Remote ischemic preconditioning of the recipient reduces myocardial ischemia-reperfusion injury of the denervated donor heart via a Katp channel-dependent mechanism.

abstract：:The fate of cell surface I-Ak and H-2Kk antigens shed by murine spleen cells in culture was studied by incubation of nonlabeled spleen cells or splenic T or B cells with culture fluids containing shed radiolabeled alloantigens. Approximately 30 to 40% of the shed alloantigens could be absorbed by syngeneic or allogene...

journal_title：Transplantation

authors： Emerson SG,Cone RE

更新日期：1982-01-01 00:00:00

abstract：:This study investigates the possibility that the active enhancing properties of bone marrow (BM) cells may be related to Ia-like determinants on their surface membranes. Less chromium was released on a cell per cell basis from nucleated baboon BM cells used as targets in complement-dependent cytotoxicity than from lab...

journal_title：Transplantation

authors： Smit JA,Myburgh JA,Gaillard VJ

更新日期：1978-08-01 00:00:00

abstract：BACKGROUND:We report long-term outcomes and side effects after transplantation for hepatocellular carcinoma (HCC) using de novo, sirolimus-based immunosuppression (IS). METHODS:A total of 70 patients with HCC (mean age: 54.4+/-7 years, female/male: 12/58) were transplanted and included in the study. Immunosuppression ...

journal_title：Transplantation

authors： Toso C,Meeberg GA,Bigam DL,Oberholzer J,Shapiro AM,Gutfreund K,Ma MM,Mason AL,Wong WW,Bain VG,Kneteman NM

更新日期：2007-05-15 00:00:00

abstract：:Control mechanisms that regulate the induction of T helper cells are a key component of conceptual schemes to understand the network of interactions controlling the immune response. In this work, using a sequential three-step culture system, we demonstrate that the generation of the T helper cells that participate in ...

journal_title：Transplantation

authors： Pilarski LM,McKenzie IF

更新日期：1985-09-01 00:00:00

abstract：:The benefits of cytomegalovirus (CMV) prophylaxis in preventing the direct effects of CMV infection and disease are well established; however, the impact of exposure to antiviral agents on preventing the indirect effects of CMV infection are poorly defined. This article reviews the results of current studies demonstra...

journal_title：Transplantation

authors： Pescovitz MD

更新日期：2006-07-27 00:00:00

abstract：BACKGROUND:Neonatal primates have been reported to receive pig hearts without hyperacute rejection (HAR). We examined the ontogeny of the anti-pig xenoantibody (XenoAb) and HAR in the neonatal and infant monkeys. METHODS:Twenty-six serum samples from 15 monkeys ages 14-192 days were subjected to hemagglutination titra...

journal_title：Transplantation

authors： Kawauchi M,Nakajima J,Endoh M,Oka T,Takamoto S

更新日期：2000-08-27 00:00:00

abstract：:The mechanism (or mechanisms) underlying the indefinite survival of DBA/2 islet allografts in strongly histoincompatible (C57BL/6xA)F1 (B6AF1) mice, induced either by the combined use of Ficoll-prepared crude islets and treatment of recipients with antilymphocyte serum (ALS), or by the use of handpicked, purified isle...

journal_title：Transplantation

authors： Gotoh M,Porter J,Monaco AP,Maki T

更新日期：1988-02-01 00:00:00

abstract：BACKGROUND:We began a clinical trial in African Americans comparing sirolimus-tacrolimus to standard immunosuppression. We report two African American male living donor kidney recipients who developed acute renal failure after exposure to sirolimus-tacrolimus. METHODS:Both patients received similar doses of sirolimus ...

journal_title：Transplantation

authors： Lawsin L,Light JA

更新日期：2003-01-15 00:00:00

abstract：BACKGROUND:The current shortage of organ donors has led many centers to use marginal and nonheart-beating donors (NHBDs). Recent research has implicated the infiltration of lymphocytes as an important mediator of ischemia-reperfusion injury (IRI). FTY720 is an immunosuppressant that promotes lymphocyte sequestration in...

journal_title：Transplantation

authors： Delbridge MS,Shrestha BM,Raftery AT,El Nahas AM,Haylor JL

更新日期：2007-07-27 00:00:00

abstract：:The aim of this study was to assess the feasibility of detecting anti-HLA antibodies in eluates from needle core biopsies of renal transplants with chronic allograft nephropathy. Two methods of screening, the enzyme-linked immunosorbent assay (ELISA) and flow cytometry (FlowPRA) were compared. Twenty renal transplants...

journal_title：Transplantation

authors： Martin L,Guignier F,Bocrie O,D'Athis P,Rageot D,Rifle G,Justrabo E,Mousson C

更新日期：2005-05-27 00:00:00

abstract：BACKGROUND:Successful pancreatic islet transplantation (PIT) has resulted in several transplant centers wanting to start PIT programs. PIT remains experimental and must be performed safely for its continued use. We describe the radiographic techniques used at our center and their results. METHODS:Between January 17, 2...

journal_title：Transplantation

authors： Goss JA,Soltes G,Goodpastor SE,Barth M,Lam R,Brunicardi FC,Froud T,Alejandro R,Ricordi C

更新日期：2003-07-15 00:00:00

abstract：BACKGROUND:The aim of the study was to assess the incidence of cytomegalovirus (CMV) infection and disease in adult liver transplant recipients, using routine preemptive therapy guided by the pp65 antigenemia test. METHODS:Antigenemia was monitored weekly after liver transplantation (OLTX) for the first 3 months, and ...

journal_title：Transplantation

authors： Kusne S,Grossi P,Irish W,St George K,Rinaldo C,Rakela J,Fung J

更新日期：1999-10-27 00:00:00

abstract：:Immunosuppression with sirolimus and low-dose tacrolimus has facilitated successful clinical islet transplantation (CIT). Because the long-term effects on the kidney are unknown and immunosuppressant drugs can be nephrotoxic, CIT is currently restricted to patients with preserved renal function or a functioning renal ...

journal_title：Transplantation

authors： Senior PA,Shapiro AM,Ackerman TE,Ryan EA,Paty BW,Bhargava R

更新日期：2004-09-27 00:00:00

abstract：BACKGROUND:Clinical trial data suggest that continuous hypothermic machine perfusion (HMP) during the entire preservation period reduces the incidence of delayed graft function and improves graft survival. This study evaluates whether short-term MP after cold storage (CS) is also effective. METHODS:Kidney function aft...

journal_title：Transplantation

authors： Gallinat A,Paul A,Efferz P,Lüer B,Kaiser G,Wohlschlaeger J,Treckmann J,Minor T

更新日期：2012-04-27 00:00:00

abstract：:Patients awaiting a renal transplant were given 1 HLA-DR antigen-matched blood in order to compare the sensitization and graft outcome of these patients with those of control patients, who had been given random blood before transplantation. No differences in sensitization, measured by the formation of HLA antibodies, ...

journal_title：Transplantation

authors： Middleton D,Martin J,Douglas J,McClelland M

更新日期：1994-10-15 00:00:00

abstract：BACKGROUND:Systemic amyloidosis complicated by heart failure is associated with high cardiovascular morbidity and mortality. Heart transplantation for patients with systemic amyloidosis is controversial due to recurrence of disease in the transplanted organ or progression of disease in other organs. METHODS:All patien...

journal_title：Transplantation

authors： Maurer MS,Raina A,Hesdorffer C,Bijou R,Colombo P,Deng M,Drusin R,Haythe J,Horn E,Lee SH,Marboe C,Naka Y,Schulman L,Scully B,Shapiro P,Prager K,Radhakrishnan J,Restaino S,Mancini D

更新日期：2007-03-15 00:00:00

abstract：:Based on a log-linear model for analyzing multiple effects, center variation in the UCLA Transplant Registry is the most influential factor in early renal graft survival. Among 68 active centers accounting for 70% of all transplants between 1985 and 1989, the 1-year graft survival (adjusted for 15 covariates) varied f...

journal_title：Transplantation

authors： Gjertson DW,Terasaki PI

更新日期：1992-02-01 00:00:00

abstract：BACKGROUND:Brain death (BD) affects the viability of lungs for transplantation. A correlation exists between high lung inflammation after BD and the decrease in female sex hormones, especially estradiol. Therefore, we investigated the effects of 17β-estradiol (E2) treatment on the lungs of female brain dead rats. METH...

journal_title：Transplantation

authors： Ricardo-da-Silva FY,Armstrong R Jr,Vidal-Dos-Santos M,Correia CJ,Coutinho E Silva RDS,da Anunciação LF,Moreira LFP,Leuvenink HGD,Breithaupt-Faloppa AC

更新日期：2020-10-07 00:00:00

abstract：BACKGROUND:Many models of transplant tolerance have been found to depend on the induction of regulatory T cells (Tregs). Innate immune signals are known to suppress Tregs thereby augmenting immunity by abrogating Treg function. Such signals may also provide a barrier to transplantation tolerance mediated by Tregs. A nu...

journal_title：Transplantation

authors： Sonawane SB,Kim JI,Lee MK,Lee SH,Duff PE,Moore DJ,Lian MM,Deng S,Choi Y,Yeh H,Caton AJ,Markmann JF

更新日期：2009-11-27 00:00:00

abstract：:Invasive aspergillosis and mucormycosis are life-threatening infections in solid organ and hematopoietic cell transplant recipients. Despite medical advancements in the care of these patients and the availability of new mold-active drugs, the outcomes remain suboptimal. Therefore, there has been increased interest in ...

journal_title：Transplantation

authors： Haidar G,Singh N

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND:There is growing interest in new therapeutic options for the treatment of end-stage liver diseases. In addition to mechanical devices supporting liver function, such as bioreactors, the transplantation of hepatocyte-like cells derived from (adult) stem cells offer great perspectives. We have generated hepato...

journal_title：Transplantation

authors： Ruhnke M,Nussler AK,Ungefroren H,Hengstler JG,Kremer B,Hoeckh W,Gottwald T,Heeckt P,Fandrich F

更新日期：2005-05-15 00:00:00

abstract：INTRODUCTION:This study examines the efficacy and toxicity of sirolimus used as primary immunosuppression in combination with reduced dose tacrolimus (calcineurin inhibitor [CI]-sparing regimen) or mycophenolate mofetil (CI-free regimen) in high-risk cadaveric renal transplantation. METHODS:Seventy subjects were treat...

journal_title：Transplantation

authors： Lo A,Egidi MF,Gaber LW,Amiri HS,Vera S,Nezakatgoo N,Gaber AO

更新日期：2004-04-27 00:00:00

abstract：BACKGROUND:Human herpesvirus-6 (HHV-6) is known to reactivate after renal transplantation and has been associated with several clinical manifestations. Risk factors for sustained viral replication, however, remain unclear. METHODS:Thirty consecutive kidney transplant patients were prospectively followed for HHV-6 repl...

journal_title：Transplantation

authors： Luiz CR,Machado CM,Canto CL,Christ SC,Pestana JO,Kotton CN,Camargo LF

更新日期：2013-03-27 00:00:00

abstract：:The H-Y (male) antigen is detectable on 50% of eight-cell mouse embryos. We show that 82% of the offspring resulting from the transfer of (C57BL/6 X A/J)F1 embryos surviving treatment with H-Y antibody and complement to the uteruses of pseudopregnant mice are female. The increased ratio of female-to-male births indica...

journal_title：Transplantation

authors： Shelton JA,Goldberg EH

更新日期：1984-01-01 00:00:00

abstract：BACKGROUND:The shortage of organs for liver transplantation has forced transplant centers to expand the donor pool by using donors traditionally labeled as marginal. One such example is liver transplantation using a donor with HELLP syndrome (hemolysis, elevated liver enzymes, and low platelets), a disorder of late pre...

journal_title：Transplantation

authors： Briceno PJ,Ortiz JA,Manzarbeitia C,Jeon H,Munoz SJ,Rothstein KD,Araya V,Gala I,Reich DJ

更新日期：2004-01-15 00:00:00

abstract：:The beneficial effect of deoxyspergualin (DSG, NKT-01) on lethal graft-versus-host disease in mice has been studied in a major histoincompatible donor-recipient combination. Suppression of the effector mechanisms responsible for the lethal outcome in this GVHD model is also noted. This study reveals: (1) DSG has a mar...

journal_title：Transplantation

authors： Nemoto K,Hayashi M,Ito J,Sugawara Y,Mae T,Fujii H,Abe F,Fujii A,Takeuchi T

更新日期：1991-03-01 00:00:00

abstract：:FK506 (tacrolimus) is a strong immunosuppressant: it has been approved as a drug for liver transplantation in Japan, the United States, and the United Kingdom. One of its main adverse effects is hyperglycemia. Thus, in this study, we investigated the mechanism and the reversibility of the hyperglycemia caused by FK506...

journal_title：Transplantation

authors： Tamura K,Fujimura T,Tsutsumi T,Nakamura K,Ogawa T,Atumaru C,Hirano Y,Ohara K,Ohtsuka K,Shimomura K

更新日期：1995-06-15 00:00:00

abstract：BACKGROUND:Registry databases offer the statistical power to analyze differences in graft survival rates that may not be detected in randomized clinical trials. This study analyses 2-year graft survival using tacrolimus (tac) or cyclosporine (CsA) with mycophenolate mofetil (MMF) and steroids. METHODS:Data reported to...

journal_title：Transplantation

authors： Bunnapradist S,Daswani A,Takemoto SK

更新日期：2003-07-15 00:00:00

abstract：:This is a short review of tolerance from the point of view of the clinician. Various examples of tolerance occurring in patients and animal models that relate to the clinical experience are described. There may be different mechanisms by which tolerance is achieved, but from the patient's point of view operational tol...

journal_title：Transplantation

authors： Calne RY

更新日期：2004-03-27 00:00:00

abstract：:The aim of this study was to investigate excretion of urinary and pancreatic juice neopterin in patients after combined pancreas-kidney transplantation and to relate it to the clinical course. The study design was a prospective observation study. Thirty consecutive patients with end-stage diabetic disease received a s...

journal_title：Transplantation

authors： Tilg H,Königsrainer A,Krausler R,Aulitzky WE,Margreiter R,Reibnegger G,Wachter H,Huber C

更新日期：1992-04-01 00:00:00