Usefulness of Oxford classification in assessing immunoglobulin A nephropathy after transplantation.

abstract：BACKGROUND:We studied whether T-cell clones, which appear in the periphery as a result of the failure of thymic negative selection during graft-versus-host disease (GVHD), have any in vivo anti-host reactivity and can cause GVHD in an adoptive transfer model. METHODS:We performed our studies in a murine model (B10.BR ...

journal_title：Transplantation

authors： van den Brink MR,Moore E,Ferrara JL,Burakoff SJ

更新日期：2000-02-15 00:00:00

abstract：BACKGROUND:Skin-autofluorescence (skin-AF) noninvasively measures the tissue accumulation of advanced glycation end products (AGEs). AGEs are nephrotoxic and potential effectors of cardiovascular mortality. We investigated whether skin-AF predicted graft loss after kidney transplantation. METHODS:A total of 302 renal ...

journal_title：Transplantation

authors： Hartog JW,Gross S,Oterdoom LH,van Ree RM,de Vries AP,Smit AJ,Schouten JP,Nawroth PP,Gans RO,van Son WJ,Bierhaus A,Bakker SJ

更新日期：2009-04-15 00:00:00

abstract：BACKGROUND:Chronic allograft nephropathy (CAN) has become the predominant limiting factor for long-term transplant survival. A cardinal histomorphologic correlate for CAN is interstitial fibrosis. Currently, no method has been established in routine use that reliably quantifies the extent of interstitial fibrosis in re...

journal_title：Transplantation

authors： Pape L,Henne T,Offner G,Strehlau J,Ehrich JH,Mengel M,Grimm PC

更新日期：2003-09-27 00:00:00

abstract：:Nonmajor histocompatibility complex (non-MHC) antigens are important targets of graft rejection and graft-versus-host disease in clinical transplantation. Little is known regarding immunity to non-MHC antigens. To study this problem we evaluated the effect of antihuman thymocyte globulin (ATG) on reactivity in autolog...

journal_title：Transplantation

authors： Harada M,Gale RP

更新日期：1981-02-01 00:00:00

abstract：BACKGROUND:Osteoarthritis is the most prevalent joint disease and a frequent cause of joint pain, functional loss, and disability. Osteoarthritis often becomes chronic, and conventional treatments have demonstrated only modest clinical benefits without lesion reversal. Cell-based therapies have shown encouraging result...

journal_title：Transplantation

authors： Orozco L,Munar A,Soler R,Alberca M,Soler F,Huguet M,Sentís J,Sánchez A,García-Sancho J

更新日期：2013-06-27 00:00:00

abstract：:Gliotoxin is an immunosuppressive secondary metabolite produced by several pathogenic fungi. It has previously been shown to prevent graft-versus-host disease in transplantation of allogeneic mouse bone marrow and to reduce the immunogenicity of human fetal pancreas. We here report on the effect of gliotoxin on the pr...

journal_title：Transplantation

authors： Sutton P,Moreland A,Hutchinson IV,Müllbacher A

更新日期：1995-11-15 00:00:00

abstract：:Organ donation after circulatory death (DCD) has been endorsed by the World Health Organization and is practiced worldwide. This overview examines current DCD practices, identifies problems and challenges, and suggests clinical strategies for possible improvement. Although there is uniform agreement on DCD donor candi...

journal_title：Transplantation

authors： Morrissey PE,Monaco AP

更新日期：2014-02-15 00:00:00

abstract：BACKGROUND:Fetal pancreatic tissue has been suggested to be less immunogenic than adult islets. Thus, transplantation of human fetal pancreatic tissue as treatment for type 1 diabetes has been gaining interest. To investigate this question, we tested the peripheral blood mononuclear cell (PBMC) responses from different...

journal_title：Transplantation

authors： Brooks-Worrell BM,Peterson KP,Peterson CM,Palmer JP,Jovanovic L

更新日期：2000-05-15 00:00:00

abstract：BACKGROUND:Microvascular endothelial cells (ECs) are central to an allograft's immunogenicity. Cold ischemia and reperfusion injury associated with static cold storage and warm reperfusion activates ECs and increases the immunogenicity of the allograft. After reperfusion, mitochondrial permeability transition pore (mPT...

journal_title：Transplantation

authors： Tran DT,Esckilsen S,Mulligan J,Mehrotra S,Atkinson C,Nadig SN

更新日期：2018-06-01 00:00:00

abstract：:Long-term graft survival is mainly influenced by early graft rejection and posttransplant graft function. The ability of both complement-dependent cytotoxicity cross-match (CDC) and flow cytometry cross-match (FCXM) to predict acute rejection episodes has been evaluated by cross-matching 40 patients who received cadav...

journal_title：Transplantation

authors： Utzig MJ,Blümke M,Wolff-Vorbeck G,Lang H,Kirste G

更新日期：1997-02-27 00:00:00

abstract：:In human organ transplantation, the correct diagnosis of rejection may be difficult using clinical and/or histopathologic criteria, and immunologic assays should therefore be considered. We have applied monoclonal antibodies in 2-color flow cytometric (FACS) analysis to study phenotypic patterns of kidney-infiltrating...

journal_title：Transplantation

authors： Tötterman TH,Hanås E,Bergström R,Larsson E,Tufveson G

更新日期：1989-05-01 00:00:00

abstract：:We retrospectively investigated the impact of pancreas transplantation on cardiovascular disease risk factors in patients with type 1 diabetic end-stage renal disease (ESRD). Two cohorts of patients, 44 simultaneous pancreas and kidney transplant patients (SPK) and 30 kidney transplant-alone patients (KTA), were inclu...

journal_title：Transplantation

authors： Luan FL,Miles CD,Cibrik DM,Ojo AO

更新日期：2007-08-27 00:00:00

abstract：BACKGROUND:We are presently investigating the therapeutic potential of herpes simplex-thymidine kinase-expressing donor T cells in the setting of a T cell-depleted allogeneic bone marrow transplantation. The generation, expansion, and selection of the gene-modified T cells require a 12-day ex vivo culture period in hig...

journal_title：Transplantation

authors： Contassot E,Murphy W,Angonin R,Pavy JJ,Bittencourt MC,Robinet E,Reynolds CW,Cahn JY,Hervé P,Tiberghien P

更新日期：1998-05-27 00:00:00

abstract：BACKGROUND:The National Marrow Donor Program (NMDP) has approximately 5 million registered potential donors and continues to add more than 30,000 new recruits to the registry monthly. However, more than 30% of potential donors are not available or decline to donate at key decision points in the donation process. Althou...

journal_title：Transplantation

authors： Myaskovsky L,Switzer GE,Dew MA,Goycoolea JM,Confer DL,Abress L

更新日期：2004-03-27 00:00:00

abstract：:We have previously shown that trophic factor supplementation (TFS) of University of Wisconsin (UW) solution enhanced kidney viability after cold storage. Here, we use an in vitro model to study the effect of TFS on early apoptotic changes after cold ischemic storage. Mitochondrial membrane potential was determined by ...

journal_title：Transplantation

authors： Kwon YS,Foley JD,Murphy CJ,McAnulty JF

更新日期：2007-01-15 00:00:00

abstract：BACKGROUND:Detection of markers predicting allograft rejection is important for risk assessment before kidney transplantation, as well as to minimize posttransplantation immunosuppression. METHODS:We studied the expression of CD25, HLA-DR, CD134, CD62L, and CD44 by flow cytometry in CD4, CD8, and CD3 cells, from pretr...

journal_title：Transplantation

authors： Hueso M,Mestre M,Benavente Y,Bas J,Grinyó JM,Navarro E

更新日期：2011-09-15 00:00:00

abstract：OBJECTIVE:Intrahepatic infusion is the most common method of islet autotransplantation. Structural and functional changes within the liver may result from a number of factors, including embolization of the terminal branches of the portal vein, the effects of high insulin concentration on surrounding hepatocytes or resp...

journal_title：Transplantation

authors： Ong SL,Pollard C,Rees Y,Garcea G,Webb M,Illouz S,Berry DP,Dennison AR

更新日期：2008-06-27 00:00:00

abstract：:The development of erythrocytosis following renal transplantation has been reported to be caused by a number of factors. These include acute and chronic rejection, hydronephrosis and renal artery stenosis. In this study, seven patients were noted to have erythrocytosis with hematocrits ranging between 53.5 and 66%. Se...

journal_title：Transplantation

authors： Dagher FJ,Ramos E,Erslev AJ,Alongi SV,Karmi SA,Caro J

更新日期：1979-12-01 00:00:00

abstract：:Mouse thyroid tissue was dissociated with collagenase, fixed in periodate-lysine-paraformaldehyde (PLP), and further dissociated with EDTA and trypsin to yield cell suspensions containing mainly follicle epithelial cells and vascular endothelial cells. H-2 complex antigens were detected on the vascular endothelial cel...

journal_title：Transplantation

authors： Parr EL,Lafferty KJ,Bowen KM,McKenzie IF

更新日期：1980-08-01 00:00:00

abstract：BACKGROUND:We recently demonstrated that inhibition of inducible nitric oxide synthase (iNOS) ameliorated severe acute lung allograft rejection. This study used a rat lung transplant model to determine (1) the time course and cellular localization of iNOS expression during the histological progression of unmodified acu...

journal_title：Transplantation

authors： Worrall NK,Boasquevisque CH,Botney MD,Misko TP,Sullivan PM,Ritter JH,Ferguson TB Jr,Patterson GA

更新日期：1997-04-27 00:00:00

abstract：BACKGROUND:Spontaneous tolerance to liver allograft has been reported previously in outbred pig models, but the lack of genetic background did not allow to analyze the impact of the major histocompatibility complex (MHC) on tolerance induction. A model of semi-identical liver allograft was therefore developed in inbred...

journal_title：Transplantation

authors： Oike F,Talpe S,Otsuka M,Dehoux JP,Lerut J,Otte JB,Gianello P

更新日期：2000-06-15 00:00:00

abstract：BACKGROUND:Thrombotic microangiopathy (TMA) is a fatal complication characterized by microvascular occlusive disorder resulting in systemic or intrarenal platelet aggregation, severe thrombocytopenia, and microangiopathic hemolytic anemia. Only sporadic case reports of TMA after cadaveric or living-donor liver transpla...

journal_title：Transplantation

authors： Tamura S,Sugawara Y,Matsui Y,Kishi Y,Akamatsu N,Kaneko J,Makuuchi M

更新日期：2005-07-27 00:00:00

abstract：BACKGROUND:Diagnosing acute rejection (AR) in kidney transplant recipients typically requires an invasive kidney biopsy. A previous study has suggested that expression of five genes in peripheral blood can indicate the presence of AR in American pediatric kidney transplant recipients. This study aims to validate if the...

journal_title：Transplantation

authors： Lee A,Jeong JC,Choi YW,Seok HY,Kim YG,Jeong KH,Moon JY,Lee TW,Ihm CG,Jeon HJ,Koo TY,Ahn C,Lim SJ,Yang J,Lee SH

更新日期：2014-10-15 00:00:00

abstract：BACKGROUND:Proteinuria is associated with endothelial dysfunction (ED) and increased mortality. We investigated whether urinary protein excretion (UPE) is correlated with markers of ED and whether these markers affect the association of proteinuria with mortality in renal transplant recipients (RTR). METHODS:Six hundr...

journal_title：Transplantation

authors： van Ree RM,Oterdoom LH,de Vries AP,Homan van der Heide JJ,van Son WJ,Navis G,Gans RO,Bakker SJ

更新日期：2008-12-27 00:00:00

abstract：BACKGROUND:Pneumocystis jiroveci pneumonia may be a life-threatening opportunistic infection in immunosuppressed solid organ transplant recipients. Despite effective treatment with high-dose trimethoprim-sulfamethoxazole and steroids, morbidity is often severe and lethality remains high. New therapeutic approaches are ...

journal_title：Transplantation

authors： Utili R,Durante-Mangoni E,Basilico C,Mattei A,Ragone E,Grossi P

更新日期：2007-09-27 00:00:00

abstract：BACKGROUND:Current histological methods cannot accurately determine the survival rate of human pancreatic islets following portal vein infusion. This is due, in part, to the low number of infused islets relative to the whole liver. In this study, we assessed the ability of confocal laser scanning microscopy (CLSM) to t...

journal_title：Transplantation

authors： Sui F,Tang W,Karunananthan J,Qi C,Li J,He N,Kandeel F,Li J

更新日期：2020-06-01 00:00:00

abstract：BACKGROUND:To better understand how different histologic patterns of allograft inflammation found on biopsies of human cardiac allografts progress to high-grade rejection, we undertook a statistical analysis of our institutional database to detect statistical patterns among different types of myocardial allograft infla...

journal_title：Transplantation

authors： Smith RN,Chang Y,Houser S,Dec GW,Grazette L

更新日期：2002-06-27 00:00:00

abstract：BACKGROUND:Pregnancy after heart transplantation (HTx) may expose the recipient to hemodynamic and immunologic risks and the newborn to toxic effects of immunosuppressive therapy. Adequate preconception counseling is crucial to identify optimal timing and to modify immunosuppressive therapy to minimize risks for both t...

journal_title：Transplantation

authors： Macera F,Occhi L,Masciocco G,Varrenti M,Frigerio M

更新日期：2018-09-01 00:00:00

abstract：BACKGROUND:Urinary neutrophil gelatinase-associated lipocalin (NGAL) has emerged an early marker protein, predicative of acute kidney injury (AKI) in various clinical settings. Here, we demonstrate urinary NGAL to allow for differential diagnosis of AKI, accurately discriminating acute allograft rejection from other ca...

journal_title：Transplantation

authors： Heyne N,Kemmner S,Schneider C,Nadalin S,Königsrainer A,Häring HU

更新日期：2012-06-27 00:00:00

abstract：BACKGROUND:Natural antibodies that react with galactose-alpha(1,3)galactose [galalpha(1,3)gal] carbohydrate epitopes exist in humans and Old World primates because of the inactivation of the alpha1,3-galactosyltransferase (alpha1,3GT) gene in these species and the subsequent production of antibodies to environmental mi...

journal_title：Transplantation

authors： Nozawa S,Xing PX,Wu GD,Gochi E,Kearns-Jonker M,Swensson J,Starnes VA,Sandrin MS,McKenzie IF,Cramer DV

更新日期：2001-07-15 00:00:00