Novel Therapeutic Approaches to Allosensitization and Antibody-mediated Rejection.

abstract：BACKGROUND:Persistent massive ascites (PMAS) longer than 14 days after living donor liver transplantation is not uncommon and associated with worse outcome. A predictive risk scoring system was constructed after analysis of recipient, graft, and surgery-related factors. METHODS:We retrospectively reviewed adult living...

journal_title：Transplantation

authors： Wu YJ,Wang SH,Elsarawy AM,Chan YC,Chen CL,Cheng BC,Li LC,Chiu CH,Lee YW,Lin YC,Wee SY,Pan CC,Kao YY,Chen YH,Lin HW,Lin LM,Lin CC

更新日期：2018-06-01 00:00:00

abstract：BACKGROUND:Chronic allograft nephropathy (CAN) is the most common cause of long-term renal-allograft dysfunction and the second most common cause of transplant loss. There are concerns that prolonged patient exposure to calcineurin inhibitors (CNIs) exacerbates or promotes the process of CAN. METHODS:In our unit, we c...

journal_title：Transplantation

authors： Afzali B,Shah S,Chowdhury P,O'sullivan H,Taylor J,Goldsmith D

更新日期：2005-02-15 00:00:00

abstract：BACKGROUND:Early allograft dysfunction (EAD) defined by serum total bilirubin (TB) of 10 mg/dL or greater or prothrombin time-international normalized ratio (PT-INR) of 1.6 or greater on postoperative day 7 (POD 7) or aminotransferase greater than 2000 IU/L within the first week, is associated with early graft loss aft...

journal_title：Transplantation

authors： Okamura Y,Yagi S,Sato T,Hata K,Ogawa E,Yoshizawa A,Kamo N,Yamashiki N,Okajima H,Kaido T,Uemoto S

更新日期：2018-03-01 00:00:00

abstract：BACKGROUND:Liver transplantation (LT) represents a curative treatment for small hepatocellular carcinoma (HCC). Potentially curable higher-stage HCC patients are denied LT due to the lack of cancer markers that predict progression and recurrence. METHODS:Thirty-eight candidates for LT with hepatitis C virus (HCV) cirr...

journal_title：Transplantation

authors： Mas VR,Fisher RA,Archer KJ,Yanek KC,Williams B,Dumur CI,Maluf DG

更新日期：2007-04-15 00:00:00

abstract：:Cytomegalovirus (CMV) is a major pathogen in transplant recipients and AIDS patients, and the virus may also play a role in allograft rejection. Previous work from this laboratory demonstrated increased cell surface expression of the adhesion molecules ICAM-1 (CD54) and LFA-3 (CD58) following CMV infection in vitro. W...

journal_title：Transplantation

authors： Craigen JL,Grundy JE

更新日期：1996-10-27 00:00:00

abstract：BACKGROUND:Knowledge on the reinnervation of transplanted organs is scarce, and the aim of the study was therefore to evaluate to what degree syngeneic pancreas grafts were reinnervated in rats. METHODS:Syngeneic pancreatico-duodenal transplantations were performed in normoglycemic Wistar-Furth rats. Native and transp...

journal_title：Transplantation

authors： Korsgren O,Jansson L,Ekblad E,Sundler F

更新日期：2001-01-15 00:00:00

abstract：:Although liver transplantation (LT) is the best treatment for patients with localized hepatocellular carcinoma (HCC), recurrence occurs in 6%-18% of patients. Several factors, particularly morphological criteria combined with dynamic parameters, known before LT modify this risk and combined in prediction models may be...

journal_title：Transplantation

authors： Berenguer M,Burra P,Ghobrial M,Hibi T,Metselaar H,Sapisochin G,Bhoori S,Kwan Man N,Mas V,Ohira M,Sangro B,van der Laan LJW

更新日期：2020-06-01 00:00:00

abstract：:Mice immunized with allogeneic cells exhibit a local component of cellular immunity that is confined to lymph nodes draining the site of immunization. After immunization of C3H mice by skin grafting or by i.p. or footpad injection of F1 hybrid spleen cells, draining lymph nodes show increased responsiveness toward the...

journal_title：Transplantation

authors： Snow C,Hilgard HR

更新日期：1981-07-01 00:00:00

abstract：:Two distinct pulmonary vascular disorders, hepatopulmonary syndrome (HPS) and portopulmonary hypertension (POPH) may occur as a consequence of hepatic parenchymal or vascular abnormalities. HPS and POPH have major clinical implications for liver transplantation. A European Respiratory Society Task Force on Pulmonary-H...

journal_title：Transplantation

authors： Krowka MJ,Fallon MB,Kawut SM,Fuhrmann V,Heimbach JK,Ramsay MA,Sitbon O,Sokol RJ

更新日期：2016-07-01 00:00:00

abstract：:The question has not been previously investigated as to whether host lymphocytes infiltrate vascularized organ allografts in indiscriminate fashion, or whether they are retained selectively because of specific antigenic recognition sites on their surfaces. By using a dual cardiac allograft model in LEW rats, we have e...

journal_title：Transplantation

authors： Tilney NL,Notis-McConarty J,Strom TB

更新日期：1978-09-01 00:00:00

abstract：:We report two cases of Kaposi's sarcoma (KS) after orthotopic liver transplantation for cirrhosis of the liver related to hepatitis C virus. Both cases were Saudi-born Arabs who were negative for human immunodeficiency virus; one patient was receiving FK506 plus prednisolone, and the other patient was receiving FK506....

journal_title：Transplantation

authors： Rezeig MA,Fashir BM,Hainau B,Al Ashgar HI

更新日期：1997-05-27 00:00:00

abstract：BACKGROUND:The novel agent sirolimus (SRL; Rapamune; rapamycin) inhibits the immune response by a mechanism distinct from those of calcineurin antagonists or antimetabolites. This randomized, controlled, multicenter, single blind, phase II trial examined the combination of SRL, steroids, and full versus reduced doses o...

journal_title：Transplantation

authors： Kahan BD,Julian BA,Pescovitz MD,Vanrenterghem Y,Neylan J

更新日期：1999-11-27 00:00:00

abstract：:Three strains of miniature swine, each homozygous for a different allele of the major histocompatibility locus (MHC), have been developed by a selective breeding scheme based on tissue typing of the offspring of each generation. Prior to breeding, the original parents were reciprocally immunized by skin grafts and lym...

journal_title：Transplantation

authors： Sachs DH,Leight G,Cone J,Schwarz S,Stuart L,Rosenberg S

更新日期：1976-12-01 00:00:00

abstract：OBJECTIVE:Exact knowledge of biliary anatomy is essential in living donor liver transplantation. The purpose of this study was to evaluate the accuracy of pretransplant magnetic resonance cholangiography (MRC) in depicting the biliary anatomy in comparison with intraoperative cholangiography (IOC). MATERIALS AND METHO...

journal_title：Transplantation

authors： Hsu HW,Tsang LL,Yap A,Huang TL,Chen TY,Lin TS,Concejero AM,Ou SY,Yu CY,Chen CL,Cheng YF

更新日期：2011-07-15 00:00:00

abstract：:The primary effects of CsA on human lymphocyte responses in vitro appear to be the inhibition of IL-2 production and the inhibition of cytotoxic T cell activation. Induction of suppressor T cell activity is resistant to the effects of CsA. These data imply two distinct subsets of lymphocytes: CsA-resistant and CsA-sen...

journal_title：Transplantation

authors： Hess AD,Colombani PM

更新日期：1988-08-01 00:00:00

abstract：:Liver-derived dendritic cell (DC) progenitors propagated in liquid culture in granulocyte/macrophage colony-stimulating factor exhibit low levels both of cell surface MHC class II antigens and of counter-receptors for CTLA-4/CD28. They fail to stimulate allogeneic T cells in mixed leukocyte cultures. To evaluate their...

journal_title：Transplantation

authors： Rastellini C,Lu L,Ricordi C,Starzl TE,Rao AS,Thomson AW

更新日期：1995-12-15 00:00:00

abstract：:Using C1q binding, Kg binding, and Raji cell radioimmunoassays, the relationship between renal allograft rejection and the circulating immune complexes was examined in 90 patients with renal transplants. The data showed that there was a significant quantitative correlation between C1q-binding and Raji-cell-binding act...

journal_title：Transplantation

authors： Fukuda M

更新日期：1983-08-01 00:00:00

abstract：BACKGROUND:The use of liver allografts from an older donor (OD) (age>50 years) is a widespread strategy to manage the disparity between supply and demand of organs for liver transplantation. This study determines the effect of OD allografts on fibrosis progression and graft survival after liver transplantation in patie...

journal_title：Transplantation

authors： Machicao VI,Bonatti H,Krishna M,Aqel BA,Lukens FJ,Nguyen JH,Rosser BG,Satyanarayana R,Grewal HP,Hewitt WR,Harnois DM,Crook JE,Steers JL,Dickson RC

更新日期：2004-01-15 00:00:00

abstract：BACKGROUND AND AIMS:Liver endothelial cells (LECs) perform an essential role in important pathophysiologic functions in the liver. Establishment of a human LEC line facilitates advances in LEC research. Here, we present immortalization of human LECs using retroviral gene transfer of simian virus 40 large T antigen (SV4...

journal_title：Transplantation

authors： Matsumura T,Takesue M,Westerman KA,Okitsu T,Sakaguchi M,Fukazawa T,Totsugawa T,Noguchi H,Yamamoto S,Stolz DB,Tanaka N,Leboulch P,Kobayashi N

更新日期：2004-05-15 00:00:00

abstract：:Untreated anephric LEW rats die ca. 9 days following transplantation of LBNF1 kidney allografts. Although treatment with ART-18, a mouse antirat IL-2R mAb (300 micrograms/kg/day x 10 days), prolonged graft survival to ca. 3 weeks, the severely impaired renal function was comparable to untreated controls (creatinine le...

journal_title：Transplantation

authors： Ueda H,Hancock WW,Cheung YC,Diamantstein T,Tilney NL,Kupiec-Weglinski JW

更新日期：1990-10-01 00:00:00

abstract：:The humoral theory states that antibodies cause the rejection of allografts. From 1917 to 1929, extensive efforts were made to produce antibodies against tumors. It was finally realized that the antibodies were produced against the transplant antigens present on transplantable tumors, not against the tumor-specific an...

journal_title：Transplantation

authors： Terasaki PI

更新日期：2012-04-27 00:00:00

abstract：BACKGROUND:The timing of an acute rejection may have a variable impact on renal allograft survival. To determine whether the time of first acute transplant rejection (ATR) is an independent predictor of long-term allograft survival, we studied 31,600 first cadaveric renal transplants that were functional on the first t...

journal_title：Transplantation

authors： Leggat JE Jr,Ojo AO,Leichtman AB,Port FK,Wolfe RA,Turenne MN,Held PJ

更新日期：1997-05-15 00:00:00

abstract：BACKGROUND:Combined lung and liver transplantation (Lu-LTx) is a therapeutic option for selected patients with coexisting lung and liver disease. For several reasons, Lu-LTx is performed in few centers and information about the technical issues, posttransplant management and long-term outcomes associated with this proc...

journal_title：Transplantation

authors： Grannas G,Neipp M,Hoeper MM,Gottlieb J,Lück R,Becker T,Simon A,Strassburg CP,Manns MP,Welte T,Haverich A,Klempnauer J,Nashan B,Strueber M

更新日期：2008-02-27 00:00:00

abstract：BACKGROUND:Mixed allogeneic bone marrow chimerism induces tolerance to solid organ grafts. Although we previously reported that partially ablative conditioning with 700 cGy of total body irradiation (TBI) is sufficient to allow for bone marrow engraftment in mice, we determined that a minimum of 1000 cGy was required i...

journal_title：Transplantation

authors： Neipp M,Gammie JS,Exner BG,Li S,Chambers WH,Pham SM,Ildstad ST

更新日期：1999-08-15 00:00:00

abstract：BACKGROUND:ABO-incompatible organ transplantation typically induces hyperacute rejection. A2-to-O liver transplantations have been successful. This study compared overall and graft survival in O recipients of A2 and O grafts based on Organ Procurement and Transplantation Network data. METHODS:Scientific Registry of Tr...

journal_title：Transplantation

authors： Kluger MD,Guarrera JV,Olsen SK,Brown RS Jr,Emond JC,Cherqui D

更新日期：2012-09-15 00:00:00

abstract：:Recipients of solid organ allografts require lifelong immunosuppression in order to prevent graft rejection and to maintain graft function. In general, such immunosuppression greatly impairs the cellular immune system, as this level of the immune system is principally responsible for self and non-self recognition. The...

journal_title：Transplantation

authors： Van Thiel DH,Finkel R,Friedlander L,Gavaler JS,Wright HI,Gordon R

更新日期：1992-08-01 00:00:00

abstract：:The production and release of cytokines and their receptors are of critical importance in mediating graft injury. In order to evaluate the expression of cytokines in renal allograft biopsies, we performed immunocytochemical studies to detect activated cells positive for TNF-alpha, IFN-gamma, and IL-2R, using an alkali...

journal_title：Transplantation

authors： Noronha IL,Eberlein-Gonska M,Hartley B,Stephens S,Cameron JS,Waldherr R

更新日期：1992-12-01 00:00:00

abstract：:The kinetics of lymphocyte recirculation in normal and allografted rats with acute cardiac rejection was studied with indium-111 (In-111) labeled splenic lymphocytes in two groups of rats. Group 1 consisted of subgroups of normal Lewis rats infused with In-111 labeled unsensitized syngeneic cells (group 1a); ACI-sensi...

journal_title：Transplantation

authors： Oluwole S,Satake K,Kuromoto N,Fawwaz R,Hardy MA

更新日期：1983-11-01 00:00:00

abstract：BACKGROUND:Two side effects of irradiation are premature ovarian failure (POF) and osteoporosis, both of which are concerns not only clinically, for patients, but also experimentally, for animals. We examine whether bone marrow transplantation (BMT) can correct the POF induced by radiation and also address whether allo...

journal_title：Transplantation

authors： Feng W,Cui Y,Zhan H,Shi M,Cui W,Guo K,Li Q,Song C,Zhang Y,Mori T,Gershwin ME,Abraham NG,Ikehara S

更新日期：2010-02-27 00:00:00

abstract：BACKGROUND:A 35-year period of clinical development resulted in orthotopic liver transplantation (OLT) becoming a standardized surgical procedure. Despite this progress, the rate of technical complications is still high. Although the main problem in most analyses is vascular or bile duct failure, we observed a remarkab...

journal_title：Transplantation

authors： Soliman T,Langer F,Puhalla H,Pokorny H,Grunberger T,Berlakovich GA,Langle F,Muhlbacher F,Steininger R

更新日期：2000-05-27 00:00:00