Prope tolerance: the future of organ transplantation--from the laboratory to the clinic.

abstract：BACKGROUND:Xenogeneic corneal fragments (guinea pig) are highly resistant to immune rejection in the anterior chamber of mouse eyes. Because guinea pigs and mice are discordant (i.e., mouse serum normally contains guinea pig reactive xenoantibodies), we wished to determine the extent to which xenogeneic corneal fragmen...

journal_title：Transplantation

authors： Tanaka K,Streilein JW

更新日期：2000-02-27 00:00:00

abstract：BACKGROUND:Recurrent hepatitis C virus (HCV) after liver transplantation (OLT) is a major cause of graft loss in HCV-positive patients. In this study, we evaluated the efficacy and safety of pegylated interferon alfa-2b (peginterferon) and ribavirin treatment for recurrent HCV after OLT and analyzed the influence of an...

journal_title：Transplantation

authors： Neumann U,Puhl G,Bahra M,Berg T,Langrehr JM,Neuhaus R,Neuhaus P

更新日期：2006-07-15 00:00:00

abstract：:In order to better understand the mechanisms of alloimmunization occurring in transplantation, we studied the immune response of an inbred rat strain (WF) to varied presentation of alloantigens (LEW). Hyperimmunized rats acutely reject transplanted allografts and demonstrate direct cytotoxic activity, as well as an ex...

journal_title：Transplantation

authors： Weir MR,Salomon DR,Cohen DJ,Carpenter CB

更新日期：1988-11-01 00:00:00

abstract：:Acute murine cytomegalovirus (MCMV) infection enhances the ability of parental spleen cells to induce graft-vs.-host immunodeficiency (GVHID) in F1 hybrid mice when the two processes occur simultaneously in the recipient. The present study assessed GVHID as the ability of spleen cells to generate in vitro cytotoxic T ...

journal_title：Transplantation

authors： Via CS,Shanley JD,Weatherly BR,Lang P,Shearer GM

更新日期：1988-08-01 00:00:00

abstract：BACKGROUND:Interleukin- (IL) 10 may be a potent regulator for controlling of allograft rejection. A single administration of IL-10 is not effective for controlling graft rejection. Gene transfer is an attractive vehicle for prolonging the expression of short-lived proteins. METHODS:Donor or recipient livers were trans...

journal_title：Transplantation

authors： Tashiro H,Shinozaki K,Yahata H,Hayamizu K,Okimoto T,Tanji H,Fudaba Y,Yamamoto H,Fan X,Ito H,Asahara T

更新日期：2000-07-27 00:00:00

abstract：BACKGROUND:Antigen sensitization alters the use of genes encoding the variable and constant regions of immunoglobulin, changing avidity, and function. Alterations in variable region genes induced by carbohydrate antigens have been studied extensively in animals but are incompletely characterized in humans. We asked how...

journal_title：Transplantation

authors： Yu PB,Parker W,Nayak JV,Platt JL

更新日期：2005-07-15 00:00:00

abstract：:Cell-mediated cytotoxicity directed toward pancreatic islets plays a significant role in the pathogenesis of type 1 diabetes mellitus. Histologically, autoimmune insulitis appears as mononuclear infiltrates that precede actual beta cell loss. Experimental studies by Bartlett et al. on the BB rat model suggest that who...

journal_title：Transplantation

authors： Drachenberg CB,Papadimitriou JC,Weir MR,Klassen DK,Hoehn-Saric E,Bartlett ST

更新日期：1996-12-27 00:00:00

abstract：:Allograft recipients who have preformed antibodies to MHC determinants or develop these antibodies post-transplantation have a higher incidence of cellular rejection and graft loss. It is unclear whether this association is an etiologic one or whether the presence of these antibodies solely identifies individuals with...

journal_title：Transplantation

authors： Hosenpud JD,Shipley GD,Morris TE,Hefeneider SH,Wagner CR

更新日期：1993-02-01 00:00:00

abstract：BACKGROUND:Preemptive kidney transplantation (prior to the institution of dialysis) avoids the morbidity and mortality of dialysis; however, detailed studies of high-risk patients are lacking. The aim of the current study was to compare recent outcomes of preemptive (P) versus nonpreemptive (NP) living donor kidney tra...

journal_title：Transplantation

authors： Innocenti GR,Wadei HM,Prieto M,Dean PG,Ramos EJ,Textor S,Khamash H,Larson TS,Cosio F,Kosberg K,Fix L,Bauer C,Stegall MD

更新日期：2007-01-27 00:00:00

abstract：BACKGROUND:Current desensitization (DES) methods are not always effective. Thus, novel, more effective approaches are desirable. Interleukin (IL)-6 is an attractive target as it promotes B-cell differentiation to plasma cells, is important for immunoglobulin production, and induces Th17 cells. Here, we undertook a phas...

journal_title：Transplantation

authors： Vo AA,Choi J,Kim I,Louie S,Cisneros K,Kahwaji J,Toyoda M,Ge S,Haas M,Puliyanda D,Reinsmoen N,Peng A,Villicana R,Jordan SC

更新日期：2015-11-01 00:00:00

abstract：:Discordant xenogeneic organ transplantation is a potential solution to the critical shortage of suitable donor organs. However, clinical application of xenotransplantation with physiologically suitable organs such as those from the pig, is currently limited by the lack of agents to prevent antibody and complement-medi...

journal_title：Transplantation

authors： Kennedy SP,Rollins SA,Burton WV,Sims PJ,Bothwell AL,Squinto SP,Zavoico GB

更新日期：1994-05-27 00:00:00

abstract：BACKGROUND:Cytomegalovirus (CMV) replication has been associated with more risk for solid organ graft rejection. We wondered whether this association still holds when patients at risk receive prophylactic treatment for CMV. METHODS:We correlated CMV infection, biopsy-proven graft rejection, and graft loss in 1,414 pat...

journal_title：Transplantation

authors： Stern M,Hirsch H,Cusini A,van Delden C,Manuel O,Meylan P,Boggian K,Mueller NJ,Dickenmann M,Members of Swiss Transplant Cohort Study.

更新日期：2014-11-15 00:00:00

abstract：BACKGROUND:The degree of fatty infiltration in hepatic grafts is known to be an important risk factor for primary graft nonfunction in cadaveric liver transplantation. However, the effect of hepatic steatosis in living-donor liver transplantation (LDLT) has not yet been well defined. In this study, we evaluated the imp...

journal_title：Transplantation

authors： Soejima Y,Shimada M,Suehiro T,Kishikawa K,Yoshizumi T,Hashimoto K,Minagawa R,Hiroshige S,Terashi T,Ninomiya M,Shiotani S,Harada N,Sugimachi K

更新日期：2003-07-27 00:00:00

abstract：BACKGROUND:This study analyzes the biochemical, serological, and virological efficacy and the safety of adefovir dipivoxil in patients with renal disturbances. METHODS:Twelve patients with lamivudine-resistant hepatitis B virus (HBV) chronic infection were treated for a median time of 15 (3-19) months. The daily dosag...

journal_title：Transplantation

authors： Fontaine H,Vallet-Pichard A,Chaix ML,Currie G,Serpaggi J,Verkarre V,Varaut A,Morales E,Nalpas B,Brosgart C,Pol S

更新日期：2005-10-27 00:00:00

abstract：:The influence of race on the outcome of cadaver renal transplantation (CRT) continues to be controversial even in the cyclosporine era. The present study examines the effect of race in 343 adult CRT performed from 1/1/82 through 10/1/88 with regard to the incidence of delayed function (DF), graft survival (GS), and pa...

journal_title：Transplantation

authors： Dawidson IJ,Coorpender L,Fisher D,Helderman H,Hull A,Palmer B,Peters P,Sagalowsky A,Sandor ZF,Toto R

更新日期：1990-01-01 00:00:00

abstract：BACKGROUND:Although proportionally more veterans live in rural areas compared to nonveterans, the impact of rurality status on kidney transplantation (KTP) access among veterans is unknown. Our objective was to study KTP rates among veterans listed for KTP and to compare the impact of rurality status on KTP rates among...

journal_title：Transplantation

authors： O'Shea AMJ,Franciscus CL,Kaboli PJ,Kalil RS

更新日期：2019-09-01 00:00:00

abstract：:Mice given a pretransplant i.v. infusion of spleen cells from donors incompatible with the recipients with respect to individual minor H antigens exhibit a delayed rejection of skin grafts from these incompatible donors. Attempts were made to detect suppressor T cells, possibly induced by the i.v. infusion of donor ce...

journal_title：Transplantation

authors： Johnson LL

更新日期：1990-01-01 00:00:00

abstract：BACKGROUND:The genetic modification of pigs is a powerful strategy that may ultimately enable successful xenotransplantation of porcine organs into humans. METHODS:Transgenic pigs were produced by microinjection of gene constructs for human complement regulatory proteins CD55 and CD59 and the enzyme alpha1,2-fucosyltr...

journal_title：Transplantation

authors： Cowan PJ,Aminian A,Barlow H,Brown AA,Chen CG,Fisicaro N,Francis DM,Goodman DJ,Han W,Kurek M,Nottle MB,Pearse MJ,Salvaris E,Shinkel TA,Stainsby GV,Stewart AB,d'Apice AJ

更新日期：2000-06-27 00:00:00

abstract：:The mechanism (or mechanisms) underlying the indefinite survival of DBA/2 islet allografts in strongly histoincompatible (C57BL/6xA)F1 (B6AF1) mice, induced either by the combined use of Ficoll-prepared crude islets and treatment of recipients with antilymphocyte serum (ALS), or by the use of handpicked, purified isle...

journal_title：Transplantation

authors： Gotoh M,Porter J,Monaco AP,Maki T

更新日期：1988-02-01 00:00:00

abstract：BACKGROUND:In an attempt to reduce chronic calcineurin inhibitor induced allograft nephropathy in first cadaver and human leukocyte antigen non-identical living-donor renal transplantation, sirolimus (Siro) or mycophenolate mofetil (MMF) was tested as adjunctive therapy, with planned dose reductions of tacrolimus (Tacr...

journal_title：Transplantation

authors： Ciancio G,Burke GW,Gaynor JJ,Mattiazzi A,Roth D,Kupin W,Nicolas M,Ruiz P,Rosen A,Miller J

更新日期：2004-01-27 00:00:00

abstract：:The recent introduction of a variety of techniques for removing T cells from bone marrow grafts has reduced the incidence of graft-versus-host disease (GVHD)-associated morbidity and mortality. Whether this advance will be translated into improved patient survival is unclear at present, mainly because these procedures...

journal_title：Transplantation

authors： Bunjes D,Heit W,Arnold R,Schmeiser T,Wiesneth M,Carbonell F,Porzsolt F,Raghavachar A,Heimpel H

更新日期：1987-04-01 00:00:00

abstract：:Cultured neonatal rat islets were transplanted across six strain combinations into nonimmunosuppressed allogeneic recipients. Islets were isolated nonenzymatically by an in vitro method and were cultured at 37 degrees C in 5% CO2 in air for 10 days prior to transplant. Transplants to nondiabetic recipients across four...

journal_title：Transplantation

authors： Serie JR,Hegre OD,Eide CR,Weinhaus AJ,Marshall S

更新日期：1987-12-01 00:00:00

abstract：BACKGROUND:New insights into mechanisms of injury in orthotopic liver transplantation (OLT) often come from experiments in small animal models. Mice are particularly suitable because of the growing availability of gene-altered animals and specific antibodies. A validated model of OLT in mice is not available and, in pa...

journal_title：Transplantation

authors： Tian Y,Rüdiger HA,Jochum W,Clavien PA

更新日期：2002-11-15 00:00:00

abstract：:This study focuses upon two discrete components of posttransplant hepatic reticuloendothelial system (RES) function-phagocytosis and killing of bacteria-under various conditions of ischemic preservation. We had previously reported that, following intravenous injection of rats with 51Cr and 125I double-labeled Escheric...

journal_title：Transplantation

authors： Klein AS,Zhadkevich M,Wang D,Margolick JB,Winkelstein JA,Bulkley GB

更新日期：1996-04-27 00:00:00

abstract：BACKGROUND:Recipient antidonor cytotoxic T-cell activity has been associated with graft loss and acute rejection in renal allograft recipients. The role of immunologic mechanisms in the development of chronic graft rejection is controversial. We analyzed all living related renal transplants performed at Children's Hosp...

journal_title：Transplantation

authors： Alexander SI,Younes SB,Yunis JJ,Zurakowski D,Mirza N,Dubey D,Drew MP,Harmon WE,Yunis EJ

更新日期：1997-06-27 00:00:00

abstract：BACKGROUND:Connective tissue growth factor (CTGF) is a key mediator of tissue fibrogenesis in kidney disease. Its involvement in renal allograft fibrosis was recently demonstrated in a mouse model. METHODS:We prospectively studied the association between urinary CTGF (CTGFu) levels and renal allograft fibrosis during ...

journal_title：Transplantation

authors： Metalidis C,van Vuuren SH,Broekhuizen R,Lerut E,Naesens M,Bakker SJ,Wetzels JF,Goldschmeding R,Kuypers DR

更新日期：2013-09-15 00:00:00

abstract：:The United Network for Organ Sharing is poised to resolve geographic disparity in liver transplantation and promote allocation based on medical urgency. At the time of writing, United Network for Organ Sharing is considering redistricting the organ procurement and transplantation network so that patient model for end-...

journal_title：Transplantation

authors： Mehrotra S,Kilambi V,Gilroy R,Ladner DP,Klintmalm GB,Kaplan B

更新日期：2015-02-01 00:00:00

abstract：:Hamster hearts transplanted into stable rat recipients of hamster livers (OLT rats) were hyperacutely rejected after transfer with unaltered rat antihamster hyperimmune serum (HS). This was followed by immediate liver xenograft rejection in 4 of 5 rats. In contrast, simple heat inactivation of the rat HS resulted in p...

journal_title：Transplantation

authors： Valdivia LA,Fung JJ,Demetris AJ,Celli S,Pan F,Tsugita M,Starzl TE

更新日期：1994-03-27 00:00:00

abstract：:Research in hepatocellular gene therapy requires a consistently reproducible cell marker to detect transplanted hepatocytes. We have used a Y-specific genomic DNA probe to accomplish this goal. This technique enables the identification of transplanted male cells in recipient female tissues. Donor hepatocytes from male...

journal_title：Transplantation

authors： Eckert JW,Buerkle CJ,Major AM,Finegold MJ,Brandt ML

更新日期：1995-01-15 00:00:00

abstract：BACKGROUND:The currently used macrolide immunosuppressants, i.e., cyclosporine and tacrolimus, exert considerable nephrotoxicity. We aimed to avoid the nephrotoxic effects by applying a cyclosporine-free regimen for the induction as well as for the maintenance treatment of renal allograft recipients using mycophenolate...

journal_title：Transplantation

authors： Zanker B,Schneeberger H,Rothenpieler U,Hillebrand G,Illner WD,Theodorakis I,Stangl M,Land W

更新日期：1998-07-15 00:00:00