-exocrine interface. In this study, the composition of collagen subtypes in the interface have been characterized and quantified in human pancreas. METHODS:Hu...

journal_title：Transplantation

authors： Hughes SJ,Clark A,McShane P,Contractor HH,Gray DW,Johnson PR

更新日期：2006-02-15 00:00:00

abstract：:Progressive microvascular endothelial damage is a characteristic feature of fulminant acute cardiac allograft rejection in the rat. Serial ultrastructural tracer studies using i.v. administered colloidal carbon and horseradish peroxidase have been performed in an adoptive transfer model to determine the role of cellul...

journal_title：Transplantation

authors： Lowry RP,Forbes RD

更新日期：1984-02-01 00:00:00

abstract：BACKGROUND:After the discontinuation of the manufacturing Liberase HI because of a small potential for prion disease transmission, Roche Diagnostics (Indianapolis, IN) developed a new enzyme product (Liberase MTF [mammalian tissue free]), which is similar to Liberase HI with the exception that no mammalian tissue is us...

journal_title：Transplantation

authors： O'Gorman D,Kin T,Imes S,Pawlick R,Senior P,Shapiro AM

更新日期：2010-08-15 00:00:00

abstract：:Despite improvements in immunosuppression, rejection occurs in 50% of liver transplant patients and may cause significant morbidity. The most frequent cause of death after liver transplantation is severe infection. Determination of the cytokine network may lead to earlier detection of patients at risk for severe rejec...

journal_title：Transplantation

authors： Platz KP,Mueller AR,Rossaint R,Steinmüller T,Lemmens HP,Lobeck H,Neuhaus P

更新日期：1996-11-27 00:00:00

abstract：BACKGROUND:Intestinal transplantation is known to be associated with a high risk of early complications and mortality. METHODS:We analyzed prospective data of 51 primary small bowel transplantations from December 1999 to August 2009 and identified perioperative factors that impact on early mortality (≤6 months after t...

journal_title：Transplantation

authors： Dopazo C,Gupte GL,Sharif K,Perera MT,Hartley J,Muiesan P,Mayer DA,Bromley P,Bennett J,Kelly DA,van Mourik I,McKiernan P,Beath SV,Mirza DF

更新日期：2012-10-27 00:00:00

abstract：BACKGROUND:Cardiovascular disease remains epidemic in transplant recipients, despite aggressive treatment of cardiovascular risk factors. Thus, novel risk factors could play a role in the genesis of cardiovascular events in this population. METHODS:We evaluated the impact of early posttransplant anemia on cardiovascul...

journal_title：Transplantation

authors： Djamali A,Becker YT,Simmons WD,Johnson CA,Premasathian N,Becker BN

更新日期：2003-09-15 00:00:00