Inhibitory effect of Multiglycosidorum tripterygii on coronary arteriosclerosis after heart transplantation.


BACKGROUND:Graft coronary arteriosclerosis (GCA) is the major limiting factor for long-term survival after heart transplantation. In this study, we investigated the effect of Multiglycosidorum tripterygii (MT) on GCA and platelet-derived growth factor A (PDGF-A) mRNA expression of transplanted hearts. METHODS:Two groups of Lewis rats (n=7/group) underwent heterotopic heart transplantation from Wistar-King donors and were treated with either cyclosporine (CsA;10 mg/kg/day) or MT (30 mg/kg/ day). Histological evaluations of rejection and coronary arteriosclerosis, as well as Northern blot analysis on graft PDGF-A mRNA expression were made 60 days after transplantation. RESULTS:Morphometric results indicated no significant difference in rejection between the CsA- and MT-treated groups. However, the extent of GCA in the MT-treated group was significantly less than that seen in the CsA-treated group (P<0.01). The expression of PDGF-A mRNA of cardiac allograft was also significantly suppressed in the MT-treated group when compared with the CsA-treated group (P<0.01). CONCLUSION:MT is superior to CsA in preventing graft coronary arteriosclerosis, and this efficacy is probably associated with the depressed expression of graft PDGF-A mRNA in the MT-treated group.






Hachida M,Zhang XL,Lu H,Hoshi H,Koyanagi H




Has Abstract


1998-06-15 00:00:00












  • Acute nephrotoxicity of tacrolimus and sirolimus in renal isografts: differential intragraft expression of transforming growth factor-beta1 and alpha-smooth muscle actin.

    abstract:BACKGROUND:Renal dysfunction early after kidney transplantation has multiple causes including ischemia-reperfusion (I/R) injury and drug-induced nephrotoxicity. This study assesses the acute nephrotoxicity of tacrolimus (Tac) and sirolimus (Sir) in a rat renal isograft model. METHODS:Lewis renal isografts and uninephr...


    pub_type: 杂志文章


    authors: Ninova D,Covarrubias M,Rea DJ,Park WD,Grande JP,Stegall MD

    更新日期:2004-08-15 00:00:00

  • Cells mediating graft rejection in the mouse. II. The Ly phenotypes of cells producing tumor allograft rejection.

    abstract::The particular T cell subsets involved in the rejection of tumor allografts were examined in mice using two different approaches. In the first, EL4 lymphoma cells or B16 melanoma cells were given to ATXBM-CBA/H mice which had been reconstituted with either naive or sensitized T cells selectively depleted with either L...


    pub_type: 杂志文章


    authors: Loveland BE,McKenzie IF

    更新日期:1982-02-01 00:00:00

  • Mechanisms of tolerance induced by PG490-88 in a bone marrow transplantation model.

    abstract:BACKGROUND:PG490-88, a semisynthetic derivative of a novel compound PG490 (triptolide) purified from a Chinese herb (Tripterygium wilfordii Hook F), is effective in prevention of murine graft-versus-host disease (GVHD). METHODS:PG490-88 was administrated into recipients in a model (B10.D2 [H2d, Mls-2b, Mls-3b]-->BALB/...


    pub_type: 杂志文章


    authors: Chen BJ,Chen Y,Cui X,Fidler JM,Chao NJ

    更新日期:2002-01-15 00:00:00

  • The role of donor-recipient relationship in long-term outcomes of living donor renal transplantation.

    abstract:BACKGROUND:Graft failure related to acute and chronic rejection remains an important problem in transplantation. An association has been reported between microchimerism and the development of tolerance. Since it has been established that cells of fetal origin can be found in maternal tissues long after parturition, and...


    pub_type: 杂志文章


    authors: Miles CD,Schaubel DE,Liu D,Port FK,Rao PS

    更新日期:2008-05-27 00:00:00

  • Inverse correlation of cyclosporine binding with sensitivity and resistance.

    abstract::The primary effects of CsA on human lymphocyte responses in vitro appear to be the inhibition of IL-2 production and the inhibition of cytotoxic T cell activation. Induction of suppressor T cell activity is resistant to the effects of CsA. These data imply two distinct subsets of lymphocytes: CsA-resistant and CsA-sen...


    pub_type: 杂志文章


    authors: Hess AD,Colombani PM

    更新日期:1988-08-01 00:00:00

  • Treatment of established bone loss after renal transplantation with etidronate.

    abstract:BACKGROUND:Osteoporosis is a well-documented complication of organ transplantation. Bisphosphonates have been shown to be effective in preventing corticosteroid-induced osteoporosis in renal transplant recipients, but data are lacking for treatment of established osteoporosis. This study reports our clinical experience...


    pub_type: 杂志文章


    authors: Arlen DJ,Lambert K,Ioannidis G,Adachi JD

    更新日期:2001-03-15 00:00:00

  • Direct evidence of a functional separation of alloreactive T lymphocytes from bystander cells infiltrating rat allografts. Interleukin 2 receptor-positive cells reacting with the monoclonal antibody ART 18 mediating second-set rejection.

    abstract::In this study we examined the functional capacity of unseparated, IL-2R positive and IL-2R negative leukocytes infiltrating BN rat hearts or kidneys grafted into allogeneic LEW rats. Upon adoptive transfer into syngeneic LEW recipients, splenocytes or day-3 graft infiltrate cells of either cardiac or renal transplants...


    pub_type: 杂志文章


    authors: Heidecke CD,Brauer R,Schneider-Eicke J,Schilling T,Wolff S,Diamantstein T

    更新日期:1990-07-01 00:00:00

  • Evidence that 15-deoxyspergualin inhibits natural antibody production but fails to prevent hyperacute rejection in a discordant xenograft model.

    abstract::Preventing hyperacute rejection (HAR) is a difficult and unsolved problem in xenotransplantation. This may be due, in part, to a lack of therapies that can suppress production of natural antibodies (NA), which are thought to be critical mediators of HAR. This study examined the effect of 15-deoxyspergualin (DSPG) and ...


    pub_type: 杂志文章


    authors: Leventhal JR,Flores HC,Gruber SA,Figueroa J,Platt JL,Manivel JC,Bach FH,Matas AJ,Bolman RM 3rd

    更新日期:1992-07-01 00:00:00

  • Complement-mediated pulmonary xenograft injury: studies in swine-to-primate orthotopic single lung transplant models.

    abstract:BACKGROUND:The pathogenesis of acute pulmonary xenograft injury has not yet been determined. The present study evaluates the role of complement in mediating pulmonary xenograft dysfunction by using cobra venom factor (CVF) to deplete recipient complement and transgenic swine, which express human regulators of complemen...


    pub_type: 杂志文章


    authors: Yeatman M,Daggett CW,Parker W,Byrne GW,Logan JS,Platt JL,Davis RD

    更新日期:1998-04-27 00:00:00

  • Ganciclovir transiently attenuates murine cytomegalovirus-associated renal allograft inflammation.

    abstract:BACKGROUND:Prophylactic ganciclovir (GCV) is used in high-risk renal transplant patients to prevent acute cytomegalovirus (CMV) disease, but its impact on inflammation within the allograft itself remains undefined. METHODS:To study the effect of GCV prophylaxis on allograft inflammation, murine CMV (MCMV)-infected all...


    pub_type: 杂志文章


    authors: Shimamura M,Saunders U,Rha B,Guo L,Cassady KA,George JF,Britt WJ

    更新日期:2011-10-15 00:00:00

  • A prospective study of human herpesvirus type 6 detected by polymerase chain reaction after liver transplantation.

    abstract::Human herpesvirus type 6 (HHV-6) causes roseola infantum (exanthema subitum) upon primary infection in young children. Thereafter it persists lifelong in the organism. Like other herpesviruses, HHV-6 can be reactivated in periods of immunosuppression - e.g., after organ transplantation. In order to study the incidence...


    pub_type: 杂志文章


    authors: Schmidt CA,Wilbron F,Weiss K,Brinkmann V,Oettle H,Lohmann R,Langrehr JM,Neuhaus P,Siegert W

    更新日期:1996-02-27 00:00:00

  • The use of marginal heart beating donor livers for transplantation in the United kingdom.

    abstract:BACKGROUND:This study investigated the use of deceased heart-beating donor livers offered for transplantation during a 10-year period, during which there has been an increasing disparity between organ supply and demand in the United Kingdom. METHODS:Summary data from the National Transplant Database were analyzed on a...


    pub_type: 杂志文章


    authors: Devey LR,Friend PJ,Forsythe JL,Mumford LL,Wigmore SJ

    更新日期:2007-07-15 00:00:00

  • The mechanism of anti-CD3 monoclonal antibodies. Mediation of cytolysis by inter-T cell bridging.

    abstract::OKT3, an anti-CD3 MAB, depletes T cells in vivo and is among the most potent inhibitors of acute allograft rejection. The mechanism of this inhibition is unknown. The present studies investigate whether anti-CD3 antibodies have the ability to crosslink CD3 on two different cells and induce TCR-dependent antibody-bridg...


    pub_type: 杂志文章


    authors: Wong JT,Eylath AA,Ghobrial I,Colvin RB

    更新日期:1990-10-01 00:00:00

  • Exercise training in solid organ transplant recipients: a systematic review and meta-analysis.

    abstract:BACKGROUND:Exercise training is effective in improving the cardiovascular risk profiles of nontransplanted patients, but the health benefits and potential harms of routine exercise training after solid organ transplantation are unclear. This study aims to assess the health benefits and harms of supervised exercise trai...


    pub_type: 杂志文章,meta分析,评审


    authors: Didsbury M,McGee RG,Tong A,Craig JC,Chapman JR,Chadban S,Wong G

    更新日期:2013-03-15 00:00:00

  • HLA matching and the United Network for Organ Sharing Allocation System: impact of HLA matching on African-American recipients of cadaveric kidney transplants.

    abstract:BACKGROUND:A recent proposal supports the elimination of allocation points for human leukocyte antigen (HLA) mismatches (MM) in cadaveric kidney transplantation. The intent is to increase access for some racial groups that might be disadvantaged by the representation of race-specific HLA in a largely white donor pool. ...


    pub_type: 评论,杂志文章


    authors: Rebellato LM,Arnold AN,Bozik KM,Haisch CE

    更新日期:2002-12-15 00:00:00

  • Effect of HLA matching on organ distribution among whites and African-Americans.

    abstract::A total of 159 patients received renal cadaveric grafts under 2 different allocation systems. System 1, a local variance (i.e., a point system different from that of United Network for Organ Sharing [UNOS]), and system 2, the current UNOS point system, differed in the relative emphasis on waiting time and HLA match. T...


    pub_type: 杂志文章


    authors: Zachary AA,Braun WE,Hayes JM,McElroy JB,Novick AC,Schulak JA,Sharp WV

    更新日期:1994-04-15 00:00:00

  • Treatment of chronic renal allograft rejection in rats with a low-molecular-weight heparin (reviparin).

    abstract:BACKGROUND:Low-molecular-weight heparin (LMWH) has been shown to prolong survival of rat cardiac allografts independently from immunosuppressive treatment. Furthermore, long-term treatment reduces the development of chronic graft vascular disease after experimental heart transplantation. The aim of the present study wa...


    pub_type: 杂志文章


    authors: Braun C,Schultz M,Fang L,Schaub M,Back WE,Herr D,Laux V,Rohmeiss P,Schnuelle P,van der Woude FJ

    更新日期:2001-07-27 00:00:00

  • Transmembrane signalling via the T cell antigen receptor heterodimer and the CD2 antigen. A synergistic pathway for activation of T cells.

    abstract::T cell surface proteins involved in transmembrane signalling resulting in the activation of T cells were investigated utilizing as probes monoclonal antibodies directed at T cell surface antigens. Here we report that mAbs that react with a framework determinant of alpha/beta heterodimer of T cell receptor for antigen,...


    pub_type: 杂志文章


    authors: Suthanthiran M

    更新日期:1989-02-01 00:00:00

  • Technetium-99m sulfur colloid accumulation as a predictor of acute renal transplant rejection.

    abstract::Renal transplantation is the preferred treatment for end-stage renal disease in children. Most transplant failures are due to allograft rejection. To date, only histopathological findings on renal biopsy can establish this diagnosis. Prior to the availability of cyclosporine, technetium-99m sulfur colloid nuclear scan...


    pub_type: 杂志文章


    authors: Massengill SF,Pena DR,Drane WE,Fennell RS,Richard GA

    更新日期:1992-12-01 00:00:00

  • CCR5, RANTES and CX3CR1 polymorphisms: possible genetic links with acute heart rejection.

    abstract:BACKGROUND:The inflammation response is modulated by the elaborated chemokine-chemokine receptor system, which also plays an important role in the development of acute rejection (AR). In this study, we hypothesized that functional genetic variants of some of these modulatory proteins might influence the outcome of AR. ...


    pub_type: 杂志文章


    authors: Simeoni E,Vassalli G,Seydoux C,Ramsay D,Noll G,von Segesser LK,Fleury S

    更新日期:2005-11-15 00:00:00

  • Racial Differences in Survival of Incident Home Hemodialysis and Kidney Transplant Patients.

    abstract:BACKGROUND:Previous studies have indicated that patients on maintenance hemodialysis have worse survival compared with kidney transplant (KTx) recipients. However, none of these studies have compared mortality of the US patients using alternative dialysis modalities such as home hemodialysis (HHD) with KTx recipients. ...


    pub_type: 杂志文章


    authors: Molnar MZ,Ravel V,Streja E,Kovesdy CP,Mehrotra R,Kalantar-Zadeh K

    更新日期:2016-10-01 00:00:00

  • Cardiovascular Parameters to 2 years After Kidney Transplantation Following Early Switch to Everolimus Without Calcineurin Inhibitor Therapy: An Analysis of the Randomized ELEVATE Study.

    abstract:BACKGROUND:Mammalian target of rapamycin inhibitors may confer cardioprotective advantages, but clinical data are limited. METHODS:In the open-label ELEVATE trial, kidney transplant patients were randomized at 10 to 14 weeks after transplant to convert from calcineurin inhibitor (CNI) to everolimus or remain on standa...


    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Holdaas H,de Fijter JW,Cruzado JM,Massari P,Nashan B,Kanellis J,Witzke O,Gutierrez-Dalmau A,Turkmen A,Wang Z,Lopez P,Bernhardt P,Kochuparampil J,van der Giet M,Murbraech K,ELEVATE Study Group.

    更新日期:2017-10-01 00:00:00

  • Tissue-Resident Lymphocytes in Solid Organ Transplantation: Innocent Passengers or the Key to Organ Transplant Survival?

    abstract::Short-term outcomes of solid organ transplantation have improved dramatically over the past several decades; however, long-term survival has remained static over the same period, and chronic rejection remains a major cause of graft failure. The importance of donor, or "passenger," lymphocytes to the induction of toler...


    pub_type: 杂志文章,评审


    authors: Prosser AC,Kallies A,Lucas M

    更新日期:2018-03-01 00:00:00

  • Response to varicella immunization in pediatric liver transplant recipients.

    abstract:BACKGROUND:Individuals undergoing therapeutic immunosuppression are at risk of severe varicella-zoster virus (VZV) infection, particularly those without evidence of previous infection. METHODS:Eleven children, median age 10 months (range 5.5 months to 7 years and 9 months) received one dose of varicella vaccine (Varil...


    pub_type: 杂志文章


    authors: Donati M,Zuckerman M,Dhawan A,Hadzic N,Heaton N,North-Lewis P,Mieli-Vergani G

    更新日期:2000-11-15 00:00:00

  • Failure of in vitro assays to predict accurately the existence of neonatally induced H-2 tolerance.

    abstract::Tolerogen-specific alloreactivity, in the form of mixed lymphocyte responses and cell mediated lympholysis, was measured in vitro using lymphocytes from mice that received neonatal inoculations of H-2 semiallogeneic hematopoietic cells. It was found that depletion of specific alloreactivity, as detected by these assay...


    pub_type: 杂志文章


    authors: Streilein JW,Strome P,Wood PJ

    更新日期:1989-10-01 00:00:00

  • Neutrophilic tubulitis as a marker for urinary tract infection in renal allograft biopsies with C4d deposition.

    abstract:BACKGROUND:Neutrophilic tubulitis accompanied by intratubular neutrophil clusters in the renal allograft is a surrogate marker for urinary tract infection (UTI). Overlapping histologic findings can occur in antibody-mediated rejection, which is characterized by peritubular capillary (PTC) deposition of C4d. This study ...


    pub_type: 杂志文章


    authors: Gupta G,Shapiro R,Girnita A,Batal I,McCauley J,Basu A,Tan H,Randhawa P

    更新日期:2009-04-15 00:00:00

  • Incidence of tuberculosis in deceased-organ donors and transmission risk to recipients in Spain.

    abstract:BACKGROUND:Globalization and migration patterns have increased the number of donors from countries with high incidence rates of tuberculosis (TB) in low incidence countries, with the subsequent increase in risk of TB transmission to the recipients. METHODS:Retrospective cohort study, including all actual deceased dono...


    pub_type: 杂志文章


    authors: Coll E,Torre-Cisneros J,Calvo R,Garrido G,Matesanz R

    更新日期:2013-07-27 00:00:00

  • Improvement in 3-month patient-reported gastrointestinal symptoms after conversion from mycophenolate mofetil to enteric-coated mycophenolate sodium in renal transplant patients.

    abstract:BACKGROUND:The benefit of conversion from mycophenolate mofetil (MMF) to enteric-coated mycophenolate sodium (EC-MPS) in terms of gastrointestinal symptom burden has been evaluated previously using patient-reported outcomes. However, data are lacking concerning the sustained effect of conversion over time, and the pote...


    pub_type: 临床试验,杂志文章,多中心研究


    authors: Bolin P,Tanriover B,Zibari GB,Lynn ML,Pirsch JD,Chan L,Cooper M,Langone AJ,Tomlanovich SJ

    更新日期:2007-12-15 00:00:00

  • Escaping from rejection.

    abstract::Since the earliest days of transplantation, immunobiologists have sought means to prevent recognition and rejection of foreign tissue. The goal of these strategies is the retention of recipient immune function while selectively avoiding graft injury. Although considerable theoretical and technical problems remain, an ...


    pub_type: 杂志文章,评审


    authors: Lynch RJ,Platt JL

    更新日期:2009-12-15 00:00:00

  • Correction of decreased guanylate cyclase activity in diabetic rats by pancreatic islet transplantation.

    abstract::We have previously demonstrated that streptozotocin-induced diabetic rats have decreased guanylate cyclase (EC activity in liver and other tissues which was returned to normal by the administration of exogenous insulin. Since successful pancreatic islet transplants have been shown to lower basal hepatic gluco...


    pub_type: 杂志文章


    authors: Vesely DL,Selawry H,Levey GS

    更新日期:1979-06-01 00:00:00