Plasminogen activator inhibitor-1 polymorphism is associated with progressive renal dysfunction after acute rejection in renal transplant recipients.

abstract：:: Hepatitis C virus (HCV) infection is common in solid organ allograft recipients and is a significant cause of morbidity and mortality after transplantation, so effective management will improve outcomes. In this review, we discuss the extent of the problem associated with HCV infection in donors and kidney, heart, a...

journal_title：Transplantation

authors： Carbone M,Mutimer D,Neuberger J

更新日期：2013-03-27 00:00:00

abstract：:We have previously demonstrated that streptozotocin-induced diabetic rats have decreased guanylate cyclase (EC 4.6.1.2) activity in liver and other tissues which was returned to normal by the administration of exogenous insulin. Since successful pancreatic islet transplants have been shown to lower basal hepatic gluco...

journal_title：Transplantation

authors： Vesely DL,Selawry H,Levey GS

更新日期：1979-06-01 00:00:00

abstract：:Acute rejection (AR) remains the biggest challenge during the first year after heart transplantation despite advances in immunosuppressive therapy. The early detection and curbing of AR are crucial to the survival of transplant recipients. However, as the criterion standard for AR, endomyocardial biopsy has several li...

journal_title：Transplantation

authors： Chen Y,Zhang L,Liu J,Zhang P,Chen X,Xie M

更新日期：2017-09-01 00:00:00

abstract：BACKGROUND:The mitochondrial respiratory chain is implicated as a major target of kidney damage after ischemia-reperfusion. This study measures changes in integrated mitochondrial function and in the activity of enzymes of the respiratory chain after cold storage and transplantation-reperfusion in vivo. METHODS:Mitoch...

journal_title：Transplantation

authors： Sammut IA,Burton K,Balogun E,Sarathchandra P,Brooks KJ,Bates TE,Green CJ

更新日期：2000-04-15 00:00:00

abstract：:Hepatic artery thrombosis is a dreadful complication of orthotopic liver transplantation. It should be suspected in cases of fulminant liver failure, delayed bile leak, or intermittent sepsis of unknown cause after liver transplantation. Accurate diagnosis is assisted by ultrasound and computerized tomography scans, b...

journal_title：Transplantation

authors： Tzakis AG,Gordon RD,Shaw BW Jr,Iwatsuki S,Starzl TE

更新日期：1985-12-01 00:00:00

abstract：:Spodoptera frugiperda (Sf9) insect cells secreted a class I MHC RT1.Aa heavy chain protein when infected with baculovirus that bore a construct that contained a honeybee melittin secretion (ms) signal attached to RT1.Aa cDNA. The RT1.Aa heavy chain protein in the culture supernatant and cell lysate immunoprecipitated ...

journal_title：Transplantation

authors： Wang M,Stepkowski SM,Wang ME,Tian L,Qu X,Tu Y,He G,Kahan BD

更新日期：1996-02-15 00:00:00

abstract：:Mouse thyroid tissue was dissociated with collagenase, fixed in periodate-lysine-paraformaldehyde (PLP), and further dissociated with EDTA and trypsin to yield cell suspensions containing mainly follicle epithelial cells and vascular endothelial cells. H-2 complex antigens were detected on the vascular endothelial cel...

journal_title：Transplantation

authors： Parr EL,Lafferty KJ,Bowen KM,McKenzie IF

更新日期：1980-08-01 00:00:00

abstract：BACKGROUND:Selective inhibition of lymphocyte activation through abrogation of signal 3-cytokine transduction emerges as a new strategy for immunosuppression. This is the first report on the novel Janus kinase (JAK)1/3 inhibitors R507 and R545 for prevention of acute allograft rejection. METHODS:Pharmacokinetic and in...

journal_title：Transplantation

authors： Deuse T,Hua X,Taylor V,Stubbendorff M,Baluom M,Chen Y,Park G,Velden J,Streichert T,Reichenspurner H,Robbins RC,Schrepfer S

更新日期：2012-10-15 00:00:00

abstract：:Liver transplantation (LT) is the most effective treatment for small and unresectable hepatocellular carcinomas (HCCs). With scarcity of deceased donor livers, living donor LT (LDLT) is the alternative to deceased donor LT (DDLT). Animal studies have suggested that regeneration of the partial liver graft encourages HC...

journal_title：Transplantation

authors： Chan SC

更新日期：2014-04-27 00:00:00

abstract：BACKGROUND:In the experiment described here, we investigated the effects of the immunosuppressants FK506 and leflunomide (Lef) on the survival of hamster hearts and liver xenografts in Lewis rats. METHODS:Lewis rats were used as recipients of hamster heart or liver grafts using different regimens of FK506 and Lef. Don...

journal_title：Transplantation

authors： Sankary HN,Yin DP,Chong AS,Ma LL,Blinder L,Shen JK,Foster P,Williams JW

更新日期：1998-10-15 00:00:00

abstract：BACKGROUND:Tacrolimus is a potent immunosuppressive agent that provides higher freedom from acute and chronic rejection than cyclosporine after liver transplantation (LTx). Initially, a steroid-free state was observed in about 70% of patients at 1 year; this did not change over the next 5 years. The present study ident...

journal_title：Transplantation

authors： Jain A,Kashyap R,Marsh W,Rohal S,Khanna A,Fung JJ

更新日期：2001-04-27 00:00:00

abstract：BACKGROUND:Sirolimus (rapamycin) is a potent immunosuppressant with a mechanism of action different from cyclosporine (CsA) or tacrolimus. METHODS:In 11 European centers, first cadaveric renal allograft recipients were randomized to CsA (n=42) or sirolimus (n=41). Dosing of these agents was concentration-controlled an...

journal_title：Transplantation

authors： Groth CG,Bäckman L,Morales JM,Calne R,Kreis H,Lang P,Touraine JL,Claesson K,Campistol JM,Durand D,Wramner L,Brattström C,Charpentier B

更新日期：1999-04-15 00:00:00

abstract：BACKGROUND:The terminal Gal alpha1,3Galactose (alphaGal) determinant is present on all porcine glycoproteins and glycolipids, but is not expressed by human cells. Consequently human sera contain anti-alphaGal natural antibodies. The human blood group B antigen [Gal alpha1,3(Fuc1,2)Galactose] is differentiated from the ...

journal_title：Transplantation

authors： McMorrow IM,Comrack CA,Nazarey PP,Sachs DH,DerSimonian H

更新日期：1997-08-15 00:00:00

abstract：:Hemorrhagic cystitis is a well known complication of allogeneic bone marrow transplantation (BMT) and is normally attributed to the use of high-dose cyclophosphamide in the preparative regimen. Hemorrhagic cystitis occurring late after BMT is unlikely to be due to the effects of this conditioning, and probably has an ...

journal_title：Transplantation

authors： Apperley JF,Rice SJ,Bishop JA,Chia YC,Krausz T,Gardner SD,Goldman JM

更新日期：1987-01-01 00:00:00

abstract：:Nonmajor histocompatibility complex (non-MHC) antigens are important targets of graft rejection and graft-versus-host disease in clinical transplantation. Little is known regarding immunity to non-MHC antigens. To study this problem we evaluated the effect of antihuman thymocyte globulin (ATG) on reactivity in autolog...

journal_title：Transplantation

authors： Harada M,Gale RP

更新日期：1981-02-01 00:00:00

abstract：BACKGROUND:The expression of xenogeneic epitopes and the activation of human complement by adult pig islets after prolonged culture have hitherto not been described. MATERIALS AND METHODS:Freshly isolated and cultured islets were analyzed by fluorescence-activated cell sorter analysis, fluorescence microscopy, and imm...

journal_title：Transplantation

authors： Mirenda V,Le Mauff B,Cassard A,Huvelin JM,Boeffard F,Faivre A,Soulillou JP,Anegon I

更新日期：1997-05-27 00:00:00

abstract：:We present a case report of a pediatric orthotopic liver transplant recipient who developed lymphoma with hypercalcemia on cyclosporine and prednisone immunosuppression. This is the first reported posttransplant lymphoproliferative disorder complicated by hypercalcemia, with a finding of an elevated 1,25 dihydroxyl vi...

journal_title：Transplantation

authors： Nakazato P,Esquivel CO,Urbach AH,Makowka L,Scantlebury V,Jaffe R,Starzl TE

更新日期：1989-12-01 00:00:00

abstract：:The following findings were noted among 45 bone marrow transplant recipients. The patients without cytomegalovirus (CMV) infection or chronic graft-versus-host disease (GVHD) showed normal lymphocyte stimulation in vitro by concanavalin A (Con A) more than 3 months after transplantation, and normal stimulation by phyt...

journal_title：Transplantation

authors： Paulin T,Ringdén O,Lönnqvist B

更新日期：1985-04-01 00:00:00

abstract：:In an attempt to investigate the nonspecificity of the effect of administration of donor splenocytes treated with mitomycin C (MMC) 7 days before transplantation in inducing immunological unresponsiveness, the survival rates of liver, heart, small bowel, and skin allografts were compared in the RT1-incompatible ACI(RT...

journal_title：Transplantation

authors： Yamaguchi Y,Harland R,Wyble C,Mori K,Bollinger RR

更新日期：1989-02-01 00:00:00

abstract：BACKGROUND:Increasing long-term allograft survival is the main challenge in organ transplantation, and allograft loss due to chronic rejection has been found to correlate with episodes of early acute rejection. It is important to understand the mechanisms that maintain the donor-specific hyporesponsive state. This stud...

journal_title：Transplantation

authors： Mittal SK,Sharma RK,Gupta A,Naik S

更新日期：2009-08-15 00:00:00

abstract：:Modification of pathogenic antibodies for autoimmune diseases illuminated the biologic relevance of B cells, plasma cells, and pathogenic antibodies in autoimmunity. They have also rejuvenated interest in how B cells mediate multiple effector functions that include antibody production, antigen presentation to T cells,...

journal_title：Transplantation

authors： Jordan SC,Ammerman N,Choi J,Huang E,Peng A,Sethi S,Najjar R,Toyoda M,Lim K,Louie S,Vo A

更新日期：2019-02-01 00:00:00

abstract：:Renal transplantation after repair of aortoiliac aneurysms with traditional prosthetic vascular grafts has been shown to be effective. Vascular surgery continues to rapidly evolve, most notably with the advancement of endovascular repair of abdominal aortic aneurysms. Controlled trials continue to support the trend to...

journal_title：Transplantation

authors： George P,Tan HP,Beebe H,Ratner LE

更新日期：2001-08-15 00:00:00

abstract：BACKGROUND:For men with significant genitourinary injury, penile transplantation is being considered as an option when reconstruction is not feasible or proves unacceptable to the injured patient. METHODS:A review of the literature was conducted to assess the current state of penile reconstruction and transplantation ...

journal_title：Transplantation

authors： Caplan AL,Kimberly LL,Parent B,Sosin M,Rodriguez ED

更新日期：2017-06-01 00:00:00

abstract：:The expression of Ia antigens on leukoagglutinin-induced blast cells was studied using a sensitive protein A-rosetting technique and quantitative absorption with conventional and monoclonal Ia antibodies. By direct testing, 40 to 60% of CBA (Iak) blast cells were shown to be Ia+ (Iak+, Ia.17+, and Ias-), expressing bo...

journal_title：Transplantation

authors： Michaelides M,McKenzie IF

更新日期：1981-05-01 00:00:00

abstract：:Pancreas transplantation utilizing portal venous and enteric exocrine drainage has potential benefits over the standard systemic venous and bladder exocrine drainage method. Unfortunately, technical difficulties are often experienced with the arterial anastomosis after the portal venous anastomosis is completed. We ha...

journal_title：Transplantation

authors： Bigam DL,Hemming AW,Sanabria JR,Cattral MS

更新日期：1999-07-27 00:00:00

abstract：:A 55-year-old woman underwent orthotopic liver transplantation for autoimmune chronic active hepatitis. Extensive portal and superior mesenteric venous thrombosis precluded standard portal venous reconstruction and necessitated use of a venous conduit from the recipient splenic vein of the donor liver. Flow through th...

journal_title：Transplantation

authors： Neelamekam TK,Geoghegan JG,Curry M,Hegarty JE,Traynor O,McEntee GP

更新日期：1997-04-15 00:00:00

abstract：BACKGROUND:The impact of the age of the donor on the outcome of living related liver transplantation is yet to be clarified. METHODS:During October 14, 1996 and December 20, 1999, 34 living related liver transplantations were performed. Of these, 26 cases were performed using the extended left lobe graft, which were c...

journal_title：Transplantation

authors： Ikegami T,Nishizaki T,Yanaga K,Shimada M,Kishikawa K,Nomoto K,Uchiyama H,Sugimachi K

更新日期：2000-12-27 00:00:00

abstract：BACKGROUND:Cidofovir (CDV) is a nucleotide analogue with proven in vitro effects against cytomegalovirus (CMV) and adenovirus and has been successfully used in the treatment of CMV retinitis in AIDS patients. METHODS:We performed a prospective study to evaluate the efficacy of CDV in 17 patients with hematological mal...

journal_title：Transplantation

authors： Platzbecker U,Bandt D,Thiede C,Helwig A,Freiberg-Richter J,Schuler U,Plettig R,Geissler G,Rethwilm A,Ehninger G,Bornhäuser M

更新日期：2001-04-15 00:00:00

abstract：BACKGROUND:Allograft rejection is mediated by cytokines. As polymorphism in cytokine genes can result in interindividual differences in cytokine production, we hypothesize that some patients may have an increased risk of rejection. METHODS:We have related polymorphisms that influence cytokine production in the tumor n...

journal_title：Transplantation

authors： Turner D,Grant SC,Yonan N,Sheldon S,Dyer PA,Sinnott PJ,Hutchinson IV

更新日期：1997-09-15 00:00:00

abstract：BACKGROUND:The chemokine receptor CCR7 plays a pivotal role in the homing of naïve T cells and regulatory T cells to secondary lymphoid organs and the migration of dendritic cells into afferent lymphatic vessels. Antigen presentation, T cell recruitment, and expansion of regulatory cells are crucial events in establish...

journal_title：Transplantation

authors： Ensminger SM,Helm SN,Ohl L,Spriewald BM,Abele S,Wollin M,Wood KJ,Weyand M,Förster R

更新日期：2008-08-27 00:00:00