Progression of renal dysfunction in cardiac transplantation after the introduction of everolimus in the immunosuppressive regime.

abstract：BACKGROUND:We have previously shown that an immunomodulatory enzyme, indoleamine 2,3-dioxygenase (IDO) in dermal fibroblasts generates a tryptophan-deficient environment that selectively inhibits proliferation and induces apoptosis of bystander CD4+ and CD8+ T cells, but not pancreatic islets. Because these immune cell...

journal_title：Transplantation

authors： Hosseini-Tabatabaei A,Jalili RB,Khosravi-Maharlooei M,Hartwell R,Kilani RT,Zhang Y,Ghahary A

更新日期：2015-07-01 00:00:00

abstract：:Renal vasoconstriction has been implicated as a major contributing factor for the nephrotoxic effects of cyclosporine. In an attempt to assess the relative contribution of thromboxane (Tx), the effects of coadministering CsA with the selective Tx synthetase inhibitor, Dazmegrel (DAZ) (Pfizer, Inc.), were determined. R...

journal_title：Transplantation

authors： Gladue RP,Newborg MF

更新日期：1991-11-01 00:00:00

abstract：:Adult bone marrow-derived mesenchymal stem cells (MSCs) are multipotential cells capable of regenerating injured tissues. In addition to their multipotency, MSCs inhibit natural killer cell cytotoxicity and T-lymphocyte alloproliferation. Several immunosuppressive mechanisms have been described, including indoleamine ...

journal_title：Transplantation

authors： Selmani Z,Naji A,Gaiffe E,Obert L,Tiberghien P,Rouas-Freiss N,Carosella ED,Deschaseaux F

更新日期：2009-05-15 00:00:00

abstract：:Pseudoaneurysms of the hepatic artery are a rare complication of liver transplantation. Early diagnosis and treatment are essential to avoid life-threatening hemorrhage. Conventional treatment consists of surgical resection and vascular reconstruction or transarterial coil embolization. More recently, percutaneous thr...

journal_title：Transplantation

authors： Patel JV,Weston MJ,Kessel DO,Prasad R,Toogood GJ,Robertson I

更新日期：2003-05-27 00:00:00

abstract：BACKGROUND:The authors investigated the cognitive status during the late postoperative phase in children who had undergone liver transplantation (LTx). METHODS:The authors examined 44 children who had undergone liver transplantation at their center. The children were 8.9+/-2.3 (mean+/-SD) years of age and had received...

journal_title：Transplantation

authors： Kaller T,Schulz KH,Sander K,Boeck A,Rogiers X,Burdelski M

更新日期：2005-05-15 00:00:00

abstract：:Several studies have reported the development of antiidiotypic antibodies to anti-HLA alloantibodies in renal allograft transplant recipients, postulating their potential beneficial role in allograft survival. In order to evaluate the role of anti-HLA antiidiotypic antibodies in human liver transplant recipients and t...

journal_title：Transplantation

authors： Chauhan B,Phelan DL,Marsh JW,Mohanakumar T

更新日期：1993-08-01 00:00:00

abstract：INTRODUCTION:Organ donation after brain death (DBD) has declined in the United Kingdom, whereas donation after cardiac death (DCD) has increased markedly. We sought to understand the reasons for the decline in DBD and determine whether the increase in DCD was a major factor. METHODS:The UK Transplant Registry was anal...

journal_title：Transplantation

authors： Summers DM,Counter C,Johnson RJ,Murphy PG,Neuberger JM,Bradley JA

更新日期：2010-12-27 00:00:00

abstract：:Natural killer (NK) cells effect hybrid resistance, in which parental hematopoietic cell grafts are rejected by F1 recipients. NK cells can also resist engraftment of fully MHC-mismatched allogeneic marrow. However, studies of NK cell-mediated alloresistance have relied on short-term proliferation, colony, or survival...

journal_title：Transplantation

authors： Lee LA,Sergio JJ,Sykes M

更新日期：1996-01-15 00:00:00

abstract：BACKGROUND:Graft-versus-host disease (GVHD) is a major complication after bone marrow transplantation, which may be refractory to immunosuppressive drugs. As preliminary case reports suggested that extracorporeal photochemotherapy (ECP) using a Therakos device might be beneficial, we conducted a pilot study to assess t...

journal_title：Transplantation

authors： Besnier DP,Chabannes D,Mahé B,Mussini JM,Baranger TA,Muller JY,Milpied N,Esnault VL

更新日期：1997-07-15 00:00:00

abstract：BACKGROUND:Calcineurin is a ubiquitously expressed calcium-dependent phosphatase that is inhibited by the immunosuppressant drugs cyclosporine and tacrolimus. Measuring calcineurin activity in transplant patients has been complicated by a lack of consistent correlation between drug level and enzyme activity, particular...

journal_title：Transplantation

authors： Pena JA,Titus L,Jackson J,Kirk AD,Gooch JL

更新日期：2013-08-15 00:00:00

abstract：BACKGROUND:According to a pooled analysis of three randomized clinical studies concerning the prevention of acute rejection in cadaveric renal transplantation, mycophenolate mofetil (MMF) proved superior to azathioprine or placebo in conjunction with cyclosporine (CsA) and steroids. MMF-treated patients showed reduced ...

journal_title：Transplantation

authors： Kim YS,Moon JI,Kim SI,Park K

更新日期：1999-08-27 00:00:00

abstract：:Cyclosporine prevents the development of diabetes in spontaneously diabetic BB rats and NOD mice. However, islet transplants have been shown to be subject to immunologic destruction in hosts treated with CsA and anti-CD4 antibody or those rendered tolerant to donor antigens. This study determines whether the minimum d...

journal_title：Transplantation

authors： Dugoni WE Jr,Bartlett ST

更新日期：1990-05-01 00:00:00

abstract：BACKGROUND:Host macrophages are abundant within fetal pig pancreas xenografts undergoing rejection, but their role is unknown. Therefore, we examined the effect of host macrophage depletion on xenograft rejection. METHODS:Nonobese diabetic (NOD) mice were given clodronate-loaded liposomes intravenously to deplete macr...

journal_title：Transplantation

authors： Fox A,Koulmanda M,Mandel TE,van Rooijen N,Harrison LC

更新日期：1998-12-15 00:00:00

abstract：:To determine the impact of different flush and reperfusion techniques on postreperfusion syndrome (PRS) and postoperative graft function, 100 transplants were randomly assigned into four groups as follows: group 1 (n=31), portal vein flush, no vena caval venting; group 2 (n=21), hepatic arterial flush, no vena caval v...

journal_title：Transplantation

authors： Millis JM,Melinek J,Csete M,Imagawa DK,Olthoff KM,Neelankanta G,Braunfeld MY,Sopher MJ,Chan SM,Pregler JL,Yersiz H,Busuttil AA,Shackleton CR,Shaked A,Busuttil RW

更新日期：1997-02-15 00:00:00

abstract：BACKGROUND:In the hamster to rat xenogeneic combination, antibodies, T cells, and natural killer (NK) cells have all been implicated in the process of rejection. 3.2.3 is a mouse IgG1kappa monoclonal antibody (mAb) directed against NKR-P1A on rat NK cells. The purpose of this study was to evaluate the effect of this mA...

journal_title：Transplantation

authors： Gourlay WA,Chambers WH,Monaco AP,Maki T

更新日期：1998-03-15 00:00:00

abstract：:India with a population of 1.2 billion has a renal transplantation rate of 3.25 per million population. The major cause of chronic kidney disease is hypertension and diabetes. The crude and age-adjusted incidence rates of end-stage renal disease are estimated to be 151 and 232 per million population, respectively, in ...

journal_title：Transplantation

authors： Abraham G,Reddy YN,Amalorpavanathan J,Daniel D,Roy-Chaudhury P,Shroff S,Reddy Y

更新日期：2012-04-27 00:00:00

abstract：:Millions of people want to donate their organs after they die for transplantation, and many of them have registered their wish to do so or told their family and friends about their decision. For most of them, however, this wish is unlikely to be fulfilled, as only a small number of deaths (1% in the United Kingdom) oc...

journal_title：Transplantation

authors： Shaw D,Georgieva D,Haase B,Gardiner D,Lewis P,Jansen N,Wind T,Samuel U,McDonald M,Ploeg R,ELPAT Working Group on Deceased Donation.

更新日期：2017-03-01 00:00:00

abstract：:Vascular endothelial cells (VEC) are clearly immunogenic and express antigens unique to vascular endothelial cells. The observation that peripheral blood monocytes also express this VEC antigen system made prospective testing feasible. Preformed antibody to the VEC/monocyte antigen system of the donor usually leads to...

journal_title：Transplantation

authors： Cerilli J,Brasile L,Galouzis T,Lempert N,Clarke J

更新日期：1985-03-01 00:00:00

abstract：BACKGROUND:Although antibody mechanisms play a pathogenetic role in liver allograft rejection, no data exist on B lymphocytes, plasma cells, complement, and chemokines in rejected liver tissue. METHODS:Liver biopsy specimens from 25 patients with acute allograft rejection (AR) (rejection activity index, RAI score: 1-9...

journal_title：Transplantation

authors： Krukemeyer MG,Moeller J,Morawietz L,Rudolph B,Neumann U,Theruvath T,Neuhaus P,Krenn V

更新日期：2004-07-15 00:00:00

abstract：:Ninety-eight renal transplant recipients who had been followed for 1-6.5 years (median 3.2 years) were reviewed to determine the effect of donor and recipient hepatitis B surface antigen status on the incidence of hepatitis and on patient survival. The cumulative risk of developing hepatitis posttransplant was signifi...

journal_title：Transplantation

authors： Chan PC,Lok AS,Cheng IK,Chan MK

更新日期：1992-01-01 00:00:00

abstract：:Pancreas transplantation utilizing portal venous and enteric exocrine drainage has potential benefits over the standard systemic venous and bladder exocrine drainage method. Unfortunately, technical difficulties are often experienced with the arterial anastomosis after the portal venous anastomosis is completed. We ha...

journal_title：Transplantation

authors： Bigam DL,Hemming AW,Sanabria JR,Cattral MS

更新日期：1999-07-27 00:00:00

abstract：BACKGROUND:Goal tacrolimus concentrations for the prevention of rejection in sensitized renal transplant recipients are not well established. METHODS:We evaluated the association between discharge tacrolimus trough concentration and the incidence of biopsy-proven acute rejection (BPAR) in 216 moderately sensitized ren...

journal_title：Transplantation

authors： Richards KR,Hager D,Muth B,Astor BC,Kaufman D,Djamali A

更新日期：2014-05-27 00:00:00

abstract：BACKGROUND:Functionally relevant polymorphisms in genes of the Th1 and Th2-inflammatory pathway influence the susceptibility to acute rejection (AR), chronic allograft nephropathy (CAN), and subclinical rejection (SR) as well as graft survival after renal transplantation. Because these findings have not been validated,...

journal_title：Transplantation

authors： Brabcova I,Petrasek J,Hribova P,Hyklova K,Bartosova K,Lacha J,Viklický O

更新日期：2007-10-27 00:00:00

abstract：:The absorption of oral cyclosporine (CsA) was studied in a canine small intestinal transplantation model. Absorption of CsA was almost absent in bowel-resected dogs. Autotransplanted dogs showed a persisting malabsorption of CsA (mean peak of 687 +/- 348 ng/ml vs. 1683 +/- 154 ng/ml in control dogs). Allotransplanted ...

journal_title：Transplantation

authors： Wassef R,Cohen Z,Nordgren S,Langer B

更新日期：1985-05-01 00:00:00

abstract：:The question has not been previously investigated as to whether host lymphocytes infiltrate vascularized organ allografts in indiscriminate fashion, or whether they are retained selectively because of specific antigenic recognition sites on their surfaces. By using a dual cardiac allograft model in LEW rats, we have e...

journal_title：Transplantation

authors： Tilney NL,Notis-McConarty J,Strom TB

更新日期：1978-09-01 00:00:00

abstract：BACKGROUND:In chronic graft-versus-host disease (cGvHD), skin fibrosis, contractures, and an increase in collagen content form the hallmark. We report a successful treatment of a cGvHD patient by topical application of halofuginone, an inhibitor of collagen alpha1(I) gene expression. METHODS:Halofuginone-containing oi...

journal_title：Transplantation

authors： Nagler A,Pines M

更新日期：1999-12-15 00:00:00

abstract：BACKGROUND:Successful islet transplantation can result in insulin independence in many patients with type 1 diabetes mellitus, but it often requires more than one islet infusion. The ability to achieve insulin independence with a single donor is an important goal in clinical islet transplantation due to the limited org...

journal_title：Transplantation

authors： Koh A,Senior P,Salam A,Kin T,Imes S,Dinyari P,Malcolm A,Toso C,Nilsson B,Korsgren O,Shapiro AM

更新日期：2010-02-27 00:00:00

abstract：BACKGROUND:Few studies have examined the effectiveness of a risk-stratified approach to screening kidney transplantation candidates for ischemic heart disease (IHD). METHODS:We retrospectively reviewed records from all adult patients (n = 514) placed on the deceased donor kidney transplantation waiting list at a singl...

journal_title：Transplantation

authors： Kasiske BL,Malik MA,Herzog CA

更新日期：2005-09-27 00:00:00

abstract：:The mixed leukocyte culture (MLC) of peripheral blood lymphocytes (PBLs) from two prospective kidney transplant recipients and their respective donors, produced a primed cell population that functioned as suppressors. The primed cells suppressed the primary and secondary MLC when added as third components, without dem...

journal_title：Transplantation

authors： Fuller L,Kyriakides G,Flaa C,Esquenazi V,Miller J

更新日期：1980-01-01 00:00:00

abstract：BACKGROUND:Progressively better therapies have largely prevented or at least effectively treated acute allograft rejection. Consequently, the long-term survival of solid organ transplants has increasingly become limited primarily by the development of chronic allograft rejection. The mechanisms of chronic rejection rem...

journal_title：Transplantation

authors： Heslan JM,Renaudin K,Thebault P,Josien R,Cuturi MC,Chiffoleau E

更新日期：2006-11-15 00:00:00