Abstract:
:Two distinct pulmonary vascular disorders, hepatopulmonary syndrome (HPS) and portopulmonary hypertension (POPH) may occur as a consequence of hepatic parenchymal or vascular abnormalities. HPS and POPH have major clinical implications for liver transplantation. A European Respiratory Society Task Force on Pulmonary-Hepatic Disorders convened in 2002 to standardize the diagnosis and guide management of these disorders. These International Liver Transplant Society diagnostic and management guidelines are based on that task force consensus and should continue to evolve as clinical experience dictates. Based on a review of over 1000 published HPS and POPH articles identified via a MEDLINE search (1985-2015), clinical guidelines were based on, selected single care reports, small series, registries, databases, and expert opinion. The paucity of randomized, controlled trials in either of these disorders was noted. Guidelines are presented in 5 parts; I. Definitions/Diagnostic criteria; II. Hepatopulmonary syndrome; III. Portopulmonary hypertension; IV. Implications for liver transplantation; and V. Suggestions for future clinical research.
journal_name
Transplantationjournal_title
Transplantationauthors
Krowka MJ,Fallon MB,Kawut SM,Fuhrmann V,Heimbach JK,Ramsay MA,Sitbon O,Sokol RJdoi
10.1097/TP.0000000000001229subject
Has Abstractpub_date
2016-07-01 00:00:00pages
1440-52issue
7eissn
0041-1337issn
1534-6080pii
00007890-201607000-00013journal_volume
100pub_type
杂志文章,实务指引相关文献
TRANSPLANTATION文献大全abstract::Brainstem death is associated with endocrine and metabolic alterations that can result in donor hemodynamic instability. It has been suggested that these changes can be reversed through hormonal manipulation of the donor. We measured thyroid hormone levels (free triiodothyronine [fT3], free tetraiodothyronine [fT4], r...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199403150-00007
更新日期:1994-03-15 00:00:00
abstract::Graft-versus-host disease (GVHD) is a common complication of bone marrow transplantation and often involves the gastrointestinal system. It is unclear whether there can be severe enough damage by GVHD to permanently injure the bowel and thereby prevent mucosal regeneration. We describe a patient who had successful tre...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199612150-00028
更新日期:1996-12-15 00:00:00
abstract::The effects of pretreatment with cyclosporine, allopurinol, or methylprednisolone on ischemia-reperfusion injury of the liver were investigated. A total of 32 adult mongrel dogs that received one of the pretreatments were divided into four groups and were subjected to 90 min liver ischemia. Serum activities of asparta...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199107000-00005
更新日期:1991-07-01 00:00:00
abstract:BACKGROUND:We assess whether remote ischemic preconditioning (rIPC) of the recipient can modify ischemia-reperfusion (IR) injury in the donor heart following orthotopic heart transplantation from brain dead donors and to examine potential mechanisms of protection. METHODS:Sixteen pigs weighing from 26 to 34.2 (mean 29...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000159137.76400.5d
更新日期:2005-06-27 00:00:00
abstract::Osteopetrotic microphthalmic mice (mi/mi) were treated by injections of suspensions of myeloid tissue, newborns i.p., and weanlings i.v. Donated syngeneic material effected permanent cure of oteopetrosis provided that the dose was large enough (10(8) cells of bone marrow). H-2-compatible allogeneic bone marrow was ini...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-197910000-00004
更新日期:1979-10-01 00:00:00
abstract::Experiments have been carried out to investigate whether the continued survival of rat kidney allografts induced by two different methods-namely, immunological enhancement or a limited course of drug treatment with cyclosporine or cyclophosphamide, is maintained by similar mechanisms. (AS X AUG)F1 or AUG strain kidney...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198508000-00008
更新日期:1985-08-01 00:00:00
abstract::EBVirus-associated B cell lymphoproliferative disorder (BLPD) is a recognized complication of primary immunodeficiency and organ as well as bone marrow transplantation. Although the nature of the immune defects that predispose to the development of BLPD are unknown, it is postulated that aberrant T cell responses are ...
journal_title:Transplantation
pub_type: 杂志文章
doi:
更新日期:1994-04-15 00:00:00
abstract::Multiple variations of the basic lymphocytotoxicity test have been reported to increase test sensitivity. Although these modifications are used routinely in crossmatch tests, as required by federal regulation, there has been no methodical assessment of the relative sensitivities and specificities of these techniques w...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199509000-00016
更新日期:1995-09-15 00:00:00
abstract::A worldwide shortage of cadaveric donors has led to the increased utilization of elderly living donors, with controversial results. In an attempt to assess the effect of donor age on graft survival and subsequent renal function, we analyzed our clinical results in 276 consecutive recipients of living related renal tra...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199102000-00005
更新日期:1991-02-01 00:00:00
abstract::There is increasing evidence that various maturational stages of B-cells infiltrate various solid organ transplants undergoing acute rejection. The presence of immature CD20 and mature CD138 plasma cells associate with more aggressive and steroid-recalcitrant graft rejection and portend poor graft outcomes. Though ass...
journal_title:Transplantation
pub_type: 社论,评审
doi:10.1097/TP.0b013e318177793e
更新日期:2008-06-27 00:00:00
abstract::The early detection of allograft rejection remains elusive after solitary pancreas transplantation (PTX). We have previously described a modified technique of cystoscopic transduodenal PTX biopsy using the Biopty gun under ultrasound guidance. During the last 2 years, we performed 24 solitary PTXs with prospective pro...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199560120-00011
更新日期:1995-12-27 00:00:00
abstract:BACKGROUND:Functionally relevant polymorphisms in genes of the Th1 and Th2-inflammatory pathway influence the susceptibility to acute rejection (AR), chronic allograft nephropathy (CAN), and subclinical rejection (SR) as well as graft survival after renal transplantation. Because these findings have not been validated,...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000285295.39275.3b
更新日期:2007-10-27 00:00:00
abstract:BACKGROUND:Intracellular concentration of reactive oxygen species is held within tight physiological limits by enzymes with scavenging and repair functions. Under extreme conditions such as prolonged cold ischemia, these enzymes may be unable to adequately protect the organ, resulting in reperfusion injury that renders...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200209270-00013
更新日期:2002-09-27 00:00:00
abstract:BACKGROUND:Human herpesvirus-6 (HHV-6) is known to reactivate after renal transplantation and has been associated with several clinical manifestations. Risk factors for sustained viral replication, however, remain unclear. METHODS:Thirty consecutive kidney transplant patients were prospectively followed for HHV-6 repl...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3182807ab7
更新日期:2013-03-27 00:00:00
abstract:BACKGROUND:Strong alloreactive T cell responses are a menace in transplantation surgery and their menagement requires understanding the basis of alloreactivity. Alloantigen recognition can be peptide independent, peptide specific, or peptide dependent. The mechanisms influencing each recognition pattern are largely unk...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200203150-00024
更新日期:2002-03-15 00:00:00
abstract:BACKGROUND:This study aims to verify the condition of recipients of solid organs from donors with central nervous system (CNS) tumors and determine the risk of disease transmission due to transplantation. METHODS:Twenty-eight brain-dead organ donors with CNS tumors and 91 recipients who received solid organs from Janu...
journal_title:Transplantation
pub_type: 杂志文章,评审
doi:10.1097/TP.0000000000002994
更新日期:2020-03-01 00:00:00
abstract::Stable renal transplant recipients (RTR) display high rates of atherosclerotic events (AE). Innate immunity and especially vascular inflammation play a role in the pathogenesis of atherosclerosis. It is illustrated both by an increased occurrence of postrenal transplant cardiovascular events in patients with elevated ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000202846.17619.a4
更新日期:2006-04-27 00:00:00
abstract:BACKGROUND:The organ donor shortage has led to a reconsideration of the use of non-heart-beating donors (NHBDs). However, graft injury due to warm ischemia in NHBD livers strongly affects posttransplant outcome. The present study was aimed at investigating the role of the cellular cyclic (c)AMP second messenger signal ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199810270-00004
更新日期:1998-10-27 00:00:00
abstract::Governmental and private programs that pay next of kin who give permission for the removal of their deceased relative's organs for transplantation exist in a number of countries. Such payments, which may be given to the relatives or paid directly for funeral expenses or hospital bills unrelated to being a donor, aim t...
journal_title:Transplantation
pub_type: 指南,杂志文章
doi:10.1097/TP.0000000000001198
更新日期:2016-09-01 00:00:00
abstract::Of 2457 patients in the North American Pediatric Renal Transplant Cooperative Study registry who were followed for 5481 patient-years after the index transplantation, we observed 136 deaths, for an average annual rate of 24.8 deaths per 1000 patient-years. Death resulted primarily from infection (n = 55, 40%), cardiov...
journal_title:Transplantation
pub_type: 杂志文章,多中心研究
doi:
更新日期:1994-02-27 00:00:00
abstract::Dendritic cell (DC) progenitors were propagated in liquid culture from nonparenchymal cells resident in normal mouse (B10.BR; H-2k, I-E+) liver in response to granulocyte-macrophage colony stimulating factor (GM-CSF). The liver-derived DC progenitors were MHC class II-/dim and did not express counter receptors for CTL...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199502270-00019
更新日期:1995-02-27 00:00:00
abstract:BACKGROUND:The mitochondrial respiratory chain is implicated as a major target of kidney damage after ischemia-reperfusion. This study measures changes in integrated mitochondrial function and in the activity of enzymes of the respiratory chain after cold storage and transplantation-reperfusion in vivo. METHODS:Mitoch...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200004150-00011
更新日期:2000-04-15 00:00:00
abstract::Renal function was observed retrospectively in a population of 228 adults who underwent a cardiac allograft at the University of Pittsburgh from June 1980 through June 1987, survived a minimum of one year, and received cyclosporine. Renal function was determined by serial measurement of serum creatinine concentration....
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199010000-00012
更新日期:1990-10-01 00:00:00
abstract::The success of kidney transplants is limited by the lack of robust improvements in long-term survival. It is now recognized that alloimmune responses are responsible for the majority of allograft failures. Development of novel therapies to decrease allosensitization is critical. The lack of new drug development in kid...
journal_title:Transplantation
pub_type: 杂志文章,评审
doi:10.1097/TP.0000000000001452
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:Proteinuria is associated with endothelial dysfunction (ED) and increased mortality. We investigated whether urinary protein excretion (UPE) is correlated with markers of ED and whether these markers affect the association of proteinuria with mortality in renal transplant recipients (RTR). METHODS:Six hundr...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3181903d25
更新日期:2008-12-27 00:00:00
abstract:BACKGROUND:Conflicting data have been reported about the effect of Toxoplasma serostatus on mortality after heart transplantation. Either a positive or a negative recipient Toxoplasma serostatus was found to be associated with increased mortality. METHODS:We evaluated the effects of T. gondii infection on survival of ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3182a9274a
更新日期:2013-12-27 00:00:00
abstract::We have tested the predictive model for risk of sensitization by donor-specific transfusions developed at the University of California, San Francisco for its applicability to the DST experience at UW/Madison. Patient sample sizes between the two groups were similar (n = 249 for UW/Madison, n = 261 for UCSF) and the tw...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198901000-00031
更新日期:1989-01-01 00:00:00
abstract:BACKGROUND:Graft coronary arteriosclerosis (GCA) is the major limiting factor for long-term survival after heart transplantation. In this study, we investigated the effect of Multiglycosidorum tripterygii (MT) on GCA and platelet-derived growth factor A (PDGF-A) mRNA expression of transplanted hearts. METHODS:Two grou...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199806150-00006
更新日期:1998-06-15 00:00:00
abstract::Ontogenic development of suppressor cells was studied in mouse embryos. It was found that liver cells of embryos at various stages of gestation were capable of interfering with the mixed leukocyte culture (MLC) reaction. The MLC reaction was also inhibited by embryonic spleen and thymus cells. However, the latter were...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-197812000-00016
更新日期:1978-12-01 00:00:00
abstract:BACKGROUND:Living kidney donors have donation-related out-of-pocket costs (direct costs) and/or ongoing daily expenses while losing income (indirect costs). Yet there is little information about how much of a subjective burden these constitute for the donors. METHODS:From December 2003 through December 2014, we survey...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000001568
更新日期:2017-09-01 00:00:00