Donor species complement after liver xenotransplantation. The mechanism of protection from hyperacute rejection.

abstract：BACKGROUND:Patients with long-term functioning organ allografts may have developed different mechanisms that explain the lack of graft rejection. However, it is not known how these mechanisms interplay or whether one of them predominates in such situations. METHODS:The authors analyzed the expression of T-cell surface...

journal_title：Transplantation

authors： Alvarez CM,Paris SC,Arango L,Arbelaez M,Garcia LF,RAD B201 study group.

更新日期：2004-11-27 00:00:00

abstract：BACKGROUND:Data on liver transplant (LT) outcomes using deceased donors with heavy drinking (HD) (>2 drinks per day) are scanty. METHODS:Using the United Network for Organ Sharing database (2002-2014), we examined outcomes after LT in adults comparing deceased HD donors with non-HD (ND) donors. RESULTS:Of 56 182 firs...

journal_title：Transplantation

authors： Arora SS,Chahal KS,Axley P,Eckhoff DE,Kuo YF,Satapathy SK,Wiesner R,Singal AK

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND:In kidney transplantation, dynamic prediction of patient and kidney graft survival (DynPG) may help to promote therapeutic alliance by delivering personalized evidence-based information about long-term graft survival for kidney transplant recipients. The objective of the current study is to externally valida...

journal_title：Transplantation

authors： Lenain R,Dantan E,Giral M,Foucher Y,Asar Ö,Naesens M,Hazzan M,Fournier MC

更新日期：2021-02-01 00:00:00

abstract：BACKGROUND:Previous studies showed the feasibility of inducing transplantation tolerance to cadaveric renal allografts in patients given pretransplant total lymphoid irradiation (TLI). Microchimerism has been theorized to be an important or necessary factor in long-term graft acceptance and tolerance in humans. METHOD...

journal_title：Transplantation

authors： Strober S,Benike C,Krishnaswamy S,Engleman EG,Grumet FC

更新日期：2000-04-27 00:00:00

abstract：BACKGROUND:Targeting 2-hr postdose cyclosporine (C2) levels to 1,000 to 1,700 mg/dL during the first 6 months after renal transplantation is recommended for triple immunosuppressive regimens. This trial determines whether lower C2 levels could be targeted safely in de novo kidney transplant recipients under a quadruple...

journal_title：Transplantation

authors： Hardinger KL,Schnitzler MA,Koch MJ,Enkvetchakul D,Desai N,Jendrisak M,Lowell JA,Miller B,Shenoy S,Brennan DC

更新日期：2004-10-27 00:00:00

abstract：BACKGROUND:Both laboratory and clinical studies have shown that dietary lipids may affect immunologic responses. This study was conducted to compare different classes of long-chain unsaturated fatty acids for their effect on allograft survival in animals receiving a donor-specific transfusion and a short course of low-...

journal_title：Transplantation

authors： Alexander JW,Valente JF,Greenberg NA,Custer DA,Ogle CK,Gibson SW,Babcock GF

更新日期：1998-05-27 00:00:00

abstract：BACKGROUND:We previously described a reduced-intensity hematopoietic cell transplantation (HCT) regimen in dog leukocyte antigen (DLA)-haploidentical littermate recipients consisting of 450 cGy total body irradiation (TBI) and anti-CD44 monoclonal antibody (mAb) S5 before and mycophenolate mofetil (MMF)/cyclosporine (C...

journal_title：Transplantation

authors： Fukuda T,Kerbauy FR,Gooley T,Santos EB,Storb R,Sandmaier BM

更新日期：2006-08-15 00:00:00

abstract：:The prevalence of angiographically proven coronary artery disease (CAD) in adults with end-stage liver disease who undergo evaluation for liver transplantation is unknown; also it is unclear if cholestatic liver disease represents an independent risk factor. Patients with end-stage liver disease over age 50 having liv...

journal_title：Transplantation

authors： Carey WD,Dumot JA,Pimentel RR,Barnes DS,Hobbs RE,Henderson JM,Vogt DP,Mayes JT,Westveer MK,Easley KA

更新日期：1995-03-27 00:00:00

abstract：:Although the clinical relevance of endothelial cell-monocyte (E-M) antigens has been demonstrated in organ graft transplantation, very limited data exist describing the nature of these antigens. The current study presents biochemical characterization of three different surface antigens of endothelial cells and monocyt...

journal_title：Transplantation

authors： Wood NL,Schook LB,Studer EJ,Mohanakumar T

更新日期：1988-04-01 00:00:00

abstract：:We have previously demonstrated that liver sinusoidal endothelial cells (LSECs) that endocytose portally injected allogeneic cells exert immunosuppressive effects on T cells with indirect allospecificity. In this study, we have demonstrated that invariant natural killer T cells plays a significant role in such immunos...

journal_title：Transplantation

authors： Shishida M,Ohdan H,Onoe T,Tanaka Y,Igarashi Y,Banshodani M,Asahara T

更新日期：2008-04-15 00:00:00

abstract：BACKGROUND:Neighborhood poverty has been associated with worse outcomes after live donor kidney transplantation (LDKT), and prior work suggests that women with kidney disease may be more susceptible to the negative influence of poverty than men. As such, our goal was to examine whether poverty differentially affects wo...

journal_title：Transplantation

authors： Purnell TS,Luo X,Crews DC,Bae S,Ruck JM,Cooper LA,Grams ME,Henderson ML,Waldram MM,Johnson M,Segev DL

更新日期：2019-10-01 00:00:00

abstract：BACKGROUND:When a deceased-donor kidney is offered to a waitlisted candidate, the decision to accept or decline the organ relies primarily upon a practitioner's experience and intuition. Such decisions must achieve a delicate balance between estimating the immediate benefit of transplantation and the potential for futu...

journal_title：Transplantation

authors： Bertsimas D,Kung J,Trichakis N,Wojciechowski D,Vagefi PA

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND:Acid sphingomyelinase knock-out (ASMKO) mice are a model of types A and B Niemann-Pick disease. In the present study, we evaluated whether bone marrow transplantation (BMT) carried out on newborn ASMKO mice could prevent or alter the Niemann-Pick disease phenotype. METHODS:Previous work from our laboratory ...

journal_title：Transplantation

authors： Miranda SR,Erlich S,Friedrich VL Jr,Haskins ME,Gatt S,Schuchman EH

更新日期：1998-04-15 00:00:00

abstract：:We have tested the effects of FK506 (FK), a new immunosuppressive agent, on a rat limb allograft model. Histoincompatible BN limb allografts were rejected in untreated F344 hosts within 11 +/- 1 days (mean +/- SD) after operation. A single injection of 2 mg/kg, 10 mg/kg, or 50 mg/kg of FK on the day of limb transplant...

journal_title：Transplantation

authors： Arai K,Hotokebuchi T,Miyahara H,Arita C,Mohtai M,Sugioka Y,Kaibara N

更新日期：1989-11-01 00:00:00

abstract：BACKGROUND:Calcineurin-inhibitor therapy is a contributing factor to the origin of interstitial fibrosis and tubular atrophy (IFTA). METHODS:We conducted a prospective randomized trial of conversion of tacrolimus to sirolimus at 1-month posttransplant in kidney transplant recipients on rapid steroid withdrawal. We com...

journal_title：Transplantation

authors： Heilman RL,Cortese C,Geiger XJ,Younan K,Wadei HM,Mai ML,Reddy KS,Gonwa TA

更新日期：2012-01-15 00:00:00

abstract：BACKGROUND:We have previously demonstrated that in a concordant hamster-to-nude rat cardiac transplant model, T-independent specific B-lymphocyte and natural killer (NK)-cell tolerance could be induced, leading to long-term xenograft (Xg) survival. Here, we investigated whether the same could be achieved in a clinicall...

journal_title：Transplantation

authors： Ji P,Xia G,Sefrioui H,Rutgeerts O,Segers C,Waer M

更新日期：1999-07-15 00:00:00

abstract：:We evaluated the influence of dialysis requiring acute tubular necrosis on patient survival, and kidney survival and function in all 182 patients who needed dialysis immediately after transplantation at the University of Minnesota Hospitals. When compared to matched control patients not requiring dialysis, there was n...

journal_title：Transplantation

authors： Brophy D,Najarian JS,Kjellstrand CM

更新日期：1980-03-01 00:00:00

abstract：:There is increasing evidence that various maturational stages of B-cells infiltrate various solid organ transplants undergoing acute rejection. The presence of immature CD20 and mature CD138 plasma cells associate with more aggressive and steroid-recalcitrant graft rejection and portend poor graft outcomes. Though ass...

journal_title：Transplantation

authors： Zarkhin V,Li L,Sarwal M

更新日期：2008-06-27 00:00:00

abstract：:Polyclonal rabbit antirat thymocyte serum (ATS) has been shown to form in situ glomerular immune aggregates following perfusion into normal rat kidney ex vivo. This may be due to the presence of T-cell-like epitopes in the rat kidney, or it may be a result of contaminating anti-connective-tissue antibodies in ATS. To ...

journal_title：Transplantation

authors： Bagchus WM,Donga J,Rozing J,Hoedemaeker PJ,Bakker WW

更新日期：1986-06-01 00:00:00

abstract：:Cyclosporine (CsA) is an immunosuppressive drug requiring dose individualization and regular control due to its highly variable pharmacokinetics. Since gastroparesis may influence the absorption of CsA, a randomized cross-over study was performed to assess the pharmacokinetics and tolerability of a novel microemulsion...

journal_title：Transplantation

authors： van der Pijl JW,Srivastava N,Denouël J,Burggraaf J,Schoemaker RC,van der Woude FJ,Cohen AF

更新日期：1996-08-27 00:00:00

abstract：:Long-term graft survival is mainly influenced by early graft rejection and posttransplant graft function. The ability of both complement-dependent cytotoxicity cross-match (CDC) and flow cytometry cross-match (FCXM) to predict acute rejection episodes has been evaluated by cross-matching 40 patients who received cadav...

journal_title：Transplantation

authors： Utzig MJ,Blümke M,Wolff-Vorbeck G,Lang H,Kirste G

更新日期：1997-02-27 00:00:00

abstract：BACKGROUND:In patients with cytomegalovirus (CMV) disease, regular monitoring of viral loads and treatment until negative are recommended. However, with more sensitive polymerase chain reaction (PCR) assays and cellular peripheral sample types, detection of low-level viremia is achievable. We compared a whole blood rea...

journal_title：Transplantation

authors： Lisboa LF,Asberg A,Kumar D,Pang X,Hartmann A,Preiksaitis JK,Pescovitz MD,Rollag H,Jardine AG,Humar A

更新日期：2011-01-27 00:00:00

abstract：BACKGROUND:Bone complications after hematopoietic stem-cell transplantation (HSCT) are relatively frequent. Evaluation of biomarkers of bone turnover and dual energy x-ray absorptiometry (DEXA) are not known in this context. METHODS:We prospectively evaluated bone mineral density, biomarkers of bone turnover, and the ...

journal_title：Transplantation

authors： Petropoulou AD,Porcher R,Herr AL,Devergie A,Brentano TF,Ribaud P,Pinto FO,Rocha V,Peffault de Latour R,Orcel P,Socié G,Robin M

更新日期：2010-06-15 00:00:00

abstract：:Patients with short-gut syndrome may develop total parenteral nutrition-associated liver disease, which may preclude them from isolated intestinal transplantation and require combined liver and intestinal transplantation. Traditionally, these multiorgan transplantations are performed using en bloc liver and intestinal...

journal_title：Transplantation

authors： Fishbein T,Florman S,Gondolesi G,Decker R

更新日期：2003-02-27 00:00:00

abstract：:In human organ transplantation, the correct diagnosis of rejection may be difficult using clinical and/or histopathologic criteria, and immunologic assays should therefore be considered. We have applied monoclonal antibodies in 2-color flow cytometric (FACS) analysis to study phenotypic patterns of kidney-infiltrating...

journal_title：Transplantation

authors： Tötterman TH,Hanås E,Bergström R,Larsson E,Tufveson G

更新日期：1989-05-01 00:00:00

abstract：BACKGROUND:During allograft rejection, up-regulation of cytokine-inducible nitric oxide synthase (iNOS) leads to the production of large amounts of nitric oxide (NO). The net effect of NO on the alloimmune response is, however, difficult to predict because of its diverse biological effects, which include potentially op...

journal_title：Transplantation

authors： Casey JJ,Wei XQ,Orr DJ,Gracie JA,Huang FP,Bolton EM,Liew FY,Bradley JA

更新日期：1997-08-27 00:00:00

abstract：:Kidney transplantation in elderly patients is a good therapeutic option, but the incidence of infections compared to younger patients must be studied. Case and control study was performed with 40 cases (patients older than 65) and 40 controls (younger than 65) receiving a kidney transplant between January 2000 and Aug...

journal_title：Transplantation

authors： Trouillhet I,Benito N,Cervera C,Rivas P,Cofán F,Almela M,Angeles Marcos M,Puig de la Bellacasa J,Pumarola T,Oppenheimer F,Moreno-Camacho A

更新日期：2005-10-15 00:00:00

abstract：:A retrospective study was performed to identify risk factors affecting the fate of liver allografts transplanted across the ABO barrier. Over a 5-year period, 30 patients received 31 emergency OLTs with ABO-incompatible allografts. One-year graft and patient survival rates were 37.1% and 48.4%, respectively. This grou...

journal_title：Transplantation

authors： Lo CM,Shaked A,Busuttil RW

更新日期：1994-09-15 00:00:00

abstract：BACKGROUND:CD200 delivers immunoregulatory signals following engagement of its receptor, CD200R. A family of CD200Rs (CD200R1-4) has been described. Spleen expresses cell surface CD200R1, while bone marrow shows predominantly expression of cell surface CD200R2/R3. We showed that dendritic cell precursors (DCp) cultured...

journal_title：Transplantation

authors： Gorczynski RM

更新日期：2006-04-15 00:00:00

abstract：BACKGROUND:Long-term acceptance of semi-identical orthotopic liver transplants (OLTs) in inbred swine is induced by a 12-day course of FK506. To study whether acceptance is attributable to central or peripheral immune mechanisms, the effect of complete thymectomy was determined. METHODS:Total thymectomy was performed ...

journal_title：Transplantation

authors： Uryuhara K,Ambiru S,Dehoux JP,Oike F,Talpe S,Gianello P

更新日期：2004-04-27 00:00:00