Fungal infections in liver transplant recipients.

Abstract:

:Sixty-two adults who underwent orthotopic liver transplantations between February 1981 and June 1983 were followed for a mean of 170 days after the operation. Twenty-six patients developed 30 episodes of significant fungal infection. Candida species and Torulopsis glabrata were responsible for 22 episodes and Aspergillus species for 6. Most fungal infections occurred in the first month after transplantation. In the first 8 weeks after transplantation, death occurred in 69% (18/26) of patients with fungal infection but in only 8% (3/36) of patients without fungal infection (P less than 0.0005). The cause of death, however, was usually multifactorial, and not solely due to the fungal infection. Fungal infections were associated with the following clinical factors: administration of preoperative steroids (P less than 0.05) and antibiotics (P less than 0.05), longer transplant operative time (P less than 0.02), longer posttransplant operative time (P less than 0.01), duration of antibiotic use after transplant surgery (P less than 0.001), and the number of steroid boluses administered to control rejection in the first 2 posttransplant months (P less than 0.01). Patients with primary biliary cirrhosis had fewer fungal infections than patients with other underlying liver diseases (P less than 0.05). A total of 41% (9/22) of Candida infections resolved, but all Aspergillus infections ended in death.

journal_name

Transplantation

journal_title

Transplantation

authors

Wajszczuk CP,Dummer JS,Ho M,Van Thiel DH,Starzl TE,Iwatsuki S,Shaw B Jr

doi

10.1097/00007890-198510000-00002

subject

Has Abstract

pub_date

1985-10-01 00:00:00

pages

347-53

issue

4

eissn

0041-1337

issn

1534-6080

journal_volume

40

pub_type

杂志文章
  • External Validation of the DynPG for Kidney Transplant Recipients.

    abstract:BACKGROUND:In kidney transplantation, dynamic prediction of patient and kidney graft survival (DynPG) may help to promote therapeutic alliance by delivering personalized evidence-based information about long-term graft survival for kidney transplant recipients. The objective of the current study is to externally valida...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0000000000003209

    authors: Lenain R,Dantan E,Giral M,Foucher Y,Asar Ö,Naesens M,Hazzan M,Fournier MC

    更新日期:2021-02-01 00:00:00

  • Long-term outcome of controlled, non-heart-beating donor liver transplantation.

    abstract:BACKGROUND:Previous reports have established the feasibility of using livers from controlled, non-heart-beating donors (CNHBD) with good immediate graft function. This has been largely borne out of necessity because of the donor shortage. METHODS:Retrospective database review for the last 7 years (1995-2002), encompas...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/01.tp.0000128327.95311.e3

    authors: Manzarbeitia CY,Ortiz JA,Jeon H,Rothstein KD,Martinez O,Araya VR,Munoz SJ,Reich DJ

    更新日期:2004-07-27 00:00:00

  • Size reduction of small bowels from adult cadaveric donors to alleviate the scarcity of pediatric size-matched organs: an anatomical and feasibility study.

    abstract:BACKGROUND:Small bowel transplantation in children weighing less than 10 kg is hindered by the lack of size-matched donors. The ability to create reduced size small bowel grafts from adult cadaveric donors suitable for use in young children has been studied. METHODS:Volumetric assessment of computed tomography scans w...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-200004150-00031

    authors: Delrivière L,Muiesan P,Marshall M,Davenport M,Dhawan A,Kane P,Karani J,Rela M,Heaton N

    更新日期:2000-04-15 00:00:00

  • The effect of cyclosporine on agonist-stimulated glomerular and mesangial cell vasodilatory prostaglandin production.

    abstract::Cyclosporine A administration produces an increase in renal vascular resistance and a decrease in glomerular filtration rate in both human and animal models. CsA usage in humans has also been shown to alter the ability of the kidney to adapt to alterations in renal hemodynamics. CsA alters the production of prostaglan...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199110000-00025

    authors: Bunke M,Wilder L,Martin A

    更新日期:1991-10-01 00:00:00

  • The graft-versus-host reaction and immune function. II. Recruitment of pre-T-cells in vivo by graft-versus-host-induced dysplastic thymuses following irradiation and bone marrow treatment.

    abstract::The graft-versus-host (GVH) reaction induces thymic dysplasia and an arrest in T cell differentiation. Studies were performed to test the effect of irradiation and reconstitution with bone marrow on GVH-induced thymic dysplasia and T cell differentiation. GVH reactions were induced in CBAxAF1 adult mice by the injecti...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:

    authors: Seddik M,Seemayer TA,Lapp WS

    更新日期:1984-03-01 00:00:00

  • Carotid atherosclerosis in renal transplant recipients: relationships with cardiovascular risk factors and plasma lipoproteins.

    abstract:BACKGROUND:Renal transplant recipients have an increased incidence of cardiovascular disease, but less data exist about cerebrovascular atherosclerosis. In this study, we assessed the prevalence of carotid lesions as evaluated by B-mode ultrasonography in a group of renal transplant recipients, and we evaluated univari...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199902150-00005

    authors: Barbagallo CM,Pinto A,Gallo S,Parrinello G,Caputo F,Sparacino V,Cefalù AB,Novo S,Licata G,Notarbartolo A,Averna MR

    更新日期:1999-02-15 00:00:00

  • Intercellular adhesion molecule-1 expression in endothelial cells is activated by cytomegalovirus immediate early proteins.

    abstract:BACKGROUND:Human cytomegalovirus (HCMV) infection is associated with allograft vasculopathy and rejection. One potential mechanism is vascular injury from immunologically mediated processes. HCMV infection has been shown to increase the constitutive expression of intercellular adhesion molecule-1 (ICAM-1). The objectiv...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199901150-00023

    authors: Burns LJ,Pooley JC,Walsh DJ,Vercellotti GM,Weber ML,Kovacs A

    更新日期:1999-01-15 00:00:00

  • Transfusion rate for 500 consecutive liver transplantations: experience of one liver transplantation center.

    abstract:BACKGROUND:Orthotopic liver transplantation (OLT) has been associated with major blood loss and the need for blood product transfusions. During the last decade, improved surgical and anesthetic management has reduced intraoperative blood loss and blood product transfusions. A first report from our group published in 20...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0b013e318250fc25

    authors: Massicotte L,Denault AY,Beaulieu D,Thibeault L,Hevesi Z,Nozza A,Lapointe R,Roy A

    更新日期:2012-06-27 00:00:00

  • Targeted endothelial delivery of nanosized catalase immunoconjugates protects lung grafts donated after cardiac death.

    abstract:BACKGROUND:Donor organ shortage represents a major problem in lung transplantation. Donation after cardiac death could help to expand the pool of organs, but the additional period of warm ischemia after cardiac arrest aggravates primary graft dysfunction. The pulmonary endothelium of the graft constitutes an important ...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0b013e318226bc6b

    authors: Preissler G,Loehe F,Huff IV,Ebersberger U,Shuvaev VV,Bittmann I,Hermanns I,Kirkpatrick JC,Fischer K,Eichhorn ME,Winter H,Jauch KW,Albelda SM,Muzykantov VR,Wiewrodt R

    更新日期:2011-08-27 00:00:00

  • Long-term improvement in renal function after cyclosporine reduction in renal transplant recipients with histologically proven chronic cyclosporine nephropathy.

    abstract:BACKGROUND:Chronic cyclosporine (CsA) nephropathy, which has been unequivocally documented in recipients of heart, heart-lung, liver, or bone marrow transplants, as well as in nontransplant situations, usually results in a progressive deterioration of renal function. In this study, we assessed the potential reversibili...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199803150-00010

    authors: Mourad G,Vela C,Ribstein J,Mimran A

    更新日期:1998-03-15 00:00:00

  • Progression of renal dysfunction in cardiac transplantation after the introduction of everolimus in the immunosuppressive regime.

    abstract::The aim of this study was to analyze, in heart transplant patients, if renal function improvement after cyclosporine replacement by everolimus persists at the middle term and its predictors. We studied prospectively 56 patients in whom conversion was consecutively made. Forty-five patients completed the follow-up peri...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0b013e31819452ce

    authors: Moro López JA,Almenar L,Martínez-Dolz L,Sánchez-Lázaro I,Agüero J,Buendía F,Ortiz V,Salvador A

    更新日期:2009-02-27 00:00:00

  • Dual-kidney transplantation with organs from expanded criteria donors: a long-term follow-up.

    abstract:BACKGROUND:Since 1995, dual-kidney transplantation using organs from marginal donors has been used at our center to expand the organ donor pool and decrease the waiting time for deceased donor kidney transplantation. This approach has allowed for a shorter waiting period without compromising outcome in the early posttr...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/01.tp.0000130452.01521.b1

    authors: Tan JC,Alfrey EJ,Dafoe DC,Millan MT,Scandling JD

    更新日期:2004-09-15 00:00:00

  • Evidence that graft coronary arteriosclerosis begins in the early phase after transplantation and progresses without chronic immunoreaction. Histopathological analysis using a retransplantation model.

    abstract::The histopathological features of chronic rejection and its initiation were assessed using rat heterotopic heart transplantation and retransplantation models. Fully allogeneic or minor, non-MHC antigen-mismatch heart grafts transplanted into recipient rats treated with a short course of FK506 showed long-term survival...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199511270-00002

    authors: Izutani H,Miyagawa S,Shirakura R,Matsumiya G,Nakata S,Shimazaki Y,Matsuda H

    更新日期:1995-11-27 00:00:00

  • Aspergillus infection in single and double lung transplant recipients.

    abstract::To investigate the clinical manifestations of Aspergillus infections in lung transplant recipients, we reviewed the mycology and autopsy reports of all double (DLT=93) and single (SLT=48) lung transplant recipients from November 1983 to May 1993. Positive Aspergillus cultures were identified in 22% of the recipients (...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199603270-00013

    authors: Westney GE,Kesten S,De Hoyos A,Chapparro C,Winton T,Maurer JR

    更新日期:1996-03-27 00:00:00

  • Simultaneous Liver Kidney Transplant in Elderly Patients With Chronic Kidney Disease: Is There an Appropriate Upper Age Cutoff?

    abstract:BACKGROUND:The aging of liver transplant (LT) recipients, the weighting of the model for end-stage liver disease score, and the increased prevalence of nonalcoholic steatohepatitis has led to an increased number of older LT recipients with pre-LT chronic kidney disease (CKD). There are limited data on the impact of inc...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0000000000003147

    authors: Goldberg DS,Vianna RM,Martin EF,Martin P,Arosemena Benitez LR,O'Brien CB,Bhamidimarri KR

    更新日期:2020-12-01 00:00:00

  • Angiotensin blockade is associated with early graft dysfunction after live donor renal transplantation.

    abstract:BACKGROUND:Activation of the renin angiotensin system may contribute to the development of delayed graft function after renal transplantation. We, therefore, examined the impact of pretransplant treatment with blockers of the renin angiotensin system on early graft function after renal transplantation. METHOD:The case...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0b013e3181c892f2

    authors: Stevens KK,Patel RK,Clancy M,Jardine AG

    更新日期:2010-03-27 00:00:00

  • Mycobacterium haemophilum infections in bone marrow transplant recipients.

    abstract::The purpose of this study was to describe the clinical presentation, treatment, and outcome of Mycobacterium haemophilum infection in patients undergoing bone marrow transplantation at a cancer center. Bone marrow transplant recipients with M haemophilum infection were identified upon culture of the organism by implem...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:

    authors: White MH,Papadopoulos EB,Small TN,Kiehn TE,Armstrong D

    更新日期:1995-11-15 00:00:00

  • Rapid rejection of HLA-A2 transgenic skin graft due to indirect allorecognition.

    abstract:BACKGROUND:At present, it is not clear whether xenogeneic MHC molecules are recognized by T cells directly or indirectly through self-MHC-restricted presentation in a transplantation setting. METHODS:We have transplanted skin from HLA-A2 transgenic (B6.A2) to nontransgenic C57BL/6 (B6) mice and investigated the subseq...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-200109270-00003

    authors: Jurcevic S,Chandler P,Sacks SH,Simpson E

    更新日期:2001-09-27 00:00:00

  • In Vivo Costimulation Blockade-Induced Regulatory T Cells Demonstrate Dominant and Specific Tolerance to Porcine Islet Xenografts.

    abstract:BACKGROUND:Although islet xenotransplantation is a promising therapy for type 1 diabetes, its clinical application has been hampered by cellular rejection and the requirement for high levels of immunosuppression. The aim of this study was to determine the role of Foxp3 regulatory T (Treg) cells in costimulation blockad...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0000000000001482

    authors: Wu J,Hu M,Qian YW,Hawthorne WJ,Burns H,Liuwantara D,Alexander SI,Yi S,O'Connell PJ

    更新日期:2017-07-01 00:00:00

  • Enhancement of tumor growth in allogeneic mice following impairment of macrophage function.

    abstract::Teratoma 402 AX is an embryo-like tumor cell line originally derived from the testicles of strain 129/J mice. This teratocarcinoma grows well in males and pregnant females but poorly in virgin females when given in small doses. Induction of growth of this tumor is syngeneic and allogeneic virgin females was achieved b...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-197510000-00005

    authors: Isa AM,Sanders BR

    更新日期:1975-10-01 00:00:00

  • Prolongation of allograft survival by combination therapy with anti-thymocyte serum and anti-immunoglobulin.

    abstract::Heterologous anti-immunoglobulin (AI) is a potent immunosuppressive agent which compares favorably to anti-thymocyte serum (ATS) in inhibiting E and EAC-rosette formation and diminishing the secondary antibody response to sheep erythrocytes and E. coli lipopolysaccharide. AI prolongs H-2 incompatible skin allograft su...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-197609000-00003

    authors: Constantian MB,Couser WG,French PJ,Davis RC

    更新日期:1976-09-01 00:00:00

  • Renal transplantation from elderly living donors.

    abstract::A worldwide shortage of cadaveric donors has led to the increased utilization of elderly living donors, with controversial results. In an attempt to assess the effect of donor age on graft survival and subsequent renal function, we analyzed our clinical results in 276 consecutive recipients of living related renal tra...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199102000-00005

    authors: Sumrani N,Delaney V,Ding ZK,Davis R,Daskalakis P,Tejani A,Butt K,Hong J

    更新日期:1991-02-01 00:00:00

  • Extensively drug-resistant Pseudomonas aeruginosa bacteremia in solid organ transplant recipients.

    abstract:BACKGROUND:We sought to determine the risk factors, molecular epidemiology, antibiotic therapy, and outcomes of bacteremia because of extensively drug-resistant (XDR) Pseudomonas aeruginosa in solid organ transplant (SOT) recipients. METHODS:All episodes of bacteremia occurring in SOT recipients were prospectively doc...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0000000000000366

    authors: Bodro M,Sabé N,Tubau F,Lladó L,Baliellas C,González-Costello J,Cruzado JM,Carratalà J

    更新日期:2015-03-01 00:00:00

  • Pathophysiological Trends During Withdrawal of Life Support: Implications for Organ Donation After Circulatory Death.

    abstract:BACKGROUND:Donation after circulatory death (DCD) provides an alternative pathway to deceased organ transplantation. Although clinical DCD lung, liver, and kidney transplantation are well established, transplantation of hearts retrieved from DCD donors has reached clinical translation only recently. Progress has been l...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0000000000001396

    authors: Iyer A,Chew HC,Gao L,Villanueva J,Hicks M,Doyle A,Kumarasinghe G,Jabbour A,Jansz PC,Feneley MP,Harvey RP,Graham RM,Dhital KK,Macdonald PS

    更新日期:2016-12-01 00:00:00

  • Factors influencing T-lymphopoiesis after allogeneic hematopoietic cell transplantation.

    abstract::In adult recipients of allogeneic hematopoietic cell transplants (HCT) studied at 1 year after grafting, there was a significant correlation between the counts of T cell receptor excision circle (TREC)-containing CD4 T cells (presumed recent thymic emigrants) and the counts of total T cells (r=0.65, P<0.001). Thus, th...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-200204150-00026

    authors: Storek J,Joseph A,Dawson MA,Douek DC,Storer B,Maloney DG

    更新日期:2002-04-15 00:00:00

  • IL-33 prolongs murine cardiac allograft survival through induction of TH2-type immune deviation.

    abstract:BACKGROUND:In Th (T helper) 1/Th2 balance in response to signals given during donor antigen presentation, induction of allograft prolongation is more often related to Th2-type than with Th1-type immunity. Here, we examined the effect of interleukin (IL)-33, a novel member of the IL-1 family, on cardiac allograft surviv...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0b013e3181d720af

    authors: Yin H,Li XY,Jin XB,Zhang BB,Gong Q,Yang H,Zheng F,Gong FL,Zhu JY

    更新日期:2010-05-27 00:00:00

  • Prolongation of heart xenograft survival in a hamster-to-rat model after therapy with a rationally designed immunosuppressive peptide.

    abstract:BACKGROUND:Modification of the aminoacid sequence of peptides derived from the HLA class I heavy chain in combination with computer rational design resulted in the development of a peptide, RDP1258, with enhanced immunosuppressive activity. METHODS:We evaluated the activity of this peptide, analyzing infiltrate by imm...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199906270-00017

    authors: Brouard S,Cuturi MC,Pignon P,Buelow R,Loth P,Moreau A,Soulillou JP

    更新日期:1999-06-27 00:00:00

  • Cariporide (HOE-642) improves cardiac allograft preservation in a porcine model of orthotopic heart transplantation.

    abstract:BACKGROUND:Acute graft dysfunction caused by ischemia-reperfusion injury is recognized as a major source of morbidity and mortality following adult heart transplantation. The aim of this study was to determine whether treating the donor and recipient with cariporide, an inhibitor of the sodium-hydrogen exchanger, could...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/01.TP.0000054619.13962.30

    authors: Ryan JB,Hicks M,Cropper JR,Garlick SR,Kesteven SH,Wilson MK,Feneley MP,Macdonald PS

    更新日期:2003-03-15 00:00:00

  • In vitro cytokine profiles and their relevance to rejection following renal transplantation.

    abstract::Graft rejection remains an important cause of renal allograft failure, despite improvements in immunosuppression and HLA typing. Although HLA matching is beneficial, ensuring an exact match it is often impractical. Thus, a reliable in vitro method for quantitating and qualitating alloreactivity is an important goal. I...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199510150-00015

    authors: Kaminski ER,Kaminski A,Bending MR,Chang R,Heads A,Szydlo RM,Pereira RS

    更新日期:1995-10-15 00:00:00

  • Mapping and transcriptional properties of RT1 class II region genes.

    abstract::The class II region of major histocompatibility complex of the rat. Rattus norvegicus (RT1) consists of RT1.B, RT1.D, and RT1.H subregions. The gene order around the H subregion was determined as RT1.A--H beta-H alpha--B by RFLP analysis of naturally occurring intra-RT1 recombinant rats with HLA DP probes. A unique re...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199108000-00035

    authors: Fujii H,Kakinuma M,Yoshiki T,Natori T

    更新日期:1991-08-01 00:00:00