Phenotypic evaluation of B-cell subsets after rituximab for treatment of acute renal allograft rejection in pediatric recipients.

abstract：:EBVirus-associated B cell lymphoproliferative disorder (BLPD) is a recognized complication of primary immunodeficiency and organ as well as bone marrow transplantation. Although the nature of the immune defects that predispose to the development of BLPD are unknown, it is postulated that aberrant T cell responses are ...

journal_title：Transplantation

authors： Mathur A,Kamat DM,Filipovich AH,Steinbuch M,Shapiro RS

更新日期：1994-04-15 00:00:00

abstract：:The incidence of interstitial pneumonitis (IP) was reviewed in 70 consecutive patients who received autologous marrow transplants for hematologic malignancies. All patients were treated with total-body irradiation (TBI), with or without other chemotherapeutic agents. Seven patients (10%) developed IP, 3 were due to cy...

journal_title：Transplantation

authors： Pecego R,Hill R,Appelbaum FR,Amos D,Buckner CD,Fefer A,Thomas ED

更新日期：1986-11-01 00:00:00

abstract：:The survival of semiallogeneic or fully allogeneic rat kidney allografts was prolonged in some strain combinations with immune complexes formed with hapten-conjugated alloantigens (TNP-Ag) of donor origin and a mouse monoclonal antihapten antibody (anti-TNP). Complexes were administered i.v. at the time of operation--...

journal_title：Transplantation

authors： Barber WH,Hutchinson IV,Morris PJ

更新日期：1983-11-01 00:00:00

abstract：BACKGROUND:The potential benefits of islet xenografting in type 1 diabetes include the intriguing, but still unanswered, possibility that the grafted xenoislets may be less subjected to human autoimmune attack. Cytokines may play a major role in the pathogenesis of autoimmune diabetes by causing impairment of insulin r...

journal_title：Transplantation

authors： Piro S,Lupi R,Dotta F,Patanè G,Rabuazzo MA,Marselli L,Santangelo C,Realacci M,Del Guerra S,Purrello F,Marchetti P

更新日期：2001-01-15 00:00:00

abstract：BACKGROUND:Induction immunosuppressive therapy with the anti-T-cell antibody Thymoglobulin decreases the incidence of acute rejection in adult kidney transplant (KTx) recipients, but limited data are available for pediatric KTx recipients. METHODS:We conducted a historical cohort study to compare rates of survival, re...

journal_title：Transplantation

authors： Khositseth S,Matas A,Cook ME,Gillingham KJ,Chavers BM

更新日期：2005-04-27 00:00:00

abstract：:Patients who require cystectomy are usually treated with an ileal conduit or intestinal neobladder for urinary control. In some of them, however, the bowel segment cannot be used because of previous abdominal surgery or radiation treatment. Bladder transplantation from cadavers may be beneficial to these patients, if ...

journal_title：Transplantation

authors： Takeuchi K,Takechi S,Ohoka H,Yokoyama M,Iwata H,Takeuchi M,Matsuda S

更新日期：1997-04-15 00:00:00

abstract：:Orthotopic liver allografts from BN donors to LEW recipients are spontaneously accepted, and the recipients develop donor-specific immunological unresponsiveness. This unresponsiveness may be mediated by suppressor T cells. Immunomagnetically purified splenic T cells from LEW rats bearing BN liver grafts were shown to...

journal_title：Transplantation

authors： Gassel HJ,Hutchinson IV,Engemann R,Morris PJ

更新日期：1992-12-01 00:00:00

abstract：BACKGROUND:In the United States, 1 in 10 infants and 1 in 20 older children die on the liver transplant waiting list. Increasing split liver transplantation could increase organ availability for these children, without decreasing transplants in adults. METHODS:Using United Network for Organ Sharing Standard Transplant...

journal_title：Transplantation

authors： Perito ER,Roll G,Dodge JL,Rhee S,Roberts JP

更新日期：2019-03-01 00:00:00

abstract：BACKGROUND:Bone marrow transplantation (BMT) is effective treatment for many hematologic disease, but performed in a population with a high endemic hepatitis B virus carrier rate, the incidence of liver function impairment and fulminant hepatitis (FH) is expected to be raised. METHODS:Forty-three hepatitis B virus car...

journal_title：Transplantation

authors： Chen PM,Chiou TJ,Fan FS,Liu JM,Hsieh RK,Yen CC,Wang WS,Liu JH

更新日期：1999-06-15 00:00:00

abstract：BACKGROUND:Urologic complications cause substantial morbidity in the pediatric population after renal transplantation, but their impact on graft survival and transplant costs is poorly understood. In this retrospective review, we evaluated the records of all pediatric renal transplant recipients at our center from 1995...

journal_title：Transplantation

authors： Englesbe MJ,Lynch RJ,Heidt DG,Thomas SE,Brooks M,Dubay DA,Pelletier SJ,Magee JC

更新日期：2008-12-15 00:00:00

abstract：BACKGROUND:The deleterious effect of steatosis on transplanted livers is mainly related to a microcirculation impairment. We investigated the effect of preservation duration on the recovery of isolated perfused rat steatotic livers and tested the effect of pentoxifylline (PTX), known to have a beneficial effect on hepa...

journal_title：Transplantation

authors： Arnault I,Bao YM,Sebagh M,Anjo A,Dimicoli JL,Lemoine A,Delvart V,Adam R

更新日期：2003-07-15 00:00:00

abstract：BACKGROUND:Increasing long-term allograft survival is the main challenge in organ transplantation, and allograft loss due to chronic rejection has been found to correlate with episodes of early acute rejection. It is important to understand the mechanisms that maintain the donor-specific hyporesponsive state. This stud...

journal_title：Transplantation

authors： Mittal SK,Sharma RK,Gupta A,Naik S

更新日期：2009-08-15 00:00:00

abstract：BACKGROUND:Progressively better therapies have largely prevented or at least effectively treated acute allograft rejection. Consequently, the long-term survival of solid organ transplants has increasingly become limited primarily by the development of chronic allograft rejection. The mechanisms of chronic rejection rem...

journal_title：Transplantation

authors： Heslan JM,Renaudin K,Thebault P,Josien R,Cuturi MC,Chiffoleau E

更新日期：2006-11-15 00:00:00

abstract：BACKGROUND:To investigate immune reactions after reduced-intensity cord-blood transplantation (RI-CBT). MATERIALS AND METHODS:We reviewed medical records of 57 adult RI-CBT recipients. Preparative regimen comprised fludarabine, total-body irradiation, and either melphalan (n=51) or busulfan (n=6). Graft-versus-host di...

journal_title：Transplantation

authors： Kishi Y,Kami M,Miyakoshi S,Kanda Y,Murashige N,Teshima T,Kusumi E,Hara S,Matsumura T,Yuji K,Masuoka K,Wake A,Morinaga S,Kanemaru M,Hayashi T,Tanaka Y,Taniguchi S,Tokyo Stem Cell Transplant Consortium.

更新日期：2005-07-15 00:00:00

abstract：BACKGROUND:This study evaluated zoom endoscopic findings according to four components in comparison with the histologic findings of acute cellular rejection (ACR) in a living-related small bowel transplantation (SBTx) patient. METHODS:A 16-year-old boy with microvillus inclusion disease underwent SBTx with a 150-cm-lo...

journal_title：Transplantation

authors： Sasaki T,Hasegawa T,Nakai H,Kimura T,Okada A,Musiake S,Doi R

更新日期：2002-02-27 00:00:00

abstract：BACKGROUND:Alpha-glutathione-S-transferase (alphaGST) has been suggested as a sensitive marker of acute cellular rejection in liver transplantation. This study evaluated the usefulness of alphaGST as a marker of acute rejection in comparison with standard liver function tests. METHODS:Daily measurements of liver funct...

journal_title：Transplantation

authors： Nagral A,Butler P,Sabin CA,Rolles K,Burroughs AK

更新日期：1998-02-15 00:00:00

abstract：:Several approaches have been attempted to manage renal allograft dysfunction in cyclosporine-prednisone (CsA-Pred)-treated patients. Conversion to conventional therapy and perioperative triple drug have been associated with high rates of acute rejection episodes, infections, or neoplasms. We report our experience in d...

journal_title：Transplantation

authors： Pascual J,Marcén R,Orofino L,Quereda C,Mampaso F,Liaño F,Ortuño J

更新日期：1991-08-01 00:00:00

abstract：:An increased frequency of kidney rejection has been reported in diabetic patients who have simultaneous pancreas and kidney transplantation compared with patients who have a kidney transplant alone. Kidney graft outcome is similar in the two groups. The mechanism for increased kidney graft rejection with a simultaneou...

journal_title：Transplantation

authors： Carroll PB,Ricordi C,Shapiro R,Rilo HR,Fontes P,Scantlebury V,Irish W,Tzakis AG,Starzl TE

更新日期：1993-04-01 00:00:00

abstract：BACKGROUND:We have previously shown that both thymic immigrants (graft to thymus pathway) and thymic emigrants (thymus to graft pathway) are involved in tolerance to renal allografts in miniature swine treated with a short course of calcineurin inhibitors. This study investigates the role of these pathways in cardiac t...

journal_title：Transplantation

authors： Yamamoto S,Teranishi K,Kamano C,Samelson-Jones E,Arakawa H,Nobori S,Okumi M,Houser S,Shimizu A,Sachs DH,Yamada K

更新日期：2006-02-27 00:00:00

abstract：BACKGROUND:Spontaneous tolerance to liver allograft has been reported previously in outbred pig models, but the lack of genetic background did not allow to analyze the impact of the major histocompatibility complex (MHC) on tolerance induction. A model of semi-identical liver allograft was therefore developed in inbred...

journal_title：Transplantation

authors： Oike F,Talpe S,Otsuka M,Dehoux JP,Lerut J,Otte JB,Gianello P

更新日期：2000-06-15 00:00:00

abstract：BACKGROUND:Donor T cells are primarily responsible for graft-versus-host disease (GVHD). Three effector pathways have been described for T-cell cytotoxicity: granzyme B/perforin, Fas/Fas ligand (FasL), and secreted molecules such as tumor necrosis factor (TNF)-alpha. Therefore, this study evaluates the gene expression ...

journal_title：Transplantation

authors： Jaksch M,Remberger M,Mattsson J

更新日期：2004-01-27 00:00:00

abstract：:The mode of action of glucocorticosteroids as immunosuppressive and antiinflammatory agents is not fully understood. Glucocorticosteroids block synthesis of interleukin 1 by interfering with the transcription of the IL-1 beta gene. Glucocorticosteroids may also induce rapid degradation of IL-1 mRNA. In the presence of...

journal_title：Transplantation

authors： Zanker B,Walz G,Wieder KJ,Strom TB

更新日期：1990-01-01 00:00:00

abstract：:Adult bone marrow-derived mesenchymal stem cells (MSCs) are multipotential cells capable of regenerating injured tissues. In addition to their multipotency, MSCs inhibit natural killer cell cytotoxicity and T-lymphocyte alloproliferation. Several immunosuppressive mechanisms have been described, including indoleamine ...

journal_title：Transplantation

authors： Selmani Z,Naji A,Gaiffe E,Obert L,Tiberghien P,Rouas-Freiss N,Carosella ED,Deschaseaux F

更新日期：2009-05-15 00:00:00

abstract：:The case studies of four patients with post-transplantation calcinosis are presented. Three of the four patients died of inanition and sepsis secondary to infection of extensive soft tissue ulcers and diffuse cutaneous vascular calcification with gangrene. The fourth patient survived following removal of all four para...

journal_title：Transplantation

authors： Perloff LJ,Spence RK,Grossman RA,Barker CF

更新日期：1979-01-01 00:00:00

abstract：BACKGROUND:Infectious complications still represent a major cause of morbidity and mortality in patients with organ transplantation. In particular, small bowel or multivisceral transplantation is complicated to a greater extent than other grafts as a consequence of infectious complications including sepsis. METHODS:Th...

journal_title：Transplantation

authors： Guaraldi G,Cocchi S,Codeluppi M,Di Benedetto F,De Ruvo N,Masetti M,Venturelli C,Pecorari M,Pinna AD,Esposito R

更新日期：2005-12-27 00:00:00

abstract：BACKGROUND:Previous studies have demonstrated that long-term tolerance of class I mismatched renal allografts in miniature swine is induced by a short course of cyclosporine (CyA), and that a total thymectomy 21 days before transplantation abrogates the induction of stable tolerance. We have now examined the effects of...

journal_title：Transplantation

authors： Yamada K,Ierino FL,Gianello PR,Shimizu A,Colvin RB,Sachs DH

更新日期：1999-04-27 00:00:00

abstract：:The effect of protein depletion on immune responsiveness was examined using a skin allograft model. Protein depletion was induced in adult Fischer (F344) male rats by the ad libitum provision of a 5% protein diet. Total serum protein, total body weight, total body nitrogen, and total body lipid were all markedly decre...

journal_title：Transplantation

authors： Austin EH,Brennan MF,Rosenberg SA

更新日期：1980-09-01 00:00:00

abstract：BACKGROUND:The long-term metabolic function of microencapsulated xenogeneic adult porcine islets (API) was assessed in a murine model of type 1 diabetes mellitus. METHODS:API were encapsulated in barium-gelled alginate and transplanted intraperitoneally in diabetic nonobese diabetic (NOD) mice given no immunosuppressi...

journal_title：Transplantation

authors： Cui H,Tucker-Burden C,Cauffiel SM,Barry AK,Iwakoshi NN,Weber CJ,Safley SA

更新日期：2009-07-27 00:00:00

abstract：BACKGROUND:Recently, methylxanthines such as pentoxifylline (PTX) were shown to be immunosuppressive in vitro. Unfortunately, when used in transplant patients, PTX was poorly active as an immunosuppressant. Here we report that the new methylxanthine derivative A802715 not only is more active than PTX, it also suppresse...

journal_title：Transplantation

authors： Lin Y,Goebels J,Rutgeerts O,Kasran A,Van Gool S,Ceuppens J,Schönharting M,Waer M

更新日期：1997-06-27 00:00:00

abstract：:Pretreatment of LEW rats with cyclosporin A (10 mg/kg/day orally for 14 days) plus 10(8) DA or (DA X LEW)F1 spleen lymphocytes on two occasions markedly prolonged the survival of subsequent DA renal allografts. The lymphocytotoxic antibody response was suppressed completely and renal biopsies showed a marked mononucle...

journal_title：Transplantation

authors： Homan WP,Williams KA,Millard PR,Morris PJ

更新日期：1981-06-01 00:00:00