A New Life: Motherhood After Heart Transplantation. A Single-center Experience and Review of Literature.

Abstract:

BACKGROUND:Pregnancy after heart transplantation (HTx) may expose the recipient to hemodynamic and immunologic risks and the newborn to toxic effects of immunosuppressive therapy. Adequate preconception counseling is crucial to identify optimal timing and to modify immunosuppressive therapy to minimize risks for both the mother and the fetus. METHODS:We describe our experience with 12 pregnancies occurred in 11 women who had undergone HTx at our center. RESULTS:Pregnancies ran without severe complications or rejections, and none of the babies have shown major defects at birth. However, as reported in the literature, weight at birth rated in lower range in most of the newborns, probably due to in utero cyclosporine exposure. Up to now, none of the babies showed clinical signs of heart disease, although more than half of the mothers had an inherited or familial cardiomyopathy. CONCLUSIONS:Despite potential mother and fetal complications, successful pregnancy and delivery are possible after HTx, provided that optimum timing, close monitoring, and therapy adjustments are guaranteed. Becoming a mother appears to be an important achievement for young women after HTx, even when there is a risk to transmit an inheritable heart disease.

journal_name

Transplantation

journal_title

Transplantation

authors

Macera F,Occhi L,Masciocco G,Varrenti M,Frigerio M

doi

10.1097/TP.0000000000002281

subject

Has Abstract

pub_date

2018-09-01 00:00:00

pages

1538-1544

issue

9

eissn

0041-1337

issn

1534-6080

journal_volume

102

pub_type

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