Abstract:
:Graft-versus-host disease (GVHD) is a common complication of bone marrow transplantation and often involves the gastrointestinal system. It is unclear whether there can be severe enough damage by GVHD to permanently injure the bowel and thereby prevent mucosal regeneration. We describe a patient who had successful treatment of GVHD, but who had such severe scarring of the bowel mucosa that the colonic epithelium could not regenerate even 50 days after biopsy-demonstrated resolution of GVHD. Surveillance cultures and histological analysis indicate that this denudation was not caused by infection or continued GVHD. This is an important observation with implications for monitoring response to GVHD therapy and using rectal biopsy to evaluate GVHD.
journal_name
Transplantationjournal_title
Transplantationauthors
Fox RJ,Vogelsang GB,Beschorner WEdoi
10.1097/00007890-199612150-00028subject
Has Abstractpub_date
1996-12-15 00:00:00pages
1681-4issue
11eissn
0041-1337issn
1534-6080journal_volume
62pub_type
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