Abstract:
BACKGROUND:The authors investigated the cognitive status during the late postoperative phase in children who had undergone liver transplantation (LTx). METHODS:The authors examined 44 children who had undergone liver transplantation at their center. The children were 8.9+/-2.3 (mean+/-SD) years of age and had received the transplant 6.1+/-2.6 years previously. In 24 of the 44 children, a living-related transplantation had been carried out. Cognitive abilities were assessed with the three subscales of the Kaufman Assessment Battery for Children (K-ABC): the sequential processing scale (SES), the simultaneous processing scale (SIS), and the achievement scale (AS). RESULTS:The children scored below the population mean but within the normal range on all subscales of the K-ABC. In the SIS and the AS, age at transplantation influenced the cognitive outcome, as the children who were younger at transplantation scored significantly better than the older children and their results were within the normal range. However, for the SES, no such differences were found. A multiple regression analysis revealed that duration of illness and height at transplantation predicts the performance in the SIS and the AS. To a lesser degree, type of transplantation (cadaveric vs. living-related) predicts performance in the AS. Performance in the SES was not predicted by any of these variables. Time since LTx and type of immunosuppressive regimen were not associated with the cognitive status after transplantation. CONCLUSIONS:Children who are younger, with a shorter duration of illness, and who are more physically developed before LTx have a better prognosis regarding their mental development. However, this result does not hold for sequential processing functions, which showed no relationship with any of these variables. This could indicate differential effects of liver disease and consecutive metabolic derangements on brain development during the preoperative phase.
journal_name
Transplantationjournal_title
Transplantationauthors
Kaller T,Schulz KH,Sander K,Boeck A,Rogiers X,Burdelski Mdoi
10.1097/01.tp.0000161251.20520.42subject
Has Abstractpub_date
2005-05-15 00:00:00pages
1252-6issue
9eissn
0041-1337issn
1534-6080pii
00007890-200505150-00056journal_volume
79pub_type
杂志文章相关文献
TRANSPLANTATION文献大全abstract::Pregnancy after solid organ transplantation, although considered high risk for maternal, fetal, and neonatal complications, has been quite successful. Tacrolimus pharmacokinetic changes during pregnancy make interpretation of whole blood trough concentrations particularly challenging. There are multiple factors that c...
journal_title:Transplantation
pub_type: 杂志文章,评审
doi:10.1097/TP.0b013e318278d367
更新日期:2013-04-15 00:00:00
abstract::Consecutive patients transplanted between January 1984 and December 1988 were followed until August 1992 to detect fatal and nonfatal thromboembolic complications, including sudden death, acute and chronic myocardial infarction, pulmonary and peripheral embolisms, stroke, and thrombophlebitis. The probability of devel...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199603150-00015
更新日期:1996-03-15 00:00:00
abstract:BACKGROUND:Pneumocystis jirovecii pneumonia (PJP) is an important infection-related complication, whose mode of transmission remains uncertain. METHODS:We investigated a nosocomial cluster of 14 PJP cases (11 confirmed and 3 probable) in kidney transplant recipients using epidemiological and genotyping methods. RESUL...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3182384b57
更新日期:2011-12-27 00:00:00
abstract::We report the largest single-center experience with extracorporeal photopheresis (ECP) for bronchiolitis obliterans syndrome (BOS) and recurrent acute rejection (AR) after lung transplantation. Lung transplant recipients undergoing ECP for BOS and recurrent AR were included (1997-2007). The rate of forced expiratory v...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31818bc024
更新日期:2008-12-15 00:00:00
abstract:BACKGROUND:Sirolimus (rapamycin) is a potent immunosuppressant with a mechanism of action different from cyclosporine (CsA) or tacrolimus. METHODS:In 11 European centers, first cadaveric renal allograft recipients were randomized to CsA (n=42) or sirolimus (n=41). Dosing of these agents was concentration-controlled an...
journal_title:Transplantation
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00007890-199904150-00017
更新日期:1999-04-15 00:00:00
abstract:BACKGROUND:Blood group-incompatible transplantation is one strategy used when a potential recipient does not have a compatible living donor. Current practice includes desensitization strategies to reduce antibody titers. However, when antibodies are low, in cardiac transplantation in neonates for example, no desensitiz...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31825b7608
更新日期:2012-08-27 00:00:00
abstract::Heart transplantation is considered nowadays the gold standard in the therapy of chronic and terminal heart insufficiency. Primary organ failure after heart transplantation is a severe complication generally related to prolonged ischemia time, poor quality of the organ, or acute rejection. All these factors can potent...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000233845.15508.89
更新日期:2006-10-27 00:00:00
abstract:BACKGROUND:The shortage of organs for liver transplantation has forced transplant centers to expand the donor pool by using donors traditionally labeled as marginal. One such example is liver transplantation using a donor with HELLP syndrome (hemolysis, elevated liver enzymes, and low platelets), a disorder of late pre...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000101510.01404.F0
更新日期:2004-01-15 00:00:00
abstract:BACKGROUND:The need for renal replacement therapy (RRT) either before or after orthotopic liver transplant (OLTX) has been reported to be a poor prognostic indicator for survival. Use of continuous veno-venous hemodialysis (CVVHD) for RRT has been reported in three series of OLTX patients with high 90-day mortality rat...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200105270-00012
更新日期:2001-05-27 00:00:00
abstract:BACKGROUND:Tacrolimus (Tac) and mycophenolate mofetil (MMF) are newly approved immunosuppressive agents. However, the safety and efficacy of the combination of MMF and Tac in primary liver transplantation has not been determined. METHODS:An Institutional Review Board-approved, open-label prospective randomized protoco...
journal_title:Transplantation
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00007890-199811270-00024
更新日期:1998-11-27 00:00:00
abstract:BACKGROUND:Better preservation strategies for the storage of donation after circulatory death grafts are essential to improve graft function and to increase the kidney donor pool. We compared continuous normothermic ex vivo kidney perfusion (NEVKP) with hypothermic anoxic machine perfusion (HAMP) and static cold storag...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000003066
更新日期:2020-05-01 00:00:00
abstract:BACKGROUND:The success of clinical xenotransplantation will depend on induction of xenotolerance. We have previously shown that combined xenothymus and vascularized xenoheart transplantation under the coverage of a tolerizing regimen (TR) can induce and maintain full xenotolerance. Here, induction/maintenance of xenoto...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000145522.26428.27
更新日期:2005-03-15 00:00:00
abstract::Graft-versus-host disease (GVHD) is a common complication of bone marrow transplantation and often involves the gastrointestinal system. It is unclear whether there can be severe enough damage by GVHD to permanently injure the bowel and thereby prevent mucosal regeneration. We describe a patient who had successful tre...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199612150-00028
更新日期:1996-12-15 00:00:00
abstract::Liver transplantation (LT) is the most effective treatment for small and unresectable hepatocellular carcinomas (HCCs). With scarcity of deceased donor livers, living donor LT (LDLT) is the alternative to deceased donor LT (DDLT). Animal studies have suggested that regeneration of the partial liver graft encourages HC...
journal_title:Transplantation
pub_type: 杂志文章,评审
doi:10.1097/01.tp.0000446266.42019.28
更新日期:2014-04-27 00:00:00
abstract:BACKGROUND:This study aimed to determine factors associated with body composition changes shortly after liver transplantation (LTx), including the influence of immunosuppressive agents. The combined resting energy expenditure (REE) and handgrip strength provided a valuable assessment in data interpretation of body comp...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000001202
更新日期:2016-08-01 00:00:00
abstract:BACKGROUND:Two side effects of irradiation are premature ovarian failure (POF) and osteoporosis, both of which are concerns not only clinically, for patients, but also experimentally, for animals. We examine whether bone marrow transplantation (BMT) can correct the POF induced by radiation and also address whether allo...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3181ca86bb
更新日期:2010-02-27 00:00:00
abstract::Requirements for sustained engraftment of fetal liver hematopoietic stem cells were evaluated in 45 dogs. Pretransplant preparative treatment with total-body irradiation, 14.7 Gy, permitted engraftment of DLA-compatible fetal liver cells. Radiation alone was inadequate in DLA-haploidentical or DLA-mismatched transplan...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198712000-00004
更新日期:1987-12-01 00:00:00
abstract::Methods are described for preparing large amounts of horse anti-human thymocyte globulin (ATG, ATGAM; The Upjohn Company) for clinical use. These methods have been used since 1968 to provide material for clinical trials. Characteristics of 40 lots of ATG are summarized. ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-197910000-00007
更新日期:1979-10-01 00:00:00
abstract:BACKGROUND:Postoperative damage of the urethral rhabdosphincter and nerve-vascular networks is a major complication of radical prostatectomy and generally causes incontinence and/or erectile dysfunction. The human skeletal muscle-derived stem cells, which have a synchronized reconstitution capacity of muscle-nerve-bloo...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000001613
更新日期:2017-10-01 00:00:00
abstract::Rat recipients of renal allografts and unilaterally nephrectomized control rats were studied to evaluate the response in blood pressure to prednisolone in diverse doses, and to determine the dosage required to achieve adequate immunosuppression without undue complication of hypertension. While a continuous infusion of...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198703000-00007
更新日期:1987-03-01 00:00:00
abstract:BACKGROUND:The impact of the age of the donor on the outcome of living related liver transplantation is yet to be clarified. METHODS:During October 14, 1996 and December 20, 1999, 34 living related liver transplantations were performed. Of these, 26 cases were performed using the extended left lobe graft, which were c...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200012270-00007
更新日期:2000-12-27 00:00:00
abstract::Publicly available program-specific data from the scientific registry of transplant recipients were used to determine the association between adult lung transplant center volume and 1-year recipient mortality from 2000 to 2007. We found a significant inverse association between the center volume of adult lung transpla...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3181ceecf7
更新日期:2010-03-27 00:00:00
abstract:BACKGROUND:In France, foreign patients, whether resident or not in France, can register on the national waiting list under certain conditions. We compared waiting time to kidney transplantation, the level of HLA matching and graft cold ischemia time between foreign patients and French patients living in mainland France...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000205182.96861.3a
更新日期:2006-04-27 00:00:00
abstract::Rejection crises after kidney transplantation could be associated with individual variability of pharmacokinetic parameters of steroids. We therefore investigated the individual pharmacokinetics of methylprednisolone on day 2 (60 mg intravenously) and day 4 (60 mg per os) in 40 patients after kidney transplantation. M...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199508270-00005
更新日期:1995-08-27 00:00:00
abstract::Patients with steroid-resistant nephrotic syndrome and focal segmental glomerulosclerosis (FGS) who develop end-stage renal disease are at risk for recurrence of the disease following renal transplantation. Recurrence of the nephrotic syndrome in renal allografts of two children with primary FGS was successfully contr...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198810000-00014
更新日期:1988-10-01 00:00:00
abstract::As donation after cardiac death practices expand, the number of institutional policies is increasing. We contacted organ procurement organizations throughout the United States and requested protocols in hospitals in their donor service areas. Sixty-four protocols were obtained with representation from 16 different sta...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e318204ee96
更新日期:2011-02-27 00:00:00
abstract:BACKGROUND:Organ donors are frequently trauma victims, but the impact of donor hemorrhagic shock and resuscitation (HSR) on pulmonary graft function has not been assessed. L-arginine treatment during reperfusion increases the production of endothelial nitric oxide and thus ameliorates ischemia-reperfusion injury. Objec...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3181a52ce1
更新日期:2009-06-15 00:00:00
abstract::Pulmonary complications are often lethal components of acute graft-vs.-host disease (GVHD). Although interstitial pneumonitis and lymphocytic bronchitis have been implicated as elements of acute GVHD, previous studies have not determined a correlation between the onset of these histopathologies or their contribution t...
journal_title:Transplantation
pub_type: 杂志文章
doi:
更新日期:1994-07-27 00:00:00
abstract:BACKGROUND:Histologic evaluation of small bowel allograft biopsies is important for the diagnosis of acute rejection. However, a standard histologic schema to grade the severity of intestinal acute rejection is not currently available. The primary goal of this study was to develop a histologic grading system for the di...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000062840.49159.2F
更新日期:2003-04-27 00:00:00
abstract:BACKGROUND:Several single nucleotide polymorphisms (SNPs) in the multidrug resistance (MDR1) gene may play a role in the interindividual variation of cyclosporine A (CsA) absorption in renal transplant patients. METHODS:An analysis of CsA absorption measured by the dose- and weight-adjusted 4 hr area under the time-co...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000264197.88129.2e
更新日期:2007-05-27 00:00:00