Limb allografts in rats immunosuppressed with FK506. I. Reversal of rejection and indefinite survival.

abstract：BACKGROUND:Intestinal transplantation is known to be associated with a high risk of early complications and mortality. METHODS:We analyzed prospective data of 51 primary small bowel transplantations from December 1999 to August 2009 and identified perioperative factors that impact on early mortality (≤6 months after t...

journal_title：Transplantation

authors： Dopazo C,Gupte GL,Sharif K,Perera MT,Hartley J,Muiesan P,Mayer DA,Bromley P,Bennett J,Kelly DA,van Mourik I,McKiernan P,Beath SV,Mirza DF

更新日期：2012-10-27 00:00:00

abstract：BACKGROUND:Modification of the aminoacid sequence of peptides derived from the HLA class I heavy chain in combination with computer rational design resulted in the development of a peptide, RDP1258, with enhanced immunosuppressive activity. METHODS:We evaluated the activity of this peptide, analyzing infiltrate by imm...

journal_title：Transplantation

authors： Brouard S,Cuturi MC,Pignon P,Buelow R,Loth P,Moreau A,Soulillou JP

更新日期：1999-06-27 00:00:00

abstract：BACKGROUND:The incidence of stroke and risk factors for different subtypes of cerebrovascular (CBV) events in renal transplant recipients have not been examined in any large prospective controlled trial. METHODS:The Assessment of Lescol in Renal Transplantation was a randomized, double-blind, placebo-controlled study ...

journal_title：Transplantation

authors： Abedini S,Holme I,Fellström B,Jardine A,Cole E,Maes B,Holdaas H,ALERT Study Group.

更新日期：2009-01-15 00:00:00

abstract：:First cadaver, unrelated kidney graft survival at one year from 50 Eurotransplant centers was analyzed and found to show marked changes in survival rates over the 20-year period from 1967 to 1986 inclusive. Full information on HLA-A, -B, and -DR matching and use of cyclosporine therapy was only available for the perio...

journal_title：Transplantation

authors： Thorogood J,van Houwelingen JC,van Rood JJ,Persijn GG

更新日期：1988-11-01 00:00:00

abstract：:To determine if cold preservation time continues to affect renal transplant outcome, prospectively collected data from 17,937 cadaveric renal transplants performed between 1982 and 1991 were analyzed. Cold preservation intervals of 1-16, 16-32, 32-48, and greater than 48 hr were studied by multi- and univariate method...

journal_title：Transplantation

authors： Peters TG,Shaver TR,Ames JE 4th,Santiago-Delpin EA,Jones KW,Blanton JW

更新日期：1995-01-27 00:00:00

abstract：BACKGROUND:Second-set rejection is generally regarded as a phenomenon mainly mediated by humoral cytotoxic antibodies, although a few discordant data have been presented. In the reported experiments, we have taken advantage of the absence of production of specific cytotoxic alloantibodies contrasting with the normal de...

journal_title：Transplantation

authors： Yoshimura R,Chargui J,Aitouche A,Veyron P,Touraine JL

更新日期：2000-04-15 00:00:00

abstract：BACKGROUND:Apoptosis is a well-documented pathway for islet cell death. One potential mechanism is overexpression of death-promoting Bax compared with antiapoptotic Bcl-2 in islets. METHODS:We isolated islets from 10 human pancreata and measured the expression of Bax mRNA and Bcl-2 mRNA by real-time quantitative polym...

journal_title：Transplantation

authors： Thomas D,Yang H,Boffa DJ,Ding R,Sharma VK,Lagman M,Li B,Hering B,Mohanakumar T,Lakey J,Kapur S,Hancock WW,Suthanthiran M

更新日期：2002-12-15 00:00:00

abstract：:Based upon encouraging experimental results, we began employing a synthetic perfusate for cadaver kidney preservation. The new perfusate contains hydroxyethyl starch (HES) as the sole colloid for oncotic support; 107 cadaver kidneys were preserved and transplanted (93 primary, 14 nonprimary) using the HES solution and...

journal_title：Transplantation

authors： Hoffmann RM,Stratta RJ,D'Alessandro AM,Sollinger HW,Kalayoglu M,Pirsch JD,Southard JH,Belzer FO

更新日期：1989-01-01 00:00:00

abstract：:Fine-needle aspiration biopsies were used for clinical monitoring of liver allografts; 21 patients with an inflammatory episode of acute rejection (12.0 +/- 3.3 CIU at the peak) were studied; all episodes were reversible. The inflammatory infiltrate consisted mainly of lymphoid cells, including lymphoid blasts, with i...

journal_title：Transplantation

authors： Lautenschlager I,Höckerstedt K,Salmela K,Isoniemi H,Holmberg C,Jalanko H,Häyry P

更新日期：1990-11-01 00:00:00

abstract：:Chronic graft-versus-host disease often results in a combined deficiency of humoral and cell-mediated immunity. Clinical and experimental studies have suggested that the decrease in B cell responsiveness is due to a failure of B cell production in the bone marrow, intrinsic B cell defects, excessive suppressor T cell ...

journal_title：Transplantation

authors： Schreiber KL,Forman J

更新日期：1993-03-01 00:00:00

abstract：BACKGROUND:In this report, we compare the long-term outcome of pediatric liver transplantation (LTx) patients maintained with tacrolimus-based and with cyclosporine (CsA)-based immunosuppressive therapy. We examine long-term patient and graft survival, the incidence of rejection, and immunosuppression-related complicat...

journal_title：Transplantation

authors： Jain A,Mazariegos G,Kashyap R,Green M,Gronsky C,Starzl TE,Fung J,Reyes J

更新日期：2000-08-27 00:00:00

abstract：:In order to understand in more detail the role of endogenous interleukin 1 receptor antagonist (IL-1ra) during bone marrow transplantation, IL-1ra serum levels of 28 patients undergoing allogeneic (n=25) or autologous (n=3) bone marrow transplantation were measured with a commercially available ELISA. In addition, the...

journal_title：Transplantation

authors： Schwaighofer H,Oberhuber G,Hebart H,Einsele H,Herold M,Nachbaur D,Eibl B,Tilg H,Kropshofer G,Ferrara JL,Niederwieser D

更新日期：1997-01-15 00:00:00

abstract：BACKGROUND:Rising numbers of patients reaching end-stage kidney disease intensify the demand for expansion of the living-kidney-donor pool. On the basis of low risk in white donors with essential hypertension, our transplant center undertook a structured program of accepting hypertensive donors if kidney function and u...

journal_title：Transplantation

authors： Textor SC,Taler SJ,Driscoll N,Larson TS,Gloor J,Griffin M,Cosio F,Schwab T,Prieto M,Nyberg S,Ishitani M,Stegall M

更新日期：2004-07-27 00:00:00

abstract：BACKGROUND:Hyperacute rejection (HAR) of pig-to-primate discordant xenografts is caused by the deposition of preexisting natural antibodies that recognize Galalpha1-3Gal (alphaGal)-terminating oligosaccharides on glycoproteins and glycolipids, followed by complement-mediated lysis of the graft's endothelium. In vitro, ...

journal_title：Transplantation

authors： Simon PM,Neethling FA,Taniguchi S,Goode PL,Zopf D,Hancock WW,Cooper DK

更新日期：1998-02-15 00:00:00

abstract：:The effect of the quinoline-3-carboxamide LS-2616 (Linomide), given alone or together with cyclosporine, was studied in the first set cardiac allograft transplantation model in the rat. PVG rat hearts were transplanted heterotopically to Wistar/Kyoto rat recipients on day 0. The recipients were given LS-2616 orally on...

journal_title：Transplantation

authors： Wanders A,Larsson E,Gerdin B,Tufveson G

更新日期：1989-02-01 00:00:00

abstract：:Graft rejection remains an important cause of renal allograft failure, despite improvements in immunosuppression and HLA typing. Although HLA matching is beneficial, ensuring an exact match it is often impractical. Thus, a reliable in vitro method for quantitating and qualitating alloreactivity is an important goal. I...

journal_title：Transplantation

authors： Kaminski ER,Kaminski A,Bending MR,Chang R,Heads A,Szydlo RM,Pereira RS

更新日期：1995-10-15 00:00:00

abstract：BACKGROUND:Sensitization to human leukocyte antigens (HLA) is a significant barrier to transplantation. Currently, no proven therapy exists to improve access to transplantation for highly sensitized patients. Here, we report a novel approach using intravenous immune globulin to modulate anti-HLA antibody and improve th...

journal_title：Transplantation

authors： Jordan SC,Vo A,Bunnapradist S,Toyoda M,Peng A,Puliyanda D,Kamil E,Tyan D

更新日期：2003-08-27 00:00:00

abstract：BACKGROUND:Recently published pediatric trial of Rituximab for the treatment of CD20+ acute renal allograft rejection (AR) demonstrated transient depletion of circulating/intragraft B cells (Zarkhin et al., Am J Transplant 2008; 8: 2607). In this study, we have evaluated phenotypic definition of circulating B-cell subs...

journal_title：Transplantation

authors： Zarkhin V,Lovelace PA,Li L,Hsieh SC,Sarwal MM

更新日期：2011-05-15 00:00:00

abstract：BACKGROUND:New insights into mechanisms of injury in orthotopic liver transplantation (OLT) often come from experiments in small animal models. Mice are particularly suitable because of the growing availability of gene-altered animals and specific antibodies. A validated model of OLT in mice is not available and, in pa...

journal_title：Transplantation

authors： Tian Y,Rüdiger HA,Jochum W,Clavien PA

更新日期：2002-11-15 00:00:00

abstract：BACKGROUND:Patients with high tacrolimus clearance eliminate more drug within a dose interval compared with those with low clearance. Delays in dosing time will result in transient periods of lower concentrations in high versus low clearance patients. Transient subtherapeutic tacrolimus concentrations may induce acute ...

journal_title：Transplantation

authors： Egeland EJ,Robertsen I,Hermann M,Midtvedt K,Størset E,Gustavsen MT,Reisæter AV,Klaasen R,Bergan S,Holdaas H,Hartmann A,Åsberg A

更新日期：2017-08-01 00:00:00

abstract：:This study investigates the possibility that the active enhancing properties of bone marrow (BM) cells may be related to Ia-like determinants on their surface membranes. Less chromium was released on a cell per cell basis from nucleated baboon BM cells used as targets in complement-dependent cytotoxicity than from lab...

journal_title：Transplantation

authors： Smit JA,Myburgh JA,Gaillard VJ

更新日期：1978-08-01 00:00:00

abstract：:The generation of Gal knockout (KO) pigs is likely to be an important advance in xenotransplantation. However, recent reports suggesting that expression of Gal may not be completely eliminated raise the possibility of a continuing anti-Gal immune response. The authors used a Gal-mismatched skin graft model to study ce...

journal_title：Transplantation

authors： Gock H,Murray-Segal L,Salvaris E,Cowan P,D'Apice AJ

更新日期：2004-03-15 00:00:00

abstract：BACKGROUND:The present study was undertaken to determine whether anti-complement 5 (C5) monoclonal antibodies (mAb) prevent hyperacute rejection (HAR) in a rat-to-presensitized mouse heart transplantation model and whether these mAb, combined with cyclosporine (CsA) and cyclophosphamide (CyP), can achieve long-term gra...

journal_title：Transplantation

authors： Wang H,Rollins SA,Gao Z,Garcia B,Zhang Z,Xing J,Li L,Kellersmann R,Matis LA,Zhong R

更新日期：1999-12-15 00:00:00

abstract：BACKGROUND:A previous donor intervention trial found that induction of mild therapeutic hypothermia in the brain-dead donor reduced the dialysis requirement after kidney transplantation. Consequences on the performance of cardiac allografts after transplantation were not explored to date. METHODS:Cohort study investig...

journal_title：Transplantation

authors： Schnuelle P,Benck U,Krämer BK,Yard BA,Zuckermann A,Wagner F,Szabo G,Borggrefe M,Karck M,Gummert J

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND:The purpose of this study was to examine the utility of the random urine protein to creatinine ratio (P/C) in evaluation and longitudinal management of proteinuria in adult renal transplant recipients with or without overt nephropathy in an outpatient clinic. METHODS:A total of 289 adult renal transplant re...

journal_title：Transplantation

authors： Torng S,Rigatto C,Rush DN,Nickerson P,Jeffery JR

更新日期：2001-10-27 00:00:00

abstract：:Several studies have reported the development of antiidiotypic antibodies to anti-HLA alloantibodies in renal allograft transplant recipients, postulating their potential beneficial role in allograft survival. In order to evaluate the role of anti-HLA antiidiotypic antibodies in human liver transplant recipients and t...

journal_title：Transplantation

authors： Chauhan B,Phelan DL,Marsh JW,Mohanakumar T

更新日期：1993-08-01 00:00:00

abstract：BACKGROUND:Although inactivated vaccines are recommended for immunocompromized patients, efficacy and safety of diphtheria and tetanus immunization in renal transplant recipients have received little attention so far. The aim of the study was to investigate the response to a standard diphtheria and tetanus booster vacc...

journal_title：Transplantation

authors： Enke BU,Bökenkamp A,Offner G,Bartmann P,Brodehl J

更新日期：1997-07-27 00:00:00

abstract：:When normal mice are exposed for short periods to ultraviolet light (UV), they support the progressive growth of transplanted syngeneic UV-induced tumors. Normal nonirradiated mice almost always reject these tumor implants. The UV-mediated suppression of the antitumor response can be adoptively transferred to normal s...

journal_title：Transplantation

authors： Spellman CW,Daynes RA

更新日期：1977-08-01 00:00:00

abstract：BACKGROUND:Donor-derived cell-free DNA (dd-cfDNA) is a potential noninvasive molecular marker of graft rejection after kidney transplant, whose diagnostic accuracy remains controversial. METHODS:We performed a systematic review and meta-analysis to evaluate the diagnostic accuracy of dd-cfDNA. Relevant literature was ...

journal_title：Transplantation

authors： Xiao H,Gao F,Pang Q,Xia Q,Zeng X,Peng J,Fan L,Liu J,Wang Z,Li H

更新日期：2020-09-02 00:00:00

abstract：:Zero-time kidney biopsies, obtained at time of transplantation, are performed in many transplant centers worldwide. Decisions on kidney discard, kidney allocation, and choice of peritransplant and posttransplant treatment are sometimes based on the histological information obtained from these biopsies. This comprehens...

journal_title：Transplantation

authors： Naesens M

更新日期：2016-07-01 00:00:00