Emerging Ethical Challenges Raised by the Evolution of Vascularized Composite Allotransplantation.

abstract：BACKGROUND:At our institution, increased kidney donation from unrelated donors accounts for a steady rise in live donor kidney transplantation rates. We compared outcomes of living related (LRT) versus living unrelated kidney transplants (LURT) and analyzed the effect of early rejection upon graft survival. METHODS:A ...

journal_title：Transplantation

authors： Fuller TF,Feng S,Brennan TV,Tomlanovich S,Bostrom A,Freise CE

更新日期：2004-10-15 00:00:00

abstract：:Stable renal transplant recipients (RTR) display high rates of atherosclerotic events (AE). Innate immunity and especially vascular inflammation play a role in the pathogenesis of atherosclerosis. It is illustrated both by an increased occurrence of postrenal transplant cardiovascular events in patients with elevated ...

journal_title：Transplantation

authors： Courivaud C,Ferrand C,Deschamps M,Tiberghien P,Chalopin JM,Duperrier A,Saas P,Ducloux D

更新日期：2006-04-27 00:00:00

abstract：:Active regulation or suppression of donor reactive cells is emerging as a key mechanism for inducing and maintaining unresponsiveness to donor alloantigens. Accumulating evidence suggests that a balance between immunoregulation and deletion of donor alloantigen reactive T cells can provide effective control of immune ...

journal_title：Transplantation

authors： Wood KJ,Luo S,Akl A

更新日期：2004-01-15 00:00:00

abstract：BACKGROUND:Gastrointestinal complications are common in patients who undergo kidney transplantation and may affect posttransplant outcomes. We examined the incidence and predictors of gastroesophageal reflux disease (GERD) and dyspepsia and their associations with graft survival and mortality after transplant. METHODS...

journal_title：Transplantation

authors： Neri L,Rocca Rey LA,Pinsky BW,Lentine KL,Salvalaggio PR,Machnicki G,Willoughby L,Burroughs TE,Takemoto SK,Schnitzler MA

更新日期：2008-02-15 00:00:00

abstract：BACKGROUND:Prophylactic ganciclovir (GCV) is used in high-risk renal transplant patients to prevent acute cytomegalovirus (CMV) disease, but its impact on inflammation within the allograft itself remains undefined. METHODS:To study the effect of GCV prophylaxis on allograft inflammation, murine CMV (MCMV)-infected all...

journal_title：Transplantation

authors： Shimamura M,Saunders U,Rha B,Guo L,Cassady KA,George JF,Britt WJ

更新日期：2011-10-15 00:00:00

abstract：:We report a case of adenovirus infection of the renal allograft in a combined kidney/pancreas transplant recipient. The clinical presentation was renal allograft failure, which eventually reversed. The pancreatic graft function remained stable. A renal biopsy showed massive tubular necrosis associated with a prominent...

journal_title：Transplantation

authors： Mathur SC,Squiers EC,Tatum AH,Szmalc FS,Daucher JW,Welker DM,Shanley PF

更新日期：1998-01-15 00:00:00

abstract：:In the literature, varying terminology for living organ donation can be found. However, there seems to be a need for a new classification to avoid confusion. Therefore, we assessed existing terminology in the light of current living organ donation practices and suggest a more straightforward classification. We propose...

journal_title：Transplantation

authors： Dor FJ,Massey EK,Frunza M,Johnson R,Lennerling A,Lovén C,Mamode N,Pascalev A,Sterckx S,Van Assche K,Zuidema WC,Weimar W

更新日期：2011-05-15 00:00:00

abstract：:The immunosuppressive effects of leflunomide and cyclosporine were evaluated in a rat neurovascularized myocutaneous allograft model. Inbred Brown-Norway and Lewis rats were served as donors and recipients, respectively. All recipients were observed for 60 days or until allograft rejection occurred. All isograft contr...

journal_title：Transplantation

authors： Yeh LS,Gregory CR,Griffey SM,Lecouteur RA,Morris RE

更新日期：1996-09-27 00:00:00

abstract：:Non-A, non-B hepatitis is a significant cause of liver disease among renal allograft recipients. In order to assess the impact and prevalence of hepatitis C in a series of renal allograft recipients, we retrospectively screened 621 consecutive patients transplanted between 1979 and 1989 and 484 cadaver organ donors re...

journal_title：Transplantation

authors： Roth D,Fernandez JA,Burke GW,Esquenazi V,Miller J

更新日期：1991-02-01 00:00:00

abstract：BACKGROUND:The shortage of cadaveric livers has sparked an interest in adult-to-adult living donor transplantation. Right lobe donor hepatectomy is frequently required to obtain a graft of adequate size for adult recipients. Careful donor selection is necessary to minimize complications and assure a functional graft. ...

journal_title：Transplantation

authors： Marcos A,Fisher RA,Ham JM,Olzinski AT,Shiffman ML,Sanyal AJ,Luketic VA,Sterling RK,Olbrisch ME,Posner MP

更新日期：2000-06-15 00:00:00

abstract：BACKGROUND:We previously reported that Lewis rat hearts transplanted into BALB/c mice developed typical acute vascular rejection (AVR). The present study was undertaken to determine the efficacy of LF15-0195, a new analogue of 15-deoxyspergualin, in the prevention of AVR and to determine whether a combination of LF15-0...

journal_title：Transplantation

authors： Wang H,Hosiawa KA,Garcia B,Shum JB,Dutartre P,Kelvin DJ,Zhong R

更新日期：2003-05-15 00:00:00

abstract：:Despite improvements in immunosuppression, rejection occurs in 50% of liver transplant patients and may cause significant morbidity. The most frequent cause of death after liver transplantation is severe infection. Determination of the cytokine network may lead to earlier detection of patients at risk for severe rejec...

journal_title：Transplantation

authors： Platz KP,Mueller AR,Rossaint R,Steinmüller T,Lemmens HP,Lobeck H,Neuhaus P

更新日期：1996-11-27 00:00:00

abstract：:Two technical modifications have been suggested for whole-pancreas transplantation with bladder drainage. The duodenal button technique (DB [Madison]) and the duodenal segment technique (DS [Iowa]) are the most commonly performed procedures (1,2). From December 1985 until May 1988 we performed 32 combined pancreas-kid...

journal_title：Transplantation

authors： D'Alessandro AM,Sollinger HW,Stratta RJ,Kalayoglu M,Pirsch JD,Belzer FO

更新日期：1989-01-01 00:00:00

abstract：:Neonatal tolerance to alloantigens and autoantigens in mice is mediated by T helper (Th)2 immunity. If a strong and pure Th2 response could be engaged to alloantigens in adult mice, it might result in allograft tolerance. In an attempt to induce Th2 immunity in adults, we studied the T-cell response to peptide I-A bet...

journal_title：Transplantation

authors： Lehmann PV,Matesic D,Benichou G,Heeger PS

更新日期：1997-07-27 00:00:00

abstract：BACKGROUND:Human CD58 is an adhesion molecule that interacts with CD2 on lymphocytes. We describe here an antibody that blocks responses of human peripheral blood mononuclear cells (PBMCs) to porcine cells and reacts with a porcine protein with homology to CD58. METHODS:Antibodies were isolated with a screen for inhib...

journal_title：Transplantation

authors： Crosby K,Yatko C,Dersimonian H,Pan L,Edge AS

更新日期：2004-04-27 00:00:00

abstract：:The potential role of donor's mature T lymphocytes on the recovery of various immunological functions and hematopoiesis was investigated in lethally irradiated BALB/c mice by studying reconstitution with normal, as compared with T-cell-depleted, syngeneic marrow grafts. Recovery of total, as well as mononuclear, perip...

journal_title：Transplantation

authors： Shalit M,Ayalon M,Weiss L,Leshem B,Kedar E,Slavin S

更新日期：1986-08-01 00:00:00

abstract：BACKGROUND:Donor hepatectomy with maximal safety while preserving graft viability is of principal concern in living donor liver transplantation. There are compelling reasons for avoiding blood transfusion, even with autologous blood, to avoid the potential risks it imposes on healthy donors. This study aims to describe...

journal_title：Transplantation

authors： Chen CL,Chen YS,de Villa VH,Wang CC,Lin CL,Goto S,Wang SH,Cheng YF,Huang TL,Jawan B,Cheung HK

更新日期：2000-06-27 00:00:00

abstract：BACKGROUND:Tolerogenic dendritic cells (Tol-DCs) play a critical role in inducing and maintaining tolerance. Recognizing that both T-cell inactivation and activation are contingent on signals provided by DCs and that graft-specific activated T cells are major mediators of transplant rejection, we aimed to create an env...

journal_title：Transplantation

authors： Lan Z,Ge W,Arp J,Jiang J,Liu W,Gordon D,Healey D,DeBenedette M,Nicolette C,Garcia B,Wang H

更新日期：2010-12-27 00:00:00

abstract：:Second clinical kidney grafts often survive longer than first grafts. Using a rat cardiac allograft model, we examined the conditions under which survival of a second graft can be longer than first graft survival. In the BUF-to-LEW combination, following rejection of the first transplant, second cardiac allografts fro...

journal_title：Transplantation

authors： Yanagiya A,Terasaki PI,Iwaki Y,Ho BB,Drinkwater DC,Laks H

更新日期：1992-10-01 00:00:00

abstract：BACKGROUND:A quantitative model of immunosuppression was previously developed based on the rejection of the allogeneic A/J murine tumor sarcoma 1 (Sa1) in immunocompetent mice. Here, the model is used to evaluate the immunologic mechanisms of graft rejection and to determine the potential of this model to detect synerg...

journal_title：Transplantation

authors： Hammond-McKibben D,Saulnier M,Zhang J,Risher N,Lake P,Weetall M

更新日期：2005-04-27 00:00:00

abstract：:Mice of the B10 background that are class II I-E nonexpressing demonstrate a relative resistance to neonatal induction of tolerance of class I alloantigens from I-E-expressing B10 strains. The majority of these injected mice delete donor-responsive and "I-E-reactive" (V beta 11+) cells in the immediate postinoculation...

journal_title：Transplantation

authors： Nassiri M,Viciana A,Streilein JW,Ruiz P

更新日期：1993-12-01 00:00:00

abstract：:Preventing hyperacute rejection (HAR) is a difficult and unsolved problem in xenotransplantation. This may be due, in part, to a lack of therapies that can suppress production of natural antibodies (NA), which are thought to be critical mediators of HAR. This study examined the effect of 15-deoxyspergualin (DSPG) and ...

journal_title：Transplantation

authors： Leventhal JR,Flores HC,Gruber SA,Figueroa J,Platt JL,Manivel JC,Bach FH,Matas AJ,Bolman RM 3rd

更新日期：1992-07-01 00:00:00

abstract：:The effect of the tritiated thymidine (3H-TdR) suicide technique on the ability of donor cells to induce fatal graft-versus-host disease (GVHD) was studied. C57BL/6 (H-2b) spleen cells were stimulated in vitro with irradiated BALB/c (H-2d) Moloney lymphoma cells in mixed culture and 3H-TdR of high-specific activity ad...

journal_title：Transplantation

authors： Cheever MA,Einstein AB Jr,Kempf RA,Fefer A

更新日期：1977-04-01 00:00:00

abstract：:Conjugation of dextran-coated superparamagnetic iron oxide (SPIO) particles with transactivator protein (Tat)-peptide and fluorescein isothiocyanate (FITC) allows cells to readily uptake SPIO particles. This makes possible high-resolution, real-time imaging of these cells by magnetic resonance imaging (MRI). First, we...

journal_title：Transplantation

authors： Kaufman CL,Williams M,Ryle LM,Smith TL,Tanner M,Ho C

更新日期：2003-10-15 00:00:00

abstract：:Spontaneous rupture of the liver has been described in association with many benign and malignant conditions. We report, to our knowledge, the first case of spontaneous rupture of the liver upon revascularization, requiring total hepatectomy and portocaval shunt, followed by successful retransplantation. Routine patho...

journal_title：Transplantation

authors： Mistry BM,Solomon H,Garvin PJ,Durham RM,Turnage S,Bacon BR,Galvin N,Varma CR

更新日期：2000-05-27 00:00:00

abstract：:Requirements for sustained engraftment of fetal liver hematopoietic stem cells were evaluated in 45 dogs. Pretransplant preparative treatment with total-body irradiation, 14.7 Gy, permitted engraftment of DLA-compatible fetal liver cells. Radiation alone was inadequate in DLA-haploidentical or DLA-mismatched transplan...

journal_title：Transplantation

authors： Cain G,Stitzel K,Gale R,Champlin R

更新日期：1987-12-01 00:00:00

abstract：BACKGROUND:Living kidney donors have donation-related out-of-pocket costs (direct costs) and/or ongoing daily expenses while losing income (indirect costs). Yet there is little information about how much of a subjective burden these constitute for the donors. METHODS:From December 2003 through December 2014, we survey...

journal_title：Transplantation

authors： Wiseman JF,Jacobs CL,Larson DB,Berglund DM,Garvey CA,Ibrahim HN,Matas AJ

更新日期：2017-09-01 00:00:00

abstract：BACKGROUND:In hamster-to-rat cardiac xenografts, long-term survival (LTS) is obtained in 60% of recipients if vascular rejection is overcome by cobra venom factor and cyclosporine (CsA). It has been suggested that this accommodation state could be due to the Th2 response. METHODS:We examined the infiltrate by using im...

journal_title：Transplantation

authors： Brouard S,Blancho G,Moreau A,Heslan JM,Cuturi MC,Soulillou JP

更新日期：1998-06-27 00:00:00

abstract：:Teratoma 402 AX is an embryo-like tumor cell line originally derived from the testicles of strain 129/J mice. This teratocarcinoma grows well in males and pregnant females but poorly in virgin females when given in small doses. Induction of growth of this tumor is syngeneic and allogeneic virgin females was achieved b...

journal_title：Transplantation

authors： Isa AM,Sanders BR

更新日期：1975-10-01 00:00:00

abstract：BACKGROUND:We explored the efficacy of the Oxford classification for assessing native immunoglobulin A nephropathy (IgAN) in posttransplantation patients compared with the glomerular injury score and Haas classification. METHODS:A total of 125 renal allograft biopsies obtained from 114 patients diagnosed with IgAN reg...

journal_title：Transplantation

authors： Lim BJ,Joo DJ,Kim MS,Kim YS,Kim SI,Kim Y,Huh KH,Koh MJ,Jeong HJ

更新日期：2013-06-27 00:00:00