Higher frequency of high-grade rejections in cardiac allograft patients after Quilty B lesions or grade 2/4 rejections.

abstract：BACKGROUND:Renal allograft rejection is associated with the expression of adhesion molecules on vascular endothelial and tubular epithelial cells. METHODS:To assess whether the number of cell adhesion molecules expressed in donor kidneys can predict early rejection or delayed graft function, kidney biopsies from 20 li...

journal_title：Transplantation

authors： Schwarz C,Regele H,Steininger R,Hansmann C,Mayer G,Oberbauer R

更新日期：2001-06-15 00:00:00

abstract：INTRODUCTION:We investigated the putative candidate biomarkers of graft rejection in peripheral blood of intestinal transplant patients. MATERIALS AND METHODS:Peripheral blood gene expression analysis was performed in intestinal transplant patients. The results were matched with concurrent graft biopsies using bioinfo...

journal_title：Transplantation

authors： Andreev VP,Tryphonopoulos P,Blomberg BB,Tsinoremas N,Weppler D,Neuman DR,Volsky A,Nishida S,Tekin A,Selvaggi G,Levi DM,Tzakis AG,Ruiz P

更新日期：2011-12-27 00:00:00

abstract：:Sixty-two adults who underwent orthotopic liver transplantations between February 1981 and June 1983 were followed for a mean of 170 days after the operation. Twenty-six patients developed 30 episodes of significant fungal infection. Candida species and Torulopsis glabrata were responsible for 22 episodes and Aspergil...

journal_title：Transplantation

authors： Wajszczuk CP,Dummer JS,Ho M,Van Thiel DH,Starzl TE,Iwatsuki S,Shaw B Jr

更新日期：1985-10-01 00:00:00

abstract：BACKGROUND:Early enteral nutrition with solutions containing prebiotics (fiber) and probiotics (Lactobacillus) is suggested to reduce bacterial translocation and minimize the incidence of infections after liver transplantation. METHODS:In a prospective, randomized placebo-controlled trial consisting of 95 patients, we...

journal_title：Transplantation

authors： Rayes N,Seehofer D,Hansen S,Boucsein K,Müller AR,Serke S,Bengmark S,Neuhaus P

更新日期：2002-07-15 00:00:00

abstract：BACKGROUND:Increasing long-term allograft survival is the main challenge in organ transplantation, and allograft loss due to chronic rejection has been found to correlate with episodes of early acute rejection. It is important to understand the mechanisms that maintain the donor-specific hyporesponsive state. This stud...

journal_title：Transplantation

authors： Mittal SK,Sharma RK,Gupta A,Naik S

更新日期：2009-08-15 00:00:00

abstract：BACKGROUND:Urinary neutrophil gelatinase-associated lipocalin (NGAL) has emerged an early marker protein, predicative of acute kidney injury (AKI) in various clinical settings. Here, we demonstrate urinary NGAL to allow for differential diagnosis of AKI, accurately discriminating acute allograft rejection from other ca...

journal_title：Transplantation

authors： Heyne N,Kemmner S,Schneider C,Nadalin S,Königsrainer A,Häring HU

更新日期：2012-06-27 00:00:00

abstract：:Allograft rejection results from a complex process involving both the innate and acquired immune systems. The innate immune system predominates in the early phase of the allogeneic response, during which chemokines and cell adhesion play essential roles, not only for leukocyte migration into the graft but also for fac...

journal_title：Transplantation

authors： Le Moine A,Goldman M,Abramowicz D

更新日期：2002-05-15 00:00:00

abstract：:Heterotopic abdominal rat heart transplantation has been extensively used to investigate ischemic-reperfusion injury, immunological consequences during heart transplantations and also to study remodeling of the myocardium due to volume unloading. We provide a unique review on the latter and present a summary of the ex...

journal_title：Transplantation

authors： Benke K,Sayour AA,Mátyás C,Ágg B,Németh BT,Oláh A,Ruppert M,Hartyánszky I,Szabolcs Z,Radovits T,Merkely B,Szabó G

更新日期：2017-03-01 00:00:00

abstract：BACKGROUND:The use of calcineurin inhibitors is associated with chronic nephrotoxicity and lower glomerular filtration rate (GFR). As a result, one strategy of transplant immunosuppression is calcineurin inhibitor elimination. METHODS:The aim of this study was to determine the outcome of a prospective randomized trial...

journal_title：Transplantation

authors： Heilman RL,Younan K,Wadei HM,Mai ML,Reddy KS,Chakkera HA,Gonwa TA

更新日期：2011-10-15 00:00:00

abstract：BACKGROUND:The pig is currently considered to be the most likely candidate for a xenogenic-organ source. Anti-pig human T-cell response via co-stimulatory molecules has been studied with great interest. The soluble form of porcine CD80 has recently been cloned and characterized, but the sequence of the transmembrane fo...

journal_title：Transplantation

authors： Wada M,Amae S,Sasaki H,Ishii T,Sano N,Nio M,Hayashi Y,Ohi R

更新日期：2003-06-15 00:00:00

abstract：:Rat, hamster, and rabbit islets were transplanted into diabetic C57BL/B6 mice. The effect on islet xenograft survival of low-temperature culture of the donor islets, alpha L3T4 treatment of the recipients for seven days, and transplantation of the grafts either in the renal capsule or in the liver via the portal vein ...

journal_title：Transplantation

authors： Lacy PE,Ricordi C,Finke EH

更新日期：1989-05-01 00:00:00

abstract：BACKGROUND:In a recent trial, targeted mild hypothermia in brain-dead organ donors significantly reduced the incidence of delayed graft function after kidney transplantation. This trial was stopped early for efficacy. Here, we report long-term graft survival for all organs along with donor critical care end points. ME...

journal_title：Transplantation

authors： Malinoski D,Patel MS,Axelrod DA,Broglio K,Lewis RJ,Groat T,Niemann CU

更新日期：2019-11-01 00:00:00

abstract：:If transplantation of endocrine tissue is to become a therapy for a significant number of insulin-dependent diabetic individuals, tissue sources other than adult human islets will be required. Because human fetal pancreatic cells may offer that alternative, we have tried to find the optimal combination of tissue cultu...

journal_title：Transplantation

authors： Beattie GM,Otonkoski T,Lopez AD,Hayek A

更新日期：1993-12-01 00:00:00

abstract：BACKGROUND:Controversy exists about the conditions effecting the development of forkhead/winghead helix transcription factor P3 (FOXP3) expressing T cells and their relevance in transplant recipients. METHODS:We generated carboxy-fluorescein diacetate succinimidyl ester-labeled CD4+CD25 high FOXP3+ cells in mixed lymp...

journal_title：Transplantation

authors： Levitsky J,Miller J,Leventhal J,Huang X,Flaa C,Wang E,Tambur A,Burt RK,Gallon L,Mathew JM

更新日期：2009-12-15 00:00:00

abstract：BACKGROUND:To confirm the results of a number of studies conducted in Europe, the United States, and Japan, this multicenter, randomized trial compared the 12-month efficacy and safety of tacrolimus- and cyclosporine-based immunosuppressive regimens in the prevention of renal allograft rejection. METHODS:A total of 44...

journal_title：Transplantation

authors： Mayer AD,Dmitrewski J,Squifflet JP,Besse T,Grabensee B,Klein B,Eigler FW,Heemann U,Pichlmayr R,Behrend M,Vanrenterghem Y,Donck J,van Hooff J,Christiaans M,Morales JM,Andres A,Johnson RW,Short C,Buchholz B,Rehmert N

更新日期：1997-08-15 00:00:00

abstract：BACKGROUND:Increasing clinical evidence suggests that delayed initial function secondary to ischemia/reperfusion injury alone, and particularly in combination with early episodes of acute rejection, reduces kidney allograft survival over time. METHODS:We investigated changes developing over the long term following a s...

journal_title：Transplantation

authors： Takada M,Nadeau KC,Shaw GD,Tilney NL

更新日期：1997-12-15 00:00:00

abstract：BACKGROUND:To define whether immunosuppressive agents that block the interleukin (IL)-2 pathway could prevent activation-induced cell death of activated T cells in the graft, we measured expression of IL-2, IL-2 receptor alpha chain (CD25), IL-15, Fas, and Fas ligand by real time reverse transcription-polymerase chain ...

journal_title：Transplantation

authors： Baan CC,Balk AH,van Riemsdijk IC,Vantrimpont PJ,Maat AP,Niesters HG,Zondervan PE,van Gelder T,Weimar W

更新日期：2003-05-27 00:00:00

abstract：BACKGROUND:To investigate immune reactions after reduced-intensity cord-blood transplantation (RI-CBT). MATERIALS AND METHODS:We reviewed medical records of 57 adult RI-CBT recipients. Preparative regimen comprised fludarabine, total-body irradiation, and either melphalan (n=51) or busulfan (n=6). Graft-versus-host di...

journal_title：Transplantation

authors： Kishi Y,Kami M,Miyakoshi S,Kanda Y,Murashige N,Teshima T,Kusumi E,Hara S,Matsumura T,Yuji K,Masuoka K,Wake A,Morinaga S,Kanemaru M,Hayashi T,Tanaka Y,Taniguchi S,Tokyo Stem Cell Transplant Consortium.

更新日期：2005-07-15 00:00:00

abstract：:The effects of dietary (10% calories) safflower (SAF), evening primrose (EPO), and fish oil (F) as sources of linoleic acid (control), gamma-linolenic acid, and long-chain n-3 fatty acids, respectively, on cardiovascular and renal responses to chronic (5 weeks) cyclosporine administration were studied in male borderli...

journal_title：Transplantation

authors： Mills DE,Ward RP,McCutcheon D,Dixon H,Ly H,Scholey J

更新日期：1992-03-01 00:00:00

abstract：:The particular T cell subsets involved in the rejection of tumor allografts were examined in mice using two different approaches. In the first, EL4 lymphoma cells or B16 melanoma cells were given to ATXBM-CBA/H mice which had been reconstituted with either naive or sensitized T cells selectively depleted with either L...

journal_title：Transplantation

authors： Loveland BE,McKenzie IF

更新日期：1982-02-01 00:00:00

abstract：:Experimental studies of vein homografts in rats have shown prolonged patency resulting from an attenuated immune response. This study examined the response to Golden Syrian hamster vein xenografts. While one group of Sprague-Dawley rats served as a control, a second group was sensitized with 5 X 10(6) viable hamster s...

journal_title：Transplantation

authors： Jordan BP,Jones JW,Rodgers GH,Flye MW

更新日期：1985-11-01 00:00:00

abstract：BACKGROUND:New strategies for improving durable functional islet mass will be instrumental in facilitating islet transplantation as a cure for type 1 diabetes mellitus. The ability to transfer immunoregulatory or cytoprotective genes into pancreatic islets may enhance survival. Adenoviral vectors (Ad5) have been used w...

journal_title：Transplantation

authors： Contreras JL,Wu H,Smyth CA,Eckstein CP,Young CJ,Seki T,Bilbao G,Curiel DT,Eckhoff DE

更新日期：2003-07-15 00:00:00

abstract：:We have previously shown that trophic factor supplementation (TFS) of University of Wisconsin (UW) solution enhanced kidney viability after cold storage. Here, we use an in vitro model to study the effect of TFS on early apoptotic changes after cold ischemic storage. Mitochondrial membrane potential was determined by ...

journal_title：Transplantation

authors： Kwon YS,Foley JD,Murphy CJ,McAnulty JF

更新日期：2007-01-15 00:00:00

abstract：:T cells must be activated before they can elicit damage to allografts, through interaction of their T cell receptor (TCR) with peptide-MHC complex and through accessory molecules. Signaling through accessory molecules or costimulatory molecules is a critical way for the immune system to fine tune T cell activation. An...

journal_title：Transplantation

authors： Kinnear G,Jones ND,Wood KJ

更新日期：2013-02-27 00:00:00

abstract：:Stable renal transplant recipients (RTR) display high rates of atherosclerotic events (AE). Innate immunity and especially vascular inflammation play a role in the pathogenesis of atherosclerosis. It is illustrated both by an increased occurrence of postrenal transplant cardiovascular events in patients with elevated ...

journal_title：Transplantation

authors： Courivaud C,Ferrand C,Deschamps M,Tiberghien P,Chalopin JM,Duperrier A,Saas P,Ducloux D

更新日期：2006-04-27 00:00:00

abstract：:The question has not been previously investigated as to whether host lymphocytes infiltrate vascularized organ allografts in indiscriminate fashion, or whether they are retained selectively because of specific antigenic recognition sites on their surfaces. By using a dual cardiac allograft model in LEW rats, we have e...

journal_title：Transplantation

authors： Tilney NL,Notis-McConarty J,Strom TB

更新日期：1978-09-01 00:00:00

abstract：:Clinical observations suggest that recipients of multiorgan transplants from the same donor can have disparate immunological reactions to each organ. We studied this phenomenon in 36 diabetic (streptozotocin-induced), bilaterally nephrectomized immunosuppressed (cyclosporine, azathioprine, prednisone) pig recipients o...

journal_title：Transplantation

authors： Gruessner RW,Nakhleh R,Tzardis P,Schechner R,Platt JL,Gruessner A,Tomadze G,Najarian JS,Sutherland DE

更新日期：1993-12-01 00:00:00

abstract：BACKGROUND:Human herpesvirus-6 (HHV-6) has been implicated in bone marrow suppression, interstitial pneumonitis, and fatal meningoencephalitis in bone marrow transplant (BMT) recipients. METHODS:We describe the case of a woman with acute myeloid leukemia in second remission who developed febrile meningoencephalitis 8 ...

journal_title：Transplantation

authors： Rieux C,Gautheret-Dejean A,Challine-Lehmann D,Kirch C,Agut H,Vernant JP

更新日期：1998-05-27 00:00:00

abstract：:Living-donor liver transplantation has provided a solution to the severe lack of cadaveric grafts for the replacement of livers afflicted with end-stage cirrhosis, fulminant disease, or inborn errors of metabolism. The pioneering experience in Japan in the early 1990s helped open wide the avenues of a new branch of sc...

journal_title：Transplantation

authors： Chen CL,Fan ST,Lee SG,Makuuchi M,Tanaka K

更新日期：2003-02-15 00:00:00

abstract：:Hepatic venoocclusive disease is a frequent lethal complication of bone marrow transplantation. It has also been associated with hepatic irradiation and administration of chemotherapeutic agents without BMT. The pathogenesis and therapy of VOD are unclear. The present studies were directed at developing a canine model...

journal_title：Transplantation

authors： Epstein RB,Min KW,Anderson SL,Syzek L

更新日期：1992-07-01 00:00:00